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UniProtKB - Q9NRD5 (PICK1_HUMAN)

Entry version 190 (02 Dec 2020)
Sequence version 2 (02 Aug 2002)
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Protein

PRKCA-binding protein

Gene

PICK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi44ZincBy similarity1
Metal bindingi46ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NRD5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-202733, Cell surface interactions at the vascular wall
R-HSA-416993, Trafficking of GluR2-containing AMPA receptors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NRD5

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NRD5

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q9NRD5, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PRKCA-binding protein
Alternative name(s):
Protein interacting with C kinase 1
Protein kinase C-alpha-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PICK1
Synonyms:PRKCABP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000100151.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:9394, PICK1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605926, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NRD5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Membrane, Synapse, Synaptosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi27 – 28KD → AA: Abolishes interaction with other proteins, but not with itself. 3 Publications2
Mutagenesisi27K → E: Abolishes interaction with GRIA2, but not with PRKCA. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		9463

MalaCards human disease database

More...MalaCardsi		PICK1

Open Targets

More...OpenTargetsi		ENSG00000100151

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		171709, Male infertility due to globozoospermia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33760

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NRD5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PICK1

Domain mapping of disease mutations (DMDM)

More...DMDMi		22095990

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000584271 – 415PRKCA-binding proteinAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei82Phosphothreonine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi413S-palmitoyl cysteine; by DHHC8By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.1 Publication
Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD).By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NRD5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NRD5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NRD5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NRD5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NRD5

PeptideAtlas

More...PeptideAtlasi		Q9NRD5

PRoteomics IDEntifications database

More...PRIDEi		Q9NRD5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82339 [Q9NRD5-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NRD5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NRD5

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9NRD5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100151, Expressed in adenohypophysis and 172 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NRD5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NRD5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100151, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer.

Interacts with CXADR.

Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2.

Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR.

Interacts with UNC5A.

Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner.

Interacts with F-actin and associates with the ARP2/3 complex.

Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9NRD5
With#Exp.IntAct
ABT1 [Q9ULW3]3EBI-79165,EBI-2602396
AEBP2 - isoform 2 [Q6ZN18-2]3EBI-79165,EBI-10255023
AKT2 [P31751]3EBI-79165,EBI-296058
ALKBH8 - isoform 2 [Q96BT7-2]3EBI-79165,EBI-13329511
AP1M1 [Q9BXS5]3EBI-79165,EBI-541426
AP1S1 - isoform 2 [P61966-2]3EBI-79165,EBI-12067760
ARHGEF3 [Q9NR81]3EBI-79165,EBI-10312733
ARHGEF5 [Q12774]3EBI-79165,EBI-602199
ARL6IP1 [Q15041]3EBI-79165,EBI-714543
ARMCX1 [Q9P291]3EBI-79165,EBI-2843626
ASIC1 [P78348]3EBI-79165,EBI-79189
ASIC2 [Q16515]3EBI-79165,EBI-79149
ATP5IF1 [Q9UII2]3EBI-79165,EBI-718459
AVPI1 [Q5T686]3EBI-79165,EBI-8640233
BAHD1 [Q8TBE0]3EBI-79165,EBI-742750
BCL2L14 [Q9BZR8]3EBI-79165,EBI-1385773
BEX1 [Q9HBH7]3EBI-79165,EBI-7162175
BLK [P51451]3EBI-79165,EBI-2105445
BLOC1S2 [Q6QNY1]3EBI-79165,EBI-465872
BOLA3 [Q53S33]3EBI-79165,EBI-12086950
BRD1 [O95696]3EBI-79165,EBI-714754
BUD31 [P41223]3EBI-79165,EBI-3904603
BYSL [Q13895]3EBI-79165,EBI-358049
C2CD5 - isoform 2 [Q86YS7-2]3EBI-79165,EBI-12380221
C4orf46 [Q504U0]3EBI-79165,EBI-6657981
C8orf33 [Q9H7E9]3EBI-79165,EBI-715389
CARD9 - isoform 2 [Q9H257-2]3EBI-79165,EBI-11530605
CBX8 [Q9HC52]3EBI-79165,EBI-712912
CCDC102B [Q68D86]3EBI-79165,EBI-10171570
CCDC103 [Q8IW40]3EBI-79165,EBI-10261970
CCNH [P51946]3EBI-79165,EBI-741406
CDC42EP2 [O14613]3EBI-79165,EBI-3438291
CDC73 [Q6P1J9]3EBI-79165,EBI-930143
CDCA7L [Q96GN5]3EBI-79165,EBI-5278764
CDK2AP1 [O14519]3EBI-79165,EBI-1052532
CDKL3 [Q8IVW4]3EBI-79165,EBI-3919850
CDKN2B [P42772]3EBI-79165,EBI-711280
CDKN2D [P55273]3EBI-79165,EBI-745859
CEP19 [Q96LK0]3EBI-79165,EBI-741885
CEP290 [O15078]3EBI-79165,EBI-1811944
CEP57L1 [Q8IYX8]3EBI-79165,EBI-1104570
CEP89 - isoform 3 [Q96ST8-3]3EBI-79165,EBI-11144046
CEP95 [Q96GE4]3EBI-79165,EBI-372775
CGGBP1 [Q9UFW8]3EBI-79165,EBI-723153
CHMP1B [Q7LBR1]3EBI-79165,EBI-2118090
COIL [P38432]3EBI-79165,EBI-945751
CPNE2 [Q96FN4]3EBI-79165,EBI-7097057
CPNE7 - isoform 2 [Q9UBL6-2]3EBI-79165,EBI-12012272
CRY2 [Q49AN0]3EBI-79165,EBI-2212355
CSNK2A2 [P19784]5EBI-79165,EBI-347451
CTSG [P08311]3EBI-79165,EBI-5462635
CUTC [Q9NTM9]3EBI-79165,EBI-714918
CWF19L2 [Q2TBE0]3EBI-79165,EBI-5453285
CYP21A2 [Q08AG9]3EBI-79165,EBI-14156412
DCTD [P32321]3EBI-79165,EBI-739870
DCUN1D5 [Q9BTE7]3EBI-79165,EBI-3924013
DDX55 [Q8NHQ9]3EBI-79165,EBI-5459844
DDX6 [P26196]3EBI-79165,EBI-351257
DMC1 [Q14565]3EBI-79165,EBI-930865
DMD [P11532]3EBI-79165,EBI-295827
DNAJB13 [P59910]3EBI-79165,EBI-11514233
DNTTIP1 [Q9H147]3EBI-79165,EBI-2795449
DNTTIP2 [Q5QJE6]3EBI-79165,EBI-5666736
