UniProtKB - Q9NRA0 (SPHK2_HUMAN)
Sphingosine kinase 2
SPHK2
Functioni
Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:19168031, PubMed:12954646).
In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219).
In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514).
In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656).
In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110).
In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity).
In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity).
Also involved in the regulation of glucose and lipid metabolism (By similarity).
By similarity6 PublicationsCatalytic activityi
- EC:2.7.1.913 Publications
- EC:2.7.1.911 PublicationThis reaction proceeds in the forward1 Publication direction.
- EC:2.7.1.91By similarity
- EC:2.7.1.91By similarity
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 247 | Proton donor/acceptorBy similarity | 1 | |
Binding sitei | 252 | ATPPROSITE-ProRule annotation | 1 | |
Binding sitei | 344 | SubstrateBy similarity | 1 | |
Binding sitei | 351 | ATPPROSITE-ProRule annotation | 1 | |
Binding sitei | 357 | ATPPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 188 – 190 | ATPPROSITE-ProRule annotation | 3 | |
Nucleotide bindingi | 220 – 224 | ATPPROSITE-ProRule annotation | 5 | |
Nucleotide bindingi | 277 – 279 | ATPPROSITE-ProRule annotation | 3 | |
Nucleotide bindingi | 622 – 624 | ATPPROSITE-ProRule annotation | 3 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- D-erythro-sphingosine kinase activity Source: UniProtKB
- histone binding Source: GO_Central
- lipid kinase activity Source: GO_Central
- NAD+ kinase activity Source: InterPro
- small GTPase binding Source: UniProtKB
- sphinganine kinase activity Source: UniProtKB
- sphingosine-1-phosphate receptor activity Source: UniProtKB
GO - Biological processi
- blood vessel development Source: Ensembl
- brain development Source: Ensembl
- cellular response to phorbol 13-acetate 12-myristate Source: UniProtKB
- epigenetic maintenance of chromatin in transcription-competent conformation Source: UniProtKB
- female pregnancy Source: Ensembl
- histone H2A-K5 acetylation Source: UniProtKB
- histone H2B-K12 acetylation Source: UniProtKB
- negative regulation of cell growth Source: UniProtKB
- negative regulation of histone deacetylase activity Source: UniProtKB
- negative regulation of histone deacetylation Source: UniProtKB
- phosphorylation Source: GO_Central
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of calcium ion import Source: UniProtKB
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of ceramide biosynthetic process Source: UniProtKB
- positive regulation of cytokine production involved in immune response Source: UniProtKB
- positive regulation of histone H3-K9 acetylation Source: UniProtKB
- positive regulation of interleukin-13 production Source: UniProtKB
- positive regulation of interleukin-6 production Source: UniProtKB
- positive regulation of mast cell activation involved in immune response Source: UniProtKB
- positive regulation of mast cell degranulation Source: UniProtKB
- positive regulation of protein kinase C signaling Source: UniProtKB
- positive regulation of tumor necrosis factor production Source: UniProtKB
- regulation of ATP biosynthetic process Source: UniProtKB
- regulation of cytochrome-c oxidase activity Source: UniProtKB
- regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- regulation of reactive oxygen species biosynthetic process Source: UniProtKB
- sphinganine-1-phosphate biosynthetic process Source: UniProtKB
