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Entry version 176 (16 Oct 2019)
Sequence version 2 (15 May 2002)
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Protein

Sialic acid synthase

Gene

NANS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS01818-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.5.1.57 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-4085001 Sialic acid metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sialic acid synthase
Alternative name(s):
N-acetylneuraminate synthase (EC:2.5.1.56)
N-acetylneuraminate-9-phosphate synthase (EC:2.5.1.57)
N-acetylneuraminic acid phosphate synthase
N-acetylneuraminic acid synthase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NANS
Synonyms:SAS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19237 NANS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605202 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NR45

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spondyloepimetaphyseal dysplasia, Genevieve type (SEMDG)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by global developmental delay with infantile onset, mental retardation, skeletal dysplasia, and short stature. Skeletal findings include flat vertebral bodies with irregular vertebral plates, irregular and flared metaphyses with vertical striations, small and irregular epiphyses, premature carpal ossification and small carpal bones.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07657129H → N in SEMDG. 1 PublicationCorresponds to variant dbSNP:rs1277263564Ensembl.1
Natural variantiVAR_076572133G → V in SEMDG. 1 PublicationCorresponds to variant dbSNP:rs878852980EnsemblClinVar.1
Natural variantiVAR_076573151R → H in SEMDG. 1 PublicationCorresponds to variant dbSNP:rs140402727EnsemblClinVar.1
Natural variantiVAR_076574188Y → H in SEMDG. 1 PublicationCorresponds to variant dbSNP:rs878852981EnsemblClinVar.1
Natural variantiVAR_076575189P → L in SEMDG. 1 PublicationCorresponds to variant dbSNP:rs1024025721Ensembl.1
Natural variantiVAR_076576237R → C in SEMDG. 1 PublicationCorresponds to variant dbSNP:rs878852982EnsemblClinVar.1
Natural variantiVAR_076577327I → II in SEMDG. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
54187

MalaCards human disease database

More...
MalaCardsi
NANS
MIMi610442 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000095380

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
168454 Spondyloepimetaphyseal dysplasia, Genevieve type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134978885

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NR45

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NANS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20978759

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000977502 – 359Sialic acid synthaseAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei61N6-acetyllysineBy similarity1
Modified residuei74N6-acetyllysineBy similarity1
Modified residuei79N6-acetyllysineCombined sources1
Modified residuei275PhosphoserineBy similarity1
Modified residuei290N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NR45

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NR45

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NR45

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NR45

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NR45

PeptideAtlas

More...
PeptideAtlasi
Q9NR45

PRoteomics IDEntifications database

More...
PRIDEi
Q9NR45

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82270

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00147874

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NR45

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NR45

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NR45

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000095380 Expressed in 220 organ(s), highest expression level in mucosa of transverse colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NR45 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NR45 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019223

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119921, 49 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NR45, 19 interactors

Molecular INTeraction database

More...
MINTi
Q9NR45

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000210444

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NR45

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NR45

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini294 – 353AFP-likePROSITE-ProRule annotationAdd BLAST60

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHMI Eukaryota
COG2089 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011081

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000284783

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NR45

KEGG Orthology (KO)

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KOi
K05304

Identification of Orthologs from Complete Genome Data

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OMAi
PWGRMTY

Database of Orthologous Groups

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OrthoDBi
1117607at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NR45

TreeFam database of animal gene trees

More...
TreeFami
TF324826

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006190 AFP_Neu5c_C
IPR036732 AFP_Neu5c_C_sf
IPR013785 Aldolase_TIM
IPR006013 Antifreeze_III
IPR013132 Neu5Ac_N
IPR013974 SAF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03102 NeuB, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00357 ANTIFREEZIII

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00858 SAF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51269 SSF51269, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50844 AFP_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9NR45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLELELCPG RWVGGQHPCF IIAEIGQNHQ GDLDVAKRMI RMAKECGADC
60 70 80 90 100
AKFQKSELEF KFNRKALERP YTSKHSWGKT YGEHKRHLEF SHDQYRELQR
110 120 130 140 150
YAEEVGIFFT ASGMDEMAVE FLHELNVPFF KVGSGDTNNF PYLEKTAKKG
160 170 180 190 200
RPMVISSGMQ SMDTMKQVYQ IVKPLNPNFC FLQCTSAYPL QPEDVNLRVI
210 220 230 240 250
SEYQKLFPDI PIGYSGHETG IAISVAAVAL GAKVLERHIT LDKTWKGSDH
260 270 280 290 300
SASLEPGELA ELVRSVRLVE RALGSPTKQL LPCEMACNEK LGKSVVAKVK
310 320 330 340 350
IPEGTILTMD MLTVKVGEPK GYPPEDIFNL VGKKVLVTVE EDDTIMEELV

DNHGKKIKS
Length:359
Mass (Da):40,308
Last modified:May 15, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E02D47F4F98592F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TBR1Q5TBR1_HUMAN
Sialic acid synthase
NANS
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TBR0Q5TBR0_HUMAN
Sialic acid synthase
NANS
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti232A → T in BAA91818 (PubMed:14702039).Curated1
Sequence conflicti321G → A in AAF75261 (PubMed:10749855).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07657129H → N in SEMDG. 1 PublicationCorresponds to variant dbSNP:rs1277263564Ensembl.1
Natural variantiVAR_01330868E → D1 PublicationCorresponds to variant dbSNP:rs1058446Ensembl.1
Natural variantiVAR_076572133G → V in SEMDG. 1 PublicationCorresponds to variant dbSNP:rs878852980EnsemblClinVar.1
Natural variantiVAR_076573151R → H in SEMDG. 1 PublicationCorresponds to variant dbSNP:rs140402727EnsemblClinVar.1
Natural variantiVAR_076574188Y → H in SEMDG. 1 PublicationCorresponds to variant dbSNP:rs878852981EnsemblClinVar.1
Natural variantiVAR_076575189P → L in SEMDG. 1 PublicationCorresponds to variant dbSNP:rs1024025721Ensembl.1
Natural variantiVAR_076576237R → C in SEMDG. 1 PublicationCorresponds to variant dbSNP:rs878852982EnsemblClinVar.1
Natural variantiVAR_076577327I → II in SEMDG. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF257466 mRNA Translation: AAF75261.1
AK001659 mRNA Translation: BAA91818.1
AK316608 mRNA Translation: BAG38195.1
AL137073 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58867.1
BC000008 mRNA Translation: AAH00008.1
BC019315 mRNA Translation: AAH19315.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6733.1

NCBI Reference Sequences

More...
RefSeqi
NP_061819.2, NM_018946.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000210444; ENSP00000210444; ENSG00000095380

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54187

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54187

UCSC genome browser

More...
UCSCi
uc004ayc.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257466 mRNA Translation: AAF75261.1
AK001659 mRNA Translation: BAA91818.1
AK316608 mRNA Translation: BAG38195.1
AL137073 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58867.1
BC000008 mRNA Translation: AAH00008.1
BC019315 mRNA Translation: AAH19315.1
CCDSiCCDS6733.1
RefSeqiNP_061819.2, NM_018946.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WVONMR-A294-359[»]
SMRiQ9NR45
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi119921, 49 interactors
IntActiQ9NR45, 19 interactors
MINTiQ9NR45
STRINGi9606.ENSP00000210444

PTM databases

iPTMnetiQ9NR45
PhosphoSitePlusiQ9NR45
SwissPalmiQ9NR45

Polymorphism and mutation databases

BioMutaiNANS
DMDMi20978759

2D gel databases

REPRODUCTION-2DPAGEiIPI00147874

Proteomic databases

EPDiQ9NR45
jPOSTiQ9NR45
MassIVEiQ9NR45
MaxQBiQ9NR45
PaxDbiQ9NR45
PeptideAtlasiQ9NR45
PRIDEiQ9NR45
ProteomicsDBi82270

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54187

Genome annotation databases

EnsembliENST00000210444; ENSP00000210444; ENSG00000095380
GeneIDi54187
KEGGihsa:54187
UCSCiuc004ayc.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54187
DisGeNETi54187

GeneCards: human genes, protein and diseases

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GeneCardsi
NANS
HGNCiHGNC:19237 NANS
HPAiHPA019223
MalaCardsiNANS
MIMi605202 gene
610442 phenotype
neXtProtiNX_Q9NR45
OpenTargetsiENSG00000095380
Orphaneti168454 Spondyloepimetaphyseal dysplasia, Genevieve type
PharmGKBiPA134978885

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IHMI Eukaryota
COG2089 LUCA
GeneTreeiENSGT00390000011081
HOGENOMiHOG000284783
InParanoidiQ9NR45
KOiK05304
OMAiPWGRMTY
OrthoDBi1117607at2759
PhylomeDBiQ9NR45
TreeFamiTF324826

Enzyme and pathway databases

BioCyciMetaCyc:HS01818-MONOMER
BRENDAi2.5.1.57 2681
ReactomeiR-HSA-4085001 Sialic acid metabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NANS human
EvolutionaryTraceiQ9NR45

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NANS

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54187
PharosiQ9NR45

Protein Ontology

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PROi
PR:Q9NR45

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000095380 Expressed in 220 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiQ9NR45 baseline and differential
GenevisibleiQ9NR45 HS

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR006190 AFP_Neu5c_C
IPR036732 AFP_Neu5c_C_sf
IPR013785 Aldolase_TIM
IPR006013 Antifreeze_III
IPR013132 Neu5Ac_N
IPR013974 SAF
PfamiView protein in Pfam
PF03102 NeuB, 1 hit
PRINTSiPR00357 ANTIFREEZIII
SMARTiView protein in SMART
SM00858 SAF, 1 hit
SUPFAMiSSF51269 SSF51269, 1 hit
PROSITEiView protein in PROSITE
PS50844 AFP_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIAS_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NR45
Secondary accession number(s): B2RE98
, Q8WUV9, Q9BWS6, Q9NVD4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: May 15, 2002
Last modified: October 16, 2019
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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