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Protein

Spectrin beta chain, non-erythrocytic 5

Gene

SPTBN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: GO_Central
  • actin filament capping Source: UniProtKB-KW
  • axon guidance Source: Reactome
  • ER to Golgi vesicle-mediated transport Source: Reactome
  • Golgi organization Source: MGI
  • lysosomal transport Source: MGI
  • MAPK cascade Source: Reactome
  • protein homooligomerization Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin capping, Actin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6807878 COPI-mediated anterograde transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spectrin beta chain, non-erythrocytic 5
Alternative name(s):
Beta-V spectrin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPTBN5
Synonyms:BSPECV, HUBSPECV, HUSPECV
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000137877.9

Human Gene Nomenclature Database

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HGNCi
HGNC:15680 SPTBN5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605916 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NRC6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51332

Open Targets

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OpenTargetsi
ENSG00000137877

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38020

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17369320

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000734661 – 3674Spectrin beta chain, non-erythrocytic 5Add BLAST3674

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NRC6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NRC6

PeptideAtlas

More...
PeptideAtlasi
Q9NRC6

PRoteomics IDEntifications database

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PRIDEi
Q9NRC6

ProteomicsDB human proteome resource

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ProteomicsDBi
82333

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NRC6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NRC6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at very low levels in many tissues, with strongest expression in cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder, and heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137877 Expressed in 97 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

More...
CleanExi
HS_SPTBN4
HS_SPTBN5

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NRC6 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probably associates with an alpha chain. Interacts (via C-terminus) with TRPC4.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119479, 4 interactors

Protein interaction database and analysis system

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IntActi
Q9NRC6, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000317790

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NRC6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NRC6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 159Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST106
Domaini177 – 282Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST106
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati307 – 416Spectrin 1Sequence analysisAdd BLAST110
Repeati428 – 529Spectrin 2Sequence analysisAdd BLAST102
Repeati642 – 742Spectrin 3Sequence analysisAdd BLAST101
Repeati747 – 810Spectrin 4Sequence analysisAdd BLAST64
Repeati900 – 996Spectrin 5Sequence analysisAdd BLAST97
Repeati1103 – 1206Spectrin 6Sequence analysisAdd BLAST104
Repeati1209 – 1311Spectrin 7Sequence analysisAdd BLAST103
Repeati1315 – 1417Spectrin 8Sequence analysisAdd BLAST103
Repeati1521 – 1624Spectrin 9Sequence analysisAdd BLAST104
Repeati1628 – 1727Spectrin 10Sequence analysisAdd BLAST100
Repeati1731 – 1835Spectrin 11Sequence analysisAdd BLAST105
Repeati1842 – 1940Spectrin 12Sequence analysisAdd BLAST99
Repeati1944 – 2046Spectrin 13Sequence analysisAdd BLAST103
Repeati2052 – 2146Spectrin 14Sequence analysisAdd BLAST95
Repeati2150 – 2253Spectrin 15Sequence analysisAdd BLAST104
Repeati2256 – 2361Spectrin 16Sequence analysisAdd BLAST106
Repeati2366 – 2467Spectrin 17Sequence analysisAdd BLAST102
Repeati2471 – 2574Spectrin 18Sequence analysisAdd BLAST104
Repeati2577 – 2680Spectrin 19Sequence analysisAdd BLAST104
Repeati2683 – 2784Spectrin 20Sequence analysisAdd BLAST102
Repeati2791 – 2890Spectrin 21Sequence analysisAdd BLAST100
Repeati2894 – 2997Spectrin 22Sequence analysisAdd BLAST104
Repeati3000 – 3103Spectrin 23Sequence analysisAdd BLAST104
Repeati3106 – 3209Spectrin 24Sequence analysisAdd BLAST104
Repeati3213 – 3311Spectrin 25Sequence analysisAdd BLAST99
Repeati3318 – 3415Spectrin 26Sequence analysisAdd BLAST98
Repeati3422 – 3488Spectrin 27Sequence analysisAdd BLAST67
Domaini3533 – 3641PHPROSITE-ProRule annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 279Actin-bindingAdd BLAST279

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the spectrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0035 Eukaryota
COG5069 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161549

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168577

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NRC6

KEGG Orthology (KO)