- sphingolipid biosynthetic process Source: Reactome
- sphingolipid metabolic process Source: GO_Central
- sphingosine biosynthetic process Source: UniProtKB
- sphingosine metabolic process Source: UniProtKB
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Lipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.1.91, 2681 |
PathwayCommonsi | Q9NRA0 |
Reactomei | R-HSA-1660661, Sphingolipid de novo biosynthesis |
SignaLinki | Q9NRA0 |
SIGNORi | Q9NRA0 |
Chemistry databases
SwissLipidsi | SLP:000000112 |
Names & Taxonomyi
Protein namesi | Recommended name: Sphingosine kinase 2Curated (EC:2.7.1.913 Publications)Short name: SK 2 Short name: SPK 2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18859, SPHK2 |
MIMi | 607092, gene |
neXtProti | NX_Q9NRA0 |
VEuPathDBi | HostDB:ENSG00000063176 |
Subcellular locationi
Nucleus
- Nucleus 6 Publications
Mitochondrion
- Mitochondrion inner membrane By similarity
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Cytoplasm and Cytosol
- Cytoplasm 5 Publications
Note: In nucleus, located in nucleosomes where it associates with core histone proteins such as histone 3 (PubMed:19729656). In brains of patients with Alzheimer's disease, may be preferentially localized in the nucleus. Cytosolic expression decrease correlates with the density of amyloid deposits (PubMed:29615132). In apoptotic cells, colocalizes with CASP1 in cell membrane where is cleaved and released from cells in an active form (PubMed:20197547).3 Publications
Lysosome
- Lysosome membrane 1 Publication
Cytosol
- cytosol Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: GO_Central
- membrane Source: UniProtKB
- nucleosome Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Lysosome, Membrane, Mitochondrion, Mitochondrion inner membrane, NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 138 | D → A: Abolishes cleavage and secretion in apoptotic cells. No effect on kinase activity. 1 Publication | 1 | |
Mutagenesisi | 212 | G → E: Decreases SPP production in nucleus. Abolishes increase of histone acetylation. No effect on association with histone 3. 1 Publication | 1 | |
Mutagenesisi | 220 | T → A: Loss of location to cell membrane. Not secreted. No effect on kinase acitivity. 1 Publication | 1 | |
Mutagenesisi | 387 | S → A: Strongly reduces phosphorylation levels. 1 Publication | 1 | |
Mutagenesisi | 419 – 421 | SVS → AVA: Abolishes nuclear export in response to PMA treatment. 1 Publication | 3 | |
Mutagenesisi | 423 – 425 | LPL → APA: Abolishes nuclear export. 1 Publication | 3 | |
Mutagenesisi | 437 | S → A: Reduces phosphorylation levels. 1 Publication | 1 | |
Mutagenesisi | 466 | S → A: Reduces phosphorylation levels. 1 Publication | 1 | |
Mutagenesisi | 477 | S → A: Reduces phosphorylation levels. 1 Publication | 1 | |
Mutagenesisi | 552 | D → A: No effect on cleavage and secretion in apoptotic cells. No effect on kinase activity. 1 Publication | 1 | |
Mutagenesisi | 614 | T → A: Abolishes phosphorylation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 56848 |
OpenTargetsi | ENSG00000063176 |
PharmGKBi | PA38719 |
Miscellaneous databases
Pharosi | Q9NRA0, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3023 |
DrugBanki | DB12764, Opaganib |
GuidetoPHARMACOLOGYi | 2205 |
Genetic variation databases
BioMutai | SPHK2 |
DMDMi | 22001996 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000181358 | 1 – 654 | Sphingosine kinase 2Add BLAST | 654 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 387 | Phosphoserine; by MAPKCombined sources1 Publication | 1 | |
