UniProtKB - Q9NRA1 (PDGFC_HUMAN)
Platelet-derived growth factor C
PDGFC
Functioni
Miscellaneous
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- growth factor receptor binding Source: GO_Central
- platelet-derived growth factor receptor binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
GO - Biological processi
- activation of transmembrane receptor protein tyrosine kinase activity Source: Ensembl
- animal organ morphogenesis Source: Ensembl
- bone development Source: Ensembl
- cellular response to amino acid stimulus Source: Ensembl
- central nervous system development Source: UniProtKB
- digestive tract development Source: Ensembl
- embryonic organ development Source: InterPro
- platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell migration Source: GO_Central
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of ERK1 and ERK2 cascade Source: GO_Central
- positive regulation of fibroblast proliferation Source: BHF-UCL
- positive regulation of MAP kinase activity Source: GO_Central
- positive regulation of phosphatidylinositol 3-kinase signaling Source: GO_Central
- positive regulation of protein autophosphorylation Source: GO_Central
- regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Keywordsi
Molecular function | Developmental protein, Growth factor, Mitogen |
Enzyme and pathway databases
PathwayCommonsi | Q9NRA1 |
Reactomei | R-HSA-186797, Signaling by PDGF [Q9NRA1-1] |
SignaLinki | Q9NRA1 |
SIGNORi | Q9NRA1 |
Names & Taxonomyi
Protein namesi | Recommended name: Platelet-derived growth factor CShort name: PDGF-C Alternative name(s): Fallotein Spinal cord-derived growth factor Short name: SCDGF VEGF-E Cleaved into the following 2 chains: |
Gene namesi | Name:PDGFC Synonyms:SCDGF ORF Names:UNQ174/PRO200 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8801, PDGFC |
MIMi | 608452, gene |
neXtProti | NX_Q9NRA1 |
VEuPathDBi | HostDB:ENSG00000145431.10 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Extracellular region or secreted
- Secreted 6 Publications
Cytosol
- cytosol 1 Publication
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasmic granule 1 Publication
Note: Sumoylated form is predominant in the nucleus (PubMed:15247255). Stored in alpha granules in platelets (PubMed:15061151).1 Publication
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Golgi apparatus
- Golgi membrane Source: Reactome
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cell surface Source: BHF-UCL
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, Nucleus, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 124 | C → S: Loss of mitogenic activity of CUB domain in coronary artery smooth muscle cells. 1 Publication | 1 | |
Mutagenesisi | 231 | R → A: Essential for cleavage by PLAT. 1 Publication | 1 | |
Mutagenesisi | 232 | K → A: Not essential for cleavage by PLAT. 1 Publication | 1 | |
Mutagenesisi | 234 | R → A: Not essential for cleavage by PLAT. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 56034 |
OpenTargetsi | ENSG00000145431 |
PharmGKBi | PA33146 |
Miscellaneous databases
Pharosi | Q9NRA1, Tbio |
Genetic variation databases
BioMutai | PDGFC |
DMDMi | 205830662 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000343871 | 23 – 345 | Platelet-derived growth factor C, latent formAdd BLAST | 323 | |
ChainiPRO_0000343872 | ? – 345 | Platelet-derived growth factor C, receptor-binding form |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 55 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Disulfide bondi | 104 ↔ 124 | PROSITE-ProRule annotation | ||
Disulfide bondi | 250 ↔ 294 | 1 Publication | ||
Disulfide bondi | 274 | Interchain (with C-286)1 Publication | ||
Disulfide bondi | 280 ↔ 335 | 1 Publication | ||
Disulfide bondi | 286 | Interchain (with C-274)1 Publication | ||
Disulfide bondi | 287 ↔ 337 | 1 Publication |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 225 – 226 | Cleavage | 2 | |
Sitei | 231 – 232 | CleavageSequence analysis | 2 | |
Sitei | 234 – 235 | CleavageSequence analysis | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Ubl conjugationProteomic databases
EPDi | Q9NRA1 |
MassIVEi | Q9NRA1 |
PaxDbi | Q9NRA1 |
PeptideAtlasi | Q9NRA1 |
PRIDEi | Q9NRA1 |
ProteomicsDBi | 5147 82318 [Q9NRA1-1] 82319 [Q9NRA1-2] 82320 [Q9NRA1-3] |
PTM databases
GlyGeni | Q9NRA1, 2 sites |
iPTMneti | Q9NRA1 |
PhosphoSitePlusi | Q9NRA1 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000145431, Expressed in parotid gland and 239 other tissues |
ExpressionAtlasi | Q9NRA1, baseline and differential |
Genevisiblei | Q9NRA1, HS |
Organism-specific databases
HPAi | ENSG00000145431, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
Interacts (via CUB domain) with PLAT (via kringle domain).
3 PublicationsBinary interactionsi
Hide detailsQ9NRA1
With | #Exp. | IntAct |
---|---|---|
PDGFRA [P16234] | 2 | EBI-8833587,EBI-2861522 |
Isoform 1 [Q9NRA1-1]
With | #Exp. | IntAct |
---|---|---|
PDGFRA - isoform 1 [P16234-1] | 2 | EBI-15499301,EBI-15499330 |
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- growth factor receptor binding Source: GO_Central
- platelet-derived growth factor receptor binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 121032, 9 interactors |
ComplexPortali | CPX-2879, Platelet-derived growth factor CC complex CPX-2887, PDGF receptor alpha - PDGF-CC complex CPX-2888, PDGF receptor alpha-beta - PDGF-CC complex CPX-2891, PDGF receptor beta - PDGF-CC complex |
DIPi | DIP-59339N |
IntActi | Q9NRA1, 5 interactors |
STRINGi | 9606.ENSP00000422464 |
Miscellaneous databases
RNActi | Q9NRA1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 163 | CUBPROSITE-ProRule annotationAdd BLAST | 118 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QUUR, Eukaryota |
GeneTreei | ENSGT00940000158645 |
HOGENOMi | CLU_037859_0_0_1 |
InParanoidi | Q9NRA1 |
OMAi | CVCRGNA |
OrthoDBi | 962163at2759 |
PhylomeDBi | Q9NRA1 |
TreeFami | TF332130 |
Family and domain databases
CDDi | cd00041, CUB, 1 hit cd00135, PDGF, 1 hit |
Gene3Di | 2.10.90.10, 1 hit 2.60.120.290, 1 hit |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR029034, Cystine-knot_cytokine IPR029817, PDGF-C IPR000072, PDGF/VEGF_dom IPR035914, Sperma_CUB_dom_sf |
PANTHERi | PTHR11633:SF5, PTHR11633:SF5, 1 hit |
Pfami | View protein in Pfam PF00431, CUB, 1 hit PF00341, PDGF, 1 hit |
SMARTi | View protein in SMART SM00042, CUB, 1 hit SM00141, PDGF, 1 hit |
SUPFAMi | SSF49854, SSF49854, 1 hit SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS50278, PDGF_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLFGLLLLT SALAGQRQGT QAESNLSSKF QFSSNKEQNG VQDPQHERII
60 70 80 90 100
TVSTNGSIHS PRFPHTYPRN TVLVWRLVAV EENVWIQLTF DERFGLEDPE
110 120 130 140 150
DDICKYDFVE VEEPSDGTIL GRWCGSGTVP GKQISKGNQI RIRFVSDEYF
160 170 180 190 200
PSEPGFCIHY NIVMPQFTEA VSPSVLPPSA LPLDLLNNAI TAFSTLEDLI
210 220 230 240 250
RYLEPERWQL DLEDLYRPTW QLLGKAFVFG RKSRVVDLNL LTEEVRLYSC
260 270 280 290 300
TPRNFSVSIR EELKRTDTIF WPGCLLVKRC GGNCACCLHN CNECQCVPSK
310 320 330 340
VTKKYHEVLQ LRPKTGVRGL HKSLTDVALE HHEECDCVCR GSTGG
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y9N2 | H0Y9N2_HUMAN | Platelet-derived growth factor C | PDGFC | 53 | Annotation score: | ||
J3KN71 | J3KN71_HUMAN | Platelet-derived growth factor C | PDGFC | 50 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 9 | L → V in AAF80597 (PubMed:10806482).Curated | 1 | |
Sequence conflicti | 18 | Q → R in AAF80597 (PubMed:10806482).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047606 | 1 – 163 | Missing in isoform 4. 2 PublicationsAdd BLAST | 163 | |
Alternative sequenceiVSP_034701 | 155 – 167 | GFCIH…VMPQF → SNRGGKIIQLHTS in isoform 3. CuratedAdd BLAST | 13 | |
Alternative sequenceiVSP_034702 | 168 – 345 | Missing in isoform 3. CuratedAdd BLAST | 178 | |
Alternative sequenceiVSP_034703 | 244 – 306 | Missing in isoform 2. CuratedAdd BLAST | 63 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF091434 mRNA Translation: AAF00049.1 AB033831 mRNA Translation: BAB03266.1 AF244813 mRNA Translation: AAF80597.1 AF260738 mRNA Translation: AAK51637.1 AM922296 mRNA Translation: CAP58278.1 AY358493 mRNA Translation: AAQ88857.1 AK300480 mRNA Translation: BAG62196.1 AC092608 Genomic DNA Translation: AAY40906.1 AC093325 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04874.1 CH471056 Genomic DNA Translation: EAX04875.1 BC136662 mRNA Translation: AAI36663.1 |
CCDSi | CCDS3795.1 [Q9NRA1-1] |
RefSeqi | NP_057289.1, NM_016205.2 [Q9NRA1-1] XP_016863945.1, XM_017008456.1 [Q9NRA1-2] |
Genome annotation databases
Ensembli | ENST00000422544; ENSP00000410048; ENSG00000145431 [Q9NRA1-2] ENST00000502773; ENSP00000422464; ENSG00000145431 [Q9NRA1-1] |
