Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP-binding protein SAR1a

Gene

SAR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39GTPBy similarity8
Nucleotide bindingi75 – 78GTPBy similarity4
Nucleotide bindingi134 – 137GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein SAR1a
Alternative name(s):
COPII-associated small GTPase
Gene namesi
Name:SAR1A
Synonyms:SAR1, SARA, SARA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000079332.14
HGNCiHGNC:10534 SAR1A
MIMi607691 gene
neXtProtiNX_Q9NR31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56681
OpenTargetsiENSG00000079332
PharmGKBiPA34942

Polymorphism and mutation databases

BioMutaiSAR1A
DMDMi14548013

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062581 – 198GTP-binding protein SAR1aAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei139PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NR31
MaxQBiQ9NR31
PaxDbiQ9NR31
PeptideAtlasiQ9NR31
PRIDEiQ9NR31
ProteomicsDBi82267
TopDownProteomicsiQ9NR31-1 [Q9NR31-1]

2D gel databases

OGPiQ9NR31

PTM databases

iPTMnetiQ9NR31
PhosphoSitePlusiQ9NR31
SwissPalmiQ9NR31

Expressioni

Gene expression databases

BgeeiENSG00000079332 Expressed in 242 organ(s), highest expression level in female gonad
CleanExiHS_SAR1A
ExpressionAtlasiQ9NR31 baseline and differential
GenevisibleiQ9NR31 HS

Organism-specific databases

HPAiCAB022545
HPA006923
HPA048368

Interactioni

Subunit structurei

Interacts with B3GAT1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Sec23aQ014052EBI-3920694,EBI-775901From Mus musculus.

Protein-protein interaction databases

BioGridi121186, 22 interactors
DIPiDIP-59790N
IntActiQ9NR31, 72 interactors
MINTiQ9NR31
STRINGi9606.ENSP00000362335

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NR31
SMRiQ9NR31
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NR31

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. SAR1 family.Curated

Phylogenomic databases

eggNOGiKOG0077 Eukaryota
ENOG410YIKI LUCA
GeneTreeiENSGT00550000074696
HOGENOMiHOG000163690
HOVERGENiHBG104997
InParanoidiQ9NR31
KOiK07953
OMAiIRPIEIF
OrthoDBiEOG091G0KFV
PhylomeDBiQ9NR31
TreeFamiTF312890

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
IPR006687 Small_GTPase_SAR1
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51422 SAR1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NR31-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFIFEWIYN GFSSVLQFLG LYKKSGKLVF LGLDNAGKTT LLHMLKDDRL
60 70 80 90 100
GQHVPTLHPT SEELTIAGMT FTTFDLGGHE QARRVWKNYL PAINGIVFLV
110 120 130 140 150
DCADHSRLVE SKVELNALMT DETISNVPIL ILGNKIDRTD AISEEKLREI
160 170 180 190
FGLYGQTTGK GNVTLKELNA RPMEVFMCSV LKRQGYGEGF RWLSQYID
Length:198
Mass (Da):22,367
Last modified:October 1, 2000 - v1
Checksum:i38A869175CBA54F3
GO
Isoform 2 (identifier: Q9NR31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Note: No experimental confirmation available.
Show »
Length:155
Mass (Da):17,500
Checksum:i5255243DB5CF522C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5E8H0Y5E8_HUMAN
GTP-binding protein SAR1a
SAR1A
115Annotation score:
Q5SQT8Q5SQT8_HUMAN
GTP-binding protein SAR1a
SAR1A
121Annotation score:
X1WI22X1WI22_HUMAN
GTP-binding protein SAR1a
SAR1A
50Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0562201 – 43Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261717 mRNA Translation: AAF81741.1
AL136724 mRNA Translation: CAB66658.1
AY008268 mRNA Translation: AAG16638.1
AK298591 mRNA Translation: BAG60781.1
AL731540 Genomic DNA No translation available.
BC003658 mRNA Translation: AAH03658.1
CCDSiCCDS7298.1 [Q9NR31-1]
RefSeqiNP_001136120.1, NM_001142648.1 [Q9NR31-1]
NP_064535.1, NM_020150.4 [Q9NR31-1]
UniGeneiHs.499960