Modified residuei | 393 | PhosphoserineBy similarity | 1 | |
Modified residuei | 399 | PhosphoserineCombined sources | 1 | |
Modified residuei | 419 | Phosphoserine; by PKD1 Publication | 1 | |
Modified residuei | 421 | Phosphoserine; by PKD1 Publication | 1 | |
Modified residuei | 477 | PhosphoserineCombined sources | 1 | |
Modified residuei | 614 | Phosphothreonine; by MAPK1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NRA0 |
jPOSTi | Q9NRA0 |
MassIVEi | Q9NRA0 |
MaxQBi | Q9NRA0 |
PaxDbi | Q9NRA0 |
PeptideAtlasi | Q9NRA0 |
PRIDEi | Q9NRA0 |
ProteomicsDBi | 82315 [Q9NRA0-1] 82316 [Q9NRA0-2] 82317 [Q9NRA0-3] 86 |
PTM databases
iPTMneti | Q9NRA0 |
PhosphoSitePlusi | Q9NRA0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000063176, Expressed in substantia nigra and 173 other tissues |
ExpressionAtlasi | Q9NRA0, baseline and differential |
Genevisiblei | Q9NRA0, HS |
Organism-specific databases
HPAi | ENSG00000063176, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Q9NRA0
With | #Exp. | IntAct |
---|---|---|
OPTN [Q96CV9] | 3 | EBI-985324,EBI-748974 |
GO - Molecular functioni
- histone binding Source: GO_Central
- small GTPase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 121208, 19 interactors |
IntActi | Q9NRA0, 7 interactors |
STRINGi | 9606.ENSP00000245222 |
Chemistry databases
BindingDBi | Q9NRA0 |
Miscellaneous databases
RNActi | Q9NRA0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 178 – 325 | DAGKcPROSITE-ProRule annotationAdd BLAST | 148 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 175 | Required for binding to sulfatide and phosphoinositides and for membrane localizatione1 PublicationAdd BLAST | 175 | |
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 245 – 248 | Substrate bindingBy similarity | 4 | |
Regioni | 400 – 509 | DisorderedSequence analysisAdd BLAST | 110 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 122 – 130 | Nuclear localization signalBy similarity | 9 | |
Motifi | 416 – 425 | Nuclear export signal1 Publication | 10 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 15 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Phylogenomic databases
eggNOGi | KOG1116, Eukaryota |
GeneTreei | ENSGT00940000161197 |
HOGENOMi | CLU_013399_1_1_1 |
InParanoidi | Q9NRA0 |
OMAi | EREDGMM |
OrthoDBi | 681139at2759 |
PhylomeDBi | Q9NRA0 |
TreeFami | TF354296 |
Family and domain databases
Gene3Di | 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR017438, ATP-NAD_kinase_N IPR001206, Diacylglycerol_kinase_cat_dom IPR016064, NAD/diacylglycerol_kinase_sf IPR045540, YegS/DAGK_C |
Pfami | View protein in Pfam PF00781, DAGK_cat, 1 hit PF19279, YegS_C, 1 hit |
SMARTi | View protein in SMART SM00046, DAGKc, 1 hit |
SUPFAMi | SSF111331, SSF111331, 1 hit |
PROSITEi | View protein in PROSITE PS50146, DAGK, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNGHLEAEEQ QDQRPDQELT GSWGHGPRST LVRAKAMAPP PPPLAASTPL
60 70 80 90 100
LHGEFGSYPA RGPRFALTLT SQALHIQRLR PKPEARPRGG LVPLAEVSGC
110 120 130 140 150
CTLRSRSPSD SAAYFCIYTY PRGRRGARRR ATRTFRADGA ATYEENRAEA
160 170 180 190 200
QRWATALTCL LRGLPLPGDG EITPDLLPRP PRLLLLVNPF GGRGLAWQWC
210 220 230 240 250
KNHVLPMISE AGLSFNLIQT ERQNHARELV QGLSLSEWDG IVTVSGDGLL
260 270 280 290 300
HEVLNGLLDR PDWEEAVKMP VGILPCGSGN ALAGAVNQHG GFEPALGLDL
310 320 330 340 350
LLNCSLLLCR GGGHPLDLLS VTLASGSRCF SFLSVAWGFV SDVDIQSERF
360 370 380 390 400
RALGSARFTL GTVLGLATLH TYRGRLSYLP ATVEPASPTP AHSLPRAKSE
410 420 430 440 450
LTLTPDPAPP MAHSPLHRSV SDLPLPLPQP ALASPGSPEP LPILSLNGGG