GeneIDi | 56034 |
KEGGi | hsa:56034 |
UCSCi | uc003iph.3, human [Q9NRA1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF091434 mRNA Translation: AAF00049.1 AB033831 mRNA Translation: BAB03266.1 AF244813 mRNA Translation: AAF80597.1 AF260738 mRNA Translation: AAK51637.1 AM922296 mRNA Translation: CAP58278.1 AY358493 mRNA Translation: AAQ88857.1 AK300480 mRNA Translation: BAG62196.1 AC092608 Genomic DNA Translation: AAY40906.1 AC093325 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04874.1 CH471056 Genomic DNA Translation: EAX04875.1 BC136662 mRNA Translation: AAI36663.1 |
CCDSi | CCDS3795.1 [Q9NRA1-1] |
RefSeqi | NP_057289.1, NM_016205.2 [Q9NRA1-1] XP_016863945.1, XM_017008456.1 [Q9NRA1-2] |
3D structure databases
SMRi | Q9NRA1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121032, 9 interactors |
ComplexPortali | CPX-2879, Platelet-derived growth factor CC complex CPX-2887, PDGF receptor alpha - PDGF-CC complex CPX-2888, PDGF receptor alpha-beta - PDGF-CC complex CPX-2891, PDGF receptor beta - PDGF-CC complex |
DIPi | DIP-59339N |
IntActi | Q9NRA1, 5 interactors |
STRINGi | 9606.ENSP00000422464 |
PTM databases
GlyGeni | Q9NRA1, 2 sites |
iPTMneti | Q9NRA1 |
PhosphoSitePlusi | Q9NRA1 |
Genetic variation databases
BioMutai | PDGFC |
DMDMi | 205830662 |
Proteomic databases
EPDi | Q9NRA1 |
MassIVEi | Q9NRA1 |
PaxDbi | Q9NRA1 |
PeptideAtlasi | Q9NRA1 |
PRIDEi | Q9NRA1 |
ProteomicsDBi | 5147 82318 [Q9NRA1-1] 82319 [Q9NRA1-2] 82320 [Q9NRA1-3] |
Protocols and materials databases
Antibodypediai | 28096, 348 antibodies |
Genome annotation databases
Ensembli | ENST00000422544; ENSP00000410048; ENSG00000145431 [Q9NRA1-2] ENST00000502773; ENSP00000422464; ENSG00000145431 [Q9NRA1-1] |
GeneIDi | 56034 |
KEGGi | hsa:56034 |
UCSCi | uc003iph.3, human [Q9NRA1-1] |
Organism-specific databases
CTDi | 56034 |
DisGeNETi | 56034 |
GeneCardsi | PDGFC |
HGNCi | HGNC:8801, PDGFC |
HPAi | ENSG00000145431, Low tissue specificity |
MIMi | 608452, gene |
neXtProti | NX_Q9NRA1 |
OpenTargetsi | ENSG00000145431 |
PharmGKBi | PA33146 |
VEuPathDBi | HostDB:ENSG00000145431.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUUR, Eukaryota |
GeneTreei | ENSGT00940000158645 |
HOGENOMi | CLU_037859_0_0_1 |
InParanoidi | Q9NRA1 |
OMAi | CVCRGNA |
OrthoDBi | 962163at2759 |
PhylomeDBi | Q9NRA1 |
TreeFami | TF332130 |
Enzyme and pathway databases
PathwayCommonsi | Q9NRA1 |
Reactomei | R-HSA-186797, Signaling by PDGF [Q9NRA1-1] |
SignaLinki | Q9NRA1 |
SIGNORi | Q9NRA1 |
Miscellaneous databases
BioGRID-ORCSi | 56034, 10 hits in 875 CRISPR screens |
ChiTaRSi | PDGFC, human |
GeneWikii | PDGFC |
GenomeRNAii | 56034 |
Pharosi | Q9NRA1, Tbio |
PROi | PR:Q9NRA1 |
RNActi | Q9NRA1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000145431, Expressed in parotid gland and 239 other tissues |
ExpressionAtlasi | Q9NRA1, baseline and differential |
Genevisiblei | Q9NRA1, HS |
Family and domain databases
CDDi | cd00041, CUB, 1 hit cd00135, PDGF, 1 hit |
Gene3Di | 2.10.90.10, 1 hit 2.60.120.290, 1 hit |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR029034, Cystine-knot_cytokine IPR029817, PDGF-C IPR000072, PDGF/VEGF_dom IPR035914, Sperma_CUB_dom_sf |
PANTHERi | PTHR11633:SF5, PTHR11633:SF5, 1 hit |
Pfami | View protein in Pfam PF00431, CUB, 1 hit PF00341, PDGF, 1 hit |
SMARTi | View protein in SMART SM00042, CUB, 1 hit SM00141, PDGF, 1 hit |
SUPFAMi | SSF49854, SSF49854, 1 hit SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS50278, PDGF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PDGFC_HUMAN | |
Accessioni | Q9NRA1Primary (citable) accession number: Q9NRA1 Secondary accession number(s): B4DU34 Q9UL22 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 22, 2008 |
Last sequence update: | July 22, 2008 | |
Last modified: | February 10, 2021 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families