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Entry version 164 (08 May 2019)
Sequence version 2 (02 Aug 2002)
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Protein

Eukaryotic translation initiation factor 4E transporter

Gene

EIF4ENIF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NRA8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E transporter
Short name:
4E-T
Short name:
eIF4E transporter
Alternative name(s):
Eukaryotic translation initiation factor 4E nuclear import factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16687 EIF4ENIF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607445 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NRA8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi30Y → A: Abolishes interaction with EIF4E. 1 Publication1
Mutagenesisi195 – 196RR → NS: Abolishes the nuclear localization. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
56478

Open Targets

More...
OpenTargetsi
ENSG00000184708

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
619 NON RARE IN EUROPE: Primary ovarian failure

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38410

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EIF4ENIF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
22095430

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000643811 – 985Eukaryotic translation initiation factor 4E transporterAdd BLAST985

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki410Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei417PhosphoserineCombined sources1
Modified residuei486N6-acetyllysineCombined sources1
Modified residuei513PhosphoserineCombined sources1
Modified residuei564PhosphoserineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei693PhosphoserineCombined sources1
Modified residuei920PhosphoserineCombined sources1
Modified residuei951PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NRA8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NRA8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NRA8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NRA8

PeptideAtlas

More...
PeptideAtlasi
Q9NRA8

PRoteomics IDEntifications database

More...
PRIDEi
Q9NRA8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82323
82324 [Q9NRA8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NRA8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NRA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184708 Expressed in 222 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NRA8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NRA8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001619
HPA002078

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EIF4E. Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha. Interacts with APOBEC3G in an RNA-dependent manner.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121148, 63 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NRA8

Protein interaction database and analysis system

More...
IntActi
Q9NRA8, 50 interactors

Molecular INTeraction database

More...
MINTi
Q9NRA8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380659

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1985
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ANRX-ray2.10C199-239[»]
6F9WX-ray2.62B954-985[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NRA8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 36EIF4E-binding7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi195 – 211Nuclear localization signalAdd BLAST17
Motifi438 – 447Nuclear export signal10
Motifi613 – 638Nuclear export signalAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi148 – 210Arg-richAdd BLAST63

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG0J Eukaryota
ENOG41110MN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012071

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232370

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NRA8

KEGG Orthology (KO)

More...
KOi
K18728

Identification of Orthologs from Complete Genome Data

More...
OMAi
PQNVPTR

Database of Orthologous Groups

More...
OrthoDBi
198628at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NRA8