460 470 480 490 500
PELAGDWGGA GDAPLSPDPL LSSPPGSPKA ALHSPVSEGA PVIPPSSGLP
510 520 530 540 550
LPTPDARVGA STCGPPDHLL PPLGTPLPPD WVTLEGDFVL MLAISPSHLG
560 570 580 590 600
ADLVAAPHAR FDDGLVHLCW VRSGISRAAL LRLFLAMERG SHFSLGCPQL
610 620 630 640 650
GYAAARAFRL EPLTPRGVLT VDGEQVEYGP LQAQMHPGIG TLLTGPPGCP
GREP
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R344 | M0R344_HUMAN | Sphingosine kinase 2 | SPHK2 | 663 | Annotation score: | ||
M0R0E9 | M0R0E9_HUMAN | Sphingosine kinase 2 | SPHK2 | 255 | Annotation score: | ||
E9PCV4 | E9PCV4_HUMAN | Sphingosine kinase 2 | SPHK2 hCG_15274 | 448 | Annotation score: | ||
M0QXX5 | M0QXX5_HUMAN | Sphingosine kinase 2 | SPHK2 | 133 | Annotation score: | ||
A0A075B7A1 | A0A075B7A1_HUMAN | Sphingosine kinase 2 | SPHK2 | 349 | Annotation score: | ||
M0QZP3 | M0QZP3_HUMAN | Sphingosine kinase 2 | SPHK2 | 72 | Annotation score: | ||
E7ET12 | E7ET12_HUMAN | Sphingosine kinase 2 | SPHK2 | 49 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 49 | P → S in CAB66636 (PubMed:11230166).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060112 | 652 | R → Q. Corresponds to variant dbSNP:rs11881285Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006217 | 1 – 36 | Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST | 36 | |
Alternative sequenceiVSP_047721 | 1 – 12 | MNGHL…EEQQD → MIGCLHARVSGPLWDAGLCP ASSRSAHTCLSLSVSDAPVS PATAPHCLLLSTAPAPPCPC HGVLNSHPFSPPFP in isoform 5. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_046910 | 13 – 71 | Missing in isoform 4. 1 PublicationAdd BLAST | 59 | |
Alternative sequenceiVSP_006218 | 292 – 390 | FEPAL…ASPTP → PREDSDSSTSSSACPLWTTA RSCPRAAASMPGSCPLLPQQ LALGFSRFIQDRVNGGGGRI GSLTCRGHTQRTLPAPAREG GGSLFLKNINVFICKKKKK in isoform 3. 1 PublicationAdd BLAST | 99 | |
Alternative sequenceiVSP_047722 | 640 – 654 | GTLLT…PGREP → ARGRTQTPALPAAPALYGRQ PGAAHGLQPVCQGAALFFHN SWLWGSQDLFRIVLTEAVGG in isoform 5. 1 PublicationAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF245447 mRNA Translation: AAF74124.1 EF107108 mRNA Translation: ABK81123.1 AL136701 mRNA Translation: CAB66636.1 AK000599 mRNA Translation: BAA91280.1 AK300541 mRNA Translation: BAG62249.1 AC022154 Genomic DNA No translation available. BC006161 mRNA Translation: AAH06161.1 BC010671 mRNA Translation: AAH10671.1 |
CCDSi | CCDS12727.1 [Q9NRA0-1] CCDS59404.1 [Q9NRA0-4] CCDS59405.1 [Q9NRA0-2] |
RefSeqi | NP_001191087.1, NM_001204158.2 [Q9NRA0-4] NP_001191088.1, NM_001204159.2 [Q9NRA0-1] NP_001191089.1, NM_001204160.2 [Q9NRA0-2] NP_064511.2, NM_020126.4 [Q9NRA0-1] XP_006723355.1, XM_006723292.1 [Q9NRA0-2] XP_011525435.1, XM_011527133.1 [Q9NRA0-1] XP_011525436.1, XM_011527134.1 [Q9NRA0-2] |
Genome annotation databases
Ensembli | ENST00000245222.9; ENSP00000245222.3; ENSG00000063176.16 ENST00000598088.5; ENSP00000469158.1; ENSG00000063176.16 ENST00000599748.5; ENSP00000471205.1; ENSG00000063176.16 [Q9NRA0-2] ENST00000600537.5; ENSP00000470092.1; ENSG00000063176.16 [Q9NRA0-4] |
GeneIDi | 56848 |
KEGGi | hsa:56848 |
MANE-Selecti | ENST00000245222.9; ENSP00000245222.3; NM_020126.5; NP_064511.2 |
UCSCi | uc002pjr.4, human [Q9NRA0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF245447 mRNA Translation: AAF74124.1 EF107108 mRNA Translation: ABK81123.1 AL136701 mRNA Translation: CAB66636.1 AK000599 mRNA Translation: BAA91280.1 AK300541 mRNA Translation: BAG62249.1 AC022154 Genomic DNA No translation available. BC006161 mRNA Translation: AAH06161.1 BC010671 mRNA Translation: AAH10671.1 |
CCDSi | CCDS12727.1 [Q9NRA0-1] CCDS59404.1 [Q9NRA0-4] CCDS59405.1 [Q9NRA0-2] |
