PDGFC

Functionⁱ

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.12 Publications

Miscellaneous

A lower molecular weight form (around 43 kDa) is present in patients with papillary thyroid carcinoma.

GO - Molecular functionⁱ

growth factor activity Source: UniProtKB-KW
platelet-derived growth factor receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10806482
protein homodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10806482

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of transmembrane receptor protein tyrosine kinase activity Source: Ensembl
animal organ morphogenesis Source: Ensembl
bone development Source: Ensembl
cellular response to amino acid stimulus Source: Ensembl
central nervous system development
Source: UniProtKB
Traceable author statementⁱ
- 10858496
digestive tract development Source: Ensembl
embryonic organ development Source: InterPro
platelet-derived growth factor receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 10806482
positive regulation of cell division Source: UniProtKB-KW
positive regulation of cell migration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10806482
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 27492130
positive regulation of ERK1 and ERK2 cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of fibroblast proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10806482
positive regulation of MAP kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of phosphatidylinositol 3-kinase signaling
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of protein autophosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of peptidyl-tyrosine phosphorylation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Growth factor, Mitogen

Molecular function

Developmental protein, Growth factor, Mitogen

Enzyme and pathway databases

Reactomeⁱ	R-HSA-186797 Signaling by PDGF
SignaLinkⁱ	Q9NRA1
SIGNORⁱ	Q9NRA1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Platelet-derived growth factor C Short name: PDGF-C Alternative name(s): Fallotein Spinal cord-derived growth factor Short name: SCDGF VEGF-E Cleaved into the following 2 chains: Platelet-derived growth factor C, latent form Short name: PDGFC latent form Platelet-derived growth factor C, receptor-binding form Short name: PDGFC receptor-binding form
Gene namesⁱ	Name:PDGFC Synonyms:SCDGF ORF Names:UNQ174/PRO200
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000145431.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8801 PDGFC
MIMⁱ	608452 gene
neXtProtⁱ	NX_Q9NRA1

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane, Nucleus, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	124	C → S: Loss of mitogenic activity of CUB domain in coronary artery smooth muscle cells. 1 Publication	1
Mutagenesisⁱ	231	R → A: Essential for cleavage by PLAT. 1 Publication	1
Mutagenesisⁱ	232	K → A: Not essential for cleavage by PLAT. 1 Publication	1
Mutagenesisⁱ	234	R → A: Not essential for cleavage by PLAT. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	56034
Open Targets More...OpenTargetsⁱ	ENSG00000145431
PharmGKBⁱ	PA33146

Polymorphism and mutation databases

BioMutaⁱ	PDGFC
DMDMⁱ	205830662

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000343872	? – 345	Platelet-derived growth factor C, receptor-binding form
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST	22
ChainⁱPRO_0000343871	23 – 345	Platelet-derived growth factor C, latent formAdd BLAST	323

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	25	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	55	N-linked (GlcNAc...) asparagineBy similarity	1
Disulfide bondⁱ	104 ↔ 124	PROSITE-ProRule annotation
Disulfide bondⁱ	250 ↔ 294	1 Publication
Disulfide bondⁱ	274	Interchain (with C-286)1 Publication
Disulfide bondⁱ	280 ↔ 335	1 Publication
Disulfide bondⁱ	286	Interchain (with C-274)1 Publication
Disulfide bondⁱ	287 ↔ 337	1 Publication

Post-translational modificationⁱ

Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG.

Sumoylated with SUMO1.1 Publication

N-glycosylated.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	225 – 226	Cleavage	2
Siteⁱ	231 – 232	CleavageSequence analysis	2
Siteⁱ	234 – 235	CleavageSequence analysis	2

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9NRA1
PaxDbⁱ	Q9NRA1
PeptideAtlas More...PeptideAtlasⁱ	Q9NRA1
PRIDEⁱ	Q9NRA1
ProteomicsDBⁱ	82318 82319 [Q9NRA1-2] 82320 [Q9NRA1-3]

