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Entry version 146 (07 Apr 2021)
Sequence version 2 (28 Mar 2018)
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Protein

Protein mono-ADP-ribosyltransferase PARP11

Gene

PARP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:25673562). Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processDifferentiation, mRNA transport, Protein transport, Spermatogenesis, Translocation, Transport
LigandNAD

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.2.30, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NR21

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein mono-ADP-ribosyltransferase PARP11Curated (EC:2.4.2.-1 Publication)
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 111 Publication
Short name:
ARTD111 Publication
Poly [ADP-ribose] polymerase 111 Publication
Short name:
PARP-111 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PARP111 PublicationImported
Synonyms:C12orf6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1186, PARP11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616706, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NR21

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000111224.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38Y → A: No effect on subcellular location at the nuclear envelope. 1 Publication1
Mutagenesisi48F → A: No effect on subcellular location at the nuclear envelope. 1 Publication1
Mutagenesisi84Y → A: Loss of subcellular location at the nuclear envelope. 1 Publication1
Mutagenesisi93Q → A: Loss of subcellular location at the nuclear envelope. 1 Publication1
Mutagenesisi102R → A: Loss of subcellular location at the nuclear envelope. 1 Publication1
Mutagenesisi205G → W: No effect on subcellular location at the nuclear envelope. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
57097

Open Targets

More...
OpenTargetsi
ENSG00000111224

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25507

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NR21, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2380189

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PARP11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74734315

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002734191 – 338Protein mono-ADP-ribosyltransferase PARP11Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13ADP-ribosyl glutamic acid1 Publication1
Modified residuei18N6-(ADP-ribosyl)lysine1 Publication1
Modified residuei56ADP-ribosylcysteine1 Publication1
Modified residuei72ADP-ribosylcysteine1 Publication1
Modified residuei87ADP-ribosyl aspartic acid1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Auto-mono-ADP-ribosylated.2 Publications

Keywords - PTMi

ADP-ribosylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NR21

PeptideAtlas

More...
PeptideAtlasi
Q9NR21

PRoteomics IDEntifications database

More...
PRIDEi
Q9NR21

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
30979
82256 [Q9NR21-1]
82257 [Q9NR21-2]
82258 [Q9NR21-4]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NR21

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111224, Expressed in buccal mucosa cell and 201 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NR21, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NR21, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000111224, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121365, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NR21, 28 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000228820

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9NR21

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NR21, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NR21

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NR21

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 106WWEPROSITE-ProRule annotationAdd BLAST85
Domaini123 – 338PARP catalyticPROSITE-ProRule annotationAdd BLAST216

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QT2S, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156857

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014825_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NR21

Identification of Orthologs from Complete Genome Data

More...
OMAi
TWNPRIF

Database of Orthologous Groups

More...
OrthoDBi
782733at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NR21

TreeFam database of animal gene trees

More...
TreeFami
TF338389

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.720.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012317, Poly(ADP-ribose)pol_cat_dom
IPR004170, WWE-dom
IPR037197, WWE_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00644, PARP, 1 hit
PF02825, WWE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117839, SSF117839, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51059, PARP_CATALYTIC, 1 hit
PS50918, WWE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NR21-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWEANPEMFH KAEELFSKTT NNEVDDMDTS DTQWGWFYLA ECGKWHMFQP
60 70 80 90 100
DTNSQCSVSS EDIEKSFKTN PCGSISFTTS KFSYKIDFAE MKQMNLTTGK
110 120 130 140 150
QRLIKRAPFS ISAFSYICEN EAIPMPPHWE NVNTQVPYQL IPLHNQTHEY
160 170 180 190 200
NEVANLFGKT MDRNRIKRIQ RIQNLDLWEF FCRKKAQLKK KRGVPQINEQ
210 220 230 240 250
MLFHGTSSEF VEAICIHNFD WRINGIHGAV FGKGTYFARD AAYSSRFCKD
260 270 280 290 300
DIKHGNTFQI HGVSLQQRHL FRTYKSMFLA RVLIGDYING DSKYMRPPSK
310 320 330
DGSYVNLYDS CVDDTWNPKI FVVFDANQIY PEYLIDFH
Length:338
Mass (Da):39,597
Last modified:March 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2019EB49823BB08F
GO
Isoform 2 (identifier: Q9NR21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.
     82-89: FSYKIDFA → MWEVAHVS

Show »
Length:257
Mass (Da):30,212
Checksum:iC31718D5A6CDD6D9
GO
Isoform 3 (identifier: Q9NR21-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Show »
Length:331
Mass (Da):38,739
Checksum:i732A46ABC0456E7E
GO
Isoform 4 (identifier: Q9NR21-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-239: GTYFAR → DNMWKL
     240-338: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:239
Mass (Da):28,098
Checksum:iA7D9F8BEF18524FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V0I3G3V0I3_HUMAN
Protein mono-ADP-ribosyltransferase...
PARP11
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WFA3F8WFA3_HUMAN
Protein mono-ADP-ribosyltransferase...
PARP11
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H8L8F5H8L8_HUMAN
Protein mono-ADP-ribosyltransferase...
PARP11
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH17569 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH31073 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0594351 – 81Missing in isoform 2. Add BLAST81
Alternative sequenceiVSP_0594361 – 7Missing in isoform 3. 7
Alternative sequenceiVSP_05943782 – 89FSYKIDFA → MWEVAHVS in isoform 2. 8
Alternative sequenceiVSP_059438234 – 239GTYFAR → DNMWKL in isoform 4. 6
Alternative sequenceiVSP_059439240 – 338Missing in isoform 4. Add BLAST99

