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UniProtKB - Q9NR99 (MXRA5_HUMAN)

Entry version 157 (25 May 2022)
Sequence version 3 (11 Jan 2011)
Previous versions | rss
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Protein

Matrix-remodeling-associated protein 5

Gene

MXRA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NR99

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NR99

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Matrix-remodeling-associated protein 5
Alternative name(s):
Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan
Short name:
Adlican
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MXRA5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7539, MXRA5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300938, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NR99

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000101825

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lung cancer (LNCR)1 Publication
Disease susceptibility may be associated with variants affecting the gene represented in this entry.
Disease descriptionA common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07240598A → D in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_072406481P → H in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs759222135Ensembl.1
Natural variantiVAR_072407611W → C in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_072408862S → N in LNCR. 1 Publication1
Natural variantiVAR_0724091028V → F in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0724101491P → A in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754393038Ensembl.1
Natural variantiVAR_0724112300R → H in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs776590689Ensembl.1
Natural variantiVAR_0724122349R → W in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs369042203Ensembl.1
Natural variantiVAR_0724132678H → R in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0724142716E → A in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1419255508Ensembl.1
Natural variantiVAR_0724152763A → G in LNCR; unknown pathological significance. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		25878

MalaCards human disease database

More...MalaCardsi		MXRA5
MIMi211980, phenotype

Open Targets

More...OpenTargetsi		ENSG00000101825

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31340

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NR99, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MXRA5

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373412

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025413127 – 2828Matrix-remodeling-associated protein 5Add BLAST2802

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi501 ↔ 555PROSITE-ProRule annotation
Disulfide bondi599 ↔ 651PROSITE-ProRule annotation
Glycosylationi633N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1403N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1735N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1875 ↔ 1928PROSITE-ProRule annotation
Disulfide bondi1972 ↔ 2025PROSITE-ProRule annotation
Glycosylationi2007N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2056N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2069 ↔ 2122PROSITE-ProRule annotation
Disulfide bondi2168 ↔ 2221PROSITE-ProRule annotation
Disulfide bondi2265 ↔ 2324PROSITE-ProRule annotation
Disulfide bondi2368 ↔ 2418PROSITE-ProRule annotation
Disulfide bondi2466 ↔ 2518PROSITE-ProRule annotation
Disulfide bondi2564 ↔ 2616PROSITE-ProRule annotation
Disulfide bondi2659 ↔ 2711PROSITE-ProRule annotation
Glycosylationi2693N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2755 ↔ 2810PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NR99

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NR99

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NR99

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NR99

PeptideAtlas

More...PeptideAtlasi		Q9NR99

PRoteomics IDEntifications database

More...PRIDEi		Q9NR99

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82314

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1495, 24 N-Linked glycans (7 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NR99, 24 sites, 23 N-linked glycans (7 sites), 4 O-linked glycans (13 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NR99

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NR99

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in kidney, also detected on liver and spleen (PubMed:27599751). Expressed by proximal tubular cells of the kidney (at protein level) (PubMed:27599751). Expression highly increases during chronic kidney disease and autosomal dominant polycystic kidney disease, where is detected in cysts (PubMed:27599751).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Over-expressed in centenarians. Expression is reduced from young to old but increased from old to centenarians.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is induced by TGFB1, in kidney tubular cells. This induction is inhibited by the vitamin D receptor activator paricalcitol (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000101825, Expressed in tendon of biceps brachii and 214 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NR99, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000101825, Tissue enhanced (cervix)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117392, 9 interactors

Protein interaction database and analysis system

More...IntActi		Q9NR99, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000217939

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NR99, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 55LRRNTAdd BLAST29
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati56 – 77LRR 1Add BLAST22
Repeati80 – 101LRR 2Add BLAST22
Repeati104 – 125LRR 3Add BLAST22
Repeati128 – 149LRR 4Add BLAST22
Repeati152 – 173LRR 5Add BLAST22
Repeati184 – 205LRR 6Add BLAST22
Domaini217 – 277LRRCTAdd BLAST61
Domaini481 – 571Ig-like C2-type 1Add BLAST91
Domaini575 – 669Ig-like C2-type 2Add BLAST95
Repeati1410 – 1434LRR 7Add BLAST25
Domaini1853 – 1946Ig-like C2-type 3Add BLAST94
Domaini1950 – 2041Ig-like C2-type 4Add BLAST92
Domaini2046 – 2140Ig-like C2-type 5Add BLAST95
Domaini2146 – 2239Ig-like C2-type 6Add BLAST94
Domaini2242 – 2343Ig-like C2-type 7Add BLAST102
Domaini2345 – 2432Ig-like C2-type 8Add BLAST88
Domaini2440 – 2534Ig-like C2-type 9Add BLAST95
Domaini2542 – 2630Ig-like C2-type 10Add BLAST89
Domaini2637 – 2722Ig-like C2-type 11Add BLAST86
Domaini2733 – 2828Ig-like C2-type 12Add BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni671 – 715DisorderedSequence analysisAdd BLAST45
Regioni933 – 962DisorderedSequence analysisAdd BLAST30
Regioni1068 – 1190DisorderedSequence analysisAdd BLAST123
Regioni1204 – 1275DisorderedSequence analysisAdd BLAST72
Regioni1367 – 1389DisorderedSequence analysisAdd BLAST23
Regioni1479 – 1499DisorderedSequence analysisAdd BLAST21
Regioni1536 – 1566DisorderedSequence analysisAdd BLAST31
Regioni1579 – 1603DisorderedSequence analysisAdd BLAST25
Regioni1669 – 1689DisorderedSequence analysisAdd BLAST21
Regioni1700 – 1719DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi686 – 715Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1087 – 1112Polar residuesSequence analysisAdd BLAST26
Compositional biasi1119 – 1147Polar residuesSequence analysisAdd BLAST29
Compositional biasi1148 – 1168Basic residuesSequence analysisAdd BLAST21
Compositional biasi1170 – 1190Polar residuesSequence analysisAdd BLAST21
Compositional biasi1204 – 1219Polar residuesSequence analysisAdd BLAST16
Compositional biasi1242 – 1275Polar residuesSequence analysisAdd BLAST34
Compositional biasi1374 – 1389Polar residuesSequence analysisAdd BLAST16
Compositional biasi1538 – 1566Polar residuesSequence analysisAdd BLAST29

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0619, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159942

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000580_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NR99

Identification of Orthologs from Complete Genome Data

More...OMAi		MRWFLEW

Database of Orthologous Groups

More...OrthoDBi		8971at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NR99

TreeFam database of animal gene trees

More...TreeFami		TF326318

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 12 hits
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07679, I-set, 6 hits
PF13855, LRR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 12 hits
SM00408, IGc2, 12 hits
SM00369, LRR_TYP, 6 hits
SM00082, LRRCT, 1 hit
SM00013, LRRNT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 12 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NR99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKRAHWGAL SVVLILLWGH PRVALACPHP CACYVPSEVH CTFRSLASVP 
        60         70         80         90        100
AGIAKHVERI NLGFNSIQAL SETSFAGLTK LELLMIHGNE IPSIPDGALR 
       110        120        130        140        150
DLSSLQVFKF SYNKLRVITG QTLQGLSNLM RLHIDHNKIE FIHPQAFNGL 
       160        170        180        190        200
TSLRLLHLEG NLLHQLHPST FSTFTFLDYF RLSTIRHLYL AENMVRTLPA 
       210        220        230        240        250
SMLRNMPLLE NLYLQGNPWT CDCEMRWFLE WDAKSRGILK CKKDKAYEGG 
       260        270        280        290        300
QLCAMCFSPK KLYKHEIHKL KDMTCLKPSI ESPLRQNRSR SIEEEQEQEE 
       310        320        330        340        350
DGGSQLILEK FQLPQWSISL NMTDEHGNMV NLVCDIKKPM DVYKIHLNQT 
       360        370        380        390        400
DPPDIDINAT VALDFECPMT RENYEKLWKL IAYYSEVPVK LHRELMLSKD 
       410        420        430        440        450
PRVSYQYRQD ADEEALYYTG VRAQILAEPE WVMQPSIDIQ LNRRQSTAKK 
       460        470        480        490        500
VLLSYYTQYS QTISTKDTRQ ARGRSWVMIE PSGAVQRDQT VLEGGPCQLS 
       510        520        530        540        550
CNVKASESPS IFWVLPDGSI LKAPMDDPDS KFSILSSGWL RIKSMEPSDS 
       560        570        580        590        600
GLYQCIAQVR DEMDRMVYRV LVQSPSTQPA EKDTVTIGKN PGESVTLPCN 
       610        620        630        640        650
ALAIPEAHLS WILPNRRIIN DLANTSHVYM LPNGTLSIPK VQVSDSGYYR 
       660        670        680        690        700
CVAVNQQGAD HFTVGITVTK KGSGLPSKRG RRPGAKALSR VREDIVEDEG 
       710        720        730        740        750
GSGMGDEENT SRRLLHPKDQ EVFLKTKDDA INGDKKAKKG RRKLKLWKHS 
       760        770        780        790        800
EKEPETNVAE GRRVFESRRR INMANKQINP ERWADILAKV RGKNLPKGTE 
       810        820        830        840        850
VPPLIKTTSP PSLSLEVTPP FPAISPPSAS PVQTVTSAEE SSADVPLLGE 
       860        870        880        890        900
EEHVLGTISS ASMGLEHNHN GVILVEPEVT STPLEEVVDD LSEKTEEITS 
       910        920        930        940        950
TEGDLKGTAA PTLISEPYEP SPTLHTLDTV YEKPTHEETA TEGWSAADVG 
       960        970        980        990       1000
SSPEPTSSEY EPPLDAVSLA ESEPMQYFDP DLETKSQPDE DKMKEDTFAH 
      1010       1020       1030       1040       1050
LTPTPTIWVN DSSTSQLFED STIGEPGVPG QSHLQGLTDN IHLVKSSLST 
      1060       1070       1080       1090       1100
QDTLLIKKGM KEMSQTLQGG NMLEGDPTHS RSSESEGQES KSITLPDSTL 
      1110       1120       1130       1140       1150
GIMSSMSPVK KPAETTVGTL LDKDTTTATT TPRQKVAPSS TMSTHPSRRR 
      1160       1170       1180       1190       1200
PNGRRRLRPN KFRHRHKQTP PTTFAPSETF STQPTQAPDI KISSQVESSL 
      1210       1220       1230       1240       1250
VPTAWVDNTV NTPKQLEMEK NAEPTSKGTP RRKHGKRPNK HRYTPSTVSS 
      1260       1270       1280       1290       1300
RASGSKPSPS PENKHRNIVT PSSETILLPR TVSLKTEGPY DSLDYMTTTR 
      1310       1320       1330       1340       1350
KIYSSYPKVQ ETLPVTYKPT SDGKEIKDDV ATNVDKHKSD ILVTGESITN 
      1360       1370       1380       1390       1400
AIPTSRSLVS TMGEFKEESS PVGFPGTPTW NPSRTAQPGR LQTGIPVTTS 
      1410       1420       1430       1440       1450
GENLTDPPLL KELEDVDFTS EFLSSLTVST PFHQEEAGSS TTLSSIKVEV 
      1460       1470       1480       1490       1500
ASSQAETTTL DQDHLETTVA ILLSETRPQN HTPTAARMKE PASSSPSTIL 
      1510       1520       1530       1540       1550
MSLGQTTTTK PALPSPRISQ ASRDSKENVF LNYVGNPETE ATPVNNEGTQ 
      1560       1570       1580       1590       1600
HMSGPNELST PSSDQDAFNL STKLELEKQV FGSRSLPRGP DSQRQDGRVH 
      1610       1620       1630       1640       1650
ASHQLTRVPA KPILPTATVR LPEMSTQSAS RYFVTSQSPR HWTNKPEITT 
      1660       1670       1680       1690       1700
YPSGALPENK QFTTPRLSST TIPLPLHMSK PSIPSKFTDR RTDQFNGYSK 
      1710       1720       1730       1740       1750
VFGNNNIPEA RNPVGKPPSP RIPHYSNGRL PFFTNKTLSF PQLGVTRRPQ 
      1760       1770       1780       1790       1800
IPTSPAPVMR ERKVIPGSYN RIHSHSTFHL DFGPPAPPLL HTPQTTGSPS 
      1810       1820       1830       1840       1850
TNLQNIPMVS STQSSISFIT SSVQSSGSFH QSSSKFFAGG PPASKFWSLG 
      1860       1870       1880       1890       1900
EKPQILTKSP QTVSVTAETD TVFPCEATGK PKPFVTWTKV STGALMTPNT 
      1910       1920       1930       1940       1950
RIQRFEVLKN GTLVIRKVQV QDRGQYMCTA SNLHGLDRMV VLLSVTVQQP 
      1960       1970       1980       1990       2000
QILASHYQDV TVYLGDTIAM ECLAKGTPAP QISWIFPDRR VWQTVSPVEG 
      2010       2020       2030       2040       2050
RITLHENRTL SIKEASFSDR GVYKCVASNA AGADSLAIRL HVAALPPVIH 
      2060       2070       2080       2090       2100
QEKLENISLP PGLSIHIHCT AKAAPLPSVR WVLGDGTQIR PSQFLHGNLF 
      2110       2120       2130       2140       2150
VFPNGTLYIR NLAPKDSGRY ECVAANLVGS ARRTVQLNVQ RAAANARITG 
      2160       2170       2180       2190       2200
TSPRRTDVRY GGTLKLDCSA SGDPWPRILW RLPSKRMIDA LFSFDSRIKV 
      2210       2220       2230       2240       2250
FANGTLVVKS VTDKDAGDYL CVARNKVGDD YVVLKVDVVM KPAKIEHKEE 
      2260       2270       2280       2290       2300
NDHKVFYGGD LKVDCVATGL PNPEISWSLP DGSLVNSFMQ SDDSGGRTKR 
      2310       2320       2330       2340       2350
YVVFNNGTLY FNEVGMREEG DYTCFAENQV GKDEMRVRVK VVTAPATIRN 
      2360       2370       2380       2390       2400
KTYLAVQVPY GDVVTVACEA KGEPMPKVTW LSPTNKVIPT SSEKYQIYQD 
      2410       2420       2430       2440       2450
GTLLIQKAQR SDSGNYTCLV RNSAGEDRKT VWIHVNVQPP KINGNPNPIT 
      2460       2470       2480       2490       2500
TVREIAAGGS RKLIDCKAEG IPTPRVLWAF PEGVVLPAPY YGNRITVHGN 
      2510       2520       2530       2540       2550
GSLDIRSLRK SDSVQLVCMA RNEGGEARLI LQLTVLEPME KPIFHDPISE 
      2560       2570       2580       2590       2600
KITAMAGHTI SLNCSAAGTP TPSLVWVLPN GTDLQSGQQL QRFYHKADGM 
      2610       2620       2630       2640       2650
LHISGLSSVD AGAYRCVARN AAGHTERLVS LKVGLKPEAN KQYHNLVSII 
      2660       2670       2680       2690       2700
NGETLKLPCT PPGAGQGRFS WTLPNGMHLE GPQTLGRVSL LDNGTLTVRE 
      2710       2720       2730       2740       2750
ASVFDRGTYV CRMETEYGPS VTSIPVIVIA YPPRITSEPT PVIYTRPGNT 
      2760       2770       2780       2790       2800
VKLNCMAMGI PKADITWELP DKSHLKAGVQ ARLYGNRFLH PQGSLTIQHA 
      2810       2820 
TQRDAGFYKC MAKNILGSDS KTTYIHVF
Length:2,828
Mass (Da):312,150
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0534732CE87C9A8F
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH11846 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH64986 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH80586 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55K → R in AAF86402 (Ref. 1) Curated1
Sequence conflicti1565Q → R in AAF86402 (Ref. 1) Curated1
Sequence conflicti2245I → V in CAB43220 (PubMed:17974005).Curated1
Sequence conflicti2353Y → C in CAB43220 (PubMed:17974005).Curated1
Sequence conflicti2640N → S in CAB43220 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07240598A → D in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_072406481P → H in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs759222135Ensembl.1
Natural variantiVAR_072407611W → C in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_056057764V → L. Corresponds to variant dbSNP:rs5983120Ensembl.1
Natural variantiVAR_060357824I → V1 PublicationCorresponds to variant dbSNP:rs5983119Ensembl.1
Natural variantiVAR_072408862S → N in LNCR. 1 Publication1
Natural variantiVAR_0724091028V → F in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0603581128A → V1 PublicationCorresponds to variant dbSNP:rs1635246Ensembl.1
Natural variantiVAR_0762571163R → H1 PublicationCorresponds to variant dbSNP:rs139106444EnsemblClinVar.1
Natural variantiVAR_0603591394G → D1 PublicationCorresponds to variant dbSNP:rs1726199Ensembl.1
Natural variantiVAR_0560581484T → A. Corresponds to variant dbSNP:rs12396910Ensembl.1
Natural variantiVAR_0724101491P → A in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754393038Ensembl.1
Natural variantiVAR_0560591665P → S. Corresponds to variant dbSNP:rs1974522Ensembl.1
Natural variantiVAR_0603602000G → S1 PublicationCorresponds to variant dbSNP:rs1635242Ensembl.1
Natural variantiVAR_0724112300R → H in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs776590689Ensembl.1
Natural variantiVAR_0724122349R → W in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs369042203Ensembl.1
Natural variantiVAR_0764372426E → D1 PublicationCorresponds to variant dbSNP:rs148675322EnsemblClinVar.1
Natural variantiVAR_0288212531L → V1 PublicationCorresponds to variant dbSNP:rs1726208EnsemblClinVar.1
Natural variantiVAR_0762582663G → W1 PublicationCorresponds to variant dbSNP:rs143264543Ensembl.1
Natural variantiVAR_0724132678H → R in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0724142716E → A in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1419255508Ensembl.1
Natural variantiVAR_0724152763A → G in LNCR; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF245505 mRNA Translation: AAF86402.1
AC004616 Genomic DNA No translation available.
BC011846 mRNA Translation: AAH11846.1 Sequence problems.
BC064986 mRNA Translation: AAH64986.1 Sequence problems.
BC080586 mRNA Translation: AAH80586.1 Sequence problems.
AL049946 mRNA Translation: CAB43220.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14124.1

Protein sequence database of the Protein Information Resource

More...PIRi		T08678

NCBI Reference Sequences

More...RefSeqi		NP_056234.2, NM_015419.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000217939.7; ENSP00000217939.5; ENSG00000101825.8

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25878

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25878

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000217939.7; ENSP00000217939.5; NM_015419.4; NP_056234.2

UCSC genome browser

More...UCSCi		uc004crg.6, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245505 mRNA Translation: AAF86402.1
AC004616 Genomic DNA No translation available.
BC011846 mRNA Translation: AAH11846.1 Sequence problems.
BC064986 mRNA Translation: AAH64986.1 Sequence problems.
BC080586 mRNA Translation: AAH80586.1 Sequence problems.
AL049946 mRNA Translation: CAB43220.1
CCDSiCCDS14124.1
PIRiT08678
RefSeqiNP_056234.2, NM_015419.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117392, 9 interactors
IntActiQ9NR99, 4 interactors
STRINGi9606.ENSP00000217939

PTM databases

GlyConnecti1495, 24 N-Linked glycans (7 sites)
GlyGeniQ9NR99, 24 sites, 23 N-linked glycans (7 sites), 4 O-linked glycans (13 sites)
iPTMnetiQ9NR99
PhosphoSitePlusiQ9NR99

Genetic variation databases

BioMutaiMXRA5
DMDMi317373412

Proteomic databases

EPDiQ9NR99
jPOSTiQ9NR99
MassIVEiQ9NR99
PaxDbiQ9NR99
PeptideAtlasiQ9NR99
PRIDEiQ9NR99
ProteomicsDBi82314

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		362, 69 antibodies from 21 providers

The DNASU plasmid repository

More...DNASUi		25878

Genome annotation databases

EnsembliENST00000217939.7; ENSP00000217939.5; ENSG00000101825.8
GeneIDi25878
KEGGihsa:25878
MANE-SelectiENST00000217939.7; ENSP00000217939.5; NM_015419.4; NP_056234.2
UCSCiuc004crg.6, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25878
DisGeNETi25878

GeneCards: human genes, protein and diseases

More...GeneCardsi		MXRA5
HGNCiHGNC:7539, MXRA5
HPAiENSG00000101825, Tissue enhanced (cervix)
MalaCardsiMXRA5
MIMi211980, phenotype
300938, gene
neXtProtiNX_Q9NR99
OpenTargetsiENSG00000101825
PharmGKBiPA31340
VEuPathDBiHostDB:ENSG00000101825

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
GeneTreeiENSGT00940000159942
HOGENOMiCLU_000580_0_0_1
InParanoidiQ9NR99
OMAiMRWFLEW
OrthoDBi8971at2759
PhylomeDBiQ9NR99
TreeFamiTF326318

Enzyme and pathway databases

PathwayCommonsiQ9NR99
SignaLinkiQ9NR99

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		25878, 8 hits in 697 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MXRA5, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MXRA5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25878
PharosiQ9NR99, Tbio

Protein Ontology

More...PROi		PR:Q9NR99
RNActiQ9NR99, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000101825, Expressed in tendon of biceps brachii and 214 other tissues
GenevisibleiQ9NR99, HS

Family and domain databases

Gene3Di2.60.40.10, 12 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT
PfamiView protein in Pfam
PF07679, I-set, 6 hits
PF13855, LRR_8, 1 hit
SMARTiView protein in SMART
SM00409, IG, 12 hits
SM00408, IGc2, 12 hits
SM00369, LRR_TYP, 6 hits
SM00082, LRRCT, 1 hit
SM00013, LRRNT, 1 hit
SUPFAMiSSF48726, SSF48726, 12 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 12 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMXRA5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NR99
Secondary accession number(s): Q6P1M7, Q9Y3Y8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 11, 2011
Last modified: May 25, 2022
This is version 157 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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