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Entry version 172 (13 Feb 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Toll-like receptor 8

Gene

TLR8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • double-stranded RNA binding Source: UniProtKB
  • drug binding Source: Ensembl
  • identical protein binding Source: IntAct
  • RNA binding Source: UniProtKB
  • signaling pattern recognition receptor activity Source: GO_Central
  • signaling receptor activity Source: UniProtKB
  • single-stranded RNA binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Toll-like receptor 8
Alternative name(s):
CD_antigen: CD288
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TLR8
ORF Names:UNQ249/PRO286
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000101916.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15632 TLR8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300366 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NR97

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 827ExtracellularSequence analysisAdd BLAST801
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei828 – 848HelicalSequence analysisAdd BLAST21
Topological domaini849 – 1041CytoplasmicSequence analysisAdd BLAST193

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi348Y → A: Abolishes activation of NF-kappa-B. 1 Publication1
Mutagenesisi378V → A: Increases activation of NF-kappa-B. 1 Publication1
Mutagenesisi405F → A: Abolishes activation of NF-kappa-B. 1 Publication1
Mutagenesisi520V → A: Strongly decreases activation of NF-kappa-B. 1 Publication1
Mutagenesisi543D → A: Abolishes activation of NF-kappa-B. 1 Publication1
Mutagenesisi574T → A: Strongly decreases activation of NF-kappa-B. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51311

Open Targets

More...
OpenTargetsi
ENSG00000101916

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38009

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5805

Drug and drug target database

More...
DrugBanki
DB00724 Imiquimod

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1758

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TLR8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20140873

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003473527 – 1041Toll-like receptor 8Add BLAST1015

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 491 Publication
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi80N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi88N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi181 ↔ 1871 Publication
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi257 ↔ 2701 Publication
Disulfide bondi260 ↔ 2671 Publication
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi358N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi395N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi416N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi443N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi479 ↔ 5091 Publication
Glycosylationi511N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi546N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi582N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi590N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi640N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi680N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi752N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi776 ↔ 8031 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NR97

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NR97

PeptideAtlas

More...
PeptideAtlasi
Q9NR97

PRoteomics IDEntifications database

More...
PRIDEi
Q9NR97

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82313

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NR97

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NR97

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101916 Expressed in 121 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NR97 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001608

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity). Homodimer. Interacts with BTK. Interacts with SMPDL3B (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119462, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-61413N

Protein interaction database and analysis system

More...
IntActi
Q9NR97, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000218032

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9NR97

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11041
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3W3GX-ray2.30A/B27-827[»]
3W3JX-ray2.00A/B27-827[»]
3W3KX-ray2.30A/B27-827[»]
3W3LX-ray2.33A/B/C/D27-827[»]
3W3MX-ray2.70A27-827[»]
3W3NX-ray2.10A/B27-827[»]
3WN4X-ray1.81A27-827[»]
4QBZX-ray2.00A/B27-827[»]
4QC0X-ray2.10A/B27-827[»]
4R07X-ray2.00A/B/C/D27-827[»]
4R08X-ray2.40A/B/C/D27-827[»]
4R09X-ray2.62A/B/C/D27-827[»]
4R0AX-ray1.90A27-827[»]
4R6AX-ray2.10A/B27-827[»]
5AWAX-ray2.20A27-827[»]
5AWBX-ray2.10A27-827[»]
5AWCX-ray2.50A/B/C/D27-827[»]
5AWDX-ray2.05A27-827[»]
5AZ5X-ray2.40A/B/C/D27-827[»]
5HDHX-ray2.60A27-827[»]
5WYXX-ray2.40A/B27-827[»]
5WYZX-ray2.30A/B27-827[»]
5Z14X-ray2.80A/B27-827[»]
5Z15X-ray2.90A/B27-827[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9NR97

