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UniProtKB - Q9NRA0 (SPHK2_HUMAN)

Protein

Sphingosine kinase 2

Gene

SPHK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by sulfatide.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.4 µM for sphingosine1 Publication

    pH dependencei

    Optimum pH is 7.5.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei247Proton donor/acceptorBy similarity1
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei252ATPPROSITE-ProRule annotation1
    Binding sitei344SubstrateBy similarity1
    Binding sitei351ATPPROSITE-ProRule annotation1
    Binding sitei357ATPPROSITE-ProRule annotation1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi188 – 190ATPPROSITE-ProRule annotation3
    Nucleotide bindingi220 – 224ATPPROSITE-ProRule annotation5
    Nucleotide bindingi277 – 279ATPPROSITE-ProRule annotation3
    Nucleotide bindingi622 – 624ATPPROSITE-ProRule annotation3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • ATP binding Source: UniProtKB-KW
    • D-erythro-sphingosine kinase activity Source: Reactome
    • NAD+ kinase activity Source: InterPro
    • Ras GTPase binding Source: UniProtKB
    • sphinganine kinase activity Source: Reactome
    • sphingosine-1-phosphate receptor activity Source: UniProtKB
    View the complete GO annotation on QuickGO ...

    GO - Biological processi

    View the complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		2.7.1.91 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-1660661 Sphingolipid de novo biosynthesis

    SIGNOR Signaling Network Open Resource

    More...    SIGNORi    		Q9NRA0

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...    SwissLipidsi    		SLP:000000112

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Sphingosine kinase 2 (EC:2.7.1.911 Publication)
    Short name:
    SK 2
    Short name:
    SPK 2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SPHK2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000063176.15

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:18859 SPHK2

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		607092 gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q9NRA0

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Lysosome, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		56848

    Open Targets

    More...    OpenTargetsi    		ENSG00000063176

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA38719

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL3023

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...    GuidetoPHARMACOLOGYi    		2205

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		SPHK2

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		22001996

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001813581 – 654Sphingosine kinase 2Add BLAST654

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei387PhosphoserineCombined sources1
    Modified residuei393PhosphoserineBy similarity1
    Modified residuei399PhosphoserineCombined sources1
    Modified residuei477PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q9NRA0

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q9NRA0

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q9NRA0

    PeptideAtlas

    More...    PeptideAtlasi    		Q9NRA0

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q9NRA0

    ProteomicsDB human proteome resource

    More...    ProteomicsDBi    		82315
    82316 [Q9NRA0-2]
    82317 [Q9NRA0-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q9NRA0

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q9NRA0

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000063176 Expressed in 160 organ(s), highest expression level in substantia nigra

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q9NRA0 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q9NRA0 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		HPA065508

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    GO - Molecular functioni

    View the complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		121208, 3 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q9NRA0, 5 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000245222

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		Q9NRA0

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...    ProteinModelPortali    		Q9NRA0

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q9NRA0

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini178 – 325DAGKcPROSITE-ProRule annotationAdd BLAST148

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 175Required for binding to sulfatide and phosphoinositides and for membrane localizationAdd BLAST175
    Regioni245 – 248Substrate bindingBy similarity4

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG1116 Eukaryota
    COG1597 LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000161197

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		HOG000111460

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...    HOVERGENi    		HBG054796

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q9NRA0

    KEGG Orthology (KO)

    More...    KOi    		K04718

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q9NRA0

    TreeFam database of animal gene trees

    More...    TreeFami    		TF354296

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		3.40.50.10330, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR017438 ATP-NAD_kinase_N
    IPR001206 Diacylglycerol_kinase_cat_dom
    IPR016064 NAD/diacylglycerol_kinase_sf

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00781 DAGK_cat, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM00046 DAGKc, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF111331 SSF111331, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS50146 DAGK, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Note: Experimental confirmation may be lacking for some isoforms.

    This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9NRA0-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MNGHLEAEEQ QDQRPDQELT GSWGHGPRST LVRAKAMAPP PPPLAASTPL 
            60         70         80         90        100
    LHGEFGSYPA RGPRFALTLT SQALHIQRLR PKPEARPRGG LVPLAEVSGC 
           110        120        130        140        150
    CTLRSRSPSD SAAYFCIYTY PRGRRGARRR ATRTFRADGA ATYEENRAEA 
           160        170        180        190        200
    QRWATALTCL LRGLPLPGDG EITPDLLPRP PRLLLLVNPF GGRGLAWQWC 
           210        220        230        240        250
    KNHVLPMISE AGLSFNLIQT ERQNHARELV QGLSLSEWDG IVTVSGDGLL 
           260        270        280        290        300
    HEVLNGLLDR PDWEEAVKMP VGILPCGSGN ALAGAVNQHG GFEPALGLDL 
           310        320        330        340        350
    LLNCSLLLCR GGGHPLDLLS VTLASGSRCF SFLSVAWGFV SDVDIQSERF 
           360        370        380        390        400
    RALGSARFTL GTVLGLATLH TYRGRLSYLP ATVEPASPTP AHSLPRAKSE 
           410        420        430        440        450
    LTLTPDPAPP MAHSPLHRSV SDLPLPLPQP ALASPGSPEP LPILSLNGGG 
           460        470        480        490        500
    PELAGDWGGA GDAPLSPDPL LSSPPGSPKA ALHSPVSEGA PVIPPSSGLP 
           510        520        530        540        550
    LPTPDARVGA STCGPPDHLL PPLGTPLPPD WVTLEGDFVL MLAISPSHLG 
           560        570        580        590        600
    ADLVAAPHAR FDDGLVHLCW VRSGISRAAL LRLFLAMERG SHFSLGCPQL 
           610        620        630        640        650
    GYAAARAFRL EPLTPRGVLT VDGEQVEYGP LQAQMHPGIG TLLTGPPGCP 

    GREP
    Length:654
    Mass (Da):69,217
    Last modified:July 26, 2002 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF73FFCEC930DA50F
    GO
    Isoform 2 (identifier: Q9NRA0-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-36: Missing.

    Show »
    Length:618
    Mass (Da):65,205
    Checksum:i1A5B06BCB6F93F1F
    GO
    Isoform 3 (identifier: Q9NRA0-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-36: Missing.
         292-390: FEPALGLDLL...ATVEPASPTP → PREDSDSSTS...NVFICKKKKK

    Show »
    Length:618
    Mass (Da):65,170
    Checksum:iD934F61C0A69EDAE
    GO
    Isoform 4 (identifier: Q9NRA0-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         13-71: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:595
    Mass (Da):62,986
    Checksum:iC24AC949EEEA059B
    GO
    Isoform 5 (identifier: Q9NRA0-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-12: MNGHLEAEEQQD → MIGCLHARVS...NSHPFSPPFP
         640-654: GTLLTGPPGCPGREP → ARGRTQTPALPAAPALYGRQPGAAHGLQPVCQGAALFFHNSWLWGSQDLFRIVLTEAVGG

    Show »
    Length:761
    Mass (Da):80,205
    Checksum:iA52BF3441102A3D3
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    M0R344M0R344_HUMAN
    Sphingosine kinase 2
    SPHK2
    		663Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    M0R0E9M0R0E9_HUMAN
    Sphingosine kinase 2
    SPHK2
    		255Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PCV4E9PCV4_HUMAN
    Sphingosine kinase 2, isoform CRA_e
    SPHK2 hCG_15274
    		448Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A075B7A1A0A075B7A1_HUMAN
    Sphingosine kinase 2
    SPHK2
    		349Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    M0QXX5M0QXX5_HUMAN
    Sphingosine kinase 2
    SPHK2
    		133Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    M0QZP3M0QZP3_HUMAN
    Sphingosine kinase 2
    SPHK2
    		72Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E7ET12E7ET12_HUMAN
    Sphingosine kinase 2
    SPHK2
    		49Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49P → S in CAB66636 (PubMed:11230166).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060112652R → Q. Corresponds to variant dbSNP:rs11881285Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0062171 – 36Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST36
    Alternative sequenceiVSP_0477211 – 12MNGHL…EEQQD → MIGCLHARVSGPLWDAGLCP ASSRSAHTCLSLSVSDAPVS PATAPHCLLLSTAPAPPCPC HGVLNSHPFSPPFP in isoform 5. 1 PublicationAdd BLAST12
    Alternative sequenceiVSP_04691013 – 71Missing in isoform 4. 1 PublicationAdd BLAST59
    Alternative sequenceiVSP_006218292 – 390FEPAL…ASPTP → PREDSDSSTSSSACPLWTTA RSCPRAAASMPGSCPLLPQQ LALGFSRFIQDRVNGGGGRI GSLTCRGHTQRTLPAPAREG GGSLFLKNINVFICKKKKK in isoform 3. 1 PublicationAdd BLAST99
    Alternative sequenceiVSP_047722640 – 654GTLLT…PGREP → ARGRTQTPALPAAPALYGRQ PGAAHGLQPVCQGAALFFHN SWLWGSQDLFRIVLTEAVGG in isoform 5. 1 PublicationAdd BLAST15

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AF245447 mRNA Translation: AAF74124.1
    EF107108 mRNA Translation: ABK81123.1
    AL136701 mRNA Translation: CAB66636.1
    AK000599 mRNA Translation: BAA91280.1
    AK300541 mRNA Translation: BAG62249.1
    AC022154 Genomic DNA No translation available.
    BC006161 mRNA Translation: AAH06161.1
    BC010671 mRNA Translation: AAH10671.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS12727.1 [Q9NRA0-1]
    CCDS59404.1 [Q9NRA0-4]
    CCDS59405.1 [Q9NRA0-2]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001191087.1, NM_001204158.2 [Q9NRA0-4]
    NP_001191088.1, NM_001204159.2 [Q9NRA0-1]
    NP_001191089.1, NM_001204160.2 [Q9NRA0-2]
    NP_064511.2, NM_020126.4 [Q9NRA0-1]
    XP_006723355.1, XM_006723292.1 [Q9NRA0-2]
    XP_011525435.1, XM_011527133.1 [Q9NRA0-1]
    XP_011525436.1, XM_011527134.1 [Q9NRA0-2]

    UniGene gene-oriented nucleotide sequence clusters

    More...    UniGenei    		Hs.528006

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000245222; ENSP00000245222; ENSG00000063176 [Q9NRA0-1]
    ENST00000598088; ENSP00000469158; ENSG00000063176 [Q9NRA0-1]
    ENST00000599748; ENSP00000471205; ENSG00000063176 [Q9NRA0-2]
    ENST00000600537; ENSP00000470092; ENSG00000063176 [Q9NRA0-4]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		56848

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:56848

    UCSC genome browser

    More...    UCSCi    		uc002pjr.4 human [Q9NRA0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF245447 mRNA Translation: AAF74124.1
    EF107108 mRNA Translation: ABK81123.1
    AL136701 mRNA Translation: CAB66636.1
    AK000599 mRNA Translation: BAA91280.1
    AK300541 mRNA Translation: BAG62249.1
    AC022154 Genomic DNA No translation available.
    BC006161 mRNA Translation: AAH06161.1
    BC010671 mRNA Translation: AAH10671.1
    CCDSiCCDS12727.1 [Q9NRA0-1]
    CCDS59404.1 [Q9NRA0-4]
    CCDS59405.1 [Q9NRA0-2]
    RefSeqiNP_001191087.1, NM_001204158.2 [Q9NRA0-4]
    NP_001191088.1, NM_001204159.2 [Q9NRA0-1]
    NP_001191089.1, NM_001204160.2 [Q9NRA0-2]
    NP_064511.2, NM_020126.4 [Q9NRA0-1]
    XP_006723355.1, XM_006723292.1 [Q9NRA0-2]
    XP_011525435.1, XM_011527133.1 [Q9NRA0-1]
    XP_011525436.1, XM_011527134.1 [Q9NRA0-2]
    UniGeneiHs.528006

    3D structure databases

    ProteinModelPortaliQ9NRA0
    SMRiQ9NRA0
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi121208, 3 interactors
    IntActiQ9NRA0, 5 interactors
    STRINGi9606.ENSP00000245222

    Chemistry databases

    BindingDBiQ9NRA0
    ChEMBLiCHEMBL3023
    GuidetoPHARMACOLOGYi2205
    SwissLipidsiSLP:000000112

    PTM databases

    iPTMnetiQ9NRA0
    PhosphoSitePlusiQ9NRA0

    Polymorphism and mutation databases

    BioMutaiSPHK2
    DMDMi22001996

    Proteomic databases

    EPDiQ9NRA0
    MaxQBiQ9NRA0
    PaxDbiQ9NRA0
    PeptideAtlasiQ9NRA0
    PRIDEiQ9NRA0
    ProteomicsDBi82315
    82316 [Q9NRA0-2]
    82317 [Q9NRA0-3]

    Protocols and materials databases

    The DNASU plasmid repository

    More...    DNASUi    		56848
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000245222; ENSP00000245222; ENSG00000063176 [Q9NRA0-1]
    ENST00000598088; ENSP00000469158; ENSG00000063176 [Q9NRA0-1]
    ENST00000599748; ENSP00000471205; ENSG00000063176 [Q9NRA0-2]
    ENST00000600537; ENSP00000470092; ENSG00000063176 [Q9NRA0-4]
    GeneIDi56848
    KEGGihsa:56848
    UCSCiuc002pjr.4 human [Q9NRA0-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		56848
    DisGeNETi56848
    EuPathDBiHostDB:ENSG00000063176.15

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		SPHK2
    HGNCiHGNC:18859 SPHK2
    HPAiHPA065508
    MIMi607092 gene
    neXtProtiNX_Q9NRA0
    OpenTargetsiENSG00000063176
    PharmGKBiPA38719

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG1116 Eukaryota
    COG1597 LUCA
    GeneTreeiENSGT00940000161197
    HOGENOMiHOG000111460
    HOVERGENiHBG054796
    InParanoidiQ9NRA0
    KOiK04718
    PhylomeDBiQ9NRA0
    TreeFamiTF354296

    Enzyme and pathway databases

    BRENDAi2.7.1.91 2681
    ReactomeiR-HSA-1660661 Sphingolipid de novo biosynthesis
    SIGNORiQ9NRA0

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		SPHK2 human

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		SPHK2

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		56848

    Protein Ontology

    More...    PROi    		PR:Q9NRA0

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000063176 Expressed in 160 organ(s), highest expression level in substantia nigra
    ExpressionAtlasiQ9NRA0 baseline and differential
    GenevisibleiQ9NRA0 HS

    Family and domain databases

    Gene3Di3.40.50.10330, 1 hit
    InterProiView protein in InterPro
    IPR017438 ATP-NAD_kinase_N
    IPR001206 Diacylglycerol_kinase_cat_dom
    IPR016064 NAD/diacylglycerol_kinase_sf
    PfamiView protein in Pfam
    PF00781 DAGK_cat, 1 hit
    SMARTiView protein in SMART
    SM00046 DAGKc, 1 hit
    SUPFAMiSSF111331 SSF111331, 1 hit
    PROSITEiView protein in PROSITE
    PS50146 DAGK, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPHK2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NRA0
    Secondary accession number(s): A0T4C8
    , B4DU87, Q9BRN1, Q9H0Q2, Q9NWU7
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2001
    Last sequence update: July 26, 2002
    Last modified: December 5, 2018
    This is version 160 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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