DPF2 [Q92785]3EBI-79165,EBI-359932
DRAP1 [Q14919]3EBI-79165,EBI-712941
DTNB - isoform 5 [O60941-5]3EBI-79165,EBI-11984733
DUPD1 [Q68J44]3EBI-79165,EBI-1054321
EAF1 [Q96JC9]3EBI-79165,EBI-769261
EEF2KMT [Q96G04]3EBI-79165,EBI-747840
EFHC2 [Q5JST6]3EBI-79165,EBI-2349927
EHHADH [Q08426]3EBI-79165,EBI-2339219
EIF1AD [Q8N9N8]3EBI-79165,EBI-750700
EIF3D [O15371]3EBI-79165,EBI-353818
EIF4A3 [P38919]3EBI-79165,EBI-299104
EIF4EBP1 [Q13541]3EBI-79165,EBI-74090
EIF4H - isoform Short [Q15056-2]3EBI-79165,EBI-12222405
EIF5A [P63241]3EBI-79165,EBI-373150
ENKD1 [Q9H0I2]3EBI-79165,EBI-744099
EPM2AIP1 [Q7L775]3EBI-79165,EBI-6255981
ESCO2 [Q56NI9]3EBI-79165,EBI-3951849
EXOSC5 [Q9NQT4]3EBI-79165,EBI-371876
FAM161A [Q3B820]3EBI-79165,EBI-719941
FAM161B [Q96MY7]3EBI-79165,EBI-7225287
FAM207A [Q9NSI2]3EBI-79165,EBI-5457304
FAM214B [Q7L5A3]3EBI-79165,EBI-745689
FAM219B [Q5XKK7]3EBI-79165,EBI-12290965
FAM90A1 [Q86YD7]3EBI-79165,EBI-6658203
FAM9A [Q8IZU1]3EBI-79165,EBI-8468186
FBXL3 [Q9UKT7]3EBI-79165,EBI-2557269
FBXL8 [Q96CD0]3EBI-79165,EBI-2321097
FGF16 [O43320]3EBI-79165,EBI-11479104
FKBP6 [O75344]3EBI-79165,EBI-744771
FLYWCH1 [Q4VC44]3EBI-79165,EBI-719415
GADD45GIP1 [Q8TAE8]3EBI-79165,EBI-372506
GAS2L2 [Q8NHY3]3EBI-79165,EBI-7960826
GLYCTK [Q8IVS8]3EBI-79165,EBI-748515
GPATCH11 - isoform 2 [Q8N954-2]3EBI-79165,EBI-12178961
GPATCH2 - isoform 2 [Q9NW75-2]4EBI-79165,EBI-12068108
GPC4 [O75487]3EBI-79165,EBI-3050469
GPKOW [Q92917]3EBI-79165,EBI-746309
GRB10 - isoform 4 [Q13322-4]3EBI-79165,EBI-12353035
GRB7 - isoform 3 [Q14451-3]3EBI-79165,EBI-11991632
GRXCR1 [A8MXD5]3EBI-79165,EBI-5235612
GTF2E2 [P29084]3EBI-79165,EBI-2853321
GTPBP2 [Q9BX10]3EBI-79165,EBI-6115579
hCG_2042749 [A0A024R4Z4]3EBI-79165,EBI-14231181
HDAC4 - isoform 2 [P56524-2]3EBI-79165,EBI-11953488
HEXIM2 [Q96MH2]3EBI-79165,EBI-5460660
HMBOX1 [Q6NT76]3EBI-79165,EBI-2549423
HMBS [P08397]3EBI-79165,EBI-9090148
HMG20A [Q9NP66]6EBI-79165,EBI-740641
HOPX [Q9BPY8]3EBI-79165,EBI-10295883
HOXA5 [P20719]3EBI-79165,EBI-8470697
HSD17B14 [Q9BPX1]3EBI-79165,EBI-742664
HSF2 [Q03933]6EBI-79165,EBI-2556750
HSF2BP [O75031]3EBI-79165,EBI-7116203
ID2 [Q02363]3EBI-79165,EBI-713450
IHO1 [Q8IYA8]3EBI-79165,EBI-8638439
IL16 - isoform 2 [Q14005-2]3EBI-79165,EBI-17178971
ILF2 [Q12905]3EBI-79165,EBI-357925
INO80B [Q9C086]3EBI-79165,EBI-715611
INO80E [Q8NBZ0]3EBI-79165,EBI-769401
INPP5J [Q15735]3EBI-79165,EBI-10236940
IP6K1 [Q92551]3EBI-79165,EBI-751911
ISCU [Q9H1K1]3EBI-79165,EBI-1047335
JRK - isoform 2 [O75564-2]3EBI-79165,EBI-17181882
KAT5 [Q92993]3EBI-79165,EBI-399080
KCTD1 [Q719H9]3EBI-79165,EBI-9027502
KCTD6 [Q8NC69]3EBI-79165,EBI-2511344
KCTD9 [Q7L273]3EBI-79165,EBI-4397613
KIAA1328 [Q86T90]3EBI-79165,EBI-3437878
L3MBTL2 [Q969R5]3EBI-79165,EBI-739909
LCLAT1 [Q6UWP7]3EBI-79165,EBI-10254507
LCN2 [P80188]3EBI-79165,EBI-11911016
LGALS14 [Q8TCE9]3EBI-79165,EBI-10274069
LMO1 [P25800]3EBI-79165,EBI-8639312
LMO3 - isoform 4 [Q8TAP4-4]3EBI-79165,EBI-11742507
LONRF1 [Q17RB8]3EBI-79165,EBI-2341787
LRRC73 [Q5JTD7]3EBI-79165,EBI-12003882
LZTFL1 [Q9NQ48]5EBI-79165,EBI-2824799
LZTS1 [Q9Y250]3EBI-79165,EBI-1216080
MAGEA4 [P43358]3EBI-79165,EBI-743122
MAGEB4 [O15481]3EBI-79165,EBI-751857
MAP2K6 [P52564]3EBI-79165,EBI-448135
MAPK9 [P45984]3EBI-79165,EBI-713568
MAPRE3 [Q9UPY8]3EBI-79165,EBI-726739
MAZ - isoform 2 [P56270-2]3EBI-79165,EBI-12068586
MBD3 - isoform 2 [O95983-2]3EBI-79165,EBI-11978579
MCM10 - isoform 2 [Q7L590-2]3EBI-79165,EBI-10233517
MEOX2 [Q6FHY5]3EBI-79165,EBI-16439278
MGC50722 [Q8IVT4]3EBI-79165,EBI-14086479
MGME1 [Q9BQP7]3EBI-79165,EBI-739561
MID2 - isoform 2 [Q9UJV3-2]3EBI-79165,EBI-10172526
MMTAG2 [Q9BU76]3EBI-79165,EBI-742459
MNS1 [Q8NEH6]3EBI-79165,EBI-743811
MOB3C [Q70IA8]3EBI-79165,EBI-9679267
MORF4L1 - isoform 2 [Q9UBU8-2]3EBI-79165,EBI-10288852
MORF4L2 [Q15014]3EBI-79165,EBI-399257
MORN3 [Q6PF18]3EBI-79165,EBI-9675802
MOS [P00540]3EBI-79165,EBI-1757866
MRI1 [Q9BV20]3EBI-79165,EBI-747381
MRNIP [Q6NTE8]3EBI-79165,EBI-2857471
MSRB3 - isoform 2 [Q8IXL7-2]3EBI-79165,EBI-10699187
MSS51 [Q4VC12]3EBI-79165,EBI-11599933
MTA1 [Q13330]3EBI-79165,EBI-714236
MTG1 [Q9BT17]3EBI-79165,EBI-2602570
NATD1 [Q8N6N6]3EBI-79165,EBI-8656665
NDEL1 [Q9GZM8]3EBI-79165,EBI-928842
NECAB2 - isoform 2 [Q7Z6G3-2]3EBI-79165,EBI-10172876
NEK6 - isoform 4 [Q9HC98-4]3EBI-79165,EBI-11750983
NME7 [Q9Y5B8]3EBI-79165,EBI-744782
NMNAT1 [Q9HAN9]3EBI-79165,EBI-3917542
NOC4L [Q9BVI4]3EBI-79165,EBI-395927
OARD1 [Q9Y530]3EBI-79165,EBI-8502288
OPTN [Q96CV9]3EBI-79165,EBI-748974
OSBP2 - isoform 2 [Q969R2-2]3EBI-79165,EBI-12211505
OSGIN1 [Q9UJX0]3EBI-79165,EBI-9057006
PAFAH1B3 [Q15102]3EBI-79165,EBI-711522
PAX6 [P26367]3EBI-79165,EBI-747278
PBX4 [Q9BYU1]3EBI-79165,EBI-10302990
PCBD1 [P61457]3EBI-79165,EBI-740475
PDCD5 [O14737]3EBI-79165,EBI-712290
PDS5A - isoform 2 [Q29RF7-3]3EBI-79165,EBI-12067280
PEBP1 [P30086]3EBI-79165,EBI-716384
PHF19 [Q5T6S3]3EBI-79165,EBI-2339674
PIBF1 [Q4G0R1]3EBI-79165,EBI-14066006
itself3EBI-79165,EBI-79165
PKN1 [Q16512]3EBI-79165,EBI-602382
PKNOX2 [Q96KN3]3EBI-79165,EBI-2692890
PLEKHA7 - isoform 2 [Q6IQ23-2]3EBI-79165,EBI-12069346
