PICK1

Functionⁱ

Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	44	ZincBy similarity		1
Metal bindingⁱ	46	ZincBy similarity		1

GO - Molecular functionⁱ

actin filament binding Source: UniProtKB
Arp2/3 complex binding Source: UniProtKB
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16314870
G protein-coupled receptor binding Source: ParkinsonsUK-UCL
identical protein binding Source: ParkinsonsUK-UCL
metal ion binding Source: UniProtKB-KW
phospholipid binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11343649
protein domain specific binding Source: ParkinsonsUK-UCL
protein kinase C binding Source: UniProtKB
signaling receptor binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to decreased oxygen levels Source: UniProtKB
cellular response to glucose starvation Source: UniProtKB
dendritic spine maintenance Source: UniProtKB
dendritic spine organization Source: UniProtKB
DNA methylation involved in embryo development
Source: UniProtKB
Non-traceable author statementⁱ
- 12138111
DNA methylation involved in gamete generation
Source: UniProtKB
Traceable author statementⁱ
- 12138111
glial cell development Source: UniProtKB
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
long-term synaptic depression Source: UniProtKB
monoamine transport
Source: UniProtKB
Inferred from direct assayⁱ
- 11343649
negative regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
neuronal ion channel clustering
Source: UniProtKB
Traceable author statementⁱ
- 11343649
positive regulation of receptor internalization Source: UniProtKB
protein kinase C-activating G protein-coupled receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 10623590
protein phosphorylation Source: UniProtKB
receptor clustering Source: UniProtKB
retrograde vesicle-mediated transport, Golgi to ER
Source: UniProtKB
Non-traceable author statementⁱ
- 10623590

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding
Ligand	Calcium, Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-416993 Trafficking of GluR2-containing AMPA receptors
SignaLinkⁱ	Q9NRD5
SIGNORⁱ	Q9NRD5

Protein family/group databases

MoonDBⁱ	Q9NRD5 Predicted

MoonDBⁱ

Q9NRD5 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PRKCA-binding protein Alternative name(s): Protein interacting with C kinase 1 Protein kinase C-alpha-binding protein
Gene namesⁱ	Name:PICK1 Synonyms:PRKCABP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100151.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9394 PICK1
MIMⁱ	605926 gene
neXtProtⁱ	NX_Q9NRD5

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	27 – 28	KD → AA: Abolishes interaction with other proteins, but not with itself. 3 Publications		2
Mutagenesisⁱ	27	K → E: Abolishes interaction with GRIA2, but not with PRKCA. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9463
MalaCards human disease database More...MalaCardsⁱ	PICK1
Open Targets More...OpenTargetsⁱ	ENSG00000100151
Orphanetⁱ	171709 Male infertility due to globozoospermia
PharmGKBⁱ	PA33760

Polymorphism and mutation databases

BioMutaⁱ	PICK1
DMDMⁱ	22095990

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000058427	1 – 415	PRKCA-binding proteinAdd BLAST		415

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	82	Phosphothreonine1 Publication		1
Lipidationⁱ	413	S-palmitoyl cysteine; by DHHC8By similarity		1

Post-translational modificationⁱ

Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.1 Publication

Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD).By similarity

Keywords - PTMⁱ

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDⁱ	Q9NRD5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NRD5
PaxDbⁱ	Q9NRD5
PeptideAtlas More...PeptideAtlasⁱ	Q9NRD5
PRIDEⁱ	Q9NRD5
ProteomicsDBⁱ	82339

PTM databases

iPTMnetⁱ	Q9NRD5
PhosphoSitePlusⁱ	Q9NRD5
SwissPalmⁱ	Q9NRD5

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000100151 Expressed in 158 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_PICK1
ExpressionAtlasⁱ	Q9NRD5 baseline and differential
Genevisibleⁱ	Q9NRD5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA067384 HPA072674

HPAⁱ

HPA067384
HPA072674

Interactionⁱ

Subunit structureⁱ

Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR. Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex. Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition.6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AES	Q08117-2	4	EBI-79165,EBI-11741437
ASIC1	P78348	3	EBI-79165,EBI-79189
ASIC2	Q16515	3	EBI-79165,EBI-79149
COIL	P38432	3	EBI-79165,EBI-945751
HMG20A	Q9NP66	4	EBI-79165,EBI-740641
HSF2	Q03933	4	EBI-79165,EBI-2556750
KCTD9	Q7L273	4	EBI-79165,EBI-4397613
MRI1	Q9BV20	4	EBI-79165,EBI-747381
TDO2	P48775	4	EBI-79165,EBI-743494
THAP6	Q8TBB0	4	EBI-79165,EBI-3925505

GO - Molecular functionⁱ

actin filament binding Source: UniProtKB
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16314870
G protein-coupled receptor binding Source: ParkinsonsUK-UCL
identical protein binding Source: ParkinsonsUK-UCL
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11343649
protein domain specific binding Source: ParkinsonsUK-UCL
protein kinase C binding Source: UniProtKB
signaling receptor binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114849, 70 interactors
CORUMⁱ	Q9NRD5
IntActⁱ	Q9NRD5, 341 interactors
Molecular INTeraction database More...MINTⁱ	Q9NRD5
STRINGⁱ	9606.ENSP00000349465

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	21 – 26	Combined sources	6
Beta strandⁱ	34 – 39	Combined sources	6
Beta strandⁱ	47 – 52	Combined sources	6
Helixⁱ	57 – 61	Combined sources	5
Beta strandⁱ	69 – 73	Combined sources	5
Helixⁱ	83 – 92	Combined sources	10
Beta strandⁱ	95 – 102	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NRD5
SMRⁱ	Q9NRD5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9NRD5

EvolutionaryTraceⁱ

Q9NRD5

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	22 – 105	PDZPROSITE-ProRule annotationAdd BLAST		84
Domainⁱ	144 – 357	AHPROSITE-ProRule annotationAdd BLAST		214

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	382 – 388	Poly-Glu		7

Domainⁱ

The AH domain mediates binding to F-actin.By similarity

The unoccupied PDZ domain is probably involved in allosteric modulation by forming an intramolecular bridge with the AH domain leading to a 'closed' formation. Binding of a PDZ ligand, such as GRIA2, allows enhanced interactions with F-actin and the Arp2/3 complex thus enhanced inhibition of actin polymerization (By similarity).By similarity

Phylogenomic databases

eggNOGⁱ	KOG3651 Eukaryota ENOG410YZG6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000033690
HOGENOMⁱ	HOG000007646
HOVERGENⁱ	HBG053600
InParanoidⁱ	Q9NRD5
OMAⁱ	TIKPMLH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08SM
PhylomeDBⁱ	Q9NRD5
TreeFamⁱ	TF314945

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07659 BAR_PICK1, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR010504 AH_dom IPR030798 Arfaptin_fam IPR001478 PDZ IPR036034 PDZ_sf IPR037959 PICK1_BAR
PANTHERⁱ	PTHR12141 PTHR12141, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06456 Arfaptin, 1 hit PF00595 PDZ, 1 hit
SMARTⁱ	View protein in SMART SM01015 Arfaptin, 1 hit SM00228 PDZ, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS50870 AH, 1 hit PS50106 PDZ, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NRD5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFADLDYDIE EDKLGIPTVP GKVTLQKDAQ NLIGISIGGG AQYCPCLYIV 
        60         70         80         90        100
QVFDNTPAAL DGTVAAGDEI TGVNGRSIKG KTKVEVAKMI QEVKGEVTIH 
       110        120        130        140        150
YNKLQADPKQ GMSLDIVLKK VKHRLVENMS SGTADALGLS RAILCNDGLV 
       160        170        180        190        200
KRLEELERTA ELYKGMTEHT KNLLRAFYEL SQTHRAFGDV FSVIGVREPQ 
       210        220        230        240        250
PAASEAFVKF ADAHRSIEKF GIRLLKTIKP MLTDLNTYLN KAIPDTRLTI 
       260        270        280        290        300
KKYLDVKFEY LSYCLKVKEM DDEEYSCIAL GEPLYRVSTG NYEYRLILRC 
       310        320        330        340        350
RQEARARFSQ MRKDVLEKME LLDQKHVQDI VFQLQRLVST MSKYYNDCYA 
       360        370        380        390        400
VLRDADVFPI EVDLAHTTLA YGLNQEEFTD GEEEEEEEDT AAGEPSRDTR 
       410 
GAAGPLDKGG SWCDS

