UniProtKB - Q9NR99 (MXRA5_HUMAN)
Protein
Matrix-remodeling-associated protein 5
Gene
MXRA5
Organism
Homo sapiens (Human)
Status
Functioni
In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli.1 Publication
GO - Molecular functioni
- extracellular matrix structural constituent Source: BHF-UCL
GO - Biological processi
- response to transforming growth factor beta Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9NR99 |
Names & Taxonomyi
Protein namesi | Recommended name: Matrix-remodeling-associated protein 5Alternative name(s): Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan Short name: Adlican |
Gene namesi | Name:MXRA5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000101825.7 |
HGNCi | HGNC:7539, MXRA5 |
MIMi | 300938, gene |
neXtProti | NX_Q9NR99 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular exosome Source: UniProtKB
- extracellular region Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Lung cancer (LNCR)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072405 | 98 | A → D in LNCR; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_072406 | 481 | P → H in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs759222135Ensembl. | 1 | |
Natural variantiVAR_072407 | 611 | W → C in LNCR; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_072408 | 862 | S → N in LNCR. 1 Publication | 1 | |
Natural variantiVAR_072409 | 1028 | V → F in LNCR; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_072410 | 1491 | P → A in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754393038Ensembl. | 1 | |
Natural variantiVAR_072411 | 2300 | R → H in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs776590689Ensembl. | 1 | |
Natural variantiVAR_072412 | 2349 | R → W in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs369042203Ensembl. | 1 | |
Natural variantiVAR_072413 | 2678 | H → R in LNCR; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_072414 | 2716 | E → A in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1419255508Ensembl. | 1 | |
Natural variantiVAR_072415 | 2763 | A → G in LNCR; unknown pathological significance. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 25878 |
MalaCardsi | MXRA5 |
MIMi | 211980, phenotype |
OpenTargetsi | ENSG00000101825 |
PharmGKBi | PA31340 |
Miscellaneous databases
Pharosi | Q9NR99, Tdark |
Polymorphism and mutation databases
BioMutai | MXRA5 |
DMDMi | 317373412 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000254131 | 27 – 2828 | Matrix-remodeling-associated protein 5Add BLAST | 2802 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 287 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 321 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 501 ↔ 555 | PROSITE-ProRule annotation | ||
Disulfide bondi | 599 ↔ 651 | PROSITE-ProRule annotation | ||
Glycosylationi | 633 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1403 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1735 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1875 ↔ 1928 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1972 ↔ 2025 | PROSITE-ProRule annotation | ||
Glycosylationi | 2007 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2056 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 2069 ↔ 2122 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2168 ↔ 2221 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2265 ↔ 2324 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2368 ↔ 2418 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2466 ↔ 2518 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2564 ↔ 2616 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2659 ↔ 2711 | PROSITE-ProRule annotation | ||
