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UniProtKB - Q9NR96 (TLR9_HUMAN)

Protein

Toll-like receptor 9

Gene

TLR9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366).By similarity3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei132CpG-DNABy similarity1
Binding sitei208CpG-DNABy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase activity Source: Reactome
  • interleukin-1 receptor binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • signaling pattern recognition receptor activity Source: GO_Central
  • siRNA binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: InterPro
  • unmethylated CpG binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-109704 PI3K Cascade
R-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Toll-like receptor 9
Alternative name(s):
CD_antigen: CD289
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TLR9
ORF Names:UNQ5798/PRO19605
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000239732.3

Human Gene Nomenclature Database

More...HGNCi		HGNC:15633 TLR9

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605474 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NR96

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 818ExtracellularSequence analysisAdd BLAST793
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei819 – 839HelicalSequence analysisAdd BLAST21
Topological domaini840 – 1032CytoplasmicSequence analysisAdd BLAST193

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54106

Open Targets

More...OpenTargetsi		ENSG00000239732

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38010

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5804

Drug and drug target database

More...DrugBanki		DB00608 Chloroquine
DB01611 Hydroxychloroquine
DB05463 ISS-1018
DB05475 SCV-07

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1759

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TLR9

Domain mapping of disease mutations (DMDM)

More...DMDMi		20140872

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003473726 – 1032Toll-like receptor 9Add BLAST1007

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi35 ↔ 45By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 110By similarity
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi178 ↔ 184By similarity
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi255 ↔ 268By similarity
Disulfide bondi258 ↔ 265By similarity
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi470 ↔ 500By similarity
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi513N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi694N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi731N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi764 ↔ 790By similarity
Disulfide bondi766 ↔ 809By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain. Cleavage requires UNC93B1. Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NR96

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NR96

PeptideAtlas

More...PeptideAtlasi		Q9NR96

PRoteomics IDEntifications database

More...PRIDEi		Q9NR96

ProteomicsDB human proteome resource

More...ProteomicsDBi		82308
82309 [Q9NR96-2]
82310 [Q9NR96-3]
82311 [Q9NR96-4]
82312 [Q9NR96-5]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1818

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NR96

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NR96

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000239732 Expressed in 69 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...CleanExi		HS_TLR9

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NR96 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer. Exists as a monomer in the absence of unmethylated cytidine-phosphate-guanosine (CpG) ligand. Proteolytic processing of an insertion loop (Z-loop) is required for homodimerization upon binding to the unmethylated CpG ligand leading to its activation (By similarity). Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with BTK (PubMed:17932028). Interacts (via transmembrane domain) with UNC93B1. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (By similarity). Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum (PubMed:20865800). Interacts with SMPDL3B (By similarity).By similarity2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		119902, 20 interactors

Database of interacting proteins

More...DIPi		DIP-52371N

Protein interaction database and analysis system

More...IntActi		Q9NR96, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000417517

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NR96

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9NR96

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NR96

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati62 – 85LRR 1Add BLAST24
Repeati87 – 110LRR 2Add BLAST24
Repeati122 – 147LRR 3Add BLAST26
Repeati150 – 166LRR 4Add BLAST17
Repeati167 – 190LRR 5Add BLAST24
Repeati198 – 221LRR 6Add BLAST24
Repeati223 – 242LRR 7Add BLAST20
Repeati243 – 268LRR 8Add BLAST26
Repeati283 – 306LRR 9Add BLAST24
Repeati308 – 332LRR 10Add BLAST25
Repeati333 – 356LRR 11Add BLAST24
Repeati363 – 386LRR 12Add BLAST24
Repeati390 – 413LRR 13Add BLAST24
Repeati415 – 440LRR 14Add BLAST26
Repeati470 – 494LRR 15Add BLAST25
Repeati496 – 519LRR 16Add BLAST24
Repeati520 – 543LRR 17Add BLAST24
Repeati545 – 572LRR 18Add BLAST28
Repeati574 – 598LRR 19Add BLAST25
Repeati600 – 622LRR 20Add BLAST23
Repeati627 – 650LRR 21Add BLAST24
Repeati652 – 675LRR 22Add BLAST24
Repeati676 – 699LRR 23Add BLAST24
Repeati701 – 723LRR 24Add BLAST23
Repeati724 – 747LRR 25Add BLAST24
Repeati749 – 772LRR 26Add BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini868 – 1016TIRPROSITE-ProRule annotationAdd BLAST149

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni47 – 51Interaction with CpG-DNABy similarity5
Regioni72 – 77Interaction with CpG-DNABy similarity6
Regioni95 – 109Interaction with CpG-DNABy similarityAdd BLAST15
Regioni179 – 181Interaction with CpG-DNABy similarity3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1747 Eukaryota
KOG4641 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162493

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG018601

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NR96

KEGG Orthology (KO)

More...KOi		K10161

Database of Orthologous Groups

More...OrthoDBi		EOG091G0BWK

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NR96

TreeFam database of animal gene trees

More...TreeFami		TF325595

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.10140, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR000157 TIR_dom
IPR027181 TLR9
IPR035897 Toll_tir_struct_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR24373:SF37 PTHR24373:SF37, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13516 LRR_6, 2 hits
PF13855 LRR_8, 7 hits
PF01582 TIR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00369 LRR_TYP, 18 hits
SM00255 TIR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52200 SSF52200, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51450 LRR, 17 hits
PS50104 TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9NR96-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGFCRSALHP LSLLVQAIML AMTLALGTLP AFLPCELQPH GLVNCNWLFL 
        60         70         80         90        100
KSVPHFSMAA PRGNVTSLSL SSNRIHHLHD SDFAHLPSLR HLNLKWNCPP 
       110        120        130        140        150
VGLSPMHFPC HMTIEPSTFL AVPTLEELNL SYNNIMTVPA LPKSLISLSL 
       160        170        180        190        200
SHTNILMLDS ASLAGLHALR FLFMDGNCYY KNPCRQALEV APGALLGLGN 
       210        220        230        240        250
LTHLSLKYNN LTVVPRNLPS SLEYLLLSYN RIVKLAPEDL ANLTALRVLD 
       260        270        280        290        300
VGGNCRRCDH APNPCMECPR HFPQLHPDTF SHLSRLEGLV LKDSSLSWLN 
       310        320        330        340        350
ASWFRGLGNL RVLDLSENFL YKCITKTKAF QGLTQLRKLN LSFNYQKRVS 
       360        370        380        390        400
FAHLSLAPSF GSLVALKELD MHGIFFRSLD ETTLRPLARL PMLQTLRLQM 
       410        420        430        440        450
NFINQAQLGI FRAFPGLRYV DLSDNRISGA SELTATMGEA DGGEKVWLQP 
       460        470        480        490        500
GDLAPAPVDT PSSEDFRPNC STLNFTLDLS RNNLVTVQPE MFAQLSHLQC 
       510        520        530        540        550
LRLSHNCISQ AVNGSQFLPL TGLQVLDLSH NKLDLYHEHS FTELPRLEAL 
       560        570        580        590        600
DLSYNSQPFG MQGVGHNFSF VAHLRTLRHL SLAHNNIHSQ VSQQLCSTSL 
       610        620        630        640        650
RALDFSGNAL GHMWAEGDLY LHFFQGLSGL IWLDLSQNRL HTLLPQTLRN 
       660        670        680        690        700
LPKSLQVLRL RDNYLAFFKW WSLHFLPKLE VLDLAGNQLK ALTNGSLPAG 
       710        720        730        740        750
TRLRRLDVSC NSISFVAPGF FSKAKELREL NLSANALKTV DHSWFGPLAS 
       760        770        780        790        800
ALQILDVSAN PLHCACGAAF MDFLLEVQAA VPGLPSRVKC GSPGQLQGLS 
       810        820        830        840        850
IFAQDLRLCL DEALSWDCFA LSLLAVALGL GVPMLHHLCG WDLWYCFHLC 
       860        870        880        890        900
LAWLPWRGRQ SGRDEDALPY DAFVVFDKTQ SAVADWVYNE LRGQLEECRG 
       910        920        930        940        950
RWALRLCLEE RDWLPGKTLF ENLWASVYGS RKTLFVLAHT DRVSGLLRAS 
       960        970        980        990       1000
FLLAQQRLLE DRKDVVVLVI LSPDGRRSRY VRLRQRLCRQ SVLLWPHQPS 
      1010       1020       1030 
GQRSFWAQLG MALTRDNHHF YNRNFCQGPT AE
Length:1,032
Mass (Da):115,860
Last modified:January 31, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71280AA9680EDCE2
GO
Isoform 2 (identifier: Q9NR96-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Show »
Length:975
Mass (Da):109,628
Checksum:i61D105163587A75F
GO
Isoform 3 (identifier: Q9NR96-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPMKWSGWRWSWGPATHTALPPPQ

