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Protein

Peroxisomal membrane protein 2

Gene

PXMP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.

Enzyme and pathway databases

ReactomeiR-HSA-389661 Glyoxylate metabolism and glycine degradation

Protein family/group databases

TCDBi9.B.192.1.3 the mpv17/pmp22 4 tms putative porin (mpv17) family

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein 2
Alternative name(s):
22 kDa peroxisomal membrane protein
Gene namesi
Name:PXMP2
Synonyms:PMP22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000176894.9
HGNCiHGNC:9716 PXMP2
MIMi617399 gene
neXtProtiNX_Q9NR77

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30CytoplasmicSequence analysisAdd BLAST30
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Topological domaini52 – 75PeroxisomalSequence analysisAdd BLAST24
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 114CytoplasmicSequence analysisAdd BLAST18
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 173PeroxisomalSequence analysisAdd BLAST38
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi5827
OpenTargetsiENSG00000176894
PharmGKBiPA34059

Polymorphism and mutation databases

DMDMi27923831

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189291 – 195Peroxisomal membrane protein 2Add BLAST195

Proteomic databases

EPDiQ9NR77
MaxQBiQ9NR77
PaxDbiQ9NR77
PeptideAtlasiQ9NR77
PRIDEiQ9NR77
ProteomicsDBi82292
TopDownProteomicsiQ9NR77

PTM databases

iPTMnetiQ9NR77
PhosphoSitePlusiQ9NR77

Expressioni

Gene expression databases

BgeeiENSG00000176894 Expressed in 91 organ(s), highest expression level in liver
CleanExiHS_PMP22
HS_PXMP2
ExpressionAtlasiQ9NR77 baseline and differential
GenevisibleiQ9NR77 HS

Interactioni

Subunit structurei

Interacts with PEX19 and SIVA1.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi111785, 24 interactors
IntActiQ9NR77, 3 interactors
MINTiQ9NR77
STRINGi9606.ENSP00000321271

Structurei

3D structure databases

ProteinModelPortaliQ9NR77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1944 Eukaryota
ENOG4111SYH LUCA
GeneTreeiENSGT00530000063005
HOGENOMiHOG000008014
HOVERGENiHBG052506
InParanoidiQ9NR77
KOiK13347
OMAiNWKVWTP
PhylomeDBiQ9NR77
TreeFamiTF105311

Family and domain databases

InterProiView protein in InterPro
IPR007248 Mpv17_PMP22
PANTHERiPTHR11266 PTHR11266, 1 hit
PfamiView protein in Pfam
PF04117 Mpv17_PMP22, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9NR77-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPAASRLRA EAGLGALPRR ALAQYLLFLR LYPVLTKAAT SGILSALGNF
60 70 80 90 100
LAQMIEKKRK KENSRSLDVG GPLRYAVYGF FFTGPLSHFF YFFMEHWIPP
110 120 130 140 150
EVPLAGLRRL LLDRLVFAPA FLMLFFLIMN FLEGKDASAF AAKMRGGFWP
160 170 180 190
ALRMNWRVWT PLQFININYV PLKFRVLFAN LAALFWYAYL ASLGK
Length:195
Mass (Da):22,253
Last modified:January 23, 2007 - v3
Checksum:i9CA7FD67F8391E94
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X249A0A087X249_HUMAN
Peroxisomal membrane protein 2
PXMP2
83Annotation score:
F5GXM0F5GXM0_HUMAN
Peroxisomal membrane protein 2
PXMP2
227Annotation score:
F5H4N4F5H4N4_HUMAN
Peroxisomal membrane protein 2
PXMP2
160Annotation score:
F5GZF7F5GZF7_HUMAN
Peroxisomal membrane protein 2
PXMP2
49Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250136 mRNA Translation: AAF73963.1
AY044439 mRNA Translation: AAK95858.1
BC073997 mRNA Translation: AAH73997.1
CCDSiCCDS9279.1
RefSeqiNP_061133.1, NM_018663.2
UniGeneiHs.430299

Genome annotation databases

EnsembliENST00000317479; ENSP00000321271; ENSG00000176894
GeneIDi5827
KEGGihsa:5827
UCSCiuc001ukt.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250136 mRNA Translation: AAF73963.1
AY044439 mRNA Translation: AAK95858.1
BC073997 mRNA Translation: AAH73997.1
CCDSiCCDS9279.1
RefSeqiNP_061133.1, NM_018663.2
UniGeneiHs.430299

3D structure databases

ProteinModelPortaliQ9NR77
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111785, 24 interactors
IntActiQ9NR77, 3 interactors
MINTiQ9NR77
STRINGi9606.ENSP00000321271

Protein family/group databases

TCDBi9.B.192.1.3 the mpv17/pmp22 4 tms putative porin (mpv17) family

PTM databases

iPTMnetiQ9NR77
PhosphoSitePlusiQ9NR77

Polymorphism and mutation databases

DMDMi27923831

Proteomic databases

EPDiQ9NR77
MaxQBiQ9NR77
PaxDbiQ9NR77
PeptideAtlasiQ9NR77
PRIDEiQ9NR77
ProteomicsDBi82292
TopDownProteomicsiQ9NR77

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317479; ENSP00000321271; ENSG00000176894
GeneIDi5827
KEGGihsa:5827
UCSCiuc001ukt.3 human

Organism-specific databases

CTDi5827
DisGeNETi5827
EuPathDBiHostDB:ENSG00000176894.9
GeneCardsiPXMP2
HGNCiHGNC:9716 PXMP2
MIMi617399 gene
neXtProtiNX_Q9NR77
OpenTargetsiENSG00000176894
PharmGKBiPA34059
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1944 Eukaryota
ENOG4111SYH LUCA
GeneTreeiENSGT00530000063005
HOGENOMiHOG000008014
HOVERGENiHBG052506
InParanoidiQ9NR77
KOiK13347
OMAiNWKVWTP
PhylomeDBiQ9NR77
TreeFamiTF105311

Enzyme and pathway databases

ReactomeiR-HSA-389661 Glyoxylate metabolism and glycine degradation

Miscellaneous databases

GenomeRNAii5827
PROiPR:Q9NR77
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176894 Expressed in 91 organ(s), highest expression level in liver
CleanExiHS_PMP22
HS_PXMP2
ExpressionAtlasiQ9NR77 baseline and differential
GenevisibleiQ9NR77 HS

Family and domain databases

InterProiView protein in InterPro
IPR007248 Mpv17_PMP22
PANTHERiPTHR11266 PTHR11266, 1 hit
PfamiView protein in Pfam
PF04117 Mpv17_PMP22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPXMP2_HUMAN
AccessioniPrimary (citable) accession number: Q9NR77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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