PTM databases

iPTMnetⁱ	Q9NRA1
PhosphoSitePlusⁱ	Q9NRA1

Expressionⁱ

Tissue specificityⁱ

Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutively expressed in parietal epithelial cells of Bowman's capsule, tubular epithelial cells and in arterial endothelial cells (at protein level). Highly expressed in the platelets, prostate, testis and uterus. Higher expression is observed in uterine leiomyomata. Weaker expression in the spleen, thymus, heart, pancreas, liver, ovary cells and small intestine, and negligible expression in the colon and peripheral blood leukocytes.9 Publications

Developmental stageⁱ

In the fetal kidney, detected in the developing mesangium, ureteric bud epithelium and the undifferentiated mesenchyme (at protein level).1 Publication

Inductionⁱ

Up-regulated by EWS-FLI1 chimeric transcription factor in tumor derived cells. Up-regulated in podocytes and interstitial cells after injury/activation of these cells. FGF2 activates PDGFC transcription via EGR1. Up-regulated by TGFB1 in concert with FGF2.4 Publications

Gene expression databases

Bgeeⁱ	ENSG00000145431 Expressed in 228 organ(s), highest expression level in parotid gland
CleanExⁱ	HS_PDGFC
ExpressionAtlasⁱ	Q9NRA1 baseline and differential
Genevisibleⁱ	Q9NRA1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA009134

HPAⁱ

HPA009134

Interactionⁱ

Subunit structureⁱ

Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts (via CUB domain) with PLAT (via kringle domain).3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PDGFRA	P16234	2	EBI-8833587,EBI-2861522
PDGFRA	P16234-1	2	EBI-15499301,EBI-15499330

GO - Molecular functionⁱ

growth factor activity Source: UniProtKB-KW
platelet-derived growth factor receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10806482
protein homodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10806482

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121032, 7 interactors
ComplexPortalⁱ	CPX-2879 Platelet-derived growth factor CC complex CPX-2887 PDGF receptor alpha - PDGF-CC complex CPX-2888 PDGF receptor alpha-beta - PDGF-CC complex CPX-2891 PDGF receptor beta - PDGF-CC complex
Database of interacting proteins More...DIPⁱ	DIP-59339N
IntActⁱ	Q9NRA1, 4 interactors
STRINGⁱ	9606.ENSP00000422464

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NRA1
SMRⁱ	Q9NRA1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	46 – 163	CUBPROSITE-ProRule annotationAdd BLAST		118

Sequence similaritiesⁱ

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IETQ Eukaryota ENOG410XQ91 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005171
HOGENOMⁱ	HOG000185996
HOVERGENⁱ	HBG057324
InParanoidⁱ	Q9NRA1
KEGG Orthology (KO) More...KOⁱ	K05450
OMAⁱ	HTYPRNM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BFZ
PhylomeDBⁱ	Q9NRA1
TreeFamⁱ	TF332130

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00041 CUB, 1 hit cd00135 PDGF, 1 hit
Gene3Dⁱ	2.10.90.10, 1 hit 2.60.120.290, 1 hit
InterProⁱ	View protein in InterPro IPR000859 CUB_dom IPR029034 Cystine-knot_cytokine IPR029817 PDGF-C IPR000072 PDGF/VEGF_dom IPR035914 Sperma_CUB_dom_sf
PANTHERⁱ	PTHR11633:SF5 PTHR11633:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00431 CUB, 1 hit PF00341 PDGF, 1 hit
SMARTⁱ	View protein in SMART SM00042 CUB, 1 hit SM00141 PDGF, 1 hit
SUPFAMⁱ	SSF49854 SSF49854, 1 hit SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 1 hit PS50278 PDGF_2, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NRA1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLFGLLLLT SALAGQRQGT QAESNLSSKF QFSSNKEQNG VQDPQHERII 
        60         70         80         90        100
TVSTNGSIHS PRFPHTYPRN TVLVWRLVAV EENVWIQLTF DERFGLEDPE 
       110        120        130        140        150
DDICKYDFVE VEEPSDGTIL GRWCGSGTVP GKQISKGNQI RIRFVSDEYF 
       160        170        180        190        200
PSEPGFCIHY NIVMPQFTEA VSPSVLPPSA LPLDLLNNAI TAFSTLEDLI 
       210        220        230        240        250
RYLEPERWQL DLEDLYRPTW QLLGKAFVFG RKSRVVDLNL LTEEVRLYSC 
       260        270        280        290        300
TPRNFSVSIR EELKRTDTIF WPGCLLVKRC GGNCACCLHN CNECQCVPSK 
       310        320        330        340 
VTKKYHEVLQ LRPKTGVRGL HKSLTDVALE HHEECDCVCR GSTGG

Length:345

Mass (Da):39,029

Last modified:July 22, 2008 - v2

Checksum:ⁱCDE9E51F40633E78

GO

Isoform 2 (identifier: Q9NRA1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
244-306: Missing.

