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UniProtKB - Q9NRA1 (PDGFC_HUMAN)

Entry version 148 (07 Apr 2021)
Sequence version 2 (22 Jul 2008)
Previous versions | rss
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Protein

Platelet-derived growth factor C

Gene

PDGFC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.12 Publications

Miscellaneous

A lower molecular weight form (around 43 kDa) is present in patients with papillary thyroid carcinoma.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NRA1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-186797, Signaling by PDGF [Q9NRA1-1]

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NRA1

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NRA1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Platelet-derived growth factor C
Short name:
PDGF-C
Alternative name(s):
Fallotein
Spinal cord-derived growth factor
Short name:
SCDGF
VEGF-E
Cleaved into the following 2 chains:
Platelet-derived growth factor C, latent form
Short name:
PDGFC latent form
Platelet-derived growth factor C, receptor-binding form
Short name:
PDGFC receptor-binding form
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDGFC
Synonyms:SCDGF
ORF Names:UNQ174/PRO200
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8801, PDGFC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608452, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NRA1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000145431.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi124C → S: Loss of mitogenic activity of CUB domain in coronary artery smooth muscle cells. 1 Publication1
Mutagenesisi231R → A: Essential for cleavage by PLAT. 1 Publication1
Mutagenesisi232K → A: Not essential for cleavage by PLAT. 1 Publication1
Mutagenesisi234R → A: Not essential for cleavage by PLAT. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		56034

Open Targets

More...OpenTargetsi		ENSG00000145431

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33146

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NRA1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PDGFC

Domain mapping of disease mutations (DMDM)

More...DMDMi		205830662

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000034387123 – 345Platelet-derived growth factor C, latent formAdd BLAST323
ChainiPRO_0000343872? – 345Platelet-derived growth factor C, receptor-binding form

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi55N-linked (GlcNAc...) asparagineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi104 ↔ 124PROSITE-ProRule annotation
Disulfide bondi250 ↔ 2941 Publication
Disulfide bondi274Interchain (with C-286)1 Publication
Disulfide bondi280 ↔ 3351 Publication
Disulfide bondi286Interchain (with C-274)1 Publication
Disulfide bondi287 ↔ 3371 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG.
Sumoylated with SUMO1.1 Publication
N-glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei225 – 226Cleavage2
Sitei231 – 232CleavageSequence analysis2
Sitei234 – 235CleavageSequence analysis2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NRA1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NRA1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NRA1

PeptideAtlas

More...PeptideAtlasi		Q9NRA1

PRoteomics IDEntifications database

More...PRIDEi		Q9NRA1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5147
82318 [Q9NRA1-1]
82319 [Q9NRA1-2]
82320 [Q9NRA1-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NRA1, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NRA1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NRA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutively expressed in parietal epithelial cells of Bowman's capsule, tubular epithelial cells and in arterial endothelial cells (at protein level). Highly expressed in the platelets, prostate, testis and uterus. Higher expression is observed in uterine leiomyomata. Weaker expression in the spleen, thymus, heart, pancreas, liver, ovary cells and small intestine, and negligible expression in the colon and peripheral blood leukocytes.9 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In the fetal kidney, detected in the developing mesangium, ureteric bud epithelium and the undifferentiated mesenchyme (at protein level).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by EWS-FLI1 chimeric transcription factor in tumor derived cells. Up-regulated in podocytes and interstitial cells after injury/activation of these cells. FGF2 activates PDGFC transcription via EGR1. Up-regulated by TGFB1 in concert with FGF2.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000145431, Expressed in parotid gland and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NRA1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NRA1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000145431, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.

Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB.

Interacts (via CUB domain) with PLAT (via kringle domain).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121032, 9 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2879, Platelet-derived growth factor CC complex
CPX-2887, PDGF receptor alpha - PDGF-CC complex
CPX-2888, PDGF receptor alpha-beta - PDGF-CC complex
CPX-2891, PDGF receptor beta - PDGF-CC complex

Database of interacting proteins

More...DIPi		DIP-59339N

Protein interaction database and analysis system

More...IntActi		Q9NRA1, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000422464

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NRA1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NRA1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 163CUBPROSITE-ProRule annotationAdd BLAST118

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUUR, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158645

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_037859_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NRA1

Identification of Orthologs from Complete Genome Data

More...OMAi		CVCRGNA

Database of Orthologous Groups

More...OrthoDBi		962163at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NRA1