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NR97

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati126 – 147LRR 11 PublicationAdd BLAST22
Repeati148 – 168LRR 21 PublicationAdd BLAST21
Repeati171 – 193LRR 31 PublicationAdd BLAST23
Repeati202 – 223LRR 41 PublicationAdd BLAST22
Repeati224 – 244LRR 51 PublicationAdd BLAST21
Repeati247 – 268LRR 61 PublicationAdd BLAST22
Repeati288 – 309LRR 71 PublicationAdd BLAST22
Repeati312 – 334LRR 81 PublicationAdd BLAST23
Repeati338 – 360LRR 91 PublicationAdd BLAST23
Repeati368 – 389LRR 101 PublicationAdd BLAST22
Repeati395 – 416LRR 111 PublicationAdd BLAST22
Repeati419 – 440LRR 121 PublicationAdd BLAST22
Repeati482 – 503LRR 131 PublicationAdd BLAST22
Repeati506 – 527LRR 141 PublicationAdd BLAST22
Repeati531 – 551LRR 151 PublicationAdd BLAST21
Repeati555 – 577LRR 161 PublicationAdd BLAST23
Repeati585 – 606LRR 171 PublicationAdd BLAST22
Repeati609 – 630LRR 181 PublicationAdd BLAST22
Repeati640 – 661LRR 191 PublicationAdd BLAST22
Repeati665 – 685LRR 201 PublicationAdd BLAST21
Repeati689 – 710LRR 211 PublicationAdd BLAST22
Repeati713 – 734LRR 221 PublicationAdd BLAST22
Repeati737 – 758LRR 231 PublicationAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini772 – 824LRRCTAdd BLAST53
Domaini878 – 1025TIRPROSITE-ProRule annotationAdd BLAST148

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4641 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160879

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230468

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018601

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NR97

KEGG Orthology (KO)

More...
KOi
K10170

Identification of Orthologs from Complete Genome Data

More...
OMAi
FDCTCDI

Database of Orthologous Groups

More...
OrthoDBi
96378at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NR97

TreeFam database of animal gene trees

More...
TreeFami
TF351113

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10140, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027175 TLR8
IPR035897 Toll_tir_struct_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR44312:SF2 PTHR44312:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 5 hits
PF01582 TIR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 15 hits
SM00082 LRRCT, 1 hit
SM00255 TIR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52200 SSF52200, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 20 hits
PS50104 TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NR97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENMFLQSSM LTCIFLLISG SCELCAEENF SRSYPCDEKK QNDSVIAECS
60 70 80 90 100
NRRLQEVPQT VGKYVTELDL SDNFITHITN ESFQGLQNLT KINLNHNPNV
110 120 130 140 150
QHQNGNPGIQ SNGLNITDGA FLNLKNLREL LLEDNQLPQI PSGLPESLTE
160 170 180 190 200
LSLIQNNIYN ITKEGISRLI NLKNLYLAWN CYFNKVCEKT NIEDGVFETL
210 220 230 240 250
TNLELLSLSF NSLSHVPPKL PSSLRKLFLS NTQIKYISEE DFKGLINLTL
260 270 280 290 300
LDLSGNCPRC FNAPFPCVPC DGGASINIDR FAFQNLTQLR YLNLSSTSLR
310 320 330 340 350
KINAAWFKNM PHLKVLDLEF NYLVGEIASG AFLTMLPRLE ILDLSFNYIK
360 370 380 390 400
GSYPQHINIS RNFSKLLSLR ALHLRGYVFQ ELREDDFQPL MQLPNLSTIN
410 420 430 440 450
LGINFIKQID FKLFQNFSNL EIIYLSENRI SPLVKDTRQS YANSSSFQRH
460 470 480 490 500
IRKRRSTDFE FDPHSNFYHF TRPLIKPQCA AYGKALDLSL NSIFFIGPNQ
510 520 530 540 550
FENLPDIACL NLSANSNAQV LSGTEFSAIP HVKYLDLTNN RLDFDNASAL
560 570 580 590 600
TELSDLEVLD LSYNSHYFRI AGVTHHLEFI QNFTNLKVLN LSHNNIYTLT
610 620 630 640 650
DKYNLESKSL VELVFSGNRL DILWNDDDNR YISIFKGLKN LTRLDLSLNR
660 670 680 690 700
LKHIPNEAFL NLPASLTELH INDNMLKFFN WTLLQQFPRL ELLDLRGNKL
710 720 730 740 750
LFLTDSLSDF TSSLRTLLLS HNRISHLPSG FLSEVSSLKH LDLSSNLLKT
760 770 780 790 800
INKSALETKT TTKLSMLELH GNPFECTCDI GDFRRWMDEH LNVKIPRLVD
810 820 830 840 850
VICASPGDQR GKSIVSLELT TCVSDVTAVI LFFFTFFITT MVMLAALAHH
860 870 880 890 900
LFYWDVWFIY NVCLAKVKGY RSLSTSQTFY DAYISYDTKD ASVTDWVINE
910 920 930 940 950
LRYHLEESRD KNVLLCLEER DWDPGLAIID NLMQSINQSK KTVFVLTKKY
960 970 980 990 1000
AKSWNFKTAF YLALQRLMDE NMDVIIFILL EPVLQHSQYL RLRQRICKSS
1010 1020 1030 1040
ILQWPDNPKA EGLFWQTLRN VVLTENDSRY NNMYVDSIKQ Y
Length:1,041
Mass (Da):119,828
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39A38B60629291C8
GO
Isoform 2 (identifier: Q9NR97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKESSLQNSSCSLGKETKK

Show »
Length:1,059
Mass (Da):121,764
Checksum:i27803D560E09D7BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti217P → S in AAF64061 (PubMed:11022119).Curated1
Sequence conflicti328A → V in AAQ88663 (PubMed:12975309).Curated1
Sequence conflicti366L → P in AAF64061 (PubMed:11022119).Curated1
Sequence conflicti410D → N in AAZ95439 (PubMed:19924287).Curated1
Sequence conflicti867V → I in AAF64061 (PubMed:11022119).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02466710M → V. Corresponds to variant dbSNP:rs5744077Ensembl.1
Natural variantiVAR_052363715R → Q. Corresponds to variant dbSNP:rs5744082Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0534121M → MKESSLQNSSCSLGKETKK in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF246971 mRNA Translation: AAF64061.1
AF245703 mRNA Translation: AAF78036.1
AB445666 mRNA Translation: BAG55063.1
DQ023132 Genomic DNA Translation: AAZ95433.1
DQ023133 Genomic DNA Translation: AAZ95434.1
DQ023134 Genomic DNA Translation: AAZ95435.1
DQ023135 Genomic DNA Translation: AAZ95436.1
DQ023136 Genomic DNA Translation: AAZ95437.1
DQ023137 Genomic DNA Translation: AAZ95438.1
DQ023138 Genomic DNA Translation: AAZ95439.1
DQ023139 Genomic DNA Translation: AAZ95440.1
DQ023140 Genomic DNA Translation: AAZ95441.1
CH471074 Genomic DNA Translation: EAW98808.1
AY358296 mRNA Translation: AAQ88663.1
AC005859 Genomic DNA No translation available.
AC139705 Genomic DNA No translation available.
CH471074 Genomic DNA Translation: EAW98809.1
BC101076 mRNA Translation: AAI01077.1
BC101077 mRNA Translation: AAI01078.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14152.1 [Q9NR97-1]
CCDS14153.1 [Q9NR97-2]

NCBI Reference Sequences

More...
RefSeqi
NP_057694.2, NM_016610.3 [Q9NR97-2]
NP_619542.1, NM_138636.5 [Q9NR97-1]
XP_011543831.1, XM_011545529.1 [Q9NR97-2]
XP_011543832.1, XM_011545530.2 [Q9NR97-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.660543

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000218032; ENSP00000218032; ENSG00000101916 [Q9NR97-1]
ENST00000311912; ENSP00000312082; ENSG00000101916 [Q9NR97-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51311

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51311

UCSC genome browser

More...
UCSCi
uc004cvd.4 human [Q9NR97-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF246971 mRNA Translation: AAF64061.1
AF245703 mRNA Translation: AAF78036.1
AB445666 mRNA Translation: BAG55063.1
DQ023132 Genomic DNA Translation: AAZ95433.1
DQ023133 Genomic DNA Translation: AAZ95434.1
DQ023134 Genomic DNA Translation: AAZ95435.1
DQ023135 Genomic DNA Translation: AAZ95436.1
DQ023136 Genomic DNA Translation: AAZ95437.1
DQ023137 Genomic DNA Translation: AAZ95438.1
DQ023138 Genomic DNA Translation: AAZ95439.1
DQ023139 Genomic DNA Translation: AAZ95440.1
DQ023140 Genomic DNA Translation: AAZ95441.1
CH471074 Genomic DNA Translation: EAW98808.1
AY358296 mRNA Translation: AAQ88663.1
AC005859 Genomic DNA No translation available.
AC139705 Genomic DNA No translation available.
CH471074 Genomic DNA Translation: EAW98809.1
BC101076 mRNA Translation: AAI01077.1
BC101077 mRNA Translation: AAI01078.1
CCDSiCCDS14152.1 [Q9NR97-1]
CCDS14153.1 [Q9NR97-2]
RefSeqiNP_057694.2, NM_016610.3 [Q9NR97-2]
NP_619542.1, NM_138636.5 [Q9NR97-1]
XP_011543831.1, XM_011545529.1 [Q9NR97-2]
XP_011543832.1, XM_011545530.2 [Q9NR97-2]
UniGeneiHs.660543