Glycosylationi | 2693 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 2755 ↔ 2810 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q9NR99 |
jPOSTi | Q9NR99 |
MassIVEi | Q9NR99 |
PaxDbi | Q9NR99 |
PeptideAtlasi | Q9NR99 |
PRIDEi | Q9NR99 |
ProteomicsDBi | 82314 |
PTM databases
GlyConnecti | 1495, 24 N-Linked glycans (7 sites) |
GlyGeni | Q9NR99, 24 sites, 4 O-linked glycans (13 sites) |
iPTMneti | Q9NR99 |
PhosphoSitePlusi | Q9NR99 |
Expressioni
Tissue specificityi
Highly expressed in kidney, also detected on liver and spleen (PubMed:27599751). Expressed by proximal tubular cells of the kidney (at protein level) (PubMed:27599751). Expression highly increases during chronic kidney disease and autosomal dominant polycystic kidney disease, where is detected in cysts (PubMed:27599751).1 Publication
Developmental stagei
Over-expressed in centenarians. Expression is reduced from young to old but increased from old to centenarians.1 Publication
Inductioni
Expression is induced by TGFB1, in kidney tubular cells. This induction is inhibited by the vitamin D receptor activator paricalcitol (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000101825, Expressed in tendon of biceps brachii and 213 other tissues |
Genevisiblei | Q9NR99, HS |
Organism-specific databases
HPAi | ENSG00000101825, Tissue enhanced (cervix, uterine, pancreas) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 117392, 3 interactors |
IntActi | Q9NR99, 4 interactors |
STRINGi | 9606.ENSP00000217939 |
Miscellaneous databases
RNActi | Q9NR99, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 55 | LRRNTAdd BLAST | 29 | |
Repeati | 56 – 77 | LRR 1Add BLAST | 22 | |
Repeati | 80 – 101 | LRR 2Add BLAST | 22 | |
Repeati | 104 – 125 | LRR 3Add BLAST | 22 | |
Repeati | 128 – 149 | LRR 4Add BLAST | 22 | |
Repeati | 152 – 173 | LRR 5Add BLAST | 22 | |
Repeati | 184 – 205 | LRR 6Add BLAST | 22 | |
Domaini | 217 – 277 | LRRCTAdd BLAST | 61 | |
Domaini | 481 – 571 | Ig-like C2-type 1Add BLAST | 91 | |
Domaini | 575 – 669 | Ig-like C2-type 2Add BLAST | 95 | |
Repeati | 1410 – 1434 | LRR 7Add BLAST | 25 | |
Domaini | 1853 – 1946 | Ig-like C2-type 3Add BLAST | 94 | |
Domaini | 1950 – 2041 | Ig-like C2-type 4Add BLAST | 92 | |
Domaini | 2046 – 2140 | Ig-like C2-type 5Add BLAST | 95 | |
Domaini | 2146 – 2239 | Ig-like C2-type 6Add BLAST | 94 | |
Domaini | 2242 – 2343 | Ig-like C2-type 7Add BLAST | 102 | |
Domaini | 2345 – 2432 | Ig-like C2-type 8Add BLAST | 88 | |
Domaini | 2440 – 2534 | Ig-like C2-type 9Add BLAST | 95 | |
Domaini | 2542 – 2630 | Ig-like C2-type 10Add BLAST | 89 | |
Domaini | 2637 – 2722 | Ig-like C2-type 11Add BLAST | 86 | |
Domaini | 2733 – 2828 | Ig-like C2-type 12Add BLAST | 96 |
Keywords - Domaini
Leucine-rich repeat, Repeat, SignalPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000159942 |
HOGENOMi | CLU_000580_0_0_1 |
InParanoidi | Q9NR99 |
OMAi | QPETTKH |
OrthoDBi | 8971at2759 |
PhylomeDBi | Q9NR99 |
TreeFami | TF326318 |
Family and domain databases
Gene3Di | 2.60.40.10, 12 hits 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF07679, I-set, 6 hits PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 12 hits SM00408, IGc2, 12 hits SM00369, LRR_TYP, 6 hits SM00082, LRRCT, 1 hit SM00013, LRRNT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 12 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 12 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9NR99-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKRAHWGAL SVVLILLWGH PRVALACPHP CACYVPSEVH CTFRSLASVP
