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Protein

Kelch-like protein 1

Gene

KLHL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in organizing the actin cytoskeleton of the brain cells.

GO - Molecular functioni

  • actin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 1
Gene namesi
Name:KLHL1
Synonyms:KIAA1490
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000150361.11
HGNCiHGNC:6352 KLHL1
MIMi605332 gene
neXtProtiNX_Q9NR64

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi57626
OpenTargetsiENSG00000150361
PharmGKBiPA30142

Polymorphism and mutation databases

BioMutaiKLHL1
DMDMi13431647

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190991 – 748Kelch-like protein 1Add BLAST748

Proteomic databases

MaxQBiQ9NR64
PaxDbiQ9NR64
PeptideAtlasiQ9NR64
PRIDEiQ9NR64
ProteomicsDBi82289

PTM databases

iPTMnetiQ9NR64
PhosphoSitePlusiQ9NR64

Expressioni

Tissue specificityi

Highly expressed in brain.

Gene expression databases

BgeeiENSG00000150361 Expressed in 49 organ(s), highest expression level in neocortex
CleanExiHS_KLHL1
ExpressionAtlasiQ9NR64 baseline and differential
GenevisibleiQ9NR64 HS

Organism-specific databases

HPAiHPA021196

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121671, 13 interactors
IntActiQ9NR64, 9 interactors
STRINGi9606.ENSP00000367075

Structurei

3D structure databases

ProteinModelPortaliQ9NR64
SMRiQ9NR64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini212 – 279BTBPROSITE-ProRule annotationAdd BLAST68
Repeati460 – 506Kelch 1Add BLAST47
Repeati507 – 553Kelch 2Add BLAST47
Repeati555 – 600Kelch 3Add BLAST46
Repeati601 – 647Kelch 4Add BLAST47
Repeati649 – 700Kelch 5Add BLAST52
Repeati701 – 747Kelch 6Add BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 88Ser-richAdd BLAST46

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118931
HOGENOMiHOG000230814
HOVERGENiHBG014286
InParanoidiQ9NR64
KOiK10442
OMAiWVKYDTQ
OrthoDBiEOG091G04QJ
PhylomeDBiQ9NR64
TreeFamiTF329218

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 6 hits
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 2 hits
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NR64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGSGRKDFD VKHILRLRWK LFSHPSPSTG GPAGGGCLQQ DGSGSFEHWG
60 70 80 90 100
PSQSRLLKSQ ERSGVSTFWK KPSSSSSSSS SPSSSSSSFN PLNGTLLPVA
110 120 130 140 150
TRLQQGAPGQ GTQQPARTLF YVESLEEEVV PGMDFPGPHE KGLVLQELKV
160 170 180 190 200
EPDNSSQATG EGCGHRLSST GHSMTPQSDL DSSSSEEFYQ AVHHAEQTFR
210 220 230 240 250
KMESYLKQQQ LCDVILIVGN RKIPAHRLVL SSVSDYFAAM FTSDVCEAKQ
260 270 280 290 300
EEIKMEGIDP NALWDLVQFA YTGCLELKED TIENLLAAAC LLQLPQVVEV
310 320 330 340 350
CCHFLMKLLH PSNCLGIRAF ADAQGCIELM KVAHSYTMEN IMEVIRNQEF
360 370 380 390 400
LLLPAEELHK LLASDDVNVP DEETIFHALM MWVKYDMQSR CNDLSMLLAF
410 420 430 440 450
IRLPLLPPQI LADLENHALF KNDLECQKLI LEAMKYHLLP ERRTLMQSPR
460 470 480 490 500
TKPRKSTVGT LYAVGGMDNN KGATTIEKYD LRTNLWIQAG MMNGRRLQFG
510 520 530 540 550
VAVIDDKLFV IGGRDGLKTL NTVECYNPKT KTWTVLPPMS THRHGLGVTV
560 570 580 590 600
LEGPIYAVGG HDGWSYLNTV ERWDPQSQQW TFVASMSIAR STVGVAALNG
610 620 630 640 650
KLYSVGGRDG SSCLSSMEYY DPHTNKWNMC APMCKRRGGV GVATCDGFLY
660 670 680 690 700
AVGGHDAPAS NHCSRLLDYV ERYDPKTDTW TMVAPLSMPR DAVGVCLLGD
710 720 730 740
RLYAVGGYDG QTYLNTMESY DPQTNEWTQM ASLNIGRAGA CVVVIKQP
Length:748
Mass (Da):82,680
Last modified:October 1, 2000 - v1
Checksum:iC11C43D8282F9FF9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H1J3F5H1J3_HUMAN
Kelch-like protein 1
KLHL1
687Annotation score:

