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Entry version 176 (07 Oct 2020)
Sequence version 2 (02 Aug 2002)
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Protein

Eukaryotic translation initiation factor 4E transporter

Gene

EIF4ENIF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671).By similarity8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, RNA-mediated gene silencing, Translation regulation, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9NRA8

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9NRA8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E transporter1 Publication
Short name:
4E-T1 Publication
Short name:
eIF4E transporter1 Publication
Alternative name(s):
Eukaryotic translation initiation factor 4E nuclear import factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF4ENIF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000184708.17

Human Gene Nomenclature Database

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HGNCi
HGNC:16687, EIF4ENIF1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607445, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9NRA8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi30 – 36YTKEELL → ATKEEAA: Abolished interaction with EIF4E2. 2 Publications7
Mutagenesisi30Y → A: Abolishes interaction with EIF4E and EIF4E2. Impaired ability to repress mRNA translation. 4 Publications1
Mutagenesisi35 – 36LL → AA: Abolished interaction with EIF4E2. 1 Publication2
Mutagenesisi54 – 61KYDSDGVW → ADSDAA: Strongly reduced interaction with EIF4E and EIF4E2. 1 Publication8
Mutagenesisi195 – 196RR → NS: Abolishes the nuclear localization. 1 Publication2
Mutagenesisi301S → A in S6A mutant; abolished phosphorylation by MAPK8/JNK1; impaired P-body assembly in response to oxidative stress when associated with A-374, A-513, A-587, A-693 and A-752. 1 Publication1
Mutagenesisi374S → A in S6A mutant; abolished phosphorylation by MAPK8/JNK1; impaired P-body assembly in response to oxidative stress when associated with A-301, A-513, A-587, A-693 and A-752. 1 Publication1
Mutagenesisi513S → A in S6A mutant; abolished phosphorylation by MAPK8/JNK1; impaired P-body assembly in response to oxidative stress when associated with A-301, A-374, A-587, A-693 and A-752. 1 Publication1
Mutagenesisi587S → A in S6A mutant; abolished phosphorylation by MAPK8/JNK1; impaired P-body assembly in response to oxidative stress when associated with A-301, A-374, A-513, A-693 and A-752. 1 Publication1
Mutagenesisi693S → A in S6A mutant; abolished phosphorylation by MAPK8/JNK1; impaired P-body assembly in response to oxidative stress when associated with A-301, A-374, A-513, A-587 and A-752. 1 Publication1
Mutagenesisi752S → A in S6A mutant; abolished phosphorylation by MAPK8/JNK1; impaired P-body assembly in response to oxidative stress when associated with A-301, A-374, A-513, A-587 and A-693. 1 Publication1
Mutagenesisi955 – 958LAKW → AAKA: Abolished interaction with LSM14A. 1 Publication4
Mutagenesisi958W → A: Abolished interaction with LSM14A. 1 Publication1
Mutagenesisi959F → A: Abolished interaction with LSM14A. 1 Publication1
Mutagenesisi961S → A: Does not affect interaction with LSM14A. 1 Publication1
Mutagenesisi970S → A: Does not affect interaction with LSM14A. 1 Publication1
Mutagenesisi978 – 981VDEL → ADEA: Abolished interaction with LSM14A. 1 Publication4
Mutagenesisi978V → A: Abolished interaction with LSM14A. 1 Publication1
Mutagenesisi982E → K: Abolished interaction with LSM14A. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
56478

Open Targets

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OpenTargetsi
ENSG00000184708

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
619, NON RARE IN EUROPE: Primary ovarian failure

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38410

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NRA8, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EIF4ENIF1

Domain mapping of disease mutations (DMDM)

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DMDMi
22095430

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000643811 – 985Eukaryotic translation initiation factor 4E transporterAdd BLAST985

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1 Publication1
Modified residuei345PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei374Phosphoserine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki410Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei417PhosphoserineCombined sources1
Modified residuei486N6-acetyllysineCombined sources1
Modified residuei513PhosphoserineCombined sources1 Publication1
Modified residuei564PhosphoserineCombined sources1
Modified residuei587PhosphoserineCombined sources1 Publication1
Modified residuei693PhosphoserineCombined sources1 Publication1
Modified residuei752Phosphoserine1 Publication1
Modified residuei920PhosphoserineCombined sources1
Modified residuei951PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by MAPK8/JNK1 and or MAPK9/JNK2 in response to oxidative stress promotes P-body assembly (PubMed:22966201). Phosphorylated during meiotic maturation (By similarity).By similarity1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NRA8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NRA8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NRA8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NRA8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NRA8

