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Entry version 146 (11 Dec 2019)
Sequence version 3 (11 Jan 2011)
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Protein

Matrix-remodeling-associated protein 5

Gene

MXRA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Matrix-remodeling-associated protein 5
Alternative name(s):
Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan
Short name:
Adlican
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MXRA5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000101825.7

Human Gene Nomenclature Database

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HGNCi
HGNC:7539 MXRA5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300938 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NR99

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lung cancer (LNCR)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07240598A → D in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_072406481P → H in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs759222135Ensembl.1
Natural variantiVAR_072407611W → C in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_072408862S → N in LNCR. 1 Publication1
Natural variantiVAR_0724091028V → F in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0724101491P → A in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754393038Ensembl.1
Natural variantiVAR_0724112300R → H in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs776590689Ensembl.1
Natural variantiVAR_0724122349R → W in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs369042203Ensembl.1
Natural variantiVAR_0724132678H → R in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0724142716E → A in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1419255508Ensembl.1
Natural variantiVAR_0724152763A → G in LNCR; unknown pathological significance. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
25878

MalaCards human disease database

More...
MalaCardsi
MXRA5
MIMi211980 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000101825

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31340

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NR99 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MXRA5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373412

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025413127 – 2828Matrix-remodeling-associated protein 5Add BLAST2802

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi501 ↔ 555PROSITE-ProRule annotation
Disulfide bondi599 ↔ 651PROSITE-ProRule annotation
Glycosylationi633N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1403N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1735N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1875 ↔ 1928PROSITE-ProRule annotation
Disulfide bondi1972 ↔ 2025PROSITE-ProRule annotation
Glycosylationi2007N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2056N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2069 ↔ 2122PROSITE-ProRule annotation
Disulfide bondi2168 ↔ 2221PROSITE-ProRule annotation
Disulfide bondi2265 ↔ 2324PROSITE-ProRule annotation
Disulfide bondi2368 ↔ 2418PROSITE-ProRule annotation
Disulfide bondi2466 ↔ 2518PROSITE-ProRule annotation
Disulfide bondi2564 ↔ 2616PROSITE-ProRule annotation
Disulfide bondi2659 ↔ 2711PROSITE-ProRule annotation
Glycosylationi2693N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2755 ↔ 2810PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NR99

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NR99

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NR99

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NR99

PeptideAtlas

More...
PeptideAtlasi
Q9NR99

PRoteomics IDEntifications database

More...
PRIDEi
Q9NR99

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82314

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1495

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NR99

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NR99

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in kidney, also detected on liver and spleen (PubMed:27599751). Expressed by proximal tubular cells of the kidney (at protein level) (PubMed:27599751). Expression highly increases during chronic kidney disease and autosomal dominant polycystic kidney disease, where is detected in cysts (PubMed:27599751).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Over-expressed in centenarians. Expression is reduced from young to old but increased from old to centenarians.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is induced by TGFB1, in kidney tubular cells. This induction is inhibited by the vitamin D receptor activator paricalcitol (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101825 Expressed in 201 organ(s), highest expression level in tendon of biceps brachii

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NR99 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000508

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117392, 3 interactors

Protein interaction database and analysis system

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IntActi
Q9NR99, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000217939

