Dual specificity tyrosine-phosphorylation-regulated kinase 4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• metal ion binding Source: UniProtKB-KW
• protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
• protein serine/threonine kinase activity Source: UniProtKB-KW
• protein tyrosine kinase activity Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS 
        60         70         80         90        100
PYEQSEILGY AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI 
       110        120        130        140        150
AYRYEVLETI GKGSFGQVAK CLDHKNNELV ALKIIRNKKR FHQQALMELK 
       160        170        180        190        200
ILEALRKKDK DNTYNVVHMK DFFYFRNHFC ITFELLGINL YELMKNNNFQ 
       210        220        230        240        250
GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ KGQASVKVID 
       260        270        280        290        300
FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 
       310        320        330        340        350
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN 
       360        370        380        390        400
RGKKRYPDSK DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI 
       410        420        430        440        450
HQSRNLKPQP RPQTLRKSNS FFPSETRKDK VQGCHHSSRK ADEITKETTE 
       460        470        480        490        500
KTKDSPTKHV QHSGDQQDCL QHGADTVQLP QLVDAPKKSE AAVGAEVSMT 
       510        520
SPGQSKNFSL KNTNVLPPIV                                  

        10         20         30         40         50
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS 
        60         70         80         90        100
PYEQSEILGY AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI 
       110        120        130        140        150
AYRYEVLETI GKGSFGQVAK CLDHKNNELV ALKIIRNKKR FHQQALMELK 
       160        170        180        190        200
ILEALRKKDK DNTYNVVHMK DFFYFRNHFC ITFELLGINL YELMKNNNFQ 
       210        220        230        240        250
GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ KGQASVKVID 
       260        270        280        290        300
FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 
       310        320        330        340        350
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN 
       360        370        380        390        400
RGKKRYPDSK DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI 
       410        420        430        440        450
HQSRNLKPQP RPQTLRKSNS FFPSETRKDK VQGCHHSSRK DEITKETTEK 
       460        470        480        490        500
TKDSPTKHVQ HSGDQQDCLQ HGADTVQLPQ LVDAPKKSEA AVGAEVSMTS 
       510 
PGQSKNFSLK NTNVLPPIV                                   

        10         20         30         40         50
MQLLPPPIRT GTKTQMDAKK PRKCDLTPFL VLKARKKQKF TSAKVGSKLS 
        60         70         80         90        100
VQIQKPPSNI KNSRMTQVFH KNTSVTSLPF VDTKGKKNTV SFPHISKKVL 
       110        120        130        140        150
LKSSLLYQEN QAHNQMPASE LKASEIPFHP SIKTQDPKAE EKSPKKQKVT 
       160        170        180        190        200
LTAAEALKLF KNQLSPYEQS EILGYAELWF LGLEAKKLDT APEKFSKTSF 
       210        220        230        240        250
DDEHGFYLKV LHDHIAYRYE VLETIGKGSF GQVAKCLDHK NNELVALKII 
       260        270        280        290        300
RNKKRFHQQA LMELKILEAL RKKDKDNTYN VVHMKDFFYF RNHFCITFEL 
       310        320        330        340        350
LGINLYELMK NNNFQGFSLS IVRRFTLSVL KCLQMLSVEK IIHCDLKPEN 
       360        370        380        390        400
IVLYQKGQAS VKVIDFGSSC YEHQKVYTYI QSRFYRSPEV ILGHPYDVAI 
       410        420        430        440        450
DMWSLGCITA ELYTGYPLFP GENEVEQLAC IMEVLGLPPA GFIQTASRRQ 
       460        470        480        490        500
TFFDSKGFPK NITNNRGKKR YPDSKDLTMV LKTYDTSFLD FLRRCLVWEP 
       510        520        530        540        550
SLRMTPDQAL KHAWIHQSRN LKPQPRPQTL RKSNSFFPSE TRKDKVQGCH 
       560        570        580        590        600
HSSRKADEIT KETTEKTKDS PTKHVQHSGD QQDCLQHGAD TVQLPQLVDA 
       610        620        630 
PKKSEAAVGA EVSMTSPGQS KNFSLKNTNV LPPIV                 

        10         20         30         40         50
MQLLPPPIRT GTKTQMDAKK PRKCDLTPFL VLKARKKQKF TSAKGPTLSE 
        60         70         80         90        100
IYMVGSKLSV QIQKPPSNIK NSRMTQVFHK NTSVTSLPFV DTKGKKNTVS 
       110        120        130        140        150
FPHISKKVLL KSSLLYQENQ AHNQMPASEL KASEIPFHPS IKTQDPKAEE 
       160        170        180        190        200
KSPKKQKVTL TAAEALKLFK NQLSPYEQSE ILGYAELWFL GLEAKKLDTA 
       210        220        230        240        250
PEKFSKTSFD DEHGFYLKVL HDHIAYRYEV LETIGKGSFG QVAKCLDHKN 
       260        270        280        290        300
NELVALKIIR NKKRFHQQAL MELKILEALR KKDKDNTYNV VHMKDFFYFR 
       310        320        330        340        350
NHFCITFELL GINLYELMKN NNFQGFSLSI VRRFTLSVLK CLQMLSVEKI 
       360        370        380        390        400
IHCDLKPENI VLYQKGQASV KVIDFGSSCY EHQKVYTYIQ SRFYRSPEVI 
       410        420        430        440        450
LGHPYDVAID MWSLGCITAE LYTGYPLFPG ENEVEQLACI MEVLGLPPAG 
       460        470        480        490        500
FIQTASRRQT FFDSKGFPKN ITNNRGKKRY PDSKDLTMVL KTYDTSFLDF 
       510        520        530        540        550
LRRCLVWEPS LRMTPDQALK HAWIHQSRNL KPQPRPQTLR KSNSFFPSET 
       560        570        580        590        600
RKDKVQGCHH SSRKADEITK ETTEKTKDSP TKHVQHSGDQ QDCLQHGADT 
       610        620        630        640 
VQLPQLVDAP KKSEAAVGAE VSMTSPGQSK NFSLKNTNVL PPIV       

        10         20         30         40         50
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS 
        60         70         80         90        100
PYEQSEILGY AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI 
       110        120        130        140        150
AYRYEVLETI GKGSFGQVAK CLDHKNNELV ALKIIRNKKR FHQQALMELK 
       160        170        180        190        200
ILEALRKKDK DNTYNVVHMK DFFYFRNHFC ITFELLGINL YELMKNNNFQ 
       210        220        230        240        250
GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ KGQASVKVID 
       260        270        280        290        300
FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 
       310        320        330        340        350
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN 
       360        370        380        390        400
RGKKRYPDSK DLTMVLKTYD TSFLDFLRRW EPSLRMTPDQ ALKHAWIHQS 
       410        420        430        440        450
RNLKPQPRPQ TLRKSNSFFP SETRKDKVQG CHHSSRKADE ITKETTEKTK 
       460        470        480        490        500
DSPTKHVQHS GDQQDCLQHG ADTVQLPQLV DAPKKSEAAV GAEVSMTSPG 
       510 
QSKNFSLKNT NVLPPIV                                     

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 12
   Human chromosome 12: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. Human and mouse protein kinases
   Human and mouse protein kinases: classification and index
6. SIMILARITY comments
   Index of protein domains and families