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KOi
K06115

Identification of Orthologs from Complete Genome Data

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OMAi
HEGHFNA

Database of Orthologous Groups

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OrthoDBi
EOG091G002Y

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NRC6

TreeFam database of animal gene trees

More...
TreeFami
TF313446

Family and domain databases

Conserved Domains Database

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CDDi
cd00014 CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF00435 Spectrin, 27 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 30 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NRC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGQPHSPRE LLGAAGHRSR RPSTELRVPP SPSLTMDSQY ETGHIRKLQA
60 70 80 90 100
RHMQMQEKTF TKWINNVFQC GQAGIKIRNL YTELADGIHL LRLLELISGE
110 120 130 140 150
ALPPPSRGRL RVHFLENSSR ALAFLRAKVP VPLIGPENIV DGDQTLILGL
160 170 180 190 200
IWVIILRFQI SHISLDKEEF GASAALLSTK EALLVWCQRK TASYTNVNIT
210 220 230 240 250
DFSRSWSDGL GFNALIHAHR PDLLDYGSLR PDRPLHNLAF AFLVAEQELG
260 270 280 290 300
IAQLLDPEDV AAAQPDERSI MTYVSLYYHY CSRLHQGQTV QRRLTKILLQ
310 320 330 340 350
LQETELLQTQ YEQLVADLLR WIAEKQMQLE ARDFPDSLPA MRQLLAAFTI
360 370 380 390 400
FRTQEKPPRL QQRGAAEALL FRLQTALQAQ NRRPFLPHEG LGLAELSQCW
410 420 430 440 450
AGLEWAEAAR SQALQQRLLQ LQRLETLARR FQHKAALRES FLKDAEQVLD
460 470 480 490 500
QARAPPASLA TVEAAVQRLG MLEAGILPQE GRFQALAEIA DILRQEQYHS
510 520 530 540 550
WADVARRQEE VTVRWQRLLQ HLQGQRKQVA DMQAVLSLLQ EVEAASHQLE
560 570 580 590 600
ELQEPARSTA CGQQLAEVVE LLQRHDLLEA QVSAHGAHVS HLAQQTAELD
610 620 630 640 650
SSLGTSVEVL QAKARTLAQL QQSLVALVRA RRALLEQTLQ RAEFLRNCEE
660 670 680 690 700
EEAWLKECGQ RVGNAALGRD LSQIAGALQK HKALEAEVHR HQAVCVDLVR
710 720 730 740 750
RGRDLSARRP PTQPDPGERA EAVQGGWQLL QTRVVGRGAR LQTALLVLQY
760 770 780 790 800
FADAAEAASW LRERRSSLER ASCGQDQAAA ETLLRRHVRL ERVLRAFAAE
810 820 830 840 850
LRRLEEQGRA ASARASLFTV NSALSPPGES LRNPGPWSEA SCHPGPGDAW
860 870 880 890 900
KMALPAEPDP DFDPNTILQT QDHLSQDYES LRALAQLRRA RLEEAMALFG
910 920 930 940 950
FCSSCGELQL WLEKQTVLLQ RVQPQADTLE VMQLKYENFL TALAVGKGLW
960 970 980 990 1000
AEVSSSAEQL RQRYPGNSTQ IQRQQEELSQ RWGQLEALKR EKAVQLAHSV
1010 1020 1030 1040 1050
EVCSFLQECG PTQVQLRDVL LQLEALQPGS SEDTCHALQL AQKKTLVLER
1060 1070 1080 1090 1100
RVHFLQSVVV KVEEPGYAES QPLQGQVETL QGLLKQVQEQ VAQRARRQAE
1110 1120 1130 1140 1150
TQARQSFLQE SQQLLLWAES VQAQLRSKEV SVDVASAQRL LREHQDLLEE
1160 1170 1180 1190 1200
IHLWQERLQQ LDAQSQPMAA LDCPDSQEVP NTLRVLGQQG QELKVLWEQR
1210 1220 1230 1240 1250
QQWLQEGLEL QKFGREVDGF TATCANHQAW LHLDNLGEDV REALSLLQQH
1260 1270 1280 1290 1300
REFGRLLSTL GPRAEALRAH GEKLVQSQHP AAHTVREQLQ SIQAQWTRLQ
1310 1320 1330 1340 1350
GRSEQRRRQL LASLQLQEWK QDVAELMQWM EEKGLMAAHE PSGARRNILQ
1360 1370 1380 1390 1400
TLKRHEAAES ELLATRRHVE ALQQVGRELL SRRPCGQEDI QTRLQGLRSK
1410 1420 1430 1440 1450
WEALNRKMTE RGDELQQAGQ QEQLLRQLQD AKEQLEQLEG ALQSSETGQD
1460 1470 1480 1490 1500
LRSSQRLQKR HQQLESESRT LAAKMAALAS MAHGMAASPA ILEETQKHLR
1510 1520 1530 1540 1550
RLELLQGHLA IRGLQLQASV ELHQFCHLSN MELSWVAEHM PHGSPTSYTE
1560 1570 1580 1590 1600
CLNGAQSLHR KHKELQVEVK AHQGQVQRVL SSGRSLAASG HPQAQHIVEQ
1610 1620 1630 1640 1650
CQELEGHWAE LERACEARAQ CLQQAVTFQQ YFLDVSELEG WVEEKRPLVS
1660 1670 1680 1690 1700
SRDYGRDEAA TLRLINKHQA LQEELAIYWS SMEELDQTAQ TLTGPEVPEQ
1710 1720 1730 1740 1750
QRVVQERLRE QLRALQELAA TRDRELEGTL RLHEFLREAE DLQGWLASQK
1760 1770 1780 1790 1800
QAAKGGESLG EDPEHALHLC TKFAKFQHQV EMGSQRVAAC RLLAESLLER
1810 1820 1830 1840 1850
GHSAGPMVRQ RQQDLQTAWS ELWELTQARG HALRDTETTL RVHRDLLEVL
1860 1870 1880 1890 1900
TQVQEKATSL PNNVARDLCG LEAQLRSHQG LERELVGTER QLQELLETAG
1910 1920 1930 1940 1950