PNKP [Q96T60]3EBI-79165,EBI-1045072
PNO1 [Q9NRX1]3EBI-79165,EBI-712787
POLL - isoform 2 [Q9UGP5-2]3EBI-79165,EBI-10320765
POLR3C [Q9BUI4]3EBI-79165,EBI-5452779
PPL [O60437]3EBI-79165,EBI-368321
PRPF18 [Q99633]3EBI-79165,EBI-2798416
PRPF31 [Q8WWY3]3EBI-79165,EBI-1567797
PRPF40A - isoform 2 [O75400-2]3EBI-79165,EBI-5280197
PSMA1 [P25786]3EBI-79165,EBI-359352
PSME3 [P61289]3EBI-79165,EBI-355546
PTRH1 [Q86Y79]3EBI-79165,EBI-2602515
QARS1 [P47897]3EBI-79165,EBI-347462
RAD51D [O75771]3EBI-79165,EBI-1055693
RASAL3 [Q86YV0]3EBI-79165,EBI-3437896
REEP6 - isoform 2 [Q96HR9-2]3EBI-79165,EBI-14065960
REL - isoform 2 [Q04864-2]3EBI-79165,EBI-10829018
RFC3 [P40938]3EBI-79165,EBI-1055010
RIMS3 [Q9UJD0]3EBI-79165,EBI-3909436
RIN1 [Q13671]3EBI-79165,EBI-366017
RNF8 [O76064]3EBI-79165,EBI-373337
RNPS1 [Q15287]3EBI-79165,EBI-395959
ROBO3 [Q96HH0]3EBI-79165,EBI-10288358
ROPN1 [Q9HAT0]3EBI-79165,EBI-1378139
RPIA [P49247]3EBI-79165,EBI-744831
RPP25 [Q9BUL9]3EBI-79165,EBI-366570
RRP8 [O43159]3EBI-79165,EBI-2008793
RXRB [P28702]3EBI-79165,EBI-748576
RXRG [P48443]3EBI-79165,EBI-712405
SCAND1 [P57086]3EBI-79165,EBI-745846
SCNM1 [Q9BWG6]3EBI-79165,EBI-748391
SEMA3B - isoform 2 [Q13214-2]3EBI-79165,EBI-11017428
SEPTIN1 [Q8WYJ6]3EBI-79165,EBI-693002
SERBP1 [Q8NC51]3EBI-79165,EBI-523558
SERTAD1 [Q9UHV2]3EBI-79165,EBI-748601
SERTAD3 [Q9UJW9]3EBI-79165,EBI-748621
SH2D4A [Q9H788]3EBI-79165,EBI-747035
SH3GLB2 [Q9NR46]3EBI-79165,EBI-749607
SHFL - isoform 4 [Q9NUL5-4]3EBI-79165,EBI-11955083
SLIRP [Q9GZT3]3EBI-79165,EBI-1050793
SMARCB1 - isoform B [Q12824-2]3EBI-79165,EBI-358436
SMARCD1 [Q96GM5]3EBI-79165,EBI-358489
SNRNP25 [Q9BV90]3EBI-79165,EBI-9675976
SNRPA1 [P09661]3EBI-79165,EBI-876439
SNRPB2 [P08579]3EBI-79165,EBI-1053651
SNW1 [Q13573]3EBI-79165,EBI-632715
SPANXN2 [Q5MJ10]3EBI-79165,EBI-12023934
SPATC1L - isoform 2 [Q9H0A9-2]3EBI-79165,EBI-11995806
SPEG - isoform 3 [Q15772-4]3EBI-79165,EBI-12175897
SSNA1 [O43805]3EBI-79165,EBI-2515299
STK19 [B7ZLI8]3EBI-79165,EBI-10176124
STK4 - isoform 2 [Q13043-2]3EBI-79165,EBI-14280485
SYT17 [Q9BSW7]3EBI-79165,EBI-745392
TBC1D22B [Q9NU19]3EBI-79165,EBI-8787464
TBC1D7 [Q9P0N9]3EBI-79165,EBI-3258000
TCEA2 [Q15560]3EBI-79165,EBI-710310
TCEANC - isoform 2 [Q8N8B7-2]3EBI-79165,EBI-11955057
TCEANC2 [Q96MN5]3EBI-79165,EBI-5462748
TDO2 [P48775]3EBI-79165,EBI-743494
TEX101 - isoform 2 [Q9BY14-2]3EBI-79165,EBI-12306161
TFIP11 [Q9UBB9]3EBI-79165,EBI-1105213
THAP6 [Q8TBB0]6EBI-79165,EBI-3925505
THAP7 [Q9BT49]3EBI-79165,EBI-741350
TLE5 - isoform 2 [Q08117-2]3EBI-79165,EBI-11741437