TreeFam database of animal gene trees

More...TreeFami		TF332130

Family and domain databases

Conserved Domains Database

More...CDDi		cd00041, CUB, 1 hit
cd00135, PDGF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.10.90.10, 1 hit
2.60.120.290, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000859, CUB_dom
IPR029034, Cystine-knot_cytokine
IPR029817, PDGF-C
IPR000072, PDGF/VEGF_dom
IPR035914, Sperma_CUB_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11633:SF5, PTHR11633:SF5, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00431, CUB, 1 hit
PF00341, PDGF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00042, CUB, 1 hit
SM00141, PDGF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49854, SSF49854, 1 hit
SSF57501, SSF57501, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01180, CUB, 1 hit
PS50278, PDGF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NRA1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLFGLLLLT SALAGQRQGT QAESNLSSKF QFSSNKEQNG VQDPQHERII 
        60         70         80         90        100
TVSTNGSIHS PRFPHTYPRN TVLVWRLVAV EENVWIQLTF DERFGLEDPE 
       110        120        130        140        150
DDICKYDFVE VEEPSDGTIL GRWCGSGTVP GKQISKGNQI RIRFVSDEYF 
       160        170        180        190        200
PSEPGFCIHY NIVMPQFTEA VSPSVLPPSA LPLDLLNNAI TAFSTLEDLI 
       210        220        230        240        250
RYLEPERWQL DLEDLYRPTW QLLGKAFVFG RKSRVVDLNL LTEEVRLYSC 
       260        270        280        290        300
TPRNFSVSIR EELKRTDTIF WPGCLLVKRC GGNCACCLHN CNECQCVPSK 
       310        320        330        340 
VTKKYHEVLQ LRPKTGVRGL HKSLTDVALE HHEECDCVCR GSTGG
Length:345
Mass (Da):39,029
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDE9E51F40633E78
GO
Isoform 2 (identifier: Q9NRA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-306: Missing.

Show »
Length:282
Mass (Da):31,808
Checksum:i8426CEB8FF9AA45B
GO
Isoform 3 (identifier: Q9NRA1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-167: GFCIHYNIVMPQF → SNRGGKIIQLHTS
     168-345: Missing.

Show »
Length:167
Mass (Da):18,784
Checksum:i60023851D9FE5E65
GO
Isoform 4 (identifier: Q9NRA1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: Missing.

Show »
Length:182
Mass (Da):20,609
Checksum:iF5B9733D3794B1B7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9N2H0Y9N2_HUMAN
Platelet-derived growth factor C
PDGFC
53Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KN71J3KN71_HUMAN
Platelet-derived growth factor C
PDGFC
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9L → V in AAF80597 (PubMed:10806482).Curated1
Sequence conflicti18Q → R in AAF80597 (PubMed:10806482).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0476061 – 163Missing in isoform 4. 2 PublicationsAdd BLAST163
Alternative sequenceiVSP_034701155 – 167GFCIH…VMPQF → SNRGGKIIQLHTS in isoform 3. CuratedAdd BLAST13
Alternative sequenceiVSP_034702168 – 345Missing in isoform 3. CuratedAdd BLAST178
Alternative sequenceiVSP_034703244 – 306Missing in isoform 2. CuratedAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF091434 mRNA Translation: AAF00049.1
AB033831 mRNA Translation: BAB03266.1
AF244813 mRNA Translation: AAF80597.1
AF260738 mRNA Translation: AAK51637.1
AM922296 mRNA Translation: CAP58278.1
AY358493 mRNA Translation: AAQ88857.1
AK300480 mRNA Translation: BAG62196.1
AC092608 Genomic DNA Translation: AAY40906.1
AC093325 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04874.1
CH471056 Genomic DNA Translation: EAX04875.1
BC136662 mRNA Translation: AAI36663.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3795.1 [Q9NRA1-1]

NCBI Reference Sequences

More...RefSeqi		NP_057289.1, NM_016205.2 [Q9NRA1-1]
XP_016863945.1, XM_017008456.1 [Q9NRA1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000422544; ENSP00000410048; ENSG00000145431 [Q9NRA1-2]
ENST00000502773; ENSP00000422464; ENSG00000145431 [Q9NRA1-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56034

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56034

UCSC genome browser

More...UCSCi		uc003iph.3, human [Q9NRA1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091434 mRNA Translation: AAF00049.1
AB033831 mRNA Translation: BAB03266.1
AF244813 mRNA Translation: AAF80597.1
AF260738 mRNA Translation: AAK51637.1
AM922296 mRNA Translation: CAP58278.1
AY358493 mRNA Translation: AAQ88857.1
AK300480 mRNA Translation: BAG62196.1
AC092608 Genomic DNA Translation: AAY40906.1
AC093325 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04874.1
CH471056 Genomic DNA Translation: EAX04875.1
BC136662 mRNA Translation: AAI36663.1
CCDSiCCDS3795.1 [Q9NRA1-1]
RefSeqiNP_057289.1, NM_016205.2 [Q9NRA1-1]
XP_016863945.1, XM_017008456.1 [Q9NRA1-2]

3D structure databases

SMRiQ9NRA1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121032, 9 interactors
ComplexPortaliCPX-2879, Platelet-derived growth factor CC complex
CPX-2887, PDGF receptor alpha - PDGF-CC complex
CPX-2888, PDGF receptor alpha-beta - PDGF-CC complex
CPX-2891, PDGF receptor beta - PDGF-CC complex
DIPiDIP-59339N
IntActiQ9NRA1, 5 interactors
STRINGi9606.ENSP00000422464

PTM databases

GlyGeniQ9NRA1, 2 sites
iPTMnetiQ9NRA1
PhosphoSitePlusiQ9NRA1

Genetic variation databases

BioMutaiPDGFC
DMDMi205830662

Proteomic databases

EPDiQ9NRA1
MassIVEiQ9NRA1
PaxDbiQ9NRA1
PeptideAtlasiQ9NRA1
PRIDEiQ9NRA1
ProteomicsDBi5147
82318 [Q9NRA1-1]
82319 [Q9NRA1-2]
82320 [Q9NRA1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28096, 353 antibodies

Genome annotation databases

EnsembliENST00000422544; ENSP00000410048; ENSG00000145431 [Q9NRA1-2]
ENST00000502773; ENSP00000422464; ENSG00000145431 [Q9NRA1-1]
GeneIDi56034
KEGGihsa:56034
UCSCiuc003iph.3, human [Q9NRA1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56034
DisGeNETi56034

GeneCards: human genes, protein and diseases

More...GeneCardsi		PDGFC
HGNCiHGNC:8801, PDGFC
HPAiENSG00000145431, Low tissue specificity
MIMi608452, gene
neXtProtiNX_Q9NRA1
OpenTargetsiENSG00000145431
PharmGKBiPA33146
VEuPathDBiHostDB:ENSG00000145431.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QUUR, Eukaryota
GeneTreeiENSGT00940000158645
HOGENOMiCLU_037859_0_0_1
InParanoidiQ9NRA1
OMAiCVCRGNA
OrthoDBi962163at2759
PhylomeDBiQ9NRA1
TreeFamiTF332130

Enzyme and pathway databases

PathwayCommonsiQ9NRA1
ReactomeiR-HSA-186797, Signaling by PDGF [Q9NRA1-1]
SignaLinkiQ9NRA1
SIGNORiQ9NRA1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56034, 10 hits in 988 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PDGFC, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PDGFC

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56034
PharosiQ9NRA1, Tbio

Protein Ontology

More...PROi		PR:Q9NRA1
RNActiQ9NRA1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000145431, Expressed in parotid gland and 239 other tissues
ExpressionAtlasiQ9NRA1, baseline and differential
GenevisibleiQ9NRA1, HS

Family and domain databases

CDDicd00041, CUB, 1 hit
cd00135, PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR029034, Cystine-knot_cytokine
IPR029817, PDGF-C
IPR000072, PDGF/VEGF_dom
IPR035914, Sperma_CUB_dom_sf
PANTHERiPTHR11633:SF5, PTHR11633:SF5, 1 hit
PfamiView protein in Pfam
PF00431, CUB, 1 hit
PF00341, PDGF, 1 hit
SMARTiView protein in SMART
SM00042, CUB, 1 hit
SM00141, PDGF, 1 hit
SUPFAMiSSF49854, SSF49854, 1 hit
SSF57501, SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS01180, CUB, 1 hit
PS50278, PDGF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDGFC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRA1
Secondary accession number(s): B4DU34
, B9EGR8, Q4W5M9, Q9UL22
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: April 7, 2021
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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