60 70 80 90 100
AGIAKHVERI NLGFNSIQAL SETSFAGLTK LELLMIHGNE IPSIPDGALR
110 120 130 140 150
DLSSLQVFKF SYNKLRVITG QTLQGLSNLM RLHIDHNKIE FIHPQAFNGL
160 170 180 190 200
TSLRLLHLEG NLLHQLHPST FSTFTFLDYF RLSTIRHLYL AENMVRTLPA
210 220 230 240 250
SMLRNMPLLE NLYLQGNPWT CDCEMRWFLE WDAKSRGILK CKKDKAYEGG
260 270 280 290 300
QLCAMCFSPK KLYKHEIHKL KDMTCLKPSI ESPLRQNRSR SIEEEQEQEE
310 320 330 340 350
DGGSQLILEK FQLPQWSISL NMTDEHGNMV NLVCDIKKPM DVYKIHLNQT
360 370 380 390 400
DPPDIDINAT VALDFECPMT RENYEKLWKL IAYYSEVPVK LHRELMLSKD
410 420 430 440 450
PRVSYQYRQD ADEEALYYTG VRAQILAEPE WVMQPSIDIQ LNRRQSTAKK
460 470 480 490 500
VLLSYYTQYS QTISTKDTRQ ARGRSWVMIE PSGAVQRDQT VLEGGPCQLS
510 520 530 540 550
CNVKASESPS IFWVLPDGSI LKAPMDDPDS KFSILSSGWL RIKSMEPSDS
560 570 580 590 600
GLYQCIAQVR DEMDRMVYRV LVQSPSTQPA EKDTVTIGKN PGESVTLPCN
610 620 630 640 650
ALAIPEAHLS WILPNRRIIN DLANTSHVYM LPNGTLSIPK VQVSDSGYYR
660 670 680 690 700
CVAVNQQGAD HFTVGITVTK KGSGLPSKRG RRPGAKALSR VREDIVEDEG
710 720 730 740 750
GSGMGDEENT SRRLLHPKDQ EVFLKTKDDA INGDKKAKKG RRKLKLWKHS
760 770 780 790 800
EKEPETNVAE GRRVFESRRR INMANKQINP ERWADILAKV RGKNLPKGTE
810 820 830 840 850
VPPLIKTTSP PSLSLEVTPP FPAISPPSAS PVQTVTSAEE SSADVPLLGE
860 870 880 890 900
EEHVLGTISS ASMGLEHNHN GVILVEPEVT STPLEEVVDD LSEKTEEITS
910 920 930 940 950
TEGDLKGTAA PTLISEPYEP SPTLHTLDTV YEKPTHEETA TEGWSAADVG
960 970 980 990 1000
SSPEPTSSEY EPPLDAVSLA ESEPMQYFDP DLETKSQPDE DKMKEDTFAH
1010 1020 1030 1040 1050
LTPTPTIWVN DSSTSQLFED STIGEPGVPG QSHLQGLTDN IHLVKSSLST
1060 1070 1080 1090 1100
QDTLLIKKGM KEMSQTLQGG NMLEGDPTHS RSSESEGQES KSITLPDSTL
1110 1120 1130 1140 1150
GIMSSMSPVK KPAETTVGTL LDKDTTTATT TPRQKVAPSS TMSTHPSRRR
1160 1170 1180 1190 1200
PNGRRRLRPN KFRHRHKQTP PTTFAPSETF STQPTQAPDI KISSQVESSL
1210 1220 1230 1240 1250
VPTAWVDNTV NTPKQLEMEK NAEPTSKGTP RRKHGKRPNK HRYTPSTVSS
1260 1270 1280 1290 1300
RASGSKPSPS PENKHRNIVT PSSETILLPR TVSLKTEGPY DSLDYMTTTR
1310 1320 1330 1340 1350
KIYSSYPKVQ ETLPVTYKPT SDGKEIKDDV ATNVDKHKSD ILVTGESITN
1360 1370 1380 1390 1400
AIPTSRSLVS TMGEFKEESS PVGFPGTPTW NPSRTAQPGR LQTGIPVTTS
1410 1420 1430 1440 1450
GENLTDPPLL KELEDVDFTS EFLSSLTVST PFHQEEAGSS TTLSSIKVEV
1460 1470 1480 1490 1500
ASSQAETTTL DQDHLETTVA ILLSETRPQN HTPTAARMKE PASSSPSTIL
1510 1520 1530 1540 1550
MSLGQTTTTK PALPSPRISQ ASRDSKENVF LNYVGNPETE ATPVNNEGTQ
1560 1570 1580 1590 1600
HMSGPNELST PSSDQDAFNL STKLELEKQV FGSRSLPRGP DSQRQDGRVH
1610 1620 1630 1640 1650
ASHQLTRVPA KPILPTATVR LPEMSTQSAS RYFVTSQSPR HWTNKPEITT
1660 1670 1680 1690 1700
YPSGALPENK QFTTPRLSST TIPLPLHMSK PSIPSKFTDR RTDQFNGYSK
1710 1720 1730 1740 1750
VFGNNNIPEA RNPVGKPPSP RIPHYSNGRL PFFTNKTLSF PQLGVTRRPQ
1760 1770 1780 1790 1800
IPTSPAPVMR ERKVIPGSYN RIHSHSTFHL DFGPPAPPLL HTPQTTGSPS
1810 1820 1830 1840 1850
TNLQNIPMVS STQSSISFIT SSVQSSGSFH QSSSKFFAGG PPASKFWSLG
1860 1870 1880 1890 1900
EKPQILTKSP QTVSVTAETD TVFPCEATGK PKPFVTWTKV STGALMTPNT
1910 1920 1930 1940 1950
RIQRFEVLKN GTLVIRKVQV QDRGQYMCTA SNLHGLDRMV VLLSVTVQQP
1960 1970 1980 1990 2000
QILASHYQDV TVYLGDTIAM ECLAKGTPAP QISWIFPDRR VWQTVSPVEG
2010 2020 2030 2040 2050
RITLHENRTL SIKEASFSDR GVYKCVASNA AGADSLAIRL HVAALPPVIH
2060 2070 2080 2090 2100
QEKLENISLP PGLSIHIHCT AKAAPLPSVR WVLGDGTQIR PSQFLHGNLF
2110 2120 2130 2140 2150
VFPNGTLYIR NLAPKDSGRY ECVAANLVGS ARRTVQLNVQ RAAANARITG
2160 2170 2180 2190 2200
TSPRRTDVRY GGTLKLDCSA SGDPWPRILW RLPSKRMIDA LFSFDSRIKV
2210 2220 2230 2240 2250
FANGTLVVKS VTDKDAGDYL CVARNKVGDD YVVLKVDVVM KPAKIEHKEE
2260 2270 2280 2290 2300
NDHKVFYGGD LKVDCVATGL PNPEISWSLP DGSLVNSFMQ SDDSGGRTKR