TLNRD1 [Q9H1K6]3EBI-79165,EBI-12344941
TPM4 [P67936]3EBI-79165,EBI-1642100
TRAF4 [Q9BUZ4]3EBI-79165,EBI-3650647
TRAF5 [O00463]3EBI-79165,EBI-523498
TRIM44 [Q96DX7]3EBI-79165,EBI-8787399
TRIM54 [Q9BYV2]3EBI-79165,EBI-2130429
TRIML2 [Q8N7C3]3EBI-79165,EBI-11059915
TRMT2A [Q8IZ69]3EBI-79165,EBI-2515774
TSGA10IP [Q3SY00]3EBI-79165,EBI-10241197
TSN [Q15631]3EBI-79165,EBI-1044160
TSTD2 [Q5T7W7]3EBI-79165,EBI-8994397
TTC23 - isoform 3 [Q5W5X9-3]3EBI-79165,EBI-9090990
TTC23L [Q6PF05]3EBI-79165,EBI-8656864
TXNDC9 [O14530]3EBI-79165,EBI-707554
TXNL4B [Q9NX01]3EBI-79165,EBI-10309345
TYW3 [Q6IPR3]3EBI-79165,EBI-10974426
UBE2E3 [Q969T4]3EBI-79165,EBI-348496
UBE2K [P61086]3EBI-79165,EBI-473850
USHBP1 [Q8N6Y0]3EBI-79165,EBI-739895
USP2 [O75604]3EBI-79165,EBI-743272
UTP3 [Q9NQZ2]3EBI-79165,EBI-714067
VAX1 - isoform 2 [Q5SQQ9-2]3EBI-79165,EBI-12227803
VEZF1 [Q14119]3EBI-79165,EBI-11980193
VPS25 [Q9BRG1]3EBI-79165,EBI-741945
WT1 - isoform 6 [P19544-6]3EBI-79165,EBI-11745701
XPA [P23025]3EBI-79165,EBI-295222
YES1 [P07947]3EBI-79165,EBI-515331
YPEL2 [Q96QA6]3EBI-79165,EBI-6658719
YTHDC1 [Q96MU7]3EBI-79165,EBI-2849854
ZBED1 [O96006]3EBI-79165,EBI-740037
ZBTB2 [Q8N680]3EBI-79165,EBI-2515601
ZBTB24 [O43167]3EBI-79165,EBI-744471
ZBTB49 [Q6ZSB9]3EBI-79165,EBI-2859943
ZFHX3 - isoform B [Q15911-2]3EBI-79165,EBI-10237226
ZFP2 [Q6ZN57]3EBI-79165,EBI-7236323
ZMAT2 [Q96NC0]3EBI-79165,EBI-2682299
ZMYND12 [Q9H0C1]3EBI-79165,EBI-12030590
ZNF165 [P49910]3EBI-79165,EBI-741694
ZNF17 [P17021]3EBI-79165,EBI-1105334
ZNF205 [O95201]3EBI-79165,EBI-747343
ZNF250 - isoform 3 [P15622-3]3EBI-79165,EBI-10177272
ZNF264 [O43296]3EBI-79165,EBI-4395808
ZNF276 [Q8N554]3EBI-79165,EBI-750821
ZNF286A [Q9HBT8]3EBI-79165,EBI-10754950
ZNF329 [Q86UD4]3EBI-79165,EBI-7233259
ZNF330 [Q9Y3S2]3EBI-79165,EBI-373456
ZNF35 [P13682]3EBI-79165,EBI-11041653
ZNF408 [Q9H9D4]3EBI-79165,EBI-347633
ZNF410 - isoform 3 [Q86VK4-3]3EBI-79165,EBI-11741890
ZNF414 [Q96IQ9]3EBI-79165,EBI-744257
ZNF417 [Q8TAU3]3EBI-79165,EBI-740727
ZNF438 [Q7Z4V0]3EBI-79165,EBI-11962468
ZNF497 [Q6ZNH5]3EBI-79165,EBI-10486136
ZNF524 [Q96C55]3EBI-79165,EBI-10283126
ZNF575 [Q86XF7]3EBI-79165,EBI-14069183
ZNF576 [Q9H609]3EBI-79165,EBI-3921014
ZNF593 [O00488]3EBI-79165,EBI-726769
ZNF624 [Q9P2J8]3EBI-79165,EBI-9116427
ZNF691 [Q5VV52]3EBI-79165,EBI-720883
ZNF71 [Q9NQZ8]3EBI-79165,EBI-7138235
ZNF764 [Q96H86]3EBI-79165,EBI-745775
ZNF774 [Q6NX45]3EBI-79165,EBI-10251462
ZSCAN21 [Q9Y5A6]3EBI-79165,EBI-10281938
ZSCAN23 [Q3MJ62]3EBI-79165,EBI-5667532
ZZZ3 [Q8IYH5]3EBI-79165,EBI-2795524