PeptideAtlas

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PeptideAtlasi
Q9NRA8

PRoteomics IDEntifications database

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PRIDEi
Q9NRA8

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
3074
82323 [Q9NRA8-1]
82324 [Q9NRA8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NRA8

MetOSite database of methionine sulfoxide sites

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MetOSitei
Q9NRA8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NRA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000184708, Expressed in testis and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NRA8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NRA8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000184708, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via YXXXXLphi motif) with EIF4E (PubMed:10856257, PubMed:16157702, PubMed:23991149, PubMed:24335285, PubMed:25923732, PubMed:28487484).

Interacts (via YXXXXLphi motif) with EIF4E2 (PubMed:23991149, PubMed:28487484).

Interacts with DDX6 (PubMed:26027925, PubMed:27342281, PubMed:28216671, PubMed:31422817, PubMed:32354837, PubMed:26489469).

Interacts with CSDE1/UNR (PubMed:27342281, PubMed:32354837).

Interacts with CNOT1; promoting association with the CCR4-NOT complex (PubMed:26027925, PubMed:27342281, PubMed:32354837, PubMed:26489469).

Interacts with LSM14A; promoting EIF4ENIF1 localization to P-bodies (PubMed:26027925, PubMed:32354837, PubMed:29510985).

Interacts with PATL1 (PubMed:26027925, PubMed:32354837).

Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha (PubMed:10856257).

Interacts with APOBEC3G in an RNA-dependent manner (PubMed:16699599).

14 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1985
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NRA8

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni131 – 161Interaction with CSDE11 PublicationAdd BLAST31
Regioni219 – 240Interaction with DDX61 PublicationAdd BLAST22
Regioni448 – 490Interaction with LSM14A1 PublicationAdd BLAST43
Regioni664 – 693DisorderedSequence analysisAdd BLAST30
Regioni695 – 713Interaction with PATL11 PublicationAdd BLAST19
Regioni707 – 803DisorderedSequence analysisAdd BLAST97
Regioni922 – 953DisorderedSequence analysisAdd BLAST32
Regioni940 – 985Interaction with LSM14A1 PublicationAdd BLAST46

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi30 – 36YXXXXLphi motif2 Publications7
Motifi195 – 211Nuclear localization signal1 PublicationAdd BLAST17
Motifi438 – 447Nuclear export signal1 Publication10
Motifi613 – 638Nuclear export signal1 PublicationAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi148 – 210Arg-richAdd BLAST63

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Intrinsically disordered protein with multiple low-complexity regions that confer binding to multiple RNA translation, deadenylation and decapping factors.2 Publications
The YXXXXLphi motif mediates interaction with eIF4E (EIF4E and EIF4E2).4 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 4E-T/EIF4E-T family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QRQE, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000012071

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NRA8

KEGG Orthology (KO)

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KOi
K18728

Identification of Orthologs from Complete Genome Data

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OMAi
YNKEELM

Database of Orthologous Groups

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OrthoDBi
198628at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NRA8