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3W3GX-ray2.30A/B27-827[»]
3W3JX-ray2.00A/B27-827[»]
3W3KX-ray2.30A/B27-827[»]
3W3LX-ray2.33A/B/C/D27-827[»]
3W3MX-ray2.70A27-827[»]
3W3NX-ray2.10A/B27-827[»]
3WN4X-ray1.81A27-827[»]
4QBZX-ray2.00A/B27-827[»]
4QC0X-ray2.10A/B27-827[»]
4R07X-ray2.00A/B/C/D27-827[»]
4R08X-ray2.40A/B/C/D27-827[»]
4R09X-ray2.62A/B/C/D27-827[»]
4R0AX-ray1.90A27-827[»]
4R6AX-ray2.10A/B27-827[»]
5AWAX-ray2.20A27-827[»]
5AWBX-ray2.10A27-827[»]
5AWCX-ray2.50A/B/C/D27-827[»]
5AWDX-ray2.05A27-827[»]
5AZ5X-ray2.40A/B/C/D27-827[»]
5HDHX-ray2.60A27-827[»]
5WYXX-ray2.40A/B27-827[»]
5WYZX-ray2.30A/B27-827[»]
5Z14X-ray2.80A/B27-827[»]
5Z15X-ray2.90A/B27-827[»]
ProteinModelPortaliQ9NR97
SMRiQ9NR97
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119462, 1 interactor
DIPiDIP-61413N
IntActiQ9NR97, 7 interactors
STRINGi9606.ENSP00000218032

Chemistry databases

BindingDBiQ9NR97
ChEMBLiCHEMBL5805
DrugBankiDB00724 Imiquimod
GuidetoPHARMACOLOGYi1758

PTM databases

iPTMnetiQ9NR97
PhosphoSitePlusiQ9NR97

Polymorphism and mutation databases

BioMutaiTLR8
DMDMi20140873

Proteomic databases

jPOSTiQ9NR97
PaxDbiQ9NR97
PeptideAtlasiQ9NR97
PRIDEiQ9NR97
ProteomicsDBi82313

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218032; ENSP00000218032; ENSG00000101916 [Q9NR97-1]
ENST00000311912; ENSP00000312082; ENSG00000101916 [Q9NR97-2]
GeneIDi51311
KEGGihsa:51311
UCSCiuc004cvd.4 human [Q9NR97-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51311
DisGeNETi51311
EuPathDBiHostDB:ENSG00000101916.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TLR8

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0176772
HGNCiHGNC:15632 TLR8
HPAiHPA001608
MIMi300366 gene
neXtProtiNX_Q9NR97
OpenTargetsiENSG00000101916
PharmGKBiPA38009

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000160879
HOGENOMiHOG000230468
HOVERGENiHBG018601
InParanoidiQ9NR97
KOiK10170
OMAiFDCTCDI
OrthoDBi96378at2759
PhylomeDBiQ9NR97
TreeFamiTF351113

Enzyme and pathway databases

ReactomeiR-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TLR8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51311

Protein Ontology

More...
PROi
PR:Q9NR97

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000101916 Expressed in 121 organ(s), highest expression level in blood
GenevisibleiQ9NR97 HS

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027175 TLR8
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR44312:SF2 PTHR44312:SF2, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 5 hits
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 15 hits
SM00082 LRRCT, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 20 hits
PS50104 TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTLR8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NR97
Secondary accession number(s): B3Y654
, D1CS70, D1CS76, Q495P4, Q6UXL6, Q9NYG9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: February 13, 2019
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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