We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q9NR20 (DYRK4_HUMAN)
Protein
Dual specificity tyrosine-phosphorylation-regulated kinase 4
Gene
DYRK4
Organism
Homo sapiens (Human)
Status
Functioni
Possible non-essential role in spermiogenesis.
By similarityCatalytic activityi
Cofactori
Mg2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 133 | ATP | 1 | |
Active sitei | 230 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 110 – 118 | ATPPROSITE-ProRule annotation | 9 | |
Nucleotide bindingi | 183 – 186 | ATPPROSITE-ProRule annotation | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: UniProtKB-KW
GO - Biological processi
- peptidyl-serine phosphorylation Source: GO_Central
- peptidyl-threonine phosphorylation Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.12.1, 2681 |
PathwayCommonsi | Q9NR20 |
SignaLinki | Q9