Length:415

Mass (Da):46,600

Last modified:August 2, 2002 - v2

Checksum:ⁱC569FD8AA5028B90

GO

Isoform 2 (identifier: Q9NRD5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
279-364: ALGEPLYRVS...ADVFPIEVDL → VSVGGGGGLV...LHSYEALLSV
365-415: Missing.

« Hide

        10         20         30         40         50
MFADLDYDIE EDKLGIPTVP GKVTLQKDAQ NLIGISIGGG AQYCPCLYIV 
        60         70         80         90        100
QVFDNTPAAL DGTVAAGDEI TGVNGRSIKG KTKVEVAKMI QEVKGEVTIH 
       110        120        130        140        150
YNKLQADPKQ GMSLDIVLKK VKHRLVENMS SGTADALGLS RAILCNDGLV 
       160        170        180        190        200
KRLEELERTA ELYKGMTEHT KNLLRAFYEL SQTHRAFGDV FSVIGVREPQ 
       210        220        230        240        250
PAASEAFVKF ADAHRSIEKF GIRLLKTIKP MLTDLNTYLN KAIPDTRLTI 
       260        270        280        290        300
KKYLDVKFEY LSYCLKVKEM DDEEYSCIVS VGGGGGLVLP PTWSARDSRW 
       310        320        330        340        350
LRPTRERPGG LGWTLVPGDL GPSSQSRSLG LGVLGTRPGT TPSVWGTLGG 
       360 
KSDFLHSYEA LLSV

Note: No experimental confirmation available.

Show »

Length:364

Mass (Da):39,808

Checksum:ⁱ16BDC48FE02023BD

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F6V107	F6V107_HUMAN	PRKCA-binding protein PRKCA-binding protein	PICK1	229	Annotation score:
F6V3V1	F6V3V1_HUMAN	PRKCA-binding protein PRKCA-binding protein	PICK1	130	Annotation score:
F6VY12	F6VY12_HUMAN	PRKCA-binding protein PRKCA-binding protein	PICK1	134	Annotation score:
F6TII1	F6TII1_HUMAN	PRKCA-binding protein PRKCA-binding protein	PICK1	38	Annotation score:
E7EX80	E7EX80_HUMAN	PRKCA-binding protein PRKCA-binding protein	PICK1	51	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	7	Y → F in AAF97502 (Ref. 2) Curated	1
Sequence conflictⁱ	16	Missing in AAF97502 (Ref. 2) Curated	1
Sequence conflictⁱ	236	N → NI in AAF97502 (Ref. 2) Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054902	279 – 364	ALGEP…IEVDL → VSVGGGGGLVLPPTWSARDS RWLRPTRERPGGLGWTLVPG DLGPSSQSRSLGLGVLGTRP GTTPSVWGTLGGKSDFLHSY EALLSV in isoform 2. 1 PublicationAdd BLAST		86
Alternative sequenceⁱVSP_054903	365 – 415	Missing in isoform 2. 1 PublicationAdd BLAST		51

