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Protein

Endophilin-B2

Gene

SH3GLB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • identical protein binding Source: IntAct

Names & Taxonomyi

Protein namesi
Recommended name:
Endophilin-B2
Alternative name(s):
SH3 domain-containing GRB2-like protein B2
Gene namesi
Name:SH3GLB2
Synonyms:KIAA1848
ORF Names:PP578
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148341.17
HGNCiHGNC:10834 SH3GLB2
MIMi609288 gene
neXtProtiNX_Q9NR46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi56904
OpenTargetsiENSG00000148341
PharmGKBiPA35740

Polymorphism and mutation databases

DMDMi41018150

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001467551 – 395Endophilin-B2Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei395PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NR46
MaxQBiQ9NR46
PaxDbiQ9NR46
PeptideAtlasiQ9NR46
PRIDEiQ9NR46
ProteomicsDBi82271
82272 [Q9NR46-2]
TopDownProteomicsiQ9NR46-1 [Q9NR46-1]

PTM databases

iPTMnetiQ9NR46
PhosphoSitePlusiQ9NR46

Expressioni

Tissue specificityi

Detected in skeletal muscle, adipocyte, brain, lung, colon and mammary gland.1 Publication

Gene expression databases

BgeeiENSG00000148341 Expressed in 210 organ(s), highest expression level in pituitary gland
CleanExiHS_SH3GLB2
ExpressionAtlasiQ9NR46 baseline and differential
GenevisibleiQ9NR46 HS

Organism-specific databases

HPAiHPA021438
HPA024734

Interactioni

Subunit structurei

Homodimer, and heterodimer with SH3GLB1.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121234, 31 interactors
IntActiQ9NR46, 33 interactors
MINTiQ9NR46
STRINGi9606.ENSP00000361640

Structurei

3D structure databases

ProteinModelPortaliQ9NR46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 287BARPROSITE-ProRule annotationAdd BLAST264
Domaini335 – 395SH3PROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 27Membrane-binding amphipathic helixBy similarityAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili116 – 132Sequence analysisAdd BLAST17
Coiled coili206 – 240Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the endophilin family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG3725 Eukaryota
ENOG410XPA6 LUCA
GeneTreeiENSGT00550000074464
HOGENOMiHOG000232056
HOVERGENiHBG054448
InParanoidiQ9NR46
KOiK21269
OMAiHTASINF
OrthoDBiEOG091G09WR
PhylomeDBiQ9NR46
TreeFamiTF313281

Family and domain databases

CDDicd11944 SH3_Endophilin_B2, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR004148 BAR_dom
IPR035640 Endophilin_B2_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR028500 SH3GLB2
PANTHERiPTHR44071:SF2 PTHR44071:SF2, 1 hit
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS50002 SH3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NR46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFNMKKLAS DAGIFFTRAV QFTEEKFGQA EKTELDAHFE NLLARADSTK
60 70 80 90 100
NWTEKILRQT EVLLQPNPSA RVEEFLYEKL DRKVPSRVTN GELLAQYMAD
110 120 130 140 150
AASELGPTTP YGKTLIKVAE AEKQLGAAER DFIHTASISF LTPLRNFLEG
160 170 180 190 200
DWKTISKERR LLQNRRLDLD ACKARLKKAK AAEAKATTVP DFQETRPRNY
210 220 230 240 250
ILSASASALW NDEVDKAEQE LRVAQTEFDR QAEVTRLLLE GISSTHVNHL
260 270 280 290 300
RCLHEFVKSQ TTYYAQCYRH MLDLQKQLGR FPGTFVGTTE PASPPLSSTS
310 320 330 340 350
PTTAAATMPV VPSVASLAPP GEASLCLEEV APPASGTRKA RVLYDYEAAD
360 370 380 390
SSELALLADE LITVYSLPGM DPDWLIGERG NKKGKVPVTY LELLS
Length:395
Mass (Da):43,974
Last modified:October 1, 2000 - v1
Checksum:i5549631DB2EB7CAA
GO
Isoform 2 (identifier: Q9NR46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-187: T → TCEGD
     280-280: R → SSQGAI

Note: No experimental confirmation available.
Show »
Length:404
Mass (Da):44,766
Checksum:i830D75563D5896D3
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZC38B7ZC38_HUMAN
Endophilin-B2
SH3GLB2
400Annotation score:
B7ZC39B7ZC39_HUMAN
Endophilin-B2
SH3GLB2
374Annotation score:
F8WFB9F8WFB9_HUMAN
Endophilin-B2
SH3GLB2
127Annotation score:
H7C1Z6H7C1Z6_HUMAN
Endophilin-B2
SH3GLB2
59Annotation score:
G5E9J1G5E9J1_HUMAN
Endophilin-B2
SH3GLB2 hCG_30604
24Annotation score:

Sequence cautioni

The sequence AAG23792 differs from that shown. Reason: Frameshift at positions 122 and 128.Curated
The sequence BAB47477 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053078305A → V. Corresponds to variant dbSNP:rs17455482Ensembl.1
Natural variantiVAR_053079319P → L. Corresponds to variant dbSNP:rs17455475Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009278187T → TCEGD in isoform 2. 1 Publication1
Alternative sequenceiVSP_009279280R → SSQGAI in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257319 mRNA Translation: AAF81226.1
AB058751 mRNA Translation: BAB47477.2 Different initiation.
AF258589 mRNA Translation: AAG23792.1 Frameshift.
AL592211 Genomic DNA No translation available.
BC014635 mRNA Translation: AAH14635.1
CCDSiCCDS6916.1 [Q9NR46-1]
CCDS69680.1 [Q9NR46-2]
RefSeqiNP_001273974.1, NM_001287045.1 [Q9NR46-2]
NP_001273975.1, NM_001287046.1 [Q9NR46-1]
NP_064530.1, NM_020145.3 [Q9NR46-1]
XP_005252158.1, XM_005252101.3
UniGeneiHs.460238

Genome annotation databases

EnsembliENST00000372554; ENSP00000361634; ENSG00000148341 [Q9NR46-2]
ENST00000372559; ENSP00000361640; ENSG00000148341 [Q9NR46-1]
ENST00000372564; ENSP00000361645; ENSG00000148341 [Q9NR46-1]
GeneIDi56904
KEGGihsa:56904
UCSCiuc004bwv.5 human [Q9NR46-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257319 mRNA Translation: AAF81226.1
AB058751 mRNA Translation: BAB47477.2 Different initiation.
AF258589 mRNA Translation: AAG23792.1 Frameshift.
AL592211 Genomic DNA No translation available.
BC014635 mRNA Translation: AAH14635.1
CCDSiCCDS6916.1 [Q9NR46-1]
CCDS69680.1 [Q9NR46-2]
RefSeqiNP_001273974.1, NM_001287045.1 [Q9NR46-2]
NP_001273975.1, NM_001287046.1 [Q9NR46-1]
NP_064530.1, NM_020145.3 [Q9NR46-1]
XP_005252158.1, XM_005252101.3
UniGeneiHs.460238

3D structure databases

ProteinModelPortaliQ9NR46
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121234, 31 interactors
IntActiQ9NR46, 33 interactors
MINTiQ9NR46
STRINGi9606.ENSP00000361640

PTM databases

iPTMnetiQ9NR46
PhosphoSitePlusiQ9NR46

Polymorphism and mutation databases

DMDMi41018150

Proteomic databases

EPDiQ9NR46
MaxQBiQ9NR46
PaxDbiQ9NR46
PeptideAtlasiQ9NR46
PRIDEiQ9NR46
ProteomicsDBi82271
82272 [Q9NR46-2]
TopDownProteomicsiQ9NR46-1 [Q9NR46-1]

Protocols and materials databases

DNASUi56904
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372554; ENSP00000361634; ENSG00000148341 [Q9NR46-2]
ENST00000372559; ENSP00000361640; ENSG00000148341 [Q9NR46-1]
ENST00000372564; ENSP00000361645; ENSG00000148341 [Q9NR46-1]
GeneIDi56904
KEGGihsa:56904
UCSCiuc004bwv.5 human [Q9NR46-1]

Organism-specific databases

CTDi56904
DisGeNETi56904
EuPathDBiHostDB:ENSG00000148341.17
GeneCardsiSH3GLB2
H-InvDBiHIX0008444
HGNCiHGNC:10834 SH3GLB2
HPAiHPA021438
HPA024734
MIMi609288 gene
neXtProtiNX_Q9NR46
OpenTargetsiENSG00000148341
PharmGKBiPA35740
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3725 Eukaryota
ENOG410XPA6 LUCA
GeneTreeiENSGT00550000074464
HOGENOMiHOG000232056
HOVERGENiHBG054448
InParanoidiQ9NR46
KOiK21269
OMAiHTASINF
OrthoDBiEOG091G09WR
PhylomeDBiQ9NR46
TreeFamiTF313281

Miscellaneous databases

ChiTaRSiSH3GLB2 human
GeneWikiiSH3GLB2
GenomeRNAii56904
PROiPR:Q9NR46
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148341 Expressed in 210 organ(s), highest expression level in pituitary gland
CleanExiHS_SH3GLB2
ExpressionAtlasiQ9NR46 baseline and differential
GenevisibleiQ9NR46 HS

Family and domain databases

CDDicd11944 SH3_Endophilin_B2, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR004148 BAR_dom
IPR035640 Endophilin_B2_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR028500 SH3GLB2
PANTHERiPTHR44071:SF2 PTHR44071:SF2, 1 hit
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSHLB2_HUMAN
AccessioniPrimary (citable) accession number: Q9NR46
Secondary accession number(s): A6NC47
, A8MPS4, Q8WY61, Q96JH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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