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Protein

Otoraplin

Gene

OTOR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cartilage condensation Source: Ensembl
  • sensory perception of sound Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Otoraplin
Alternative name(s):
Fibrocyte-derived protein
Melanoma inhibitory activity-like protein
Gene namesi
Name:OTOR
Synonyms:FDP, MIAL
ORF Names:UNQ3054/PRO9873
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125879.4
HGNCiHGNC:8517 OTOR
MIMi606067 gene
neXtProtiNX_Q9NRC9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi56914
OpenTargetsiENSG00000125879
PharmGKBiPA32843

Polymorphism and mutation databases

BioMutaiOTOR
DMDMi13124388

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000001903318 – 128OtoraplinAdd BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 37By similarity
Disulfide bondi55 ↔ 127By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9NRC9
PeptideAtlasiQ9NRC9
PRIDEiQ9NRC9
ProteomicsDBi82336

PTM databases

iPTMnetiQ9NRC9
PhosphoSitePlusiQ9NRC9

Expressioni

Tissue specificityi

Highly expressed in cochlea.

Gene expression databases

BgeeiENSG00000125879 Expressed in 24 organ(s), highest expression level in cochlea
CleanExiHS_OTOR
GenevisibleiQ9NRC9 HS

Organism-specific databases

HPAiHPA024335

Interactioni

Protein-protein interaction databases

IntActiQ9NRC9, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9NRC9
SMRiQ9NRC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 110SH3PROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Belongs to the MIA/OTOR family.Curated

Keywords - Domaini

SH3 domain, Signal

Phylogenomic databases

eggNOGiENOG410IY1J Eukaryota
ENOG4111P4M LUCA
GeneTreeiENSGT00390000010535
HOGENOMiHOG000063668
HOVERGENiHBG000503
InParanoidiQ9NRC9
OMAiMGTVGYF
OrthoDBiEOG091G0RVX
PhylomeDBiQ9NRC9
TreeFamiTF332724

Family and domain databases

CDDicd11891 MIAL, 1 hit
InterProiView protein in InterPro
IPR035554 Otoraplin_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARILLLFLP GLVAVCAVHG IFMDRLASKK LCADDECVYT ISLASAQEDY
60 70 80 90 100
NAPDCRFINV KKGQQIYVYS KLVKENGAGE FWAGSVYGDG QDEMGVVGYF
110 120
PRNLVKEQRV YQEATKEVPT TDIDFFCE
Length:128
Mass (Da):14,332
Last modified:October 1, 2000 - v1
Checksum:i9BB52C7F5D4FB700
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02453731L → P1 PublicationCorresponds to variant dbSNP:rs6135876Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233261 mRNA Translation: AAF82078.1
AF243505 mRNA Translation: AAG42356.1
AJ242552 mRNA Translation: CAC27443.1
AJ252324
, AJ252325, AJ252326, AJ252327 Genomic DNA Translation: CAC28085.1
AY359082 mRNA Translation: AAQ89441.1
AL034428 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10282.1
CH471133 Genomic DNA Translation: EAX10283.1
BC101688 mRNA Translation: AAI01689.1
BC101690 mRNA Translation: AAI01691.1
CCDSiCCDS13124.1
RefSeqiNP_064542.1, NM_020157.3
UniGeneiHs.41119

Genome annotation databases

EnsembliENST00000246081; ENSP00000246081; ENSG00000125879
GeneIDi56914
KEGGihsa:56914
UCSCiuc002wpj.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233261 mRNA Translation: AAF82078.1
AF243505 mRNA Translation: AAG42356.1
AJ242552 mRNA Translation: CAC27443.1
AJ252324
, AJ252325, AJ252326, AJ252327 Genomic DNA Translation: CAC28085.1
AY359082 mRNA Translation: AAQ89441.1
AL034428 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10282.1
CH471133 Genomic DNA Translation: EAX10283.1
BC101688 mRNA Translation: AAI01689.1
BC101690 mRNA Translation: AAI01691.1
CCDSiCCDS13124.1
RefSeqiNP_064542.1, NM_020157.3
UniGeneiHs.41119

3D structure databases

ProteinModelPortaliQ9NRC9
SMRiQ9NRC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NRC9, 1 interactor

PTM databases

iPTMnetiQ9NRC9
PhosphoSitePlusiQ9NRC9

Polymorphism and mutation databases

BioMutaiOTOR
DMDMi13124388

Proteomic databases

PaxDbiQ9NRC9
PeptideAtlasiQ9NRC9
PRIDEiQ9NRC9
ProteomicsDBi82336

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246081; ENSP00000246081; ENSG00000125879
GeneIDi56914
KEGGihsa:56914
UCSCiuc002wpj.5 human

Organism-specific databases

CTDi56914
DisGeNETi56914
EuPathDBiHostDB:ENSG00000125879.4
GeneCardsiOTOR
HGNCiHGNC:8517 OTOR
HPAiHPA024335
MIMi606067 gene
neXtProtiNX_Q9NRC9
OpenTargetsiENSG00000125879
PharmGKBiPA32843
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY1J Eukaryota
ENOG4111P4M LUCA
GeneTreeiENSGT00390000010535
HOGENOMiHOG000063668
HOVERGENiHBG000503
InParanoidiQ9NRC9
OMAiMGTVGYF
OrthoDBiEOG091G0RVX
PhylomeDBiQ9NRC9
TreeFamiTF332724

Miscellaneous databases

GeneWikiiOTOR
GenomeRNAii56914
PROiPR:Q9NRC9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125879 Expressed in 24 organ(s), highest expression level in cochlea
CleanExiHS_OTOR
GenevisibleiQ9NRC9 HS

Family and domain databases

CDDicd11891 MIAL, 1 hit
InterProiView protein in InterPro
IPR035554 Otoraplin_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOTOR_HUMAN
AccessioniPrimary (citable) accession number: Q9NRC9
Secondary accession number(s): D3DW22, Q3MIU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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