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB026491 mRNA Translation: BAA89294.1 AF231710 mRNA Translation: AAF97502.1 AL049654 mRNA Translation: CAB41082.1 CR456550 mRNA Translation: CAG30436.1 AK092818 mRNA Translation: BAG52614.1 AL031587 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60208.1 BC017561 mRNA Translation: AAH17561.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13965.1 [Q9NRD5-1]
PIRⁱ	JC7167
NCBI Reference Sequences More...RefSeqⁱ	NP_001034672.1, NM_001039583.1 [Q9NRD5-1] NP_001034673.1, NM_001039584.1 [Q9NRD5-1] NP_036539.1, NM_012407.3 [Q9NRD5-1]
UniGeneⁱ	Hs.180871

Genome annotation databases

Ensemblⁱ	ENST00000356976; ENSP00000349465; ENSG00000100151 [Q9NRD5-1] ENST00000404072; ENSP00000385205; ENSG00000100151 [Q9NRD5-1]
GeneIDⁱ	9463
KEGGⁱ	hsa:9463
UCSC genome browser More...UCSCⁱ	uc003auq.4 human [Q9NRD5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NRD5	Protein interacting with PRKCA 1, isoform CRA_a		HUMAN		415	UniRef100_Q9NRD5
PRKCA-binding protein		CALJA		415
PRKCA-binding protein		MACMU		415
PRKCA-binding protein		MACFA		415
Uncharacterized protein		CHLSB		415
+13
Q9NRD5-2	Protein interacting with PRKCA 1, isoform CRA_b		HUMAN		364	UniRef100_A0A024R1R7

Protein	Similar proteins		Species	Score	Length	Source
Q9NRD5	Protein interacting with PRKCA 1, isoform CRA_a		HUMAN		415	UniRef90_Q9NRD5
PRKCA-binding protein		CALJA		415
PRKCA-binding protein		MACMU		415
PRKCA-binding protein		MACFA		415
Uncharacterized protein		CHLSB		415
+20
Q9NRD5-2	Protein interacting with PRKCA 1		RABIT		293	UniRef90_G1SME7
Protein interacting with PRKCA 1, isoform CRA_b		HUMAN		364
UPI000A32A245		MESAU		316

Protein	Similar proteins		Species	Score	Length	Source
Q9NRD5	Protein interacting with PRKCA 1, isoform CRA_a		HUMAN		415	UniRef50_Q9NRD5
PRKCA-binding protein		CALJA		415
PRKCA-binding protein		MACMU		415
PRKCA-binding protein		MACFA		415
Uncharacterized protein		CHLSB		415
+156
Q9NRD5-2	Uncharacterized protein		HELRO		359	UniRef50_T1G203
Protein interacting with PRKCA 1, isoform CRA_b		HUMAN		364
Protein interacting with PRKCA 1		RABIT		293
Uncharacterized protein (Fragment)		IXORI		367
PRKCA-binding protein		HYDVU		371
+21

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB026491 mRNA Translation: BAA89294.1 AF231710 mRNA Translation: AAF97502.1 AL049654 mRNA Translation: CAB41082.1 CR456550 mRNA Translation: CAG30436.1 AK092818 mRNA Translation: BAG52614.1 AL031587 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60208.1 BC017561 mRNA Translation: AAH17561.1
CCDSⁱ	CCDS13965.1 [Q9NRD5-1]
PIRⁱ	JC7167
RefSeqⁱ	NP_001034672.1, NM_001039583.1 [Q9NRD5-1] NP_001034673.1, NM_001039584.1 [Q9NRD5-1] NP_036539.1, NM_012407.3 [Q9NRD5-1]
UniGeneⁱ	Hs.180871

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2GZV	X-ray	1.12	A	19-105	[»]
	6AR4	X-ray	1.69	A/B	1-105	[»]
	6BJN	X-ray	2.43	A/B	1-105	[»]
	6BJO	X-ray	1.75	A/B	1-105	[»]
ProteinModelPortalⁱ	Q9NRD5
SMRⁱ	Q9NRD5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114849, 70 interactors
CORUMⁱ	Q9NRD5
IntActⁱ	Q9NRD5, 341 interactors
MINTⁱ	Q9NRD5
STRINGⁱ	9606.ENSP00000349465

Protein family/group databases

MoonDBⁱ	Q9NRD5 Predicted

MoonDBⁱ

Q9NRD5 Predicted

PTM databases

iPTMnetⁱ	Q9NRD5
PhosphoSitePlusⁱ	Q9NRD5
SwissPalmⁱ	Q9NRD5

Polymorphism and mutation databases

BioMutaⁱ	PICK1
DMDMⁱ	22095990

Proteomic databases

EPDⁱ	Q9NRD5
MaxQBⁱ	Q9NRD5
PaxDbⁱ	Q9NRD5
PeptideAtlasⁱ	Q9NRD5
PRIDEⁱ	Q9NRD5
ProteomicsDBⁱ	82339

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9463
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000356976; ENSP00000349465; ENSG00000100151 [Q9NRD5-1] ENST00000404072; ENSP00000385205; ENSG00000100151 [Q9NRD5-1]
GeneIDⁱ	9463
KEGGⁱ	hsa:9463
UCSCⁱ	uc003auq.4 human [Q9NRD5-1]

Organism-specific databases

CTDⁱ	9463
DisGeNETⁱ	9463
EuPathDBⁱ	HostDB:ENSG00000100151.15
GeneCardsⁱ	PICK1
H-InvDBⁱ	HIX0175461
HGNCⁱ	HGNC:9394 PICK1
HPAⁱ	HPA067384 HPA072674
MalaCardsⁱ	PICK1
MIMⁱ	605926 gene
neXtProtⁱ	NX_Q9NRD5
OpenTargetsⁱ	ENSG00000100151
Orphanetⁱ	171709 Male infertility due to globozoospermia
PharmGKBⁱ	PA33760
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3651 Eukaryota ENOG410YZG6 LUCA
GeneTreeⁱ	ENSGT00440000033690
HOGENOMⁱ	HOG000007646
HOVERGENⁱ	HBG053600
InParanoidⁱ	Q9NRD5
OMAⁱ	TIKPMLH
OrthoDBⁱ	EOG091G08SM
PhylomeDBⁱ	Q9NRD5
TreeFamⁱ	TF314945

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-416993 Trafficking of GluR2-containing AMPA receptors
SignaLinkⁱ	Q9NRD5
SIGNORⁱ	Q9NRD5

Miscellaneous databases

ChiTaRSⁱ	PICK1 human
EvolutionaryTraceⁱ	Q9NRD5
GeneWikiⁱ	PICK1
GenomeRNAiⁱ	9463
Protein Ontology More...PROⁱ	PR:Q9NRD5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100151 Expressed in 158 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_PICK1
ExpressionAtlasⁱ	Q9NRD5 baseline and differential
Genevisibleⁱ	Q9NRD5 HS

Family and domain databases

CDDⁱ	cd07659 BAR_PICK1, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR010504 AH_dom IPR030798 Arfaptin_fam IPR001478 PDZ IPR036034 PDZ_sf IPR037959 PICK1_BAR
PANTHERⁱ	PTHR12141 PTHR12141, 1 hit
Pfamⁱ	View protein in Pfam PF06456 Arfaptin, 1 hit PF00595 PDZ, 1 hit
SMARTⁱ	View protein in SMART SM01015 Arfaptin, 1 hit SM00228 PDZ, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS50870 AH, 1 hit PS50106 PDZ, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PICK1_HUMAN
Accessionⁱ	Q9NRD5Primary (citable) accession number: Q9NRD5 Secondary accession number(s): B3KS52, O95906
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
	Last sequence update:	August 2, 2002
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NRD5 (PICK1_HUMAN)

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PRKCA-binding protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Endosome

Golgi apparatus

Mitochondrion

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