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UniProtKB - Q9NR46 (SHLB2_HUMAN)
Protein
Endophilin-B2
Gene
SH3GLB2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- identical protein binding Source: IntAct
GO - Biological processi
- membrane organization Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9NR46 |
SignaLinki | Q9NR46 |
SIGNORi | Q9NR46 |
Names & Taxonomyi
Protein namesi | Recommended name: Endophilin-B2Alternative name(s): SH3 domain-containing GRB2-like protein B2 |
Gene namesi | Name:SH3GLB2 Synonyms:KIAA1848 ORF Names:PP578 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10834, SH3GLB2 |
MIMi | 609288, gene |
neXtProti | NX_Q9NR46 |
VEuPathDBi | HostDB:ENSG00000148341 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 56904 |
OpenTargetsi | ENSG00000148341 |
PharmGKBi | PA35740 |
Miscellaneous databases
Pharosi | Q9NR46, Tbio |
Genetic variation databases
BioMutai | SH3GLB2 |
DMDMi | 41018150 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000146755 | 1 – 395 | Endophilin-B2Add BLAST | 395 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 10 | PhosphoserineCombined sources | 1 | |
Modified residuei | 395 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9NR46 |
jPOSTi | Q9NR46 |
MassIVEi | Q9NR46 |
MaxQBi | Q9NR46 |
PaxDbi | Q9NR46 |
PeptideAtlasi | Q9NR46 |
PRIDEi | Q9NR46 |
ProteomicsDBi | 82271 [Q9NR46-1] 82272 [Q9NR46-2] |
TopDownProteomicsi | Q9NR46-1 [Q9NR46-1] |
PTM databases
GlyGeni | Q9NR46, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NR46 |
PhosphoSitePlusi | Q9NR46 |
Expressioni
Tissue specificityi
Detected in skeletal muscle, adipocyte, brain, lung, colon and mammary gland.1 Publication
Gene expression databases
Bgeei | ENSG00000148341, Expressed in pituitary gland and 222 other tissues |
ExpressionAtlasi | Q9NR46, baseline and differential |
Genevisiblei | Q9NR46, HS |
Organism-specific databases
HPAi | ENSG00000148341, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer, and heterodimer with SH3GLB1.
Binary interactionsi
Q9NR46
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 121234, 78 interactors |
IntActi | Q9NR46, 42 interactors |
MINTi | Q9NR46 |
STRINGi | 9606.ENSP00000361634 |
Miscellaneous databases
RNActi | Q9NR46, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 287 | BARPROSITE-ProRule annotationAdd BLAST | 264 | |
Domaini | 335 – 395 | SH3PROSITE-ProRule annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 27 | Membrane-binding amphipathic helixBy similarityAdd BLAST | 27 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 116 – 132 | Sequence analysisAdd BLAST | 17 | |
Coiled coili | 206 – 240 | Sequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the endophilin family.Curated
Keywords - Domaini
Coiled coil, SH3 domainPhylogenomic databases
eggNOGi | KOG3725, Eukaryota |
GeneTreei | ENSGT00940000155841 |
InParanoidi | Q9NR46 |
OMAi | FGETTPY |
OrthoDBi | 803053at2759 |
PhylomeDBi | Q9NR46 |
TreeFami | TF313281 |
Family and domain databases
CDDi | cd11944, SH3_Endophilin_B2, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR004148, BAR_dom IPR035640, Endophilin_B2_SH3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF03114, BAR, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00721, BAR, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51021, BAR, 1 hit PS50002, SH3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NR46-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDFNMKKLAS DAGIFFTRAV QFTEEKFGQA EKTELDAHFE NLLARADSTK
60 70 80 90 100
NWTEKILRQT EVLLQPNPSA RVEEFLYEKL DRKVPSRVTN GELLAQYMAD
110 120 130 140 150
AASELGPTTP YGKTLIKVAE AEKQLGAAER DFIHTASISF LTPLRNFLEG
160 170 180 190 200
DWKTISKERR LLQNRRLDLD ACKARLKKAK AAEAKATTVP DFQETRPRNY
210 220 230 240 250
ILSASASALW NDEVDKAEQE LRVAQTEFDR QAEVTRLLLE GISSTHVNHL
260 270 280 290 300
RCLHEFVKSQ TTYYAQCYRH MLDLQKQLGR FPGTFVGTTE PASPPLSSTS
310 320 330 340 350
PTTAAATMPV VPSVASLAPP GEASLCLEEV APPASGTRKA RVLYDYEAAD
360 370 380 390
SSELALLADE LITVYSLPGM DPDWLIGERG NKKGKVPVTY LELLS
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7ZC38 | B7ZC38_HUMAN | Endophilin-B2 | SH3GLB2 | 400 | Annotation score: | ||
B7ZC39 | B7ZC39_HUMAN | Endophilin-B2 | SH3GLB2 | 374 | Annotation score: | ||
F8WFB9 | F8WFB9_HUMAN | Endophilin-B2 | SH3GLB2 | 127 | Annotation score: | ||
H7C1Z6 | H7C1Z6_HUMAN | Endophilin-B2 | SH3GLB2 | 59 | Annotation score: | ||
G5E9J1 | G5E9J1_HUMAN | Endophilin-B2 | SH3GLB2 hCG_30604 | 24 | Annotation score: |
Sequence cautioni
The sequence AAG23792 differs from that shown. Reason: Frameshift.Curated