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NR99 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 55LRRNTAdd BLAST29
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati56 – 77LRR 1Add BLAST22
Repeati80 – 101LRR 2Add BLAST22
Repeati104 – 125LRR 3Add BLAST22
Repeati128 – 149LRR 4Add BLAST22
Repeati152 – 173LRR 5Add BLAST22
Repeati184 – 205LRR 6Add BLAST22
Domaini217 – 277LRRCTAdd BLAST61
Domaini481 – 571Ig-like C2-type 1Add BLAST91
Domaini575 – 669Ig-like C2-type 2Add BLAST95
Repeati1410 – 1434LRR 7Add BLAST25
Domaini1853 – 1946Ig-like C2-type 3Add BLAST94
Domaini1950 – 2041Ig-like C2-type 4Add BLAST92
Domaini2046 – 2140Ig-like C2-type 5Add BLAST95
Domaini2146 – 2239Ig-like C2-type 6Add BLAST94
Domaini2242 – 2343Ig-like C2-type 7Add BLAST102
Domaini2345 – 2432Ig-like C2-type 8Add BLAST88
Domaini2440 – 2534Ig-like C2-type 9Add BLAST95
Domaini2542 – 2630Ig-like C2-type 10Add BLAST89
Domaini2637 – 2722Ig-like C2-type 11Add BLAST86
Domaini2733 – 2828Ig-like C2-type 12Add BLAST96