Sequence cautioni

The sequence BAA96014 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252283 mRNA Translation: AAF81719.1
AF252279 Genomic DNA Translation: AAF81716.1
AB040923 mRNA Translation: BAA96014.1 Different initiation.
AK291435 mRNA Translation: BAF84124.1
AL160391 Genomic DNA No translation available.
AL162378 Genomic DNA No translation available.
AL353738 Genomic DNA No translation available.
AL356384 Genomic DNA No translation available.
CH471093 Genomic DNA Translation: EAW80503.1
CCDSiCCDS9445.1
RefSeqiNP_001273654.1, NM_001286725.1
NP_065917.1, NM_020866.2
UniGeneiHs.508201

Genome annotation databases

EnsembliENST00000377844; ENSP00000367075; ENSG00000150361
GeneIDi57626
KEGGihsa:57626
UCSCiuc001vip.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252283 mRNA Translation: AAF81719.1
AF252279 Genomic DNA Translation: AAF81716.1
AB040923 mRNA Translation: BAA96014.1 Different initiation.
AK291435 mRNA Translation: BAF84124.1
AL160391 Genomic DNA No translation available.
AL162378 Genomic DNA No translation available.
AL353738 Genomic DNA No translation available.
AL356384 Genomic DNA No translation available.
CH471093 Genomic DNA Translation: EAW80503.1
CCDSiCCDS9445.1
RefSeqiNP_001273654.1, NM_001286725.1
NP_065917.1, NM_020866.2
UniGeneiHs.508201

3D structure databases

ProteinModelPortaliQ9NR64
SMRiQ9NR64
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121671, 13 interactors
IntActiQ9NR64, 9 interactors
STRINGi9606.ENSP00000367075

PTM databases

iPTMnetiQ9NR64
PhosphoSitePlusiQ9NR64

Polymorphism and mutation databases

BioMutaiKLHL1
DMDMi13431647

Proteomic databases

MaxQBiQ9NR64
PaxDbiQ9NR64
PeptideAtlasiQ9NR64
PRIDEiQ9NR64
ProteomicsDBi82289

Protocols and materials databases

DNASUi57626
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377844; ENSP00000367075; ENSG00000150361
GeneIDi57626
KEGGihsa:57626
UCSCiuc001vip.4 human

Organism-specific databases

CTDi57626
DisGeNETi57626
EuPathDBiHostDB:ENSG00000150361.11
GeneCardsiKLHL1
HGNCiHGNC:6352 KLHL1
HPAiHPA021196
MIMi605332 gene
neXtProtiNX_Q9NR64
OpenTargetsiENSG00000150361
PharmGKBiPA30142
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118931
HOGENOMiHOG000230814
HOVERGENiHBG014286
InParanoidiQ9NR64
KOiK10442
OMAiWVKYDTQ
OrthoDBiEOG091G04QJ
PhylomeDBiQ9NR64
TreeFamiTF329218

Miscellaneous databases

ChiTaRSiKLHL1 human
GeneWikiiKLHL1
GenomeRNAii57626
PROiPR:Q9NR64
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150361 Expressed in 49 organ(s), highest expression level in neocortex
CleanExiHS_KLHL1
ExpressionAtlasiQ9NR64 baseline and differential
GenevisibleiQ9NR64 HS

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 6 hits
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 2 hits
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLHL1_HUMAN
AccessioniPrimary (citable) accession number: Q9NR64
Secondary accession number(s): A8K5X0
, Q5VZ64, Q9H4X4, Q9NR65, Q9P238
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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