TreeFam database of animal gene trees

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TreeFami
TF101531

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018862, eIF4E-T

The PANTHER Classification System

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PANTHERi
PTHR12269, PTHR12269, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10477, EIF4E-T, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MDRRSMGETE SGDAFLDLKK PPASKCPHRY TKEELLDIKE LPHSKQRPSC
60 70 80 90 100
LSEKYDSDGV WDPEKWHASL YPASGRSSPV ESLKKELDTD RPSLVRRIVD
110 120 130 140 150
PRERVKEDDL DVVLSPQRRS FGGGCHVTAA VSSRRSGSPL EKDSDGLRLL
160 170 180 190 200
GGRRIGSGRI ISARTFEKDH RLSDKDLRDL RDRDRERDFK DKRFRREFGD
210 220 230 240 250
SKRVFGERRR NDSYTEEEPE WFSAGPTSQS ETIELTGFDD KILEEDHKGR
260 270 280 290 300
KRTRRRTASV KEGIVECNGG VAEEDEVEVI LAQEPAADQE VPRDAVLPEQ
310 320 330 340 350
SPGDFDFNEF FNLDKVPCLA SMIEDVLGEG SVSASRFSRW FSNPSRSGSR
360 370 380 390 400
SSSLGSTPHE ELERLAGLEQ AILSPGQNSG NYFAPIPLED HAENKVDILE
410 420 430 440 450
MLQKAKVDLK PLLSSLSANK EKLKESSHSG VVLSVEEVEA GLKGLKVDQQ
460 470 480 490 500
VKNSTPFMAE HLEETLSAVT NNRQLKKDGD MTAFNKLVST MKASGTLPSQ
510 520 530 540 550
PKVSRNLESH LMSPAEIPGQ PVPKNILQEL LGQPVQRPAS SNLLSGLMGS
560 570 580 590 600
LEPTTSLLGQ RAPSPPLSQV FQTRAASADY LRPRIPSPIG FTPGPQQLLG
610 620 630 640 650
DPFQGMRKPM SPITAQMSQL ELQQAALEGL ALPHDLAVQA ANFYQPGFGK
660 670 680 690 700
PQVDRTRDGF RNRQQRVTKS PAPVHRGNSS SPAPAASITS MLSPSFTPTS
710 720 730 740 750
VIRKMYESKE KSKEEPASGK AALGDSKEDT QKASEENLLS SSSVPSADRD
760 770 780 790 800
SSPTTNSKLS ALQRSSCSTP LSQANRYTKE QDYRPKATGR KTPTLASPVP
810 820 830 840 850
TTPFLRPVHQ VPLVPHVPMV RPAHQLHPGL VQRMLAQGVH PQHLPSLLQT
860 870 880 890 900
GVLPPGMDLS HLQGISGPIL GQPFYPLPAA SHPLLNPRPG TPLHLAMVQQ
910 920 930 940 950
QLQRSVLHPP GSGSHAAAVS VQTTPQNVPS RSGLPHMHSQ LEHRPSQRSS
960 970 980
SPVGLAKWFG SDVLQQPLPS MPAKVISVDE LEYRQ
Length:985
Mass (Da):108,201
Last modified:August 2, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C898E0488903C04
GO
Isoform 2 (identifier: Q9NRA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-262: Missing.
     493-504: Missing.
     616-616: Q → QQ

Show »
Length:811
Mass (Da):88,226
Checksum:iB93D3AE24B15E7C0
GO
Isoform 3 (identifier: Q9NRA8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     616-616: Q → QQ

Show »
Length:986
Mass (Da):108,329
Checksum:iCBED6CC9160D72C0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYZ7B0QYZ7_HUMAN
Eukaryotic translation initiation f...
EIF4ENIF1
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKL4B1AKL4_HUMAN
Eukaryotic translation initiation f...
EIF4ENIF1
961Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKL5B1AKL5_HUMAN
Eukaryotic translation initiation f...
EIF4ENIF1
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKL6B1AKL6_HUMAN
Eukaryotic translation initiation f...
EIF4ENIF1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0J7H7C0J7_HUMAN
Eukaryotic translation initiation f...
EIF4ENIF1
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15092 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11194 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti114L → F in AAF81693 (PubMed:10856257).Curated1
Sequence conflicti825Q → R in AAH33028 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003783100 – 262Missing in isoform 2. 1 PublicationAdd BLAST163
Alternative sequenceiVSP_003784493 – 504Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_047042616Q → QQ in isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF240775 mRNA Translation: AAF81693.1
CR456386 mRNA Translation: CAG30272.1
AK025254 mRNA Translation: BAB15092.1 Different initiation.
AK074768 mRNA Translation: BAC11194.1 Different initiation.
AK314636 mRNA Translation: BAG37198.1
AL096701 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59977.1
BC032941 mRNA Translation: AAH32941.1
BC033028 mRNA Translation: AAH33028.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13898.1 [Q9NRA8-1]
CCDS54520.1 [Q9NRA8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001157973.1, NM_001164501.1 [Q9NRA8-1]
NP_001157974.1, NM_001164502.1 [Q9NRA8-2]
NP_062817.2, NM_019843.3 [Q9NRA8-1]
XP_005261743.1, XM_005261686.2 [Q9NRA8-3]
XP_005261744.1, XM_005261687.2 [Q9NRA8-3]
XP_005261745.1, XM_005261688.2 [Q9NRA8-3]
XP_011528582.1, XM_011530280.1 [Q9NRA8-1]
XP_011528583.1, XM_011530281.2 [Q9NRA8-3]
XP_016884353.1, XM_017028864.1 [Q9NRA8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330125; ENSP00000328103; ENSG00000184708 [Q9NRA8-1]
ENST00000344710; ENSP00000342927; ENSG00000184708 [Q9NRA8-2]
ENST00000397525; ENSP00000380659; ENSG00000184708 [Q9NRA8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56478