« Hide

        10         20         30         40         50
MSLFGLLLLT SALAGQRQGT QAESNLSSKF QFSSNKEQNG VQDPQHERII 
        60         70         80         90        100
TVSTNGSIHS PRFPHTYPRN TVLVWRLVAV EENVWIQLTF DERFGLEDPE 
       110        120        130        140        150
DDICKYDFVE VEEPSDGTIL GRWCGSGTVP GKQISKGNQI RIRFVSDEYF 
       160        170        180        190        200
PSEPGFCIHY NIVMPQFTEA VSPSVLPPSA LPLDLLNNAI TAFSTLEDLI 
       210        220        230        240        250
RYLEPERWQL DLEDLYRPTW QLLGKAFVFG RKSRVVDLNL LTEEVLQLRP 
       260        270        280 
KTGVRGLHKS LTDVALEHHE ECDCVCRGST GG

Note: No experimental confirmation available.

Show »

Length:282

Mass (Da):31,808

Checksum:ⁱ8426CEB8FF9AA45B

GO

Isoform 3 (identifier: Q9NRA1-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
155-167: GFCIHYNIVMPQF → SNRGGKIIQLHTS
168-345: Missing.

« Hide

        10         20         30         40         50
MSLFGLLLLT SALAGQRQGT QAESNLSSKF QFSSNKEQNG VQDPQHERII 
        60         70         80         90        100
TVSTNGSIHS PRFPHTYPRN TVLVWRLVAV EENVWIQLTF DERFGLEDPE 
       110        120        130        140        150
DDICKYDFVE VEEPSDGTIL GRWCGSGTVP GKQISKGNQI RIRFVSDEYF 
       160 
PSEPSNRGGK IIQLHTS

Note: No experimental confirmation available.

Show »

Length:167

Mass (Da):18,784

Checksum:ⁱ60023851D9FE5E65

GO

Isoform 4 (identifier: Q9NRA1-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-163: Missing.

« Hide

        10         20         30         40         50
MPQFTEAVSP SVLPPSALPL DLLNNAITAF STLEDLIRYL EPERWQLDLE 
        60         70         80         90        100
DLYRPTWQLL GKAFVFGRKS RVVDLNLLTE EVRLYSCTPR NFSVSIREEL 
       110        120        130        140        150
KRTDTIFWPG CLLVKRCGGN CACCLHNCNE CQCVPSKVTK KYHEVLQLRP 
       160        170        180 
KTGVRGLHKS LTDVALEHHE ECDCVCRGST GG

Note: No experimental confirmation available.

Show »

Length:182

Mass (Da):20,609

Checksum:ⁱF5B9733D3794B1B7

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y9N2	H0Y9N2_HUMAN	Platelet-derived growth factor C Platelet-derived growth factor C	PDGFC	53	Annotation score:
J3KN71	J3KN71_HUMAN	Platelet-derived growth factor C Platelet-derived growth factor C	PDGFC	50	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	9	L → V in AAF80597 (PubMed:10806482).Curated		1
Sequence conflictⁱ	18	Q → R in AAF80597 (PubMed:10806482).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_047606	1 – 163	Missing in isoform 4. 2 PublicationsAdd BLAST	163
Alternative sequenceⁱVSP_034701	155 – 167	GFCIH…VMPQF → SNRGGKIIQLHTS in isoform 3. CuratedAdd BLAST	13
Alternative sequenceⁱVSP_034702	168 – 345	Missing in isoform 3. CuratedAdd BLAST	178
Alternative sequenceⁱVSP_034703	244 – 306	Missing in isoform 2. CuratedAdd BLAST	63