Genome annotation databases

EnsembliENST00000373238; ENSP00000362335; ENSG00000079332 [Q9NR31-1]
ENST00000373241; ENSP00000362338; ENSG00000079332 [Q9NR31-1]
ENST00000373242; ENSP00000362339; ENSG00000079332 [Q9NR31-1]
ENST00000431664; ENSP00000399698; ENSG00000079332 [Q9NR31-1]
GeneIDi56681
KEGGihsa:56681
UCSCiuc010qjh.3 human [Q9NR31-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261717 mRNA Translation: AAF81741.1
AL136724 mRNA Translation: CAB66658.1
AY008268 mRNA Translation: AAG16638.1
AK298591 mRNA Translation: BAG60781.1
AL731540 Genomic DNA No translation available.
BC003658 mRNA Translation: AAH03658.1
CCDSiCCDS7298.1 [Q9NR31-1]
RefSeqiNP_001136120.1, NM_001142648.1 [Q9NR31-1]
NP_064535.1, NM_020150.4 [Q9NR31-1]
UniGeneiHs.499960

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GAOX-ray2.00A/B10-198[»]
ProteinModelPortaliQ9NR31
SMRiQ9NR31
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121186, 22 interactors
DIPiDIP-59790N
IntActiQ9NR31, 72 interactors
MINTiQ9NR31
STRINGi9606.ENSP00000362335

PTM databases

iPTMnetiQ9NR31
PhosphoSitePlusiQ9NR31
SwissPalmiQ9NR31

Polymorphism and mutation databases

BioMutaiSAR1A
DMDMi14548013

2D gel databases

OGPiQ9NR31

Proteomic databases

EPDiQ9NR31
MaxQBiQ9NR31
PaxDbiQ9NR31
PeptideAtlasiQ9NR31
PRIDEiQ9NR31
ProteomicsDBi82267
TopDownProteomicsiQ9NR31-1 [Q9NR31-1]

Protocols and materials databases

DNASUi56681
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373238; ENSP00000362335; ENSG00000079332 [Q9NR31-1]
ENST00000373241; ENSP00000362338; ENSG00000079332 [Q9NR31-1]
ENST00000373242; ENSP00000362339; ENSG00000079332 [Q9NR31-1]
ENST00000431664; ENSP00000399698; ENSG00000079332 [Q9NR31-1]
GeneIDi56681
KEGGihsa:56681
UCSCiuc010qjh.3 human [Q9NR31-1]

Organism-specific databases

CTDi56681
DisGeNETi56681
EuPathDBiHostDB:ENSG00000079332.14
GeneCardsiSAR1A
HGNCiHGNC:10534 SAR1A
HPAiCAB022545
HPA006923
HPA048368
MIMi607691 gene
neXtProtiNX_Q9NR31
OpenTargetsiENSG00000079332
PharmGKBiPA34942
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0077 Eukaryota
ENOG410YIKI LUCA
GeneTreeiENSGT00550000074696
HOGENOMiHOG000163690
HOVERGENiHBG104997
InParanoidiQ9NR31
KOiK07953
OMAiIRPIEIF
OrthoDBiEOG091G0KFV
PhylomeDBiQ9NR31
TreeFamiTF312890

Miscellaneous databases

ChiTaRSiSAR1A human
EvolutionaryTraceiQ9NR31
GenomeRNAii56681
PROiPR:Q9NR31
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079332 Expressed in 242 organ(s), highest expression level in female gonad
CleanExiHS_SAR1A
ExpressionAtlasiQ9NR31 baseline and differential
GenevisibleiQ9NR31 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
IPR006687 Small_GTPase_SAR1
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51422 SAR1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAR1A_HUMAN
AccessioniPrimary (citable) accession number: Q9NR31
Secondary accession number(s): B4DQ19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again