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114849, 389 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9NRD5

Protein interaction database and analysis system

More...IntActi		Q9NRD5, 378 interactors

Molecular INTeraction database

More...MINTi		Q9NRD5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000385205

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NRD5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1415
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Small Angle Scattering Biological Data Bank

More...SASBDBi		Q9NRD5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NRD5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9NRD5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 105PDZPROSITE-ProRule annotationAdd BLAST84
Domaini144 – 357AHPROSITE-ProRule annotationAdd BLAST214

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi382 – 388Poly-Glu7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The AH domain mediates binding to F-actin.By similarity
The unoccupied PDZ domain is probably involved in allosteric modulation by forming an intramolecular bridge with the AH domain leading to a 'closed' formation. Binding of a PDZ ligand, such as GRIA2, allows enhanced interactions with F-actin and the Arp2/3 complex thus enhanced inhibition of actin polymerization (By similarity).By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3651, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183040

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_032347_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NRD5

Identification of Orthologs from Complete Genome Data

More...OMAi		FTQISAH

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NRD5

TreeFam database of animal gene trees

More...TreeFami		TF314945

Family and domain databases

Conserved Domains Database

More...CDDi		cd07659, BAR_PICK1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1270.60, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR010504, AH_dom
IPR030798, Arfaptin_fam
IPR001478, PDZ
IPR036034, PDZ_sf
IPR037959, PICK1_BAR

The PANTHER Classification System

More...PANTHERi		PTHR12141, PTHR12141, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06456, Arfaptin, 1 hit
PF00595, PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01015, Arfaptin, 1 hit
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103657, SSF103657, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50870, AH, 1 hit
PS50106, PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRD5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFADLDYDIE EDKLGIPTVP GKVTLQKDAQ NLIGISIGGG AQYCPCLYIV 
        60         70         80         90        100
QVFDNTPAAL DGTVAAGDEI TGVNGRSIKG KTKVEVAKMI QEVKGEVTIH 
       110        120        130        140        150
YNKLQADPKQ GMSLDIVLKK VKHRLVENMS SGTADALGLS RAILCNDGLV 
       160        170        180        190        200
KRLEELERTA ELYKGMTEHT KNLLRAFYEL SQTHRAFGDV FSVIGVREPQ 
       210        220        230        240        250
PAASEAFVKF ADAHRSIEKF GIRLLKTIKP MLTDLNTYLN KAIPDTRLTI 
       260        270        280        290        300
KKYLDVKFEY LSYCLKVKEM DDEEYSCIAL GEPLYRVSTG NYEYRLILRC 
       310        320        330        340        350
RQEARARFSQ MRKDVLEKME LLDQKHVQDI VFQLQRLVST MSKYYNDCYA 
       360        370        380        390        400
VLRDADVFPI EVDLAHTTLA YGLNQEEFTD GEEEEEEEDT AAGEPSRDTR 
       410 
GAAGPLDKGG SWCDS
Length:415
Mass (Da):46,600
Last modified:August 2, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC569FD8AA5028B90
GO
Isoform 2 (identifier: Q9NRD5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     279-364: ALGEPLYRVS...ADVFPIEVDL → VSVGGGGGLV...LHSYEALLSV
     365-415: Missing.

Show »
Length:364
Mass (Da):39,808
Checksum:i16BDC48FE02023BD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6V107F6V107_HUMAN
PRKCA-binding protein
PICK1
229Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6V3V1F6V3V1_HUMAN
PRKCA-binding protein
PICK1
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VY12F6VY12_HUMAN
PRKCA-binding protein
PICK1
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TII1F6TII1_HUMAN
PRKCA-binding protein
PICK1
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EX80E7EX80_HUMAN
PRKCA-binding protein
PICK1
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7Y → F in AAF97502 (Ref. 2) Curated1
Sequence conflicti16Missing in AAF97502 (Ref. 2) Curated1
Sequence conflicti236N → NI in AAF97502 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054902279 – 364ALGEP…IEVDL → VSVGGGGGLVLPPTWSARDS RWLRPTRERPGGLGWTLVPG DLGPSSQSRSLGLGVLGTRP GTTPSVWGTLGGKSDFLHSY EALLSV in isoform 2. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_054903365 – 415Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB026491 mRNA Translation: BAA89294.1
AF231710 mRNA Translation: AAF97502.1
AL049654 mRNA Translation: CAB41082.1
CR456550 mRNA Translation: CAG30436.1
AK092818 mRNA Translation: BAG52614.1
AL031587 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60208.1
BC017561 mRNA Translation: AAH17561.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13965.1 [Q9NRD5-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JC7167

NCBI Reference Sequences

More...RefSeqi		NP_001034672.1, NM_001039583.1 [Q9NRD5-1]
NP_001034673.1, NM_001039584.1 [Q9NRD5-1]
NP_036539.1, NM_012407.3 [Q9NRD5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356976; ENSP00000349465; ENSG00000100151 [Q9NRD5-1]
ENST00000404072; ENSP00000385205; ENSG00000100151 [Q9NRD5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9463