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF091434 mRNA Translation: AAF00049.1 AB033831 mRNA Translation: BAB03266.1 AF244813 mRNA Translation: AAF80597.1 AF260738 mRNA Translation: AAK51637.1 AM922296 mRNA Translation: CAP58278.1 AY358493 mRNA Translation: AAQ88857.1 AK300480 mRNA Translation: BAG62196.1 AC092608 Genomic DNA Translation: AAY40906.1 AC093325 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04874.1 CH471056 Genomic DNA Translation: EAX04875.1 BC136662 mRNA Translation: AAI36663.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3795.1 [Q9NRA1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_057289.1, NM_016205.2 [Q9NRA1-1] XP_016863945.1, XM_017008456.1 [Q9NRA1-2]
UniGeneⁱ	Hs.570855

Genome annotation databases

Ensemblⁱ	ENST00000422544; ENSP00000410048; ENSG00000145431 [Q9NRA1-2] ENST00000502773; ENSP00000422464; ENSG00000145431 [Q9NRA1-1]
GeneIDⁱ	56034
KEGGⁱ	hsa:56034
UCSC genome browser More...UCSCⁱ	uc003iph.3 human [Q9NRA1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NRA1	Platelet derived growth factor C		GORGO		345	UniRef100_Q9NRA1
Platelet-derived growth factor C (Fragment)		MACMU		105
Isoform 4 of Platelet-derived growth factor C		HUMAN		182

Protein	Similar proteins		Species	Score	Length	Source
Q9NRA1	Platelet derived growth factor C		GORGO		345	UniRef90_Q9NRA1
Platelet-derived growth factor C (Fragment)		MACMU		105
Isoform 4 of Platelet-derived growth factor C		HUMAN		182
Uncharacterized protein		PIG		396
platelet-derived growth factor C isoform X2		DELLE		380
+102
Q9NRA1-2	Uncharacterized protein		MACMU		282	UniRef90_Q9NRA1-2
PDGFC isoform 4		PONAB		282
PDGFC isoform 5		PANTR		282
Platelet derived growth factor C		FELCA		282
platelet-derived growth factor C isoform X2		URSMA		282
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9NRA1	Platelet derived growth factor C		GORGO		345	UniRef50_Q9NRA1
Platelet-derived growth factor C (Fragment)		MACMU		105
Isoform 4 of Platelet-derived growth factor C		HUMAN		182
Uncharacterized protein		PIG		396
platelet-derived growth factor C isoform X1		PHYCD		380
+138
Q9NRA1-2	platelet-derived growth factor C isoform X2		URSMA		282	UniRef50_Q9NRA1-2
Uncharacterized protein		MACMU		282
PDGFC isoform 5		PANTR		282
PDGFC isoform 4		PONAB		282
Platelet derived growth factor C		FELCA		282
+6
Q9NRA1-3	Platelet-derived growth factor C		FUKDA		187	UniRef50_Q9NRA1-3
UPI000DF6D096		VULVU		165
UPI000529F373		COLST		172

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF091434 mRNA Translation: AAF00049.1 AB033831 mRNA Translation: BAB03266.1 AF244813 mRNA Translation: AAF80597.1 AF260738 mRNA Translation: AAK51637.1 AM922296 mRNA Translation: CAP58278.1 AY358493 mRNA Translation: AAQ88857.1 AK300480 mRNA Translation: BAG62196.1 AC092608 Genomic DNA Translation: AAY40906.1 AC093325 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04874.1 CH471056 Genomic DNA Translation: EAX04875.1 BC136662 mRNA Translation: AAI36663.1
CCDSⁱ	CCDS3795.1 [Q9NRA1-1]
RefSeqⁱ	NP_057289.1, NM_016205.2 [Q9NRA1-1] XP_016863945.1, XM_017008456.1 [Q9NRA1-2]
UniGeneⁱ	Hs.570855

3D structure databases

ProteinModelPortalⁱ	Q9NRA1
SMRⁱ	Q9NRA1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121032, 7 interactors
ComplexPortalⁱ	CPX-2879 Platelet-derived growth factor CC complex CPX-2887 PDGF receptor alpha - PDGF-CC complex CPX-2888 PDGF receptor alpha-beta - PDGF-CC complex CPX-2891 PDGF receptor beta - PDGF-CC complex
DIPⁱ	DIP-59339N
IntActⁱ	Q9NRA1, 4 interactors
STRINGⁱ	9606.ENSP00000422464