TreeFam database of animal gene trees

More...
TreeFami
TF101531

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018862 eIF4E-T

The PANTHER Classification System

More...
PANTHERi
PTHR12269 PTHR12269, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10477 EIF4E-T, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRRSMGETE SGDAFLDLKK PPASKCPHRY TKEELLDIKE LPHSKQRPSC
60 70 80 90 100
LSEKYDSDGV WDPEKWHASL YPASGRSSPV ESLKKELDTD RPSLVRRIVD
110 120 130 140 150
PRERVKEDDL DVVLSPQRRS FGGGCHVTAA VSSRRSGSPL EKDSDGLRLL
160 170 180 190 200
GGRRIGSGRI ISARTFEKDH RLSDKDLRDL RDRDRERDFK DKRFRREFGD
210 220 230 240 250
SKRVFGERRR NDSYTEEEPE WFSAGPTSQS ETIELTGFDD KILEEDHKGR
260 270 280 290 300
KRTRRRTASV KEGIVECNGG VAEEDEVEVI LAQEPAADQE VPRDAVLPEQ
310 320 330 340 350
SPGDFDFNEF FNLDKVPCLA SMIEDVLGEG SVSASRFSRW FSNPSRSGSR
360 370 380 390 400
SSSLGSTPHE ELERLAGLEQ AILSPGQNSG NYFAPIPLED HAENKVDILE
410 420 430 440 450
MLQKAKVDLK PLLSSLSANK EKLKESSHSG VVLSVEEVEA GLKGLKVDQQ
460 470 480 490 500
VKNSTPFMAE HLEETLSAVT NNRQLKKDGD MTAFNKLVST MKASGTLPSQ
510 520 530 540 550
PKVSRNLESH LMSPAEIPGQ PVPKNILQEL LGQPVQRPAS SNLLSGLMGS
560 570 580 590 600
LEPTTSLLGQ RAPSPPLSQV FQTRAASADY LRPRIPSPIG FTPGPQQLLG
610 620 630 640 650
DPFQGMRKPM SPITAQMSQL ELQQAALEGL ALPHDLAVQA ANFYQPGFGK
660 670 680 690 700
PQVDRTRDGF RNRQQRVTKS PAPVHRGNSS SPAPAASITS MLSPSFTPTS
710 720 730 740 750
VIRKMYESKE KSKEEPASGK AALGDSKEDT QKASEENLLS SSSVPSADRD
760 770 780 790 800
SSPTTNSKLS ALQRSSCSTP LSQANRYTKE QDYRPKATGR KTPTLASPVP
810 820 830 840 850
TTPFLRPVHQ VPLVPHVPMV RPAHQLHPGL VQRMLAQGVH PQHLPSLLQT
860 870 880 890 900
GVLPPGMDLS HLQGISGPIL GQPFYPLPAA SHPLLNPRPG TPLHLAMVQQ
910 920 930 940 950
QLQRSVLHPP GSGSHAAAVS VQTTPQNVPS RSGLPHMHSQ LEHRPSQRSS
960 970 980
SPVGLAKWFG SDVLQQPLPS MPAKVISVDE LEYRQ
Length:985
Mass (Da):108,201
Last modified:August 2, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C898E0488903C04
GO
Isoform 2 (identifier: Q9NRA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-262: Missing.
     493-504: Missing.
     616-616: Q → QQ

Note: No experimental confirmation available.
Show »
Length:811
Mass (Da):88,226
Checksum:iB93D3AE24B15E7C0
GO
Isoform 3 (identifier: Q9NRA8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     616-616: Q → QQ

Note: No experimental confirmation available.
Show »
Length:986
Mass (Da):108,329
Checksum:iCBED6CC9160D72C0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYZ7B0QYZ7_HUMAN
Eukaryotic translation initiation f...
EIF4ENIF1
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKL4B1AKL4_HUMAN
Eukaryotic translation initiation f...
EIF4ENIF1
961Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKL5B1AKL5_HUMAN
Eukaryotic translation initiation f...
EIF4ENIF1
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0J7H7C0J7_HUMAN
Eukaryotic translation initiation f...
EIF4ENIF1
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKL6B1AKL6_HUMAN
Eukaryotic translation initiation f...
EIF4ENIF1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15092 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11194 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti114L → F in AAF81693 (PubMed:10856257).Curated1
Sequence conflicti825Q → R in AAH33028 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003783100 – 262Missing in isoform 2. 1 PublicationAdd BLAST163
Alternative sequenceiVSP_003784493 – 504Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_047042616Q → QQ in isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF240775 mRNA Translation: AAF81693.1
CR456386 mRNA Translation: CAG30272.1
AK025254 mRNA Translation: BAB15092.1 Different initiation.
AK074768 mRNA Translation: BAC11194.1 Different initiation.
AK314636 mRNA Translation: BAG37198.1
AL096701 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59977.1
BC032941 mRNA Translation: AAH32941.1
BC033028 mRNA Translation: AAH33028.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13898.1 [Q9NRA8-1]
CCDS54520.1 [Q9NRA8-2]

NCBI Reference Sequences

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RefSeqi
NP_001157973.1, NM_001164501.1 [Q9NRA8-1]
NP_001157974.1, NM_001164502.1 [Q9NRA8-2]
NP_062817.2, NM_019843.3 [Q9NRA8-1]
XP_005261743.1, XM_005261686.2 [Q9NRA8-3]
XP_005261744.1, XM_005261687.2 [Q9NRA8-3]
XP_005261745.1, XM_005261688.2 [Q9NRA8-3]
XP_011528582.1, XM_011530280.1 [Q9NRA8-1]
XP_011528583.1, XM_011530281.2 [Q9NRA8-3]
XP_016884353.1, XM_017028864.1 [Q9NRA8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000330125; ENSP00000328103; ENSG00000184708 [Q9NRA8-1]
ENST00000344710; ENSP00000342927; ENSG00000184708 [Q9NRA8-2]
ENST00000397525; ENSP00000380659; ENSG00000184708 [Q9NRA8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56478

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:56478

UCSC genome browser

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UCSCi
uc003akz.3 human [Q9NRA8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240775 mRNA Translation: AAF81693.1
CR456386 mRNA Translation: CAG30272.1
AK025254 mRNA Translation: BAB15092.1 Different initiation.
AK074768 mRNA Translation: BAC11194.1 Different initiation.
AK314636 mRNA Translation: BAG37198.1
AL096701 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59977.1
BC032941 mRNA Translation: AAH32941.1
BC033028 mRNA Translation: AAH33028.1
CCDSiCCDS13898.1 [Q9NRA8-1]
CCDS54520.1 [Q9NRA8-2]
RefSeqiNP_001157973.1, NM_001164501.1 [Q9NRA8-1]
NP_001157974.1, NM_001164502.1 [Q9NRA8-2]
NP_062817.2, NM_019843.3 [Q9NRA8-1]
XP_005261743.1, XM_005261686.2 [Q9NRA8-3]
XP_005261744.1, XM_005261687.2 [Q9NRA8-3]
XP_005261745.1, XM_005261688.2 [Q9NRA8-3]
XP_011528582.1, XM_011530280.1 [Q9NRA8-1]
XP_011528583.1, XM_011530281.2 [Q9NRA8-3]
XP_016884353.1, XM_017028864.1 [Q9NRA8-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ANRX-ray2.10C199-239[»]
6F9WX-ray2.62B954-985[»]
SMRiQ9NRA8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121148, 63 interactors
CORUMiQ9NRA8
IntActiQ9NRA8, 50 interactors
MINTiQ9NRA8
STRINGi9606.ENSP00000380659

PTM databases

iPTMnetiQ9NRA8
PhosphoSitePlusiQ9NRA8

Polymorphism and mutation databases

BioMutaiEIF4ENIF1
DMDMi22095430

Proteomic databases

EPDiQ9NRA8
jPOSTiQ9NRA8
MaxQBiQ9NRA8
PaxDbiQ9NRA8
PeptideAtlasiQ9NRA8
PRIDEiQ9NRA8
ProteomicsDBi82323
82324 [Q9NRA8-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
56478
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330125; ENSP00000328103; ENSG00000184708 [Q9NRA8-1]
ENST00000344710; ENSP00000342927; ENSG00000184708 [Q9NRA8-2]
ENST00000397525; ENSP00000380659; ENSG00000184708 [Q9NRA8-1]
GeneIDi56478
KEGGihsa:56478
UCSCiuc003akz.3 human [Q9NRA8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56478
DisGeNETi56478

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EIF4ENIF1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0016395
HGNCiHGNC:16687 EIF4ENIF1
HPAiHPA001619
HPA002078
MIMi607445 gene
neXtProtiNX_Q9NRA8
OpenTargetsiENSG00000184708
Orphaneti619 NON RARE IN EUROPE: Primary ovarian failure
PharmGKBiPA38410

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG0J Eukaryota
ENOG41110MN LUCA
GeneTreeiENSGT00390000012071
HOGENOMiHOG000232370
InParanoidiQ9NRA8
KOiK18728
OMAiPQNVPTR
OrthoDBi198628at2759
PhylomeDBiQ9NRA8
TreeFamiTF101531

Enzyme and pathway databases

SIGNORiQ9NRA8

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
EIF4ENIF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56478

Protein Ontology

More...
PROi
PR:Q9NRA8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184708 Expressed in 222 organ(s), highest expression level in testis
ExpressionAtlasiQ9NRA8 baseline and differential
GenevisibleiQ9NRA8 HS

Family and domain databases

InterProiView protein in InterPro
IPR018862 eIF4E-T
PANTHERiPTHR12269 PTHR12269, 1 hit
PfamiView protein in Pfam
PF10477 EIF4E-T, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei4ET_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRA8
Secondary accession number(s): B1AKL2
, B1AKL3, B2RBF1, Q8NCF2, Q9H708
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 2, 2002
Last modified: May 8, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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