RVQKLCPGPQ AHAVQQRQQA VTQAWAVLQR RMEQRRAQLE RARLLARFRT
1960 1970 1980 1990 2000
AVRDYASWAA RVRQDLQVEE SSQEPSSGPL KLSAHQWLRA ELEAREKLWQ
2010 2020 2030 2040 2050
QATQLGQQAL LAAGTPTKEV QEELRALQDQ RDQVYQTWAR KQERLQAEQQ
2060 2070 2080 2090 2100
EQLFLRECGR LEEILAAQEV SLKTSALGSS VEEVEQLIRK HEVFLKVLTA
2110 2120 2130 2140 2150
QDKKEAALRE RLKTLRRPRV RDRLPILLQR RMRVKELAES RGHALHASLL
2160 2170 2180 2190 2200
MASFTQAATQ AEDWIQAWAQ QLKEPVPPGD LRDKLKPLLK HQAFEAEVQA
2210 2220 2230 2240 2250
HEEVMTSVAK KGEALLAQSH PRAGEVSQRL QGLRKHWEDL RQAMALRGQE
2260 2270 2280 2290 2300
LEDRRNFLEF LQRVDLAEAW IQEKEVKMNV GDLGQDLEHC LQLRRRLREF
2310 2320 2330 2340 2350
RGNSAGDTVG DACIRSISDL SLQLKNRDPE EVKIICQRRS QLNNRWASFH
2360 2370 2380 2390 2400
GNLLRYQQQL EGALEIHVLS RELDNVTKRI QEKEALIQAL DCGKDLESVQ
2410 2420 2430 2440 2450
RLLRKHEELE REVHPIQAQV ESLEREVGRL CQRSPEAAHG LRHRQQEVAE
2460 2470 2480 2490 2500
SWWQLRSRAQ KRREALDALH QAQKLQAMLQ ELLVSAQRLR AQMDTSPAPR
2510 2520 2530 2540 2550
SPVEARRMLE EHQECKAELD SWTDSISLAR STGQQLLTAG HPFSSDIRQV
2560 2570 2580 2590 2600
LAGLEQELSS LEGAWQEHQL QLQQALELQL FLSSVEKMER WLCSKEDSLA
2610 2620 2630 2640 2650
SEGLWDPLAP MEPLLWKHKM LEWDLEVQAG KISALEATAR GLHQGGHPEA
2660 2670 2680 2690 2700
QSALGRCQAM LLRKEALFRQ AGTRRHRLEE LRQLQAFLQD SQEVAAWLRE
2710 2720 2730 2740 2750
KNLVALEEGL LDTAMLPAQL QKQQNFQAEL DASMHQQQEL QREGQRLLQG
2760 2770 2780 2790 2800
GHPASEAIQE RLEELGALWG ELQDNSQKKV AKLQKACEAL RLRRSMEELE
2810 2820 2830 2840 2850
NWLEPIEVEL RAPTVGQALP GVGELLGTQR ELEAAVDKKA RQAEALLGQA
2860 2870 2880 2890 2900
QAFVREGHCL AQDVEEQARR LLQRFKSLRE PLQERRTALE ARSLLLKFFR
2910 2920 2930 2940 2950
DADEEMAWVQ EKLPLAAAQD YGQSLSAVRH LQEQHQNLES EMSSHEALTR
2960 2970 2980 2990 3000
VVLGTGYKLV QAGHFAAHEV AARVQQLEKA MAHLRAEAAR RRLLLQQAQE
3010 3020 3030 3040 3050
AQQFLTELLE AGSWLAERGH VLDSEDMGHS AEATQALLRR LEATKRDLEA
3060 3070 3080 3090 3100
FSPRIERLQQ TAALLESRKN PESPKVLAQL QAVREAHAEL LRRAEARGHG
3110 3120 3130 3140 3150
LQEQLQLHQL ERETLLLDAW LTTKAATAES QDYGQDLEGV KVLEEKFDAF
3160 3170 3180 3190 3200
RKEVQSLGQA KVYALRKLAG TLERGAPRRY PHIQAQRSRI EAAWERLDQA
3210 3220 3230 3240 3250
IKARTENLAA AHEVHSFQQA AAELQGRMQE KTALMKGEDG GHSLSSVRTL
3260 3270 3280 3290 3300
QQQHRRLERE LEAMEKEVAR LQTEACRLGQ LHPAAPGGLA KVQEAWATLQ
3310 3320 3330 3340 3350
AKAQERGQWL AQAAQGHAFL GRCQELLAWA QERQELASSE ELAEDVAGAE
3360 3370 3380 3390 3400
QLLGQHEELG QEIRECRLQA QDLRQEGQQL VDNSHFMSAE VTECLQELEG
3410 3420 3430 3440 3450
RLQELEEAWA LRWQRCAESW GLQKLRQRLE QAEAWLACWE GLLLKPDYGH
3460 3470 3480 3490 3500
SVSDVELLLH RHQDLEKLLA AQEEKFAQMQ KTEMEQELLL QPQELKPGRA
3510 3520 3530 3540 3550
GSSLTSFQWR PSGHQGLGAQ LAETRDPQDA KGTPTMEGSL EFKQHLLPGG
3560 3570 3580 3590 3600
RQPSSSSWDS CRGNLQGSSL SLFLDERMAA EKVASIALLD LTGARCERLR
3610 3620 3630 3640 3650
GRHGRKHTFS LRLTSGAEIL FAAPSEEQAE SWWRALGSTA AQSLSPKLKA
3660 3670
KPVSSLNECT TKDARPGCLL RSDP
Length:3,674
Mass (Da):416,750
Last modified:October 1, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83D1F94ADE670E13
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti433H → R in AAF65317 (PubMed:10764729).Curated1
Sequence conflicti1035C → R in AAF65317 (PubMed:10764729).Curated1
Sequence conflicti1053H → Y in AAF65317 (PubMed:10764729).Curated1
Sequence conflicti3564N → T in AAF65317 (PubMed:10764729).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0220501345R → H. Corresponds to variant dbSNP:rs2290559Ensembl.1
Natural variantiVAR_0243951367R → T. Corresponds to variant dbSNP:rs2290558Ensembl.1
Natural variantiVAR_0243962862Q → R. Corresponds to variant dbSNP:rs1456235Ensembl.1
Natural variantiVAR_0243973275A → G. Corresponds to variant dbSNP:rs1197660Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF233523 mRNA Translation: AAF65317.1
AC020659 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS61599.1

NCBI Reference Sequences

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RefSeqi
NP_057726.4, NM_016642.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.709819

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000320955; ENSP00000317790; ENSG00000137877

Database of genes from NCBI RefSeq genomes

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GeneIDi
51332

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51332

UCSC genome browser

More...
UCSCi
uc001zos.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233523 mRNA Translation: AAF65317.1
AC020659 Genomic DNA No translation available.
CCDSiCCDS61599.1
RefSeqiNP_057726.4, NM_016642.3
UniGeneiHs.709819

3D structure databases

ProteinModelPortaliQ9NRC6
SMRiQ9NRC6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119479, 4 interactors
IntActiQ9NRC6, 2 interactors
STRINGi9606.ENSP00000317790

PTM databases

iPTMnetiQ9NRC6
PhosphoSitePlusiQ9NRC6

Polymorphism and mutation databases

DMDMi17369320

Proteomic databases

EPDiQ9NRC6
PaxDbiQ9NRC6
PeptideAtlasiQ9NRC6
PRIDEiQ9NRC6
ProteomicsDBi82333

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320955; ENSP00000317790; ENSG00000137877
GeneIDi51332
KEGGihsa:51332
UCSCiuc001zos.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51332
DisGeNETi51332
EuPathDBiHostDB:ENSG00000137877.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPTBN5

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0012162
HGNCiHGNC:15680 SPTBN5
MIMi605916 gene
neXtProtiNX_Q9NRC6
OpenTargetsiENSG00000137877
PharmGKBiPA38020

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0035 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000161549
HOGENOMiHOG000168577
InParanoidiQ9NRC6
KOiK06115
OMAiHEGHFNA
OrthoDBiEOG091G002Y
PhylomeDBiQ9NRC6
TreeFamiTF313446

Enzyme and pathway databases

ReactomeiR-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6807878 COPI-mediated anterograde transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SPTBN5 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SPTBN5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51332

Protein Ontology

More...
PROi
PR:Q9NRC6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137877 Expressed in 97 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_SPTBN4
HS_SPTBN5
GenevisibleiQ9NRC6 HS

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00435 Spectrin, 27 hits
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 30 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPTN5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRC6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2014
Last modified: December 5, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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