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9463

UCSC genome browser

More...UCSCi		uc003auq.4, human [Q9NRD5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026491 mRNA Translation: BAA89294.1
AF231710 mRNA Translation: AAF97502.1
AL049654 mRNA Translation: CAB41082.1
CR456550 mRNA Translation: CAG30436.1
AK092818 mRNA Translation: BAG52614.1
AL031587 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60208.1
BC017561 mRNA Translation: AAH17561.1
CCDSiCCDS13965.1 [Q9NRD5-1]
PIRiJC7167
RefSeqiNP_001034672.1, NM_001039583.1 [Q9NRD5-1]
NP_001034673.1, NM_001039584.1 [Q9NRD5-1]
NP_036539.1, NM_012407.3 [Q9NRD5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GZVX-ray1.12A19-105[»]
6AR4X-ray1.69A/B1-105[»]
6BJNX-ray2.43A/B1-105[»]
6BJOX-ray1.75A/B1-105[»]
SASBDBiQ9NRD5
SMRiQ9NRD5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114849, 389 interactors
CORUMiQ9NRD5
IntActiQ9NRD5, 378 interactors
MINTiQ9NRD5
STRINGi9606.ENSP00000385205

Protein family/group databases

MoonDBiQ9NRD5, Predicted

PTM databases

iPTMnetiQ9NRD5
PhosphoSitePlusiQ9NRD5
SwissPalmiQ9NRD5

Polymorphism and mutation databases

BioMutaiPICK1
DMDMi22095990

Proteomic databases

EPDiQ9NRD5
jPOSTiQ9NRD5
MassIVEiQ9NRD5
MaxQBiQ9NRD5
PaxDbiQ9NRD5
PeptideAtlasiQ9NRD5
PRIDEiQ9NRD5
ProteomicsDBi82339 [Q9NRD5-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9NRD5, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12276, 432 antibodies

The DNASU plasmid repository

More...DNASUi		9463

Genome annotation databases

EnsembliENST00000356976; ENSP00000349465; ENSG00000100151 [Q9NRD5-1]
ENST00000404072; ENSP00000385205; ENSG00000100151 [Q9NRD5-1]
GeneIDi9463
KEGGihsa:9463
UCSCiuc003auq.4, human [Q9NRD5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9463
DisGeNETi9463
EuPathDBiHostDB:ENSG00000100151.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		PICK1
HGNCiHGNC:9394, PICK1
HPAiENSG00000100151, Low tissue specificity
MalaCardsiPICK1
MIMi605926, gene
neXtProtiNX_Q9NRD5
OpenTargetsiENSG00000100151
Orphaneti171709, Male infertility due to globozoospermia
PharmGKBiPA33760

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3651, Eukaryota
GeneTreeiENSGT00950000183040
HOGENOMiCLU_032347_1_0_1
InParanoidiQ9NRD5
OMAiFTQISAH
PhylomeDBiQ9NRD5
TreeFamiTF314945

Enzyme and pathway databases

PathwayCommonsiQ9NRD5
ReactomeiR-HSA-202733, Cell surface interactions at the vascular wall
R-HSA-416993, Trafficking of GluR2-containing AMPA receptors
SignaLinkiQ9NRD5
SIGNORiQ9NRD5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9463, 4 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PICK1, human
EvolutionaryTraceiQ9NRD5

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PICK1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9463
PharosiQ9NRD5, Tbio

Protein Ontology

More...PROi		PR:Q9NRD5
RNActiQ9NRD5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100151, Expressed in adenohypophysis and 172 other tissues
ExpressionAtlasiQ9NRD5, baseline and differential
GenevisibleiQ9NRD5, HS

Family and domain databases

CDDicd07659, BAR_PICK1, 1 hit
Gene3Di1.20.1270.60, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR010504, AH_dom
IPR030798, Arfaptin_fam
IPR001478, PDZ
IPR036034, PDZ_sf
IPR037959, PICK1_BAR
PANTHERiPTHR12141, PTHR12141, 1 hit
PfamiView protein in Pfam
PF06456, Arfaptin, 1 hit
PF00595, PDZ, 1 hit
SMARTiView protein in SMART
SM01015, Arfaptin, 1 hit
SM00228, PDZ, 1 hit
SUPFAMiSSF103657, SSF103657, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50870, AH, 1 hit
PS50106, PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPICK1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRD5
Secondary accession number(s): B3KS52, O95906
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 2, 2002
Last modified: December 2, 2020
This is version 190 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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