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF263540 mRNA Translation: AAF91391.1
AK299372 mRNA Translation: BAG61362.1
CR749294 mRNA Translation: CAH18149.1
AC005842 Genomic DNA No translation available.
AC006207 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88853.1
BC017569 mRNA Translation: AAH17569.1 Different initiation.
BC031073 mRNA Translation: AAH31073.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS66281.1 [Q9NR21-2]
CCDS8523.2 [Q9NR21-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001273450.1, NM_001286521.1 [Q9NR21-2]
NP_001273451.1, NM_001286522.1 [Q9NR21-2]
NP_065100.2, NM_020367.5 [Q9NR21-4]
XP_005253768.1, XM_005253711.4
XP_011519272.1, XM_011520970.1 [Q9NR21-1]
XP_011519273.1, XM_011520971.2
XP_011519275.1, XM_011520973.2 [Q9NR21-1]
XP_016875159.1, XM_017019670.1
XP_016875160.1, XM_017019671.1 [Q9NR21-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000228820; ENSP00000228820; ENSG00000111224 [Q9NR21-4]
ENST00000416739; ENSP00000392392; ENSG00000111224 [Q9NR21-5]
ENST00000427057; ENSP00000397058; ENSG00000111224 [Q9NR21-2]
ENST00000447133; ENSP00000405385; ENSG00000111224 [Q9NR21-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57097

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57097

UCSC genome browser

More...
UCSCi
uc001qml.4, human [Q9NR21-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263540 mRNA Translation: AAF91391.1
AK299372 mRNA Translation: BAG61362.1
CR749294 mRNA Translation: CAH18149.1
AC005842 Genomic DNA No translation available.
AC006207 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88853.1
BC017569 mRNA Translation: AAH17569.1 Different initiation.
BC031073 mRNA Translation: AAH31073.1 Different initiation.
CCDSiCCDS66281.1 [Q9NR21-2]
CCDS8523.2 [Q9NR21-4]
RefSeqiNP_001273450.1, NM_001286521.1 [Q9NR21-2]
NP_001273451.1, NM_001286522.1 [Q9NR21-2]
NP_065100.2, NM_020367.5 [Q9NR21-4]
XP_005253768.1, XM_005253711.4
XP_011519272.1, XM_011520970.1 [Q9NR21-1]
XP_011519273.1, XM_011520971.2
XP_011519275.1, XM_011520973.2 [Q9NR21-1]
XP_016875159.1, XM_017019670.1
XP_016875160.1, XM_017019671.1 [Q9NR21-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DK6NMR-A22-110[»]
SMRiQ9NR21
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121365, 17 interactors
IntActiQ9NR21, 28 interactors
STRINGi9606.ENSP00000228820

Chemistry databases

BindingDBiQ9NR21
ChEMBLiCHEMBL2380189

PTM databases

PhosphoSitePlusiQ9NR21

Genetic variation databases

BioMutaiPARP11
DMDMi74734315

Proteomic databases

PaxDbiQ9NR21
PeptideAtlasiQ9NR21
PRIDEiQ9NR21
ProteomicsDBi30979
82256 [Q9NR21-1]
82257 [Q9NR21-2]
82258 [Q9NR21-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
10533, 130 antibodies

The DNASU plasmid repository

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DNASUi
57097

Genome annotation databases

EnsembliENST00000228820; ENSP00000228820; ENSG00000111224 [Q9NR21-4]
ENST00000416739; ENSP00000392392; ENSG00000111224 [Q9NR21-5]
ENST00000427057; ENSP00000397058; ENSG00000111224 [Q9NR21-2]
ENST00000447133; ENSP00000405385; ENSG00000111224 [Q9NR21-2]
GeneIDi57097
KEGGihsa:57097
UCSCiuc001qml.4, human [Q9NR21-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57097
DisGeNETi57097

GeneCards: human genes, protein and diseases

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GeneCardsi
PARP11
HGNCiHGNC:1186, PARP11
HPAiENSG00000111224, Low tissue specificity
MIMi616706, gene
neXtProtiNX_Q9NR21
OpenTargetsiENSG00000111224
PharmGKBiPA25507
VEuPathDBiHostDB:ENSG00000111224.13

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QT2S, Eukaryota
GeneTreeiENSGT00940000156857
HOGENOMiCLU_014825_1_0_1
InParanoidiQ9NR21
OMAiTWNPRIF
OrthoDBi782733at2759
PhylomeDBiQ9NR21
TreeFamiTF338389

Enzyme and pathway databases

BRENDAi2.4.2.30, 2681
PathwayCommonsiQ9NR21

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
57097, 28 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PARP11, human
EvolutionaryTraceiQ9NR21

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57097
PharosiQ9NR21, Tbio

Protein Ontology

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PROi
PR:Q9NR21
RNActiQ9NR21, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111224, Expressed in buccal mucosa cell and 201 other tissues
ExpressionAtlasiQ9NR21, baseline and differential
GenevisibleiQ9NR21, HS

Family and domain databases

Gene3Di3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR012317, Poly(ADP-ribose)pol_cat_dom
IPR004170, WWE-dom
IPR037197, WWE_dom_sf
PfamiView protein in Pfam
PF00644, PARP, 1 hit
PF02825, WWE, 1 hit
SUPFAMiSSF117839, SSF117839, 1 hit
PROSITEiView protein in PROSITE
PS51059, PARP_CATALYTIC, 1 hit
PS50918, WWE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAR11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NR21
Secondary accession number(s): B4DRQ0
, F8WBZ7, Q68DS1, Q8N5Y9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 28, 2018
Last modified: April 7, 2021
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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