The sequence BAB47477 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053078 | 305 | A → V. Corresponds to variant dbSNP:rs17455482Ensembl. | 1 | |
Natural variantiVAR_053079 | 319 | P → L. Corresponds to variant dbSNP:rs17455475Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009278 | 187 | T → TCEGD in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_009279 | 280 | R → SSQGAI in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF257319 mRNA Translation: AAF81226.1 AB058751 mRNA Translation: BAB47477.2 Different initiation. AF258589 mRNA Translation: AAG23792.1 Frameshift. AL592211 Genomic DNA No translation available. BC014635 mRNA Translation: AAH14635.1 |
CCDSi | CCDS6916.1 [Q9NR46-1] CCDS69680.1 [Q9NR46-2] |
RefSeqi | NP_001273974.1, NM_001287045.1 [Q9NR46-2] NP_001273975.1, NM_001287046.1 [Q9NR46-1] NP_064530.1, NM_020145.3 [Q9NR46-1] XP_005252158.1, XM_005252101.3 |
Genome annotation databases
Ensembli | ENST00000372554; ENSP00000361634; ENSG00000148341 [Q9NR46-2] ENST00000372559; ENSP00000361640; ENSG00000148341 ENST00000372564; ENSP00000361645; ENSG00000148341 |
GeneIDi | 56904 |
KEGGi | hsa:56904 |
MANE-Selecti | ENST00000372564.8; ENSP00000361645.3; NM_020145.4; NP_064530.1 |
UCSCi | uc004bwv.5, human [Q9NR46-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF257319 mRNA Translation: AAF81226.1 AB058751 mRNA Translation: BAB47477.2 Different initiation. AF258589 mRNA Translation: AAG23792.1 Frameshift. AL592211 Genomic DNA No translation available. BC014635 mRNA Translation: AAH14635.1 |
CCDSi | CCDS6916.1 [Q9NR46-1] CCDS69680.1 [Q9NR46-2] |
RefSeqi | NP_001273974.1, NM_001287045.1 [Q9NR46-2] NP_001273975.1, NM_001287046.1 [Q9NR46-1] NP_064530.1, NM_020145.3 [Q9NR46-1] XP_005252158.1, XM_005252101.3 |
3D structure databases
SMRi | Q9NR46 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121234, 78 interactors |
IntActi | Q9NR46, 42 interactors |
MINTi | Q9NR46 |
STRINGi | 9606.ENSP00000361634 |
PTM databases
GlyGeni | Q9NR46, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NR46 |
PhosphoSitePlusi | Q9NR46 |
Genetic variation databases
BioMutai | SH3GLB2 |
DMDMi | 41018150 |
Proteomic databases
EPDi | Q9NR46 |
jPOSTi | Q9NR46 |
MassIVEi | Q9NR46 |
MaxQBi | Q9NR46 |
PaxDbi | Q9NR46 |
PeptideAtlasi | Q9NR46 |
PRIDEi | Q9NR46 |
ProteomicsDBi | 82271 [Q9NR46-1] 82272 [Q9NR46-2] |
TopDownProteomicsi | Q9NR46-1 [Q9NR46-1] |
Protocols and materials databases
ABCDi | Q9NR46, 1 sequenced antibody |
Antibodypediai | 17774, 148 antibodies from 24 providers |
DNASUi | 56904 |
Genome annotation databases
Ensembli | ENST00000372554; ENSP00000361634; ENSG00000148341 [Q9NR46-2] ENST00000372559; ENSP00000361640; ENSG00000148341 ENST00000372564; ENSP00000361645; ENSG00000148341 |
GeneIDi | 56904 |
KEGGi | hsa:56904 |
MANE-Selecti | ENST00000372564.8; ENSP00000361645.3; NM_020145.4; NP_064530.1 |
UCSCi | uc004bwv.5, human [Q9NR46-1] |
Organism-specific databases
CTDi | 56904 |
DisGeNETi | 56904 |
GeneCardsi | SH3GLB2 |
HGNCi | HGNC:10834, SH3GLB2 |
HPAi | ENSG00000148341, Low tissue specificity |
MIMi | 609288, gene |
neXtProti | NX_Q9NR46 |
OpenTargetsi | ENSG00000148341 |
PharmGKBi | PA35740 |
VEuPathDBi | HostDB:ENSG00000148341 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3725, Eukaryota |
GeneTreei | ENSGT00940000155841 |
InParanoidi | Q9NR46 |
OMAi | FGETTPY |
OrthoDBi | 803053at2759 |
PhylomeDBi | Q9NR46 |
TreeFami | TF313281 |
Enzyme and pathway databases
PathwayCommonsi | Q9NR46 |
SignaLinki | Q9NR46 |
SIGNORi | Q9NR46 |
Miscellaneous databases
BioGRID-ORCSi | 56904, 4 hits in 1049 CRISPR screens |
ChiTaRSi | SH3GLB2, human |
GeneWikii | SH3GLB2 |
GenomeRNAii | 56904 |
Pharosi | Q9NR46, Tbio |
PROi | PR:Q9NR46 |
RNActi | Q9NR46, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000148341, Expressed in pituitary gland and 222 other tissues |
ExpressionAtlasi | Q9NR46, baseline and differential |
Genevisiblei | Q9NR46, HS |
Family and domain databases
CDDi | cd11944, SH3_Endophilin_B2, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR004148, BAR_dom IPR035640, Endophilin_B2_SH3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF03114, BAR, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00721, BAR, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51021, BAR, 1 hit PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SHLB2_HUMAN | |
Accessioni | Q9NR46Primary (citable) accession number: Q9NR46 Secondary accession number(s): A6NC47 Q96JH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families