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Protein

Poly [ADP-ribose] polymerase 11

Gene

PARP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity (PubMed:25673562).By similarity1 Publication

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

GO - Molecular functioni

  • NAD+ ADP-ribosyltransferase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processDifferentiation, mRNA transport, Protein transport, Spermatogenesis, Translocation, Transport
LigandNAD

Enzyme and pathway databases

BRENDAi2.4.2.30 2681

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 11 (EC:2.4.2.30)
Short name:
PARP-11
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 11
Short name:
ARTD11
Gene namesi
Name:PARP11
Synonyms:C12orf6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111224.13
HGNCiHGNC:1186 PARP11
MIMi616706 gene
neXtProtiNX_Q9NR21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38Y → A: No effect on subcellular location at the nuclear envelope. 1 Publication1
Mutagenesisi48F → A: No effect on subcellular location at the nuclear envelope. 1 Publication1
Mutagenesisi84Y → A: Loss of subcellular location at the nuclear envelope. 1 Publication1
Mutagenesisi93Q → A: Loss of subcellular location at the nuclear envelope. 1 Publication1
Mutagenesisi102R → A: Loss of subcellular location at the nuclear envelope. 1 Publication1
Mutagenesisi205G → W: No effect on subcellular location at the nuclear envelope. 1 Publication1

Organism-specific databases

DisGeNETi57097
OpenTargetsiENSG00000111224
PharmGKBiPA25507

Chemistry databases

ChEMBLiCHEMBL2380189

Polymorphism and mutation databases

DMDMi74734315

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002734191 – 338Poly [ADP-ribose] polymerase 11Add BLAST338

Post-translational modificationi

In vitro, can undergo mono-ADP-ribosylation.1 Publication

Keywords - PTMi

ADP-ribosylation

Proteomic databases

PaxDbiQ9NR21
PeptideAtlasiQ9NR21
PRIDEiQ9NR21
ProteomicsDBi82256
82257 [Q9NR21-2]
82258 [Q9NR21-4]

PTM databases

iPTMnetiQ9NR21
PhosphoSitePlusiQ9NR21

Expressioni

Gene expression databases

BgeeiENSG00000111224 Expressed in 186 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_PARP11
ExpressionAtlasiQ9NR21 baseline and differential
GenevisibleiQ9NR21 HS

Organism-specific databases

HPAiHPA026895

Interactioni

Protein-protein interaction databases

BioGridi121365, 11 interactors
IntActiQ9NR21, 10 interactors
STRINGi9606.ENSP00000228820

Structurei

Secondary structure

1338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NR21
SMRiQ9NR21
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NR21

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 106WWEPROSITE-ProRule annotationAdd BLAST85
Domaini123 – 338PARP catalyticPROSITE-ProRule annotationAdd BLAST216

Phylogenomic databases

eggNOGiENOG410IJ12 Eukaryota
ENOG4110TY6 LUCA
GeneTreeiENSGT00760000119084
HOGENOMiHOG000237349
HOVERGENiHBG056772
InParanoidiQ9NR21
KOiK15259
OMAiWENVNTE
OrthoDBiEOG091G14UY
PhylomeDBiQ9NR21
TreeFamiTF338389