Show »
Length:1,055
Mass (Da):118,517
Checksum:i4072A104D14022F6
GO
Isoform 4 (identifier: Q9NR96-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLYSSCKSRLLDSVEQDFHLEIAKK

Show »
Length:1,056
Mass (Da):118,652
Checksum:i9159C051473E88FC
GO
Isoform 5 (identifier: Q9NR96-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MGFCRSALHPLSLLVQ → M

Show »
Length:1,017
Mass (Da):114,237
Checksum:i7EF80765E4675C9C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti200N → S in AAQ89443 (PubMed:12975309).Curated1
Sequence conflicti330F → L in AAQ89443 (PubMed:12975309).Curated1
Sequence conflicti530H → R in AAF78037 (PubMed:11022120).Curated1
Sequence conflicti688Q → R in AAF78037 (PubMed:11022120).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0246685R → C. Corresponds to variant dbSNP:rs5743842Ensembl.1
Natural variantiVAR_05236479H → Q. Corresponds to variant dbSNP:rs5743843Ensembl.1
Natural variantiVAR_034555863R → Q. Corresponds to variant dbSNP:rs5743845Ensembl.1
Natural variantiVAR_052365882A → T. Corresponds to variant dbSNP:rs5743846Ensembl.1
Natural variantiVAR_036077901R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs755472700Ensembl.1
Natural variantiVAR_036078933T → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs746622200Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0065201 – 57Missing in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0065231 – 16MGFCR…SLLVQ → M in isoform 5. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0065211M → MPMKWSGWRWSWGPATHTAL PPPQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_0065221M → MLYSSCKSRLLDSVEQDFHL EIAKK in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF259262 mRNA Translation: AAF72189.1
AF259263 mRNA Translation: AAF72190.1
AF245704 mRNA Translation: AAF78037.1
AF246972 mRNA Translation: AAG01734.1
AF246973 mRNA Translation: AAG01735.1
AF246974 mRNA Translation: AAG01736.1
AB045180 mRNA Translation: BAB19259.1
EU170540 Genomic DNA Translation: ABW37075.1
EU170541 Genomic DNA Translation: ABW37076.1
EU170542 Genomic DNA Translation: ABW37077.1
EU170543 Genomic DNA Translation: ABW37078.1
AB445673 mRNA Translation: BAG55070.1
DQ019992 Genomic DNA Translation: AAZ95513.1
DQ019993 Genomic DNA Translation: AAZ95514.1
DQ019994 Genomic DNA Translation: AAZ95515.1
DQ019995 Genomic DNA Translation: AAZ95516.1
DQ019996 Genomic DNA Translation: AAZ95517.1
DQ019999 Genomic DNA Translation: AAZ95520.1
AY359085 mRNA Translation: AAQ89443.1
CH471055 Genomic DNA Translation: EAW65191.1
BC032713 mRNA Translation: AAH32713.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2848.1 [Q9NR96-1]

NCBI Reference Sequences

More...RefSeqi		NP_059138.1, NM_017442.3 [Q9NR96-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.87968

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000360658; ENSP00000353874; ENSG00000239732 [Q9NR96-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54106