RefSeqi | NP_001191087.1, NM_001204158.2 [Q9NRA0-4] NP_001191088.1, NM_001204159.2 [Q9NRA0-1] NP_001191089.1, NM_001204160.2 [Q9NRA0-2] NP_064511.2, NM_020126.4 [Q9NRA0-1] XP_006723355.1, XM_006723292.1 [Q9NRA0-2] XP_011525435.1, XM_011527133.1 [Q9NRA0-1] XP_011525436.1, XM_011527134.1 [Q9NRA0-2] |
3D structure databases
AlphaFoldDBi | Q9NRA0 |
SMRi | Q9NRA0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121208, 19 interactors |
IntActi | Q9NRA0, 7 interactors |
STRINGi | 9606.ENSP00000245222 |
Chemistry databases
BindingDBi | Q9NRA0 |
ChEMBLi | CHEMBL3023 |
DrugBanki | DB12764, Opaganib |
GuidetoPHARMACOLOGYi | 2205 |
SwissLipidsi | SLP:000000112 |
PTM databases
iPTMneti | Q9NRA0 |
PhosphoSitePlusi | Q9NRA0 |
Genetic variation databases
BioMutai | SPHK2 |
DMDMi | 22001996 |
Proteomic databases
EPDi | Q9NRA0 |
jPOSTi | Q9NRA0 |
MassIVEi | Q9NRA0 |
MaxQBi | Q9NRA0 |
PaxDbi | Q9NRA0 |
PeptideAtlasi | Q9NRA0 |
PRIDEi | Q9NRA0 |
ProteomicsDBi | 82315 [Q9NRA0-1] 82316 [Q9NRA0-2] 82317 [Q9NRA0-3] 86 |
Protocols and materials databases
Antibodypediai | 31745, 453 antibodies from 37 providers |
DNASUi | 56848 |
Genome annotation databases
Ensembli | ENST00000245222.9; ENSP00000245222.3; ENSG00000063176.16 ENST00000598088.5; ENSP00000469158.1; ENSG00000063176.16 ENST00000599748.5; ENSP00000471205.1; ENSG00000063176.16 [Q9NRA0-2] ENST00000600537.5; ENSP00000470092.1; ENSG00000063176.16 [Q9NRA0-4] |
GeneIDi | 56848 |
KEGGi | hsa:56848 |
MANE-Selecti | ENST00000245222.9; ENSP00000245222.3; NM_020126.5; NP_064511.2 |
UCSCi | uc002pjr.4, human [Q9NRA0-1] |
Organism-specific databases
CTDi | 56848 |
DisGeNETi | 56848 |
GeneCardsi | SPHK2 |
HGNCi | HGNC:18859, SPHK2 |
HPAi | ENSG00000063176, Low tissue specificity |
MIMi | 607092, gene |
neXtProti | NX_Q9NRA0 |
OpenTargetsi | ENSG00000063176 |
PharmGKBi | PA38719 |
VEuPathDBi | HostDB:ENSG00000063176 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1116, Eukaryota |
GeneTreei | ENSGT00940000161197 |
HOGENOMi | CLU_013399_1_1_1 |
InParanoidi | Q9NRA0 |
OMAi | EREDGMM |
OrthoDBi | 681139at2759 |
PhylomeDBi | Q9NRA0 |
TreeFami | TF354296 |
Enzyme and pathway databases
BRENDAi | 2.7.1.91, 2681 |
PathwayCommonsi | Q9NRA0 |
Reactomei | R-HSA-1660661, Sphingolipid de novo biosynthesis |
SignaLinki | Q9NRA0 |
SIGNORi | Q9NRA0 |
Miscellaneous databases
BioGRID-ORCSi | 56848, 26 hits in 1083 CRISPR screens |
ChiTaRSi | SPHK2, human |
GeneWikii | SPHK2 |
GenomeRNAii | 56848 |
Pharosi | Q9NRA0, Tchem |
PROi | PR:Q9NRA0 |
RNActi | Q9NRA0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000063176, Expressed in substantia nigra and 173 other tissues |
ExpressionAtlasi | Q9NRA0, baseline and differential |
Genevisiblei | Q9NRA0, HS |
Family and domain databases
Gene3Di | 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR017438, ATP-NAD_kinase_N IPR001206, Diacylglycerol_kinase_cat_dom IPR016064, NAD/diacylglycerol_kinase_sf IPR045540, YegS/DAGK_C |
Pfami | View protein in Pfam PF00781, DAGK_cat, 1 hit PF19279, YegS_C, 1 hit |
SMARTi | View protein in SMART SM00046, DAGKc, 1 hit |
SUPFAMi | SSF111331, SSF111331, 1 hit |
PROSITEi | View protein in PROSITE PS50146, DAGK, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SPHK2_HUMAN | |
Accessioni | Q9NRA0Primary (citable) accession number: Q9NRA0 Secondary accession number(s): A0T4C8 Q9NWU7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 24, 2001 |
Last sequence update: | July 26, 2002 | |
Last modified: | May 25, 2022 | |
This is version 180 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot