UniProtKB - Q9NR96 (TLR9_HUMAN)
Toll-like receptor 9
TLR9
Functioni
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028).
Controls lymphocyte response to Helicobacter infection (By similarity).
Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366).
By similarity3 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 132 | DNA; binds CpG-DNABy similarity | 1 | |
Binding sitei | 208 | DNA; binds CpG-DNABy similarity | 1 |
GO - Molecular functioni
- interleukin-1 receptor binding Source: UniProtKB
- NAD+ nucleosidase activity Source: InterPro
- pattern recognition receptor activity Source: GO_Central
- protein homodimerization activity Source: UniProtKB
- siRNA binding Source: UniProtKB
- transmembrane signaling receptor activity Source: InterPro
- unmethylated CpG binding Source: UniProtKB
GO - Biological processi
- defense response to bacterium Source: UniProtKB
- defense response to Gram-negative bacterium Source: UniProtKB
- defense response to virus Source: GO_Central
- I-kappaB kinase/NF-kappaB signaling Source: GO_Central
- I-kappaB phosphorylation Source: BHF-UCL
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: BHF-UCL
- maintenance of gastrointestinal epithelium Source: BHF-UCL
- MyD88-dependent toll-like receptor signaling pathway Source: InterPro
- negative regulation of ATPase-coupled calcium transmembrane transporter activity Source: CACAO
- negative regulation of interleukin-6 production Source: BHF-UCL
- negative regulation of interleukin-8 production Source: BHF-UCL
- negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
- negative regulation of toll-like receptor signaling pathway Source: BHF-UCL
- positive regulation of B cell activation Source: UniProtKB
- positive regulation of B cell proliferation Source: UniProtKB
- positive regulation of chemokine production Source: BHF-UCL
- positive regulation of gene expression Source: CACAO
- positive regulation of granulocyte macrophage colony-stimulating factor production Source: CACAO
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
- positive regulation of immunoglobulin production Source: UniProtKB
- positive regulation of inflammatory response Source: BHF-UCL
- positive regulation of interferon-alpha production Source: UniProtKB
- positive regulation of interferon-beta production Source: UniProtKB
- positive regulation of interferon-gamma production Source: UniProtKB
- positive regulation of interleukin-10 production Source: BHF-UCL
- positive regulation of interleukin-12 production Source: BHF-UCL
- positive regulation of interleukin-18 production Source: BHF-UCL
- positive regulation of interleukin-6 production Source: BHF-UCL
- positive regulation of interleukin-8 production Source: BHF-UCL
- positive regulation of JNK cascade Source: BHF-UCL
- positive regulation of JUN kinase activity Source: BHF-UCL
- positive regulation of MAPK cascade Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
- positive regulation of NIK/NF-kappaB signaling Source: BHF-UCL
- positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
- positive regulation of toll-like receptor signaling pathway Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of tumor necrosis factor production Source: BHF-UCL
- regulation of B cell differentiation Source: UniProtKB
- regulation of toll-like receptor 9 signaling pathway Source: UniProtKB
- response to molecule of bacterial origin Source: BHF-UCL
- toll-like receptor 9 signaling pathway Source: InterPro
- toll-like receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | Receptor |
Biological process | Immunity, Inflammatory response, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | Q9NR96 |
Reactomei | R-HSA-109704, PI3K Cascade R-HSA-1679131, Trafficking and processing of endosomal TLR R-HSA-168138, Toll Like Receptor 9 (TLR9) Cascade R-HSA-9679191, Potential therapeutics for SARS R-HSA-975110, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975138, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975155, MyD88 dependent cascade initiated on endosome |
SignaLinki | Q9NR96 |
SIGNORi | Q9NR96 |
Names & Taxonomyi
Protein namesi | Recommended name: Toll-like receptor 9Alternative name(s): CD_antigen: CD289 |
Gene namesi | Name:TLR9 ORF Names:UNQ5798/PRO19605 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15633, TLR9 |
MIMi | 605474, gene |
neXtProti | NX_Q9NR96 |
VEuPathDBi | HostDB:ENSG00000239732 |
Subcellular locationi
Lysosome
- Lysosome By similarity
Endosome
- Endosome By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
Other locations
- phagosome By similarity
Note: Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. Exit from the ER requires UNC93B1. Endolysosomal localization is required for proteolytic cleavage and subsequent activation. Intracellular localization of the active receptor may prevent from responding to self nucleic acid.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: Reactome
Endosome
- endolysosome Source: UniProtKB
- endolysosome membrane Source: Reactome
- endosome Source: UniProtKB
- endosome membrane Source: Reactome
Extracellular region or secreted
- extracellular region Source: UniProtKB
Golgi apparatus
- Golgi membrane Source: Reactome
Lysosome
- endolysosome Source: UniProtKB
- endolysosome membrane Source: Reactome
- lysosome Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: BHF-UCL
- basolateral plasma membrane Source: BHF-UCL
- plasma membrane Source: BHF-UCL
Other locations
- cytoplasm Source: BHF-UCL
- early phagosome Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 818 | ExtracellularSequence analysisAdd BLAST | 793 | |
Transmembranei | 819 – 839 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 840 – 1032 | CytoplasmicSequence analysisAdd BLAST | 193 |
Keywords - Cellular componenti
Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 54106 |
OpenTargetsi | ENSG00000239732 |
PharmGKBi | PA38010 |
Miscellaneous databases
Pharosi | Q9NR96, Tclin |
Chemistry databases
ChEMBLi | CHEMBL5804 |
DrugBanki | DB00608, Chloroquine DB05530, CPG 10101 DB05475, Golotimod DB01611, Hydroxychloroquine DB05463, ISS-1018 |
DrugCentrali | Q9NR96 |
GuidetoPHARMACOLOGYi | 1759 |
Genetic variation databases
BioMutai | TLR9 |
DMDMi | 20140872 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000034737 | 26 – 1032 | Toll-like receptor 9Add BLAST | 1007 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 35 ↔ 45 | By similarity | ||
Glycosylationi | 64 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 98 ↔ 110 | By similarity | ||
Glycosylationi | 129 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 178 ↔ 184 | By similarity | ||
Glycosylationi | 200 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 210 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 242 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 255 ↔ 268 | By similarity | ||
Disulfide bondi | 258 ↔ 265 | By similarity | ||
Glycosylationi | 300 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 340 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 469 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 470 ↔ 500 | By similarity | ||
Glycosylationi | 474 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 513 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 567 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 694 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 731 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 764 ↔ 790 | By similarity | ||
Disulfide bondi | 766 ↔ 809 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q9NR96 |
MassIVEi | Q9NR96 |
MaxQBi | Q9NR96 |
PaxDbi | Q9NR96 |
PeptideAtlasi | Q9NR96 |
PRIDEi | Q9NR96 |
PTM databases
GlyGeni | Q9NR96, 15 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9NR96 |
PhosphoSitePlusi | Q9NR96 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000239732, Expressed in blood and 84 other tissues |
Genevisiblei | Q9NR96, HS |
Organism-specific databases
HPAi | ENSG00000239732, Tissue enhanced (brain, lymphoid tissue) |
Interactioni
Subunit structurei
Monomer and homodimer. Exists as a monomer in the absence of unmethylated cytidine-phosphate-guanosine (CpG) ligand. Proteolytic processing of an insertion loop (Z-loop) is required for homodimerization upon binding to the unmethylated CpG ligand leading to its activation (By similarity).
Interacts with MYD88 via their respective TIR domains (By similarity).
Interacts with BTK (PubMed:17932028).
Interacts (via transmembrane domain) with UNC93B1.
Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (By similarity).
Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum (PubMed:20865800).
Interacts with SMPDL3B (By similarity).
By similarity2 PublicationsGO - Molecular functioni
- interleukin-1 receptor binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119902, 66 interactors |
DIPi | DIP-52371N |
IntActi | Q9NR96, 15 interactors |
STRINGi | 9606.ENSP00000353874 |
Chemistry databases
BindingDBi | Q9NR96 |
Miscellaneous databases
RNActi | Q9NR96, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 62 – 85 | LRR 1Add BLAST | 24 | |
Repeati | 87 – 110 | LRR 2Add BLAST | 24 | |
Repeati | 122 – 147 | LRR 3Add BLAST | 26 | |
Repeati | 150 – 166 | LRR 4Add BLAST | 17 | |
Repeati | 167 – 190 | LRR 5Add BLAST | 24 | |
Repeati | 198 – 221 | LRR 6Add BLAST | 24 | |
Repeati | 223 – 242 | LRR 7Add BLAST | 20 | |
Repeati | 243 – 268 | LRR 8Add BLAST | 26 | |
Repeati | 283 – 306 | LRR 9Add BLAST | 24 | |
Repeati | 308 – 332 | LRR 10Add BLAST | 25 | |
Repeati | 333 – 356 | LRR 11Add BLAST | 24 | |
Repeati | 363 – 386 | LRR 12Add BLAST | 24 | |
Repeati | 390 – 413 | LRR 13Add BLAST | 24 | |
Repeati | 415 – 440 | LRR 14Add BLAST | 26 | |
Repeati | 470 – 494 | LRR 15Add BLAST | 25 | |
Repeati | 496 – 519 | LRR 16Add BLAST | 24 | |
Repeati | 520 – 543 | LRR 17Add BLAST | 24 | |
Repeati | 545 – 572 | LRR 18Add BLAST | 28 | |
Repeati | 574 – 598 | LRR 19Add BLAST | 25 | |
Repeati | 600 – 622 | LRR 20Add BLAST | 23 | |
Repeati | 627 – 650 | LRR 21Add BLAST | 24 | |
Repeati | 652 – 675 | LRR 22Add BLAST | 24 | |
Repeati | 676 – 699 | LRR 23Add BLAST | 24 | |
Repeati | 701 – 723 | LRR 24Add BLAST | 23 | |
Repeati | 724 – 747 | LRR 25Add BLAST | 24 | |
Repeati | 749 – 772 | LRR 26Add BLAST | 24 | |
Domaini | 868 – 1013 | TIRPROSITE-ProRule annotationAdd BLAST | 146 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 47 – 51 | DNA binding; binds CpG-DNABy similarity | 5 | |
Regioni | 72 – 77 | DNA binding; binds CpG-DNABy similarity | 6 | |
Regioni | 95 – 109 | DNA binding; binds CpG-DNABy similarityAdd BLAST | 15 | |
Regioni | 179 – 181 | DNA binding; binds CpG-DNABy similarity | 3 |
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1747, Eukaryota KOG4641, Eukaryota |
GeneTreei | ENSGT00940000162493 |
HOGENOMi | CLU_006000_2_0_1 |
InParanoidi | Q9NR96 |
OrthoDBi | 264244at2759 |
PhylomeDBi | Q9NR96 |
TreeFami | TF325595 |
Family and domain databases
Gene3Di | 3.40.50.10140, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR041283, LRR_12 IPR032675, LRR_dom_sf IPR000157, TIR_dom IPR027181, TLR9 IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR47410:SF3, PTHR47410:SF3, 1 hit |
Pfami | View protein in Pfam PF18837, LRR_12, 1 hit PF13516, LRR_6, 2 hits PF13855, LRR_8, 7 hits PF01582, TIR, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 18 hits SM00255, TIR, 1 hit |
SUPFAMi | SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 17 hits PS50104, TIR, 1 hit |
s (5)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGFCRSALHP LSLLVQAIML AMTLALGTLP AFLPCELQPH GLVNCNWLFL