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56478

UCSC genome browser

More...
UCSCi
uc003akz.3, human [Q9NRA8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240775 mRNA Translation: AAF81693.1
CR456386 mRNA Translation: CAG30272.1
AK025254 mRNA Translation: BAB15092.1 Different initiation.
AK074768 mRNA Translation: BAC11194.1 Different initiation.
AK314636 mRNA Translation: BAG37198.1
AL096701 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59977.1
BC032941 mRNA Translation: AAH32941.1
BC033028 mRNA Translation: AAH33028.1
CCDSiCCDS13898.1 [Q9NRA8-1]
CCDS54520.1 [Q9NRA8-2]
RefSeqiNP_001157973.1, NM_001164501.1 [Q9NRA8-1]
NP_001157974.1, NM_001164502.1 [Q9NRA8-2]
NP_062817.2, NM_019843.3 [Q9NRA8-1]
XP_005261743.1, XM_005261686.2 [Q9NRA8-3]
XP_005261744.1, XM_005261687.2 [Q9NRA8-3]
XP_005261745.1, XM_005261688.2 [Q9NRA8-3]
XP_011528582.1, XM_011530280.1 [Q9NRA8-1]
XP_011528583.1, XM_011530281.2 [Q9NRA8-3]
XP_016884353.1, XM_017028864.1 [Q9NRA8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ANRX-ray2.10C199-239[»]
6F9WX-ray2.62B954-985[»]
6X2RX-ray2.30D434-448[»]
SMRiQ9NRA8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121148, 82 interactors
CORUMiQ9NRA8
IntActiQ9NRA8, 56 interactors
MINTiQ9NRA8
STRINGi9606.ENSP00000380659

PTM databases

iPTMnetiQ9NRA8
MetOSiteiQ9NRA8
PhosphoSitePlusiQ9NRA8

Polymorphism and mutation databases

BioMutaiEIF4ENIF1
DMDMi22095430

Proteomic databases

EPDiQ9NRA8
jPOSTiQ9NRA8
MassIVEiQ9NRA8
MaxQBiQ9NRA8
PaxDbiQ9NRA8
PeptideAtlasiQ9NRA8
PRIDEiQ9NRA8
ProteomicsDBi3074
82323 [Q9NRA8-1]
82324 [Q9NRA8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
279, 296 antibodies

The DNASU plasmid repository

More...
DNASUi
56478

Genome annotation databases

EnsembliENST00000330125; ENSP00000328103; ENSG00000184708 [Q9NRA8-1]
ENST00000344710; ENSP00000342927; ENSG00000184708 [Q9NRA8-2]
ENST00000397525; ENSP00000380659; ENSG00000184708 [Q9NRA8-1]
GeneIDi56478
KEGGihsa:56478
UCSCiuc003akz.3, human [Q9NRA8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56478
DisGeNETi56478
EuPathDBiHostDB:ENSG00000184708.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EIF4ENIF1
HGNCiHGNC:16687, EIF4ENIF1
HPAiENSG00000184708, Low tissue specificity
MIMi607445, gene
neXtProtiNX_Q9NRA8
OpenTargetsiENSG00000184708
Orphaneti619, NON RARE IN EUROPE: Primary ovarian failure
PharmGKBiPA38410

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QRQE, Eukaryota
GeneTreeiENSGT00390000012071
InParanoidiQ9NRA8
KOiK18728
OMAiYNKEELM
OrthoDBi198628at2759
PhylomeDBiQ9NRA8
TreeFamiTF101531

Enzyme and pathway databases

PathwayCommonsiQ9NRA8
SIGNORiQ9NRA8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
56478, 37 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EIF4ENIF1, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
EIF4ENIF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56478
PharosiQ9NRA8, Tbio

Protein Ontology

More...
PROi
PR:Q9NRA8
RNActiQ9NRA8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184708, Expressed in testis and 236 other tissues
ExpressionAtlasiQ9NRA8, baseline and differential
GenevisibleiQ9NRA8, HS

Family and domain databases

InterProiView protein in InterPro
IPR018862, eIF4E-T
PANTHERiPTHR12269, PTHR12269, 1 hit
PfamiView protein in Pfam
PF10477, EIF4E-T, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei4ET_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRA8
Secondary accession number(s): B1AKL2
, B1AKL3, B2RBF1, Q8NCF2, Q9H708
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 2, 2002
Last modified: October 7, 2020
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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