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159942

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168306

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NR99

Identification of Orthologs from Complete Genome Data

More...
OMAi
HIDHNKI

Database of Orthologous Groups

More...
OrthoDBi
8971at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NR99

TreeFam database of animal gene trees

More...
TreeFami
TF326318

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 12 hits
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 6 hits
PF13855 LRR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 12 hits
SM00408 IGc2, 12 hits
SM00369 LRR_TYP, 6 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NR99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKRAHWGAL SVVLILLWGH PRVALACPHP CACYVPSEVH CTFRSLASVP
60 70 80 90 100
AGIAKHVERI NLGFNSIQAL SETSFAGLTK LELLMIHGNE IPSIPDGALR
110 120 130 140 150
DLSSLQVFKF SYNKLRVITG QTLQGLSNLM RLHIDHNKIE FIHPQAFNGL
160 170 180 190 200
TSLRLLHLEG NLLHQLHPST FSTFTFLDYF RLSTIRHLYL AENMVRTLPA
210 220 230 240 250
SMLRNMPLLE NLYLQGNPWT CDCEMRWFLE WDAKSRGILK CKKDKAYEGG
260 270 280 290 300
QLCAMCFSPK KLYKHEIHKL KDMTCLKPSI ESPLRQNRSR SIEEEQEQEE
310 320 330 340 350
DGGSQLILEK FQLPQWSISL NMTDEHGNMV NLVCDIKKPM DVYKIHLNQT
360 370 380 390 400
DPPDIDINAT VALDFECPMT RENYEKLWKL IAYYSEVPVK LHRELMLSKD
410 420 430 440 450
PRVSYQYRQD ADEEALYYTG VRAQILAEPE WVMQPSIDIQ LNRRQSTAKK
460 470 480 490 500
VLLSYYTQYS QTISTKDTRQ ARGRSWVMIE PSGAVQRDQT VLEGGPCQLS
510 520 530 540 550
CNVKASESPS IFWVLPDGSI LKAPMDDPDS KFSILSSGWL RIKSMEPSDS
560 570 580 590 600
GLYQCIAQVR DEMDRMVYRV LVQSPSTQPA EKDTVTIGKN PGESVTLPCN
610 620 630 640 650
ALAIPEAHLS WILPNRRIIN DLANTSHVYM LPNGTLSIPK VQVSDSGYYR
660 670 680 690 700
CVAVNQQGAD HFTVGITVTK KGSGLPSKRG RRPGAKALSR VREDIVEDEG
710 720 730 740 750
GSGMGDEENT SRRLLHPKDQ EVFLKTKDDA INGDKKAKKG RRKLKLWKHS
760 770 780 790 800
EKEPETNVAE GRRVFESRRR INMANKQINP ERWADILAKV RGKNLPKGTE
810 820 830 840 850
VPPLIKTTSP PSLSLEVTPP FPAISPPSAS PVQTVTSAEE SSADVPLLGE
860 870 880 890 900
EEHVLGTISS ASMGLEHNHN GVILVEPEVT STPLEEVVDD LSEKTEEITS
910 920 930 940 950
TEGDLKGTAA PTLISEPYEP SPTLHTLDTV YEKPTHEETA TEGWSAADVG
960 970 980 990 1000
SSPEPTSSEY EPPLDAVSLA ESEPMQYFDP DLETKSQPDE DKMKEDTFAH
1010 1020 1030 1040 1050
LTPTPTIWVN DSSTSQLFED STIGEPGVPG QSHLQGLTDN IHLVKSSLST
1060 1070 1080 1090 1100
QDTLLIKKGM KEMSQTLQGG NMLEGDPTHS RSSESEGQES KSITLPDSTL
1110 1120 1130 1140 1150
GIMSSMSPVK KPAETTVGTL LDKDTTTATT TPRQKVAPSS TMSTHPSRRR
1160 1170 1180 1190 1200
PNGRRRLRPN KFRHRHKQTP PTTFAPSETF STQPTQAPDI KISSQVESSL
1210 1220 1230 1240 1250
VPTAWVDNTV NTPKQLEMEK NAEPTSKGTP RRKHGKRPNK HRYTPSTVSS
1260 1270 1280 1290 1300
RASGSKPSPS PENKHRNIVT PSSETILLPR TVSLKTEGPY DSLDYMTTTR
1310 1320 1330 1340 1350
KIYSSYPKVQ ETLPVTYKPT SDGKEIKDDV ATNVDKHKSD ILVTGESITN
1360 1370 1380 1390 1400
AIPTSRSLVS TMGEFKEESS PVGFPGTPTW NPSRTAQPGR LQTGIPVTTS
1410 1420 1430 1440 1450
GENLTDPPLL KELEDVDFTS EFLSSLTVST PFHQEEAGSS TTLSSIKVEV
1460 1470 1480 1490 1500
ASSQAETTTL DQDHLETTVA ILLSETRPQN HTPTAARMKE PASSSPSTIL
1510 1520 1530 1540 1550
MSLGQTTTTK PALPSPRISQ ASRDSKENVF LNYVGNPETE ATPVNNEGTQ
1560 1570 1580 1590 1600
HMSGPNELST PSSDQDAFNL STKLELEKQV FGSRSLPRGP DSQRQDGRVH
1610 1620 1630 1640 1650
ASHQLTRVPA KPILPTATVR LPEMSTQSAS RYFVTSQSPR HWTNKPEITT
1660 1670 1680 1690 1700
YPSGALPENK QFTTPRLSST TIPLPLHMSK PSIPSKFTDR RTDQFNGYSK
1710 1720 1730 1740 1750
VFGNNNIPEA RNPVGKPPSP RIPHYSNGRL PFFTNKTLSF PQLGVTRRPQ
1760 1770 1780 1790 1800
IPTSPAPVMR ERKVIPGSYN RIHSHSTFHL DFGPPAPPLL HTPQTTGSPS
1810 1820 1830 1840 1850
TNLQNIPMVS STQSSISFIT SSVQSSGSFH QSSSKFFAGG PPASKFWSLG
1860 1870 1880 1890 1900
EKPQILTKSP QTVSVTAETD TVFPCEATGK PKPFVTWTKV STGALMTPNT
1910 1920 1930 1940 1950
RIQRFEVLKN GTLVIRKVQV QDRGQYMCTA SNLHGLDRMV VLLSVTVQQP
1960 1970 1980 1990 2000
QILASHYQDV TVYLGDTIAM ECLAKGTPAP QISWIFPDRR VWQTVSPVEG
2010 2020 2030 2040 2050
RITLHENRTL SIKEASFSDR GVYKCVASNA AGADSLAIRL HVAALPPVIH
2060 2070 2080 2090 2100
QEKLENISLP PGLSIHIHCT AKAAPLPSVR WVLGDGTQIR PSQFLHGNLF
2110 2120 2130 2140 2150
VFPNGTLYIR NLAPKDSGRY ECVAANLVGS ARRTVQLNVQ RAAANARITG
2160 2170 2180 2190 2200
TSPRRTDVRY GGTLKLDCSA SGDPWPRILW RLPSKRMIDA LFSFDSRIKV
2210 2220 2230 2240 2250
FANGTLVVKS VTDKDAGDYL CVARNKVGDD YVVLKVDVVM KPAKIEHKEE
2260 2270 2280 2290 2300
NDHKVFYGGD LKVDCVATGL PNPEISWSLP DGSLVNSFMQ SDDSGGRTKR
2310 2320 2330 2340 2350
YVVFNNGTLY FNEVGMREEG DYTCFAENQV GKDEMRVRVK VVTAPATIRN
2360 2370 2380 2390 2400
KTYLAVQVPY GDVVTVACEA KGEPMPKVTW LSPTNKVIPT SSEKYQIYQD
2410 2420 2430 2440 2450
GTLLIQKAQR SDSGNYTCLV RNSAGEDRKT VWIHVNVQPP KINGNPNPIT
2460 2470 2480 2490 2500
TVREIAAGGS RKLIDCKAEG IPTPRVLWAF PEGVVLPAPY YGNRITVHGN
2510 2520 2530 2540 2550
GSLDIRSLRK SDSVQLVCMA RNEGGEARLI LQLTVLEPME KPIFHDPISE
2560 2570 2580 2590 2600
KITAMAGHTI SLNCSAAGTP TPSLVWVLPN GTDLQSGQQL QRFYHKADGM
2610 2620 2630 2640 2650
LHISGLSSVD AGAYRCVARN AAGHTERLVS LKVGLKPEAN KQYHNLVSII
2660 2670 2680 2690 2700
NGETLKLPCT PPGAGQGRFS WTLPNGMHLE GPQTLGRVSL LDNGTLTVRE
2710 2720 2730 2740 2750
ASVFDRGTYV CRMETEYGPS VTSIPVIVIA YPPRITSEPT PVIYTRPGNT
2760 2770 2780 2790 2800
VKLNCMAMGI PKADITWELP DKSHLKAGVQ ARLYGNRFLH PQGSLTIQHA
2810 2820
TQRDAGFYKC MAKNILGSDS KTTYIHVF
Length:2,828
Mass (Da):312,150
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0534732CE87C9A8F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH11846 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH64986 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH80586 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55K → R in AAF86402 (Ref. 1) Curated1
Sequence conflicti1565Q → R in AAF86402 (Ref. 1) Curated1
Sequence conflicti2245I → V in CAB43220 (PubMed:17974005).Curated1
Sequence conflicti2353Y → C in CAB43220 (PubMed:17974005).Curated1
Sequence conflicti2640N → S in CAB43220 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07240598A → D in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_072406481P → H in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs759222135Ensembl.1
Natural variantiVAR_072407611W → C in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_056057764V → L. Corresponds to variant dbSNP:rs5983120Ensembl.1
Natural variantiVAR_060357824I → V1 PublicationCorresponds to variant dbSNP:rs5983119Ensembl.1
Natural variantiVAR_072408862S → N in LNCR. 1 Publication1
Natural variantiVAR_0724091028V → F in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0603581128A → V1 PublicationCorresponds to variant dbSNP:rs1635246Ensembl.1
Natural variantiVAR_0762571163R → H1 PublicationCorresponds to variant dbSNP:rs139106444Ensembl.1
Natural variantiVAR_0603591394G → D1 PublicationCorresponds to variant dbSNP:rs1726199Ensembl.1
Natural variantiVAR_0560581484T → A. Corresponds to variant dbSNP:rs12396910Ensembl.1
Natural variantiVAR_0724101491P → A in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754393038Ensembl.1
Natural variantiVAR_0560591665P → S. Corresponds to variant dbSNP:rs1974522Ensembl.1
Natural variantiVAR_0603602000G → S1 PublicationCorresponds to variant dbSNP:rs1635242Ensembl.1
Natural variantiVAR_0724112300R → H in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs776590689Ensembl.1
Natural variantiVAR_0724122349R → W in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs369042203Ensembl.1
Natural variantiVAR_0764372426E → D1 PublicationCorresponds to variant dbSNP:rs148675322Ensembl.1
Natural variantiVAR_0288212531L → V1 PublicationCorresponds to variant dbSNP:rs1726208Ensembl.1
Natural variantiVAR_0762582663G → W1 PublicationCorresponds to variant dbSNP:rs143264543Ensembl.1
Natural variantiVAR_0724132678H → R in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0724142716E → A in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1419255508Ensembl.1
Natural variantiVAR_0724152763A → G in LNCR; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF245505 mRNA Translation: AAF86402.1
AC004616 Genomic DNA No translation available.
BC011846 mRNA Translation: AAH11846.1 Sequence problems.
BC064986 mRNA Translation: AAH64986.1 Sequence problems.
BC080586 mRNA Translation: AAH80586.1 Sequence problems.
AL049946 mRNA Translation: CAB43220.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14124.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T08678

