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Protein

F-box only protein 6

Gene

FBXO6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair, Ubl conjugation pathway, Unfolded protein response

Enzyme and pathway databases

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 6
Alternative name(s):
F-box protein that recognizes sugar chains 2
F-box/G-domain protein 2
Gene namesi
Name:FBXO6
Synonyms:FBG2, FBS2, FBX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116663.10
HGNCiHGNC:13585 FBXO6
MIMi605647 gene
neXtProtiNX_Q9NRD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi241 – 242YW → AA: Abolishes interaction with glycosylated concanavalin-A in vitro. 1 Publication2

Organism-specific databases

DisGeNETi26270
OpenTargetsiENSG00000116663
PharmGKBiPA28046

Polymorphism and mutation databases

BioMutaiFBXO6
DMDMi24636846

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198821 – 293F-box only protein 6Add BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei258PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NRD1
MaxQBiQ9NRD1
PaxDbiQ9NRD1
PeptideAtlasiQ9NRD1
PRIDEiQ9NRD1
ProteomicsDBi82338

PTM databases

iPTMnetiQ9NRD1
PhosphoSitePlusiQ9NRD1

Expressioni

Gene expression databases

BgeeiENSG00000116663 Expressed in 156 organ(s), highest expression level in blood
CleanExiHS_FBXO6
ExpressionAtlasiQ9NRD1 baseline and differential
GenevisibleiQ9NRD1 HS

Organism-specific databases

HPAiHPA051175

Interactioni

Subunit structurei

Interacts with VCP (By similarity). Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with CHEK1 and CUL1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632083EBI-3938499,EBI-307486

Protein-protein interaction databases

BioGridi117654, 622 interactors
IntActiQ9NRD1, 5 interactors
MINTiQ9NRD1
STRINGi9606.ENSP00000365944

Structurei

3D structure databases

ProteinModelPortaliQ9NRD1
SMRiQ9NRD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 57F-boxPROSITE-ProRule annotationAdd BLAST48
Domaini78 – 259FBAPROSITE-ProRule annotationAdd BLAST182

Phylogenomic databases

eggNOGiENOG410IK6V Eukaryota
ENOG4111MF5 LUCA
GeneTreeiENSGT00390000003865
HOGENOMiHOG000231084
HOVERGENiHBG003593
InParanoidiQ9NRD1
KOiK10100
OMAiEMCLKSQ
OrthoDBiEOG091G0G3L
PhylomeDBiQ9NRD1
TreeFamiTF320527

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR007397 F-box-assoc_dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR008979 Galactose-bd-like_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF04300 FBA, 1 hit
SMARTiView protein in SMART
SM01198 FBA, 1 hit
SM00256 FBOX, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS51114 FBA, 1 hit
PS50181 FBOX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NRD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAPHSKAAL DSINELPENI LLELFTHVPA RQLLLNCRLV CSLWRDLIDL
60 70 80 90 100
MTLWKRKCLR EGFITKDWDQ PVADWKIFYF LRSLHRNLLR NPCAEEDMFA
110 120 130 140 150
WQIDFNGGDR WKVESLPGAH GTDFPDPKVK KYFVTSYEMC LKSQLVDLVA
160 170 180 190 200
EGYWEELLDT FRPDIVVKDW FAARADCGCT YQLKVQLASA DYFVLASFEP
210 220 230 240 250
PPVTIQQWNN ATWTEVSYTF SDYPRGVRYI LFQHGGRDTQ YWAGWYGPRV
260 270 280 290
TNSSIVVSPK MTRNQASSEA QPGQKHGQEE AAQSPYRAVV QIF
Length:293
Mass (Da):33,933
Last modified:October 1, 2000 - v1
Checksum:iEA4235CD9CCD80FF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQ72J3KQ72_HUMAN
F-box only protein 6
FBXO6
249Annotation score:

Sequence cautioni

The sequence AAF04470 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18E → D in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti51M → L in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti61E → K in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti96E → N in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti114E → D in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti123D → E in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti132Y → S in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti139M → L in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti143 – 144SQ → WE in AAF04470 (PubMed:10531035).Curated2
Sequence conflicti149 – 152VAEG → LADR in AAF04470 (PubMed:10531035).Curated4
Sequence conflicti287R → G in AAF04470 (PubMed:10531035).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04903960R → Q. Corresponds to variant dbSNP:rs3125818Ensembl.1
Natural variantiVAR_022158201P → T. Corresponds to variant dbSNP:rs2294639Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129536 mRNA Translation: AAF04470.1 Different initiation.
AF233223 mRNA Translation: AAF67153.1
AK314989 mRNA Translation: BAG37485.1
AL031731 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71696.1
BC020880 mRNA Translation: AAH20880.1
CCDSiCCDS133.1
RefSeqiNP_060908.1, NM_018438.5
XP_005263505.1, XM_005263448.4
XP_005263506.1, XM_005263449.4
XP_005263508.1, XM_005263451.4
XP_006710634.1, XM_006710571.3
XP_011539534.1, XM_011541232.2
XP_016856496.1, XM_017001007.1
UniGeneiHs.464419

Genome annotation databases

EnsembliENST00000376753; ENSP00000365944; ENSG00000116663
GeneIDi26270
KEGGihsa:26270
UCSCiuc001aso.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

hFBG2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129536 mRNA Translation: AAF04470.1 Different initiation.
AF233223 mRNA Translation: AAF67153.1
AK314989 mRNA Translation: BAG37485.1
AL031731 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71696.1
BC020880 mRNA Translation: AAH20880.1
CCDSiCCDS133.1
RefSeqiNP_060908.1, NM_018438.5
XP_005263505.1, XM_005263448.4
XP_005263506.1, XM_005263449.4
XP_005263508.1, XM_005263451.4
XP_006710634.1, XM_006710571.3
XP_011539534.1, XM_011541232.2
XP_016856496.1, XM_017001007.1
UniGeneiHs.464419

3D structure databases

ProteinModelPortaliQ9NRD1
SMRiQ9NRD1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117654, 622 interactors
IntActiQ9NRD1, 5 interactors
MINTiQ9NRD1
STRINGi9606.ENSP00000365944

PTM databases

iPTMnetiQ9NRD1
PhosphoSitePlusiQ9NRD1

Polymorphism and mutation databases

BioMutaiFBXO6
DMDMi24636846

Proteomic databases

EPDiQ9NRD1
MaxQBiQ9NRD1
PaxDbiQ9NRD1
PeptideAtlasiQ9NRD1
PRIDEiQ9NRD1
ProteomicsDBi82338

Protocols and materials databases

DNASUi26270
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376753; ENSP00000365944; ENSG00000116663
GeneIDi26270
KEGGihsa:26270
UCSCiuc001aso.4 human

Organism-specific databases

CTDi26270
DisGeNETi26270
EuPathDBiHostDB:ENSG00000116663.10
GeneCardsiFBXO6
HGNCiHGNC:13585 FBXO6
HPAiHPA051175
MIMi605647 gene
neXtProtiNX_Q9NRD1
OpenTargetsiENSG00000116663
PharmGKBiPA28046
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK6V Eukaryota
ENOG4111MF5 LUCA
GeneTreeiENSGT00390000003865
HOGENOMiHOG000231084
HOVERGENiHBG003593
InParanoidiQ9NRD1
KOiK10100
OMAiEMCLKSQ
OrthoDBiEOG091G0G3L
PhylomeDBiQ9NRD1
TreeFamiTF320527

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiFBXO6 human
GeneWikiiFBXO6
GenomeRNAii26270
PROiPR:Q9NRD1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116663 Expressed in 156 organ(s), highest expression level in blood
CleanExiHS_FBXO6
ExpressionAtlasiQ9NRD1 baseline and differential
GenevisibleiQ9NRD1 HS

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR007397 F-box-assoc_dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR008979 Galactose-bd-like_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF04300 FBA, 1 hit
SMARTiView protein in SMART
SM01198 FBA, 1 hit
SM00256 FBOX, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS51114 FBA, 1 hit
PS50181 FBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX6_HUMAN
AccessioniPrimary (citable) accession number: Q9NRD1
Secondary accession number(s): B1AK42, B2RC88, Q9UKT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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