Family and domain databases

Gene3Di3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004170 WWE-dom
IPR037197 WWE_dom_sf
PfamiView protein in Pfam
PF00644 PARP, 1 hit
PF02825 WWE, 1 hit
SUPFAMiSSF117839 SSF117839, 1 hit
PROSITEiView protein in PROSITE
PS51059 PARP_CATALYTIC, 1 hit
PS50918 WWE, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NR21-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWEANPEMFH KAEELFSKTT NNEVDDMDTS DTQWGWFYLA ECGKWHMFQP
60 70 80 90 100
DTNSQCSVSS EDIEKSFKTN PCGSISFTTS KFSYKIDFAE MKQMNLTTGK
110 120 130 140 150
QRLIKRAPFS ISAFSYICEN EAIPMPPHWE NVNTQVPYQL IPLHNQTHEY
160 170 180 190 200
NEVANLFGKT MDRNRIKRIQ RIQNLDLWEF FCRKKAQLKK KRGVPQINEQ
210 220 230 240 250
MLFHGTSSEF VEAICIHNFD WRINGIHGAV FGKGTYFARD AAYSSRFCKD
260 270 280 290 300
DIKHGNTFQI HGVSLQQRHL FRTYKSMFLA RVLIGDYING DSKYMRPPSK
310 320 330
DGSYVNLYDS CVDDTWNPKI FVVFDANQIY PEYLIDFH
Length:338
Mass (Da):39,597
Last modified:March 28, 2018 - v2
Checksum:i2019EB49823BB08F
GO
Isoform 2 (identifier: Q9NR21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.
     82-89: FSYKIDFA → MWEVAHVS

Show »
Length:257
Mass (Da):30,212
Checksum:iC31718D5A6CDD6D9
GO
Isoform 3 (identifier: Q9NR21-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:331
Mass (Da):38,739
Checksum:i732A46ABC0456E7E
GO
Isoform 4 (identifier: Q9NR21-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-239: GTYFAR → DNMWKL
     240-338: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:239
Mass (Da):28,098
Checksum:iA7D9F8BEF18524FD
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V0I3G3V0I3_HUMAN
Poly [ADP-ribose] polymerase 11
PARP11
185Annotation score:
F8WFA3F8WFA3_HUMAN
Poly [ADP-ribose] polymerase 11
PARP11
50Annotation score:
F5H8L8F5H8L8_HUMAN
Poly [ADP-ribose] polymerase 11
PARP11
46Annotation score:

Sequence cautioni

The sequence AAH17569 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH31073 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0594351 – 81Missing in isoform 2. Add BLAST81
Alternative sequenceiVSP_0594361 – 7Missing in isoform 3. 7
Alternative sequenceiVSP_05943782 – 89FSYKIDFA → MWEVAHVS in isoform 2. 8
Alternative sequenceiVSP_059438234 – 239GTYFAR → DNMWKL in isoform 4. 6
Alternative sequenceiVSP_059439240 – 338Missing in isoform 4. Add BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263540 mRNA Translation: AAF91391.1
AK299372 mRNA Translation: BAG61362.1
CR749294 mRNA Translation: CAH18149.1
AC005842 Genomic DNA No translation available.
AC006207 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88853.1
BC017569 mRNA Translation: AAH17569.1 Different initiation.
BC031073 mRNA Translation: AAH31073.1 Different initiation.
CCDSiCCDS66281.1 [Q9NR21-2]
CCDS8523.2 [Q9NR21-4]
RefSeqiNP_001273450.1, NM_001286521.1 [Q9NR21-2]
NP_001273451.1, NM_001286522.1 [Q9NR21-2]
NP_065100.2, NM_020367.5 [Q9NR21-4]
XP_005253768.1, XM_005253711.4
XP_011519272.1, XM_011520970.1 [Q9NR21-1]
XP_011519273.1, XM_011520971.2
XP_011519275.1, XM_011520973.2 [Q9NR21-1]
XP_016875159.1, XM_017019670.1
XP_016875160.1, XM_017019671.1 [Q9NR21-2]
UniGeneiHs.657268