NCBI Reference Sequences

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RefSeqi
NP_056234.2, NM_015419.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000217939; ENSP00000217939; ENSG00000101825

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25878

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25878

UCSC genome browser

More...
UCSCi
uc004crg.6 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245505 mRNA Translation: AAF86402.1
AC004616 Genomic DNA No translation available.
BC011846 mRNA Translation: AAH11846.1 Sequence problems.
BC064986 mRNA Translation: AAH64986.1 Sequence problems.
BC080586 mRNA Translation: AAH80586.1 Sequence problems.
AL049946 mRNA Translation: CAB43220.1
CCDSiCCDS14124.1
PIRiT08678
RefSeqiNP_056234.2, NM_015419.3

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi117392, 3 interactors
IntActiQ9NR99, 4 interactors
STRINGi9606.ENSP00000217939

PTM databases

GlyConnecti1495
iPTMnetiQ9NR99
PhosphoSitePlusiQ9NR99

Polymorphism and mutation databases

BioMutaiMXRA5
DMDMi317373412

Proteomic databases

EPDiQ9NR99
jPOSTiQ9NR99
MassIVEiQ9NR99
PaxDbiQ9NR99
PeptideAtlasiQ9NR99
PRIDEiQ9NR99
ProteomicsDBi82314

Genome annotation databases

EnsembliENST00000217939; ENSP00000217939; ENSG00000101825
GeneIDi25878
KEGGihsa:25878
UCSCiuc004crg.6 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25878
DisGeNETi25878
EuPathDBiHostDB:ENSG00000101825.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MXRA5
HGNCiHGNC:7539 MXRA5
HPAiHPA000508
MalaCardsiMXRA5
MIMi211980 phenotype
300938 gene
neXtProtiNX_Q9NR99
OpenTargetsiENSG00000101825
PharmGKBiPA31340

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000159942
HOGENOMiHOG000168306
InParanoidiQ9NR99
OMAiHIDHNKI
OrthoDBi8971at2759
PhylomeDBiQ9NR99
TreeFamiTF326318

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MXRA5 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MXRA5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25878
PharosiQ9NR99 Tdark

Protein Ontology

More...
PROi
PR:Q9NR99
RNActiQ9NR99 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000101825 Expressed in 201 organ(s), highest expression level in tendon of biceps brachii
GenevisibleiQ9NR99 HS

Family and domain databases

Gene3Di2.60.40.10, 12 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF07679 I-set, 6 hits
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00409 IG, 12 hits
SM00408 IGc2, 12 hits
SM00369 LRR_TYP, 6 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SUPFAMiSSF48726 SSF48726, 12 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMXRA5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NR99
Secondary accession number(s): Q6P1M7, Q9Y3Y8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 11, 2011
Last modified: December 11, 2019
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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