60 70 80 90 100
KSVPHFSMAA PRGNVTSLSL SSNRIHHLHD SDFAHLPSLR HLNLKWNCPP
110 120 130 140 150
VGLSPMHFPC HMTIEPSTFL AVPTLEELNL SYNNIMTVPA LPKSLISLSL
160 170 180 190 200
SHTNILMLDS ASLAGLHALR FLFMDGNCYY KNPCRQALEV APGALLGLGN
210 220 230 240 250
LTHLSLKYNN LTVVPRNLPS SLEYLLLSYN RIVKLAPEDL ANLTALRVLD
260 270 280 290 300
VGGNCRRCDH APNPCMECPR HFPQLHPDTF SHLSRLEGLV LKDSSLSWLN
310 320 330 340 350
ASWFRGLGNL RVLDLSENFL YKCITKTKAF QGLTQLRKLN LSFNYQKRVS
360 370 380 390 400
FAHLSLAPSF GSLVALKELD MHGIFFRSLD ETTLRPLARL PMLQTLRLQM
410 420 430 440 450
NFINQAQLGI FRAFPGLRYV DLSDNRISGA SELTATMGEA DGGEKVWLQP
460 470 480 490 500
GDLAPAPVDT PSSEDFRPNC STLNFTLDLS RNNLVTVQPE MFAQLSHLQC
510 520 530 540 550
LRLSHNCISQ AVNGSQFLPL TGLQVLDLSH NKLDLYHEHS FTELPRLEAL
560 570 580 590 600
DLSYNSQPFG MQGVGHNFSF VAHLRTLRHL SLAHNNIHSQ VSQQLCSTSL
610 620 630 640 650
RALDFSGNAL GHMWAEGDLY LHFFQGLSGL IWLDLSQNRL HTLLPQTLRN
660 670 680 690 700
LPKSLQVLRL RDNYLAFFKW WSLHFLPKLE VLDLAGNQLK ALTNGSLPAG
710 720 730 740 750
TRLRRLDVSC NSISFVAPGF FSKAKELREL NLSANALKTV DHSWFGPLAS
760 770 780 790 800
ALQILDVSAN PLHCACGAAF MDFLLEVQAA VPGLPSRVKC GSPGQLQGLS
810 820 830 840 850
IFAQDLRLCL DEALSWDCFA LSLLAVALGL GVPMLHHLCG WDLWYCFHLC
860 870 880 890 900
LAWLPWRGRQ SGRDEDALPY DAFVVFDKTQ SAVADWVYNE LRGQLEECRG
910 920 930 940 950
RWALRLCLEE RDWLPGKTLF ENLWASVYGS RKTLFVLAHT DRVSGLLRAS
960 970 980 990 1000
FLLAQQRLLE DRKDVVVLVI LSPDGRRSRY VRLRQRLCRQ SVLLWPHQPS
1010 1020 1030
GQRSFWAQLG MALTRDNHHF YNRNFCQGPT AE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 200 | N → S in AAQ89443 (PubMed:12975309).Curated | 1 | |
Sequence conflicti | 330 | F → L in AAQ89443 (PubMed:12975309).Curated | 1 | |
Sequence conflicti | 530 | H → R in AAF78037 (PubMed:11022120).Curated | 1 | |
Sequence conflicti | 688 | Q → R in AAF78037 (PubMed:11022120).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024668 | 5 | R → C. Corresponds to variant dbSNP:rs5743842EnsemblClinVar. | 1 | |
Natural variantiVAR_052364 | 79 | H → Q. Corresponds to variant dbSNP:rs5743843Ensembl. | 1 | |
Natural variantiVAR_034555 | 863 | R → Q. Corresponds to variant dbSNP:rs5743845EnsemblClinVar. | 1 | |
Natural variantiVAR_052365 | 882 | A → T. Corresponds to variant dbSNP:rs5743846Ensembl. | 1 | |
Natural variantiVAR_036077 | 901 | R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs755472700Ensembl. | 1 | |
Natural variantiVAR_036078 | 933 | T → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs746622200Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006520 | 1 – 57 | Missing in isoform 2. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_006523 | 1 – 16 | MGFCR…SLLVQ → M in isoform 5. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_006521 | 1 | M → MPMKWSGWRWSWGPATHTAL PPPQ in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_006522 | 1 | M → MLYSSCKSRLLDSVEQDFHL EIAKK in isoform 4. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF259262 mRNA Translation: AAF72189.1 AF259263 mRNA Translation: AAF72190.1 AF245704 mRNA Translation: AAF78037.1 AF246972 mRNA Translation: AAG01734.1 AF246973 mRNA Translation: AAG01735.1 AF246974 mRNA Translation: AAG01736.1 AB045180 mRNA Translation: BAB19259.1 EU170540 Genomic DNA Translation: ABW37075.1 EU170541 Genomic DNA Translation: ABW37076.1 EU170542 Genomic DNA Translation: ABW37077.1 EU170543 Genomic DNA Translation: ABW37078.1 AB445673 mRNA Translation: BAG55070.1 DQ019992 Genomic DNA Translation: AAZ95513.1 DQ019993 Genomic DNA Translation: AAZ95514.1 DQ019994 Genomic DNA Translation: AAZ95515.1 DQ019995 Genomic DNA Translation: AAZ95516.1 DQ019996 Genomic DNA Translation: AAZ95517.1 DQ019999 Genomic DNA Translation: AAZ95520.1 AY359085 mRNA Translation: AAQ89443.1 CH471055 Genomic DNA Translation: EAW65191.1 BC032713 mRNA Translation: AAH32713.1 |
CCDSi | CCDS2848.1 [Q9NR96-1] |
RefSeqi | NP_059138.1, NM_017442.3 [Q9NR96-1] |
Genome annotation databases
Ensembli | ENST00000360658; ENSP00000353874; ENSG00000239732 |
GeneIDi | 54106 |
KEGGi | hsa:54106 |
MANE-Selecti | ENST00000360658.3; ENSP00000353874.2; NM_017442.4; NP_059138.1 |
UCSCi | uc003dda.2, human [Q9NR96-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF259262 mRNA Translation: AAF72189.1 AF259263 mRNA Translation: AAF72190.1 AF245704 mRNA Translation: AAF78037.1 AF246972 mRNA Translation: AAG01734.1 AF246973 mRNA Translation: AAG01735.1 AF246974 mRNA Translation: AAG01736.1 AB045180 mRNA Translation: BAB19259.1 EU170540 Genomic DNA Translation: ABW37075.1 EU170541 Genomic DNA Translation: ABW37076.1 EU170542 Genomic DNA Translation: ABW37077.1 EU170543 Genomic DNA Translation: ABW37078.1 AB445673 mRNA Translation: BAG55070.1 DQ019992 Genomic DNA Translation: AAZ95513.1 DQ019993 Genomic DNA Translation: AAZ95514.1 DQ019994 Genomic DNA Translation: AAZ95515.1 DQ019995 Genomic DNA Translation: AAZ95516.1 DQ019996 Genomic DNA Translation: AAZ95517.1 DQ019999 Genomic DNA Translation: AAZ95520.1 AY359085 mRNA Translation: AAQ89443.1 CH471055 Genomic DNA Translation: EAW65191.1 BC032713 mRNA Translation: AAH32713.1 |
CCDSi | CCDS2848.1 [Q9NR96-1] |
RefSeqi | NP_059138.1, NM_017442.3 [Q9NR96-1] |
3D structure databases
SMRi | Q9NR96 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119902, 66 interactors |
DIPi | DIP-52371N |
IntActi | Q9NR96, 15 interactors |
STRINGi | 9606.ENSP00000353874 |
Chemistry databases
BindingDBi | Q9NR96 |
ChEMBLi | CHEMBL5804 |
DrugBanki | DB00608, Chloroquine DB05530, CPG 10101 DB05475, Golotimod DB01611, Hydroxychloroquine DB05463, ISS-1018 |
DrugCentrali | Q9NR96 |
GuidetoPHARMACOLOGYi | 1759 |
PTM databases
GlyGeni | Q9NR96, 15 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9NR96 |
PhosphoSitePlusi | Q9NR96 |
Genetic variation databases
BioMutai | TLR9 |
DMDMi | 20140872 |
Proteomic databases
jPOSTi | Q9NR96 |
MassIVEi | Q9NR96 |
MaxQBi | Q9NR96 |
PaxDbi | Q9NR96 |
PeptideAtlasi | Q9NR96 |
PRIDEi | Q9NR96 |
Protocols and materials databases
Antibodypediai | 34940, 1077 antibodies from 43 providers |
DNASUi | 54106 |
Genome annotation databases
Ensembli | ENST00000360658; ENSP00000353874; ENSG00000239732 |
GeneIDi | 54106 |
KEGGi | hsa:54106 |
MANE-Selecti | ENST00000360658.3; ENSP00000353874.2; NM_017442.4; NP_059138.1 |
UCSCi | uc003dda.2, human [Q9NR96-1] |
Organism-specific databases
CTDi | 54106 |
DisGeNETi | 54106 |
GeneCardsi | TLR9 |
HGNCi | HGNC:15633, TLR9 |
HPAi | ENSG00000239732, Tissue enhanced (brain, lymphoid tissue) |
MIMi | 605474, gene |
neXtProti | NX_Q9NR96 |
OpenTargetsi | ENSG00000239732 |
PharmGKBi | PA38010 |
VEuPathDBi | HostDB:ENSG00000239732 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1747, Eukaryota KOG4641, Eukaryota |
GeneTreei | ENSGT00940000162493 |
HOGENOMi | CLU_006000_2_0_1 |
InParanoidi | Q9NR96 |
OrthoDBi | 264244at2759 |
PhylomeDBi | Q9NR96 |
TreeFami | TF325595 |
Enzyme and pathway databases
PathwayCommonsi | Q9NR96 |
Reactomei | R-HSA-109704, PI3K Cascade R-HSA-1679131, Trafficking and processing of endosomal TLR R-HSA-168138, Toll Like Receptor 9 (TLR9) Cascade R-HSA-9679191, Potential therapeutics for SARS R-HSA-975110, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975138, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975155, MyD88 dependent cascade initiated on endosome |
SignaLinki | Q9NR96 |
SIGNORi | Q9NR96 |
Miscellaneous databases
BioGRID-ORCSi | 54106, 6 hits in 1031 CRISPR screens |
GeneWikii | TLR9 |
GenomeRNAii | 54106 |
Pharosi | Q9NR96, Tclin |
PROi | PR:Q9NR96 |
RNActi | Q9NR96, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000239732, Expressed in blood and 84 other tissues |
Genevisiblei | Q9NR96, HS |
Family and domain databases
Gene3Di | 3.40.50.10140, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR041283, LRR_12 IPR032675, LRR_dom_sf IPR000157, TIR_dom IPR027181, TLR9 IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR47410:SF3, PTHR47410:SF3, 1 hit |
Pfami | View protein in Pfam PF18837, LRR_12, 1 hit PF13516, LRR_6, 2 hits PF13855, LRR_8, 7 hits PF01582, TIR, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 18 hits SM00255, TIR, 1 hit |
SUPFAMi | SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 17 hits PS50104, TIR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TLR9_HUMAN | |
Accessioni | Q9NR96Primary (citable) accession number: Q9NR96 Secondary accession number(s): B3Y661 Q9NYC3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 31, 2002 |
Last sequence update: | January 31, 2002 | |
Last modified: | February 23, 2022 | |
This is version 190 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families