Genome annotation databases

EnsembliENST00000228820; ENSP00000228820; ENSG00000111224 [Q9NR21-4]
ENST00000416739; ENSP00000392392; ENSG00000111224 [Q9NR21-5]
ENST00000427057; ENSP00000397058; ENSG00000111224 [Q9NR21-2]
ENST00000447133; ENSP00000405385; ENSG00000111224 [Q9NR21-2]
GeneIDi57097
KEGGihsa:57097
UCSCiuc001qml.4 human [Q9NR21-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263540 mRNA Translation: AAF91391.1
AK299372 mRNA Translation: BAG61362.1
CR749294 mRNA Translation: CAH18149.1
AC005842 Genomic DNA No translation available.
AC006207 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88853.1
BC017569 mRNA Translation: AAH17569.1 Different initiation.
BC031073 mRNA Translation: AAH31073.1 Different initiation.
CCDSiCCDS66281.1 [Q9NR21-2]
CCDS8523.2 [Q9NR21-4]
RefSeqiNP_001273450.1, NM_001286521.1 [Q9NR21-2]
NP_001273451.1, NM_001286522.1 [Q9NR21-2]
NP_065100.2, NM_020367.5 [Q9NR21-4]
XP_005253768.1, XM_005253711.4
XP_011519272.1, XM_011520970.1 [Q9NR21-1]
XP_011519273.1, XM_011520971.2
XP_011519275.1, XM_011520973.2 [Q9NR21-1]
XP_016875159.1, XM_017019670.1
XP_016875160.1, XM_017019671.1 [Q9NR21-2]
UniGeneiHs.657268

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DK6NMR-A22-110[»]
ProteinModelPortaliQ9NR21
SMRiQ9NR21
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121365, 11 interactors
IntActiQ9NR21, 10 interactors
STRINGi9606.ENSP00000228820

Chemistry databases

ChEMBLiCHEMBL2380189

PTM databases

iPTMnetiQ9NR21
PhosphoSitePlusiQ9NR21

Polymorphism and mutation databases

DMDMi74734315

Proteomic databases

PaxDbiQ9NR21
PeptideAtlasiQ9NR21
PRIDEiQ9NR21
ProteomicsDBi82256
82257 [Q9NR21-2]
82258 [Q9NR21-4]

Protocols and materials databases

DNASUi57097
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228820; ENSP00000228820; ENSG00000111224 [Q9NR21-4]
ENST00000416739; ENSP00000392392; ENSG00000111224 [Q9NR21-5]
ENST00000427057; ENSP00000397058; ENSG00000111224 [Q9NR21-2]
ENST00000447133; ENSP00000405385; ENSG00000111224 [Q9NR21-2]
GeneIDi57097
KEGGihsa:57097
UCSCiuc001qml.4 human [Q9NR21-4]

Organism-specific databases

CTDi57097
DisGeNETi57097
EuPathDBiHostDB:ENSG00000111224.13
GeneCardsiPARP11
HGNCiHGNC:1186 PARP11
HPAiHPA026895
MIMi616706 gene
neXtProtiNX_Q9NR21
OpenTargetsiENSG00000111224
PharmGKBiPA25507
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ12 Eukaryota
ENOG4110TY6 LUCA
GeneTreeiENSGT00760000119084
HOGENOMiHOG000237349
HOVERGENiHBG056772
InParanoidiQ9NR21
KOiK15259
OMAiWENVNTE
OrthoDBiEOG091G14UY
PhylomeDBiQ9NR21
TreeFamiTF338389

Enzyme and pathway databases

BRENDAi2.4.2.30 2681

Miscellaneous databases

ChiTaRSiPARP11 human
EvolutionaryTraceiQ9NR21
GenomeRNAii57097
PROiPR:Q9NR21
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111224 Expressed in 186 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_PARP11
ExpressionAtlasiQ9NR21 baseline and differential
GenevisibleiQ9NR21 HS

Family and domain databases

Gene3Di3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004170 WWE-dom
IPR037197 WWE_dom_sf
PfamiView protein in Pfam
PF00644 PARP, 1 hit
PF02825 WWE, 1 hit
SUPFAMiSSF117839 SSF117839, 1 hit
PROSITEiView protein in PROSITE
PS51059 PARP_CATALYTIC, 1 hit
PS50918 WWE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAR11_HUMAN
AccessioniPrimary (citable) accession number: Q9NR21
Secondary accession number(s): B4DRQ0
, F8WBZ7, Q68DS1, Q8N5Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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