Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

F-box only protein 6

Gene

FBXO6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair, Ubl conjugation pathway, Unfolded protein response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box only protein 6
Alternative name(s):
F-box protein that recognizes sugar chains 2
F-box/G-domain protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBXO6
Synonyms:FBG2, FBS2, FBX6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000116663.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13585 FBXO6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605647 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NRD1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi241 – 242YW → AA: Abolishes interaction with glycosylated concanavalin-A in vitro. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
26270

Open Targets

More...
OpenTargetsi
ENSG00000116663

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28046

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FBXO6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
24636846

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001198821 – 293F-box only protein 6Add BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei258PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NRD1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NRD1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NRD1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NRD1

PeptideAtlas

More...
PeptideAtlasi
Q9NRD1

PRoteomics IDEntifications database

More...
PRIDEi
Q9NRD1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82338

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NRD1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NRD1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116663 Expressed in 156 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_FBXO6

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NRD1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NRD1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051175

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with VCP (By similarity). Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with CHEK1 and CUL1.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632083EBI-3938499,EBI-307486

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117654, 623 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NRD1

Protein interaction database and analysis system

More...
IntActi
Q9NRD1, 5 interactors

Molecular INTeraction database

More...
MINTi
Q9NRD1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365944

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NRD1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NRD1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 57F-boxPROSITE-ProRule annotationAdd BLAST48
Domaini78 – 259FBAPROSITE-ProRule annotationAdd BLAST182

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK6V Eukaryota
ENOG4111MF5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159980

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231084

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003593

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NRD1

KEGG Orthology (KO)

More...
KOi
K10100

Identification of Orthologs from Complete Genome Data

More...
OMAi
DATWTEV

Database of Orthologous Groups

More...
OrthoDBi
922544at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NRD1

TreeFam database of animal gene trees

More...
TreeFami
TF320527

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007397 F-box-assoc_dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR039752 F-box_only
IPR008979 Galactose-bd-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12125 PTHR12125, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12937 F-box-like, 1 hit
PF04300 FBA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01198 FBA, 1 hit
SM00256 FBOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 1 hit
SSF81383 SSF81383, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51114 FBA, 1 hit
PS50181 FBOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NRD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAPHSKAAL DSINELPENI LLELFTHVPA RQLLLNCRLV CSLWRDLIDL
60 70 80 90 100
MTLWKRKCLR EGFITKDWDQ PVADWKIFYF LRSLHRNLLR NPCAEEDMFA
110 120 130 140 150
WQIDFNGGDR WKVESLPGAH GTDFPDPKVK KYFVTSYEMC LKSQLVDLVA
160 170 180 190 200
EGYWEELLDT FRPDIVVKDW FAARADCGCT YQLKVQLASA DYFVLASFEP
210 220 230 240 250
PPVTIQQWNN ATWTEVSYTF SDYPRGVRYI LFQHGGRDTQ YWAGWYGPRV
260 270 280 290
TNSSIVVSPK MTRNQASSEA QPGQKHGQEE AAQSPYRAVV QIF
Length:293
Mass (Da):33,933
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA4235CD9CCD80FF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQ72J3KQ72_HUMAN
F-box only protein 6
FBXO6
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF04470 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18E → D in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti51M → L in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti61E → K in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti96E → N in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti114E → D in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti123D → E in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti132Y → S in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti139M → L in AAF04470 (PubMed:10531035).Curated1
Sequence conflicti143 – 144SQ → WE in AAF04470 (PubMed:10531035).Curated2
Sequence conflicti149 – 152VAEG → LADR in AAF04470 (PubMed:10531035).Curated4
Sequence conflicti287R → G in AAF04470 (PubMed:10531035).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04903960R → Q. Corresponds to variant dbSNP:rs3125818Ensembl.1
Natural variantiVAR_022158201P → T. Corresponds to variant dbSNP:rs2294639Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF129536 mRNA Translation: AAF04470.1 Different initiation.
AF233223 mRNA Translation: AAF67153.1
AK314989 mRNA Translation: BAG37485.1
AL031731 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71696.1
BC020880 mRNA Translation: AAH20880.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS133.1

NCBI Reference Sequences

More...
RefSeqi
NP_060908.1, NM_018438.5
XP_005263505.1, XM_005263448.4
XP_005263506.1, XM_005263449.4
XP_005263508.1, XM_005263451.4
XP_006710634.1, XM_006710571.3
XP_011539534.1, XM_011541232.2
XP_016856496.1, XM_017001007.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.464419

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000376753; ENSP00000365944; ENSG00000116663

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26270

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26270

UCSC genome browser

More...
UCSCi
uc001aso.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

hFBG2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129536 mRNA Translation: AAF04470.1 Different initiation.
AF233223 mRNA Translation: AAF67153.1
AK314989 mRNA Translation: BAG37485.1
AL031731 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71696.1
BC020880 mRNA Translation: AAH20880.1
CCDSiCCDS133.1
RefSeqiNP_060908.1, NM_018438.5
XP_005263505.1, XM_005263448.4
XP_005263506.1, XM_005263449.4
XP_005263508.1, XM_005263451.4
XP_006710634.1, XM_006710571.3
XP_011539534.1, XM_011541232.2
XP_016856496.1, XM_017001007.1
UniGeneiHs.464419

3D structure databases

ProteinModelPortaliQ9NRD1
SMRiQ9NRD1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117654, 623 interactors
CORUMiQ9NRD1
IntActiQ9NRD1, 5 interactors
MINTiQ9NRD1
STRINGi9606.ENSP00000365944

PTM databases

iPTMnetiQ9NRD1
PhosphoSitePlusiQ9NRD1

Polymorphism and mutation databases

BioMutaiFBXO6
DMDMi24636846

Proteomic databases

EPDiQ9NRD1
jPOSTiQ9NRD1
MaxQBiQ9NRD1
PaxDbiQ9NRD1
PeptideAtlasiQ9NRD1
PRIDEiQ9NRD1
ProteomicsDBi82338

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
26270
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376753; ENSP00000365944; ENSG00000116663
GeneIDi26270
KEGGihsa:26270
UCSCiuc001aso.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26270
DisGeNETi26270
EuPathDBiHostDB:ENSG00000116663.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FBXO6
HGNCiHGNC:13585 FBXO6
HPAiHPA051175
MIMi605647 gene
neXtProtiNX_Q9NRD1
OpenTargetsiENSG00000116663
PharmGKBiPA28046

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IK6V Eukaryota
ENOG4111MF5 LUCA
GeneTreeiENSGT00940000159980
HOGENOMiHOG000231084
HOVERGENiHBG003593
InParanoidiQ9NRD1
KOiK10100
OMAiDATWTEV
OrthoDBi922544at2759
PhylomeDBiQ9NRD1
TreeFamiTF320527

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FBXO6 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FBXO6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26270

Protein Ontology

More...
PROi
PR:Q9NRD1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116663 Expressed in 156 organ(s), highest expression level in blood
CleanExiHS_FBXO6
ExpressionAtlasiQ9NRD1 baseline and differential
GenevisibleiQ9NRD1 HS

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR007397 F-box-assoc_dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR039752 F-box_only
IPR008979 Galactose-bd-like_sf
PANTHERiPTHR12125 PTHR12125, 1 hit
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF04300 FBA, 1 hit
SMARTiView protein in SMART
SM01198 FBA, 1 hit
SM00256 FBOX, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS51114 FBA, 1 hit
PS50181 FBOX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBX6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRD1
Secondary accession number(s): B1AK42, B2RC88, Q9UKT3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 1, 2000
Last modified: January 16, 2019
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again