PTM databases

iPTMnetⁱ	Q9NRA1
PhosphoSitePlusⁱ	Q9NRA1

Polymorphism and mutation databases

BioMutaⁱ	PDGFC
DMDMⁱ	205830662

Proteomic databases

EPDⁱ	Q9NRA1
PaxDbⁱ	Q9NRA1
PeptideAtlasⁱ	Q9NRA1
PRIDEⁱ	Q9NRA1
ProteomicsDBⁱ	82318 82319 [Q9NRA1-2] 82320 [Q9NRA1-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000422544; ENSP00000410048; ENSG00000145431 [Q9NRA1-2] ENST00000502773; ENSP00000422464; ENSG00000145431 [Q9NRA1-1]
GeneIDⁱ	56034
KEGGⁱ	hsa:56034
UCSCⁱ	uc003iph.3 human [Q9NRA1-1]

Organism-specific databases

CTDⁱ	56034
DisGeNETⁱ	56034
EuPathDBⁱ	HostDB:ENSG00000145431.10
GeneCardsⁱ	PDGFC
HGNCⁱ	HGNC:8801 PDGFC
HPAⁱ	HPA009134
MIMⁱ	608452 gene
neXtProtⁱ	NX_Q9NRA1
OpenTargetsⁱ	ENSG00000145431
PharmGKBⁱ	PA33146
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IETQ Eukaryota ENOG410XQ91 LUCA
GeneTreeⁱ	ENSGT00390000005171
HOGENOMⁱ	HOG000185996
HOVERGENⁱ	HBG057324
InParanoidⁱ	Q9NRA1
KOⁱ	K05450
OMAⁱ	HTYPRNM
OrthoDBⁱ	EOG091G0BFZ
PhylomeDBⁱ	Q9NRA1
TreeFamⁱ	TF332130

Enzyme and pathway databases

Reactomeⁱ	R-HSA-186797 Signaling by PDGF
SignaLinkⁱ	Q9NRA1
SIGNORⁱ	Q9NRA1

Miscellaneous databases

ChiTaRSⁱ	PDGFC human
GeneWikiⁱ	PDGFC
GenomeRNAiⁱ	56034
Protein Ontology More...PROⁱ	PR:Q9NRA1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000145431 Expressed in 228 organ(s), highest expression level in parotid gland
CleanExⁱ	HS_PDGFC
ExpressionAtlasⁱ	Q9NRA1 baseline and differential
Genevisibleⁱ	Q9NRA1 HS

Family and domain databases

CDDⁱ	cd00041 CUB, 1 hit cd00135 PDGF, 1 hit
Gene3Dⁱ	2.10.90.10, 1 hit 2.60.120.290, 1 hit
InterProⁱ	View protein in InterPro IPR000859 CUB_dom IPR029034 Cystine-knot_cytokine IPR029817 PDGF-C IPR000072 PDGF/VEGF_dom IPR035914 Sperma_CUB_dom_sf
PANTHERⁱ	PTHR11633:SF5 PTHR11633:SF5, 1 hit
Pfamⁱ	View protein in Pfam PF00431 CUB, 1 hit PF00341 PDGF, 1 hit
SMARTⁱ	View protein in SMART SM00042 CUB, 1 hit SM00141 PDGF, 1 hit
SUPFAMⁱ	SSF49854 SSF49854, 1 hit SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 1 hit PS50278 PDGF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PDGFC_HUMAN
Accessionⁱ	Q9NRA1Primary (citable) accession number: Q9NRA1 Secondary accession number(s): B4DU34 , B9EGR8, Q4W5M9, Q9UL22
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
	Last sequence update:	July 22, 2008
	Last modified:	November 7, 2018
	This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NRA1 (PDGFC_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Platelet-derived growth factor C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Nucleus

Cytosol

Other locations

Cytosol

Endoplasmic reticulum

Extracellular region or secreted

Golgi apparatus

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