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Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 4

Gene

DYRK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible non-essential role in spermiogenesis.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei133ATP1
Active sitei230Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi110 – 118ATPPROSITE-ProRule annotation9
Nucleotide bindingi183 – 186ATPPROSITE-ProRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9NR20

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC:2.7.12.1)
Gene namesi
Name:DYRK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000010219.13
HGNCiHGNC:3095 DYRK4
MIMi609181 gene
neXtProtiNX_Q9NR20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi133K → R: Loss of kinase activity. 1 Publication1
Mutagenesisi264Y → F: Abolishes kinase activity. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000010219
PharmGKBiPA27552

Chemistry databases

ChEMBLiCHEMBL1075115
GuidetoPHARMACOLOGYi2013

Polymorphism and mutation databases

BioMutaiDYRK4
DMDMi68566308

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859401 – 520Dual specificity tyrosine-phosphorylation-regulated kinase 4Add BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei264Phosphotyrosine; by autocatalysis1 Publication1

Post-translational modificationi

Autophosphorylation on Tyr-264 in the activation loop is required for kinase activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NR20
MaxQBiQ9NR20
PaxDbiQ9NR20
PeptideAtlasiQ9NR20
PRIDEiQ9NR20
ProteomicsDBi82254
82255 [Q9NR20-2]

PTM databases

iPTMnetiQ9NR20
PhosphoSitePlusiQ9NR20

Expressioni

Gene expression databases

BgeeiENSG00000010219
CleanExiHS_DYRK4
ExpressionAtlasiQ9NR20 baseline and differential
GenevisibleiQ9NR20 HS

Organism-specific databases

HPAiHPA028065
HPA056073

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114326, 16 interactors
IntActiQ9NR20, 13 interactors
STRINGi9606.ENSP00000010132

Chemistry databases

BindingDBiQ9NR20

Structurei

3D structure databases

ProteinModelPortaliQ9NR20
SMRiQ9NR20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 400Protein kinasePROSITE-ProRule annotationAdd BLAST297

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0667 Eukaryota
ENOG410XPET LUCA
GeneTreeiENSGT00760000119032
HOGENOMiHOG000220863
HOVERGENiHBG051426
InParanoidiQ9NR20
KOiK18669
PhylomeDBiQ9NR20
TreeFamiTF314624

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NR20-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS
60 70 80 90 100
PYEQSEILGY AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI
110 120 130 140 150
AYRYEVLETI GKGSFGQVAK CLDHKNNELV ALKIIRNKKR FHQQALMELK
160 170 180 190 200
ILEALRKKDK DNTYNVVHMK DFFYFRNHFC ITFELLGINL YELMKNNNFQ
210 220 230 240 250
GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ KGQASVKVID
260 270 280 290 300
FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG
310 320 330 340 350
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN
360 370 380 390 400
RGKKRYPDSK DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI
410 420 430 440 450
HQSRNLKPQP RPQTLRKSNS FFPSETRKDK VQGCHHSSRK ADEITKETTE
460 470 480 490 500
KTKDSPTKHV QHSGDQQDCL QHGADTVQLP QLVDAPKKSE AAVGAEVSMT
510 520
SPGQSKNFSL KNTNVLPPIV
Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Length:520
Mass (Da):59,608
Last modified:May 10, 2005 - v2
Checksum:i33FECD8249DDB223
GO
Isoform 2 (identifier: Q9NR20-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     441-441: Missing.

Show »
Length:519
Mass (Da):59,537
Checksum:i2ACD1BC87AA1591B
GO
Isoform 3 (identifier: Q9NR20-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQLLPPPIRT...YQENQAHNQM

Note: No experimental confirmation available.
Show »
Length:635
Mass (Da):72,577
Checksum:i42F432C350F65F2D
GO
Isoform 4 (identifier: Q9NR20-4) [UniParc]FASTAAdd to basket
Also known as: DYRK4-L

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQLLPPPIRT...YQENQAHNQM

Note: Contains a bipartite nuclear localization signal at positions 19-37.1 Publication
Show »
Length:644
Mass (Da):73,569
Checksum:i688041E86A28626C
GO
Isoform 5 (identifier: Q9NR20-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-382: Missing.

Note: Due to an alternative splicing donor site in exon 19. Markedly reduced enzymatic activity.1 Publication
Show »
Length:517
Mass (Da):59,293
Checksum:i0C076681A026AC27
GO

Sequence cautioni

The sequence AAF91393 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK308260 differs from that shown. Reason: Frameshift at position 470.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165N → I in BAF85011 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03390061A → T. Corresponds to variant dbSNP:rs12306130Ensembl.1
Natural variantiVAR_04046570A → S1 Publication1
Natural variantiVAR_01072195V → I1 PublicationCorresponds to variant dbSNP:rs746486416Ensembl.1
Natural variantiVAR_010722189N → S1 PublicationCorresponds to variant dbSNP:rs3741927Ensembl.1
Natural variantiVAR_014948454D → V. Corresponds to variant dbSNP:rs1801016Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0571321M → MQLLPPPIRTGTKTQMDAKK PRKCDLTPFLVLKARKKQKF TSAKVGSKLSVQIQKPPSNI KNSRMTQVFHKNTSVTSLPF VDTKGKKNTVSFPHISKKVL LKSSLLYQENQAHNQM in isoform 3. 1 Publication1
Alternative sequenceiVSP_0571331M → MQLLPPPIRTGTKTQMDAKK PRKCDLTPFLVLKARKKQKF TSAKGPTLSEIYMVGSKLSV QIQKPPSNIKNSRMTQVFHK NTSVTSLPFVDTKGKKNTVS FPHISKKVLLKSSLLYQENQ AHNQM in isoform 4. 1 Publication1
Alternative sequenceiVSP_057134380 – 382Missing in isoform 5. 1 Publication3
Alternative sequenceiVSP_013745441Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263541 mRNA Translation: AAF91393.1 Different initiation.
AK292322 mRNA Translation: BAF85011.1
AK308260 mRNA No translation available.
BC031244 mRNA Translation: AAH31244.1
Y09305 mRNA Translation: CAA70488.1
CCDSiCCDS8530.1 [Q9NR20-1]
RefSeqiNP_003836.1, NM_003845.2 [Q9NR20-1]
UniGeneiHs.439530

Genome annotation databases

EnsembliENST00000010132; ENSP00000010132; ENSG00000010219 [Q9NR20-1]
ENST00000540757; ENSP00000441755; ENSG00000010219 [Q9NR20-1]
GeneIDi8798
KEGGihsa:8798
UCSCiuc001qmx.5 human [Q9NR20-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDYRK4_HUMAN
AccessioniPrimary (citable) accession number: Q9NR20
Secondary accession number(s): A8K8F7, Q8NEF2, Q92631
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 10, 2005
Last modified: June 20, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

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