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54106

UCSC genome browser

More...UCSCi		uc003dda.2 human [Q9NR96-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF259262 mRNA Translation: AAF72189.1
AF259263 mRNA Translation: AAF72190.1
AF245704 mRNA Translation: AAF78037.1
AF246972 mRNA Translation: AAG01734.1
AF246973 mRNA Translation: AAG01735.1
AF246974 mRNA Translation: AAG01736.1
AB045180 mRNA Translation: BAB19259.1
EU170540 Genomic DNA Translation: ABW37075.1
EU170541 Genomic DNA Translation: ABW37076.1
EU170542 Genomic DNA Translation: ABW37077.1
EU170543 Genomic DNA Translation: ABW37078.1
AB445673 mRNA Translation: BAG55070.1
DQ019992 Genomic DNA Translation: AAZ95513.1
DQ019993 Genomic DNA Translation: AAZ95514.1
DQ019994 Genomic DNA Translation: AAZ95515.1
DQ019995 Genomic DNA Translation: AAZ95516.1
DQ019996 Genomic DNA Translation: AAZ95517.1
DQ019999 Genomic DNA Translation: AAZ95520.1
AY359085 mRNA Translation: AAQ89443.1
CH471055 Genomic DNA Translation: EAW65191.1
BC032713 mRNA Translation: AAH32713.1
CCDSiCCDS2848.1 [Q9NR96-1]
RefSeqiNP_059138.1, NM_017442.3 [Q9NR96-1]
UniGeneiHs.87968

3D structure databases

ProteinModelPortaliQ9NR96
SMRiQ9NR96
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119902, 20 interactors
DIPiDIP-52371N
IntActiQ9NR96, 12 interactors
STRINGi9606.ENSP00000417517

Chemistry databases

BindingDBiQ9NR96
ChEMBLiCHEMBL5804
DrugBankiDB00608 Chloroquine
DB01611 Hydroxychloroquine
DB05463 ISS-1018
DB05475 SCV-07
GuidetoPHARMACOLOGYi1759

PTM databases

GlyConnecti1818
iPTMnetiQ9NR96
PhosphoSitePlusiQ9NR96

Polymorphism and mutation databases

BioMutaiTLR9
DMDMi20140872

Proteomic databases

MaxQBiQ9NR96
PaxDbiQ9NR96
PeptideAtlasiQ9NR96
PRIDEiQ9NR96
ProteomicsDBi82308
82309 [Q9NR96-2]
82310 [Q9NR96-3]
82311 [Q9NR96-4]
82312 [Q9NR96-5]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		54106
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360658; ENSP00000353874; ENSG00000239732 [Q9NR96-1]
GeneIDi54106
KEGGihsa:54106
UCSCiuc003dda.2 human [Q9NR96-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54106
DisGeNETi54106
EuPathDBiHostDB:ENSG00000239732.3

GeneCards: human genes, protein and diseases

More...GeneCardsi		TLR9

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0163454
HGNCiHGNC:15633 TLR9
MIMi605474 gene
neXtProtiNX_Q9NR96
OpenTargetsiENSG00000239732
PharmGKBiPA38010

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1747 Eukaryota
KOG4641 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000162493
HOVERGENiHBG018601
InParanoidiQ9NR96
KOiK10161
OrthoDBiEOG091G0BWK
PhylomeDBiQ9NR96
TreeFamiTF325595

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TLR9 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TLR9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54106

Protein Ontology

More...PROi		PR:Q9NR96

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000239732 Expressed in 69 organ(s), highest expression level in blood
CleanExiHS_TLR9
GenevisibleiQ9NR96 HS

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR000157 TIR_dom
IPR027181 TLR9
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR24373:SF37 PTHR24373:SF37, 1 hit
PfamiView protein in Pfam
PF13516 LRR_6, 2 hits
PF13855 LRR_8, 7 hits
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 18 hits
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 17 hits
PS50104 TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTLR9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NR96
Secondary accession number(s): B3Y661
, D1CS56, Q6UVZ2, Q9HD68, Q9HD69, Q9HD70, Q9NYC2, Q9NYC3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: December 5, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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