2310 2320 2330 2340 2350
YVVFNNGTLY FNEVGMREEG DYTCFAENQV GKDEMRVRVK VVTAPATIRN
2360 2370 2380 2390 2400
KTYLAVQVPY GDVVTVACEA KGEPMPKVTW LSPTNKVIPT SSEKYQIYQD
2410 2420 2430 2440 2450
GTLLIQKAQR SDSGNYTCLV RNSAGEDRKT VWIHVNVQPP KINGNPNPIT
2460 2470 2480 2490 2500
TVREIAAGGS RKLIDCKAEG IPTPRVLWAF PEGVVLPAPY YGNRITVHGN
2510 2520 2530 2540 2550
GSLDIRSLRK SDSVQLVCMA RNEGGEARLI LQLTVLEPME KPIFHDPISE
2560 2570 2580 2590 2600
KITAMAGHTI SLNCSAAGTP TPSLVWVLPN GTDLQSGQQL QRFYHKADGM
2610 2620 2630 2640 2650
LHISGLSSVD AGAYRCVARN AAGHTERLVS LKVGLKPEAN KQYHNLVSII
2660 2670 2680 2690 2700
NGETLKLPCT PPGAGQGRFS WTLPNGMHLE GPQTLGRVSL LDNGTLTVRE
2710 2720 2730 2740 2750
ASVFDRGTYV CRMETEYGPS VTSIPVIVIA YPPRITSEPT PVIYTRPGNT
2760 2770 2780 2790 2800
VKLNCMAMGI PKADITWELP DKSHLKAGVQ ARLYGNRFLH PQGSLTIQHA
2810 2820
TQRDAGFYKC MAKNILGSDS KTTYIHVF
Sequence cautioni
The sequence AAH11846 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH64986 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH80586 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 | K → R in AAF86402 (Ref. 1) Curated | 1 | |
Sequence conflicti | 1565 | Q → R in AAF86402 (Ref. 1) Curated | 1 | |
Sequence conflicti | 2245 | I → V in CAB43220 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 2353 | Y → C in CAB43220 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 2640 | N → S in CAB43220 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072405 | 98 | A → D in LNCR; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_072406 | 481 | P → H in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs759222135Ensembl. | 1 | |
Natural variantiVAR_072407 | 611 | W → C in LNCR; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_056057 | 764 | V → L. Corresponds to variant dbSNP:rs5983120Ensembl. | 1 | |
Natural variantiVAR_060357 | 824 | I → V1 PublicationCorresponds to variant dbSNP:rs5983119Ensembl. | 1 | |
Natural variantiVAR_072408 | 862 | S → N in LNCR. 1 Publication | 1 | |
Natural variantiVAR_072409 | 1028 | V → F in LNCR; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_060358 | 1128 | A → V1 PublicationCorresponds to variant dbSNP:rs1635246Ensembl. | 1 | |
Natural variantiVAR_076257 | 1163 | R → H1 PublicationCorresponds to variant dbSNP:rs139106444EnsemblClinVar. | 1 | |
Natural variantiVAR_060359 | 1394 | G → D1 PublicationCorresponds to variant dbSNP:rs1726199Ensembl. | 1 | |
Natural variantiVAR_056058 | 1484 | T → A. Corresponds to variant dbSNP:rs12396910Ensembl. | 1 | |
Natural variantiVAR_072410 | 1491 | P → A in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754393038Ensembl. | 1 | |
Natural variantiVAR_056059 | 1665 | P → S. Corresponds to variant dbSNP:rs1974522Ensembl. | 1 | |
Natural variantiVAR_060360 | 2000 | G → S1 PublicationCorresponds to variant dbSNP:rs1635242Ensembl. | 1 | |
Natural variantiVAR_072411 | 2300 | R → H in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs776590689Ensembl. | 1 | |
Natural variantiVAR_072412 | 2349 | R → W in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs369042203Ensembl. | 1 | |
Natural variantiVAR_076437 | 2426 | E → D1 PublicationCorresponds to variant dbSNP:rs148675322EnsemblClinVar. | 1 | |
Natural variantiVAR_028821 | 2531 | L → V1 PublicationCorresponds to variant dbSNP:rs1726208EnsemblClinVar. | 1 | |
Natural variantiVAR_076258 | 2663 | G → W1 PublicationCorresponds to variant dbSNP:rs143264543Ensembl. | 1 | |
Natural variantiVAR_072413 | 2678 | H → R in LNCR; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_072414 | 2716 | E → A in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1419255508Ensembl. | 1 | |
Natural variantiVAR_072415 | 2763 | A → G in LNCR; unknown pathological significance. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF245505 mRNA Translation: AAF86402.1 AC004616 Genomic DNA No translation available. BC011846 mRNA Translation: AAH11846.1 Sequence problems. BC064986 mRNA Translation: AAH64986.1 Sequence problems. BC080586 mRNA Translation: AAH80586.1 Sequence problems. AL049946 mRNA Translation: CAB43220.1 |
CCDSi | CCDS14124.1 |
PIRi | T08678 |
RefSeqi | NP_056234.2, NM_015419.3 |
Genome annotation databases
Ensembli | ENST00000217939; ENSP00000217939; ENSG00000101825 |
GeneIDi | 25878 |
KEGGi | hsa:25878 |
UCSCi | uc004crg.6, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF245505 mRNA Translation: AAF86402.1 AC004616 Genomic DNA No translation available. BC011846 mRNA Translation: AAH11846.1 Sequence problems. BC064986 mRNA Translation: AAH64986.1 Sequence problems. BC080586 mRNA Translation: AAH80586.1 Sequence problems. AL049946 mRNA Translation: CAB43220.1 |
CCDSi | CCDS14124.1 |
PIRi | T08678 |
RefSeqi | NP_056234.2, NM_015419.3 |
3D structure databases
SMRi | Q9NR99 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117392, 3 interactors |
IntActi | Q9NR99, 4 interactors |
STRINGi | 9606.ENSP00000217939 |
PTM databases
GlyConnecti | 1495, 24 N-Linked glycans (7 sites) |
GlyGeni | Q9NR99, 24 sites, 4 O-linked glycans (13 sites) |
iPTMneti | Q9NR99 |
PhosphoSitePlusi | Q9NR99 |
Polymorphism and mutation databases
BioMutai | MXRA5 |
DMDMi | 317373412 |
Proteomic databases
EPDi | Q9NR99 |
jPOSTi | Q9NR99 |
MassIVEi | Q9NR99 |
PaxDbi | Q9NR99 |
PeptideAtlasi | Q9NR99 |
PRIDEi | Q9NR99 |
ProteomicsDBi | 82314 |
Protocols and materials databases
Antibodypediai | 362, 65 antibodies |
Genome annotation databases
Ensembli | ENST00000217939; ENSP00000217939; ENSG00000101825 |
GeneIDi | 25878 |
KEGGi | hsa:25878 |
UCSCi | uc004crg.6, human |
Organism-specific databases
CTDi | 25878 |
DisGeNETi | 25878 |
EuPathDBi | HostDB:ENSG00000101825.7 |
GeneCardsi | MXRA5 |
HGNCi | HGNC:7539, MXRA5 |
HPAi | ENSG00000101825, Tissue enhanced (cervix, uterine, pancreas) |
MalaCardsi | MXRA5 |
MIMi | 211980, phenotype 300938, gene |
neXtProti | NX_Q9NR99 |
OpenTargetsi | ENSG00000101825 |
PharmGKBi | PA31340 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000159942 |
HOGENOMi | CLU_000580_0_0_1 |
InParanoidi | Q9NR99 |
OMAi | QPETTKH |
OrthoDBi | 8971at2759 |
PhylomeDBi | Q9NR99 |
TreeFami | TF326318 |
Enzyme and pathway databases
PathwayCommonsi | Q9NR99 |
Miscellaneous databases
BioGRID-ORCSi | 25878, 1 hit in 470 CRISPR screens |
ChiTaRSi | MXRA5, human |
GeneWikii | MXRA5 |
GenomeRNAii | 25878 |
Pharosi | Q9NR99, Tdark |
PROi | PR:Q9NR99 |
RNActi | Q9NR99, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101825, Expressed in tendon of biceps brachii and 213 other tissues |
Genevisiblei | Q9NR99, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 12 hits 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF07679, I-set, 6 hits PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 12 hits SM00408, IGc2, 12 hits SM00369, LRR_TYP, 6 hits SM00082, LRRCT, 1 hit SM00013, LRRNT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 12 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 12 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MXRA5_HUMAN | |
Accessioni | Q9NR99Primary (citable) accession number: Q9NR99 Secondary accession number(s): Q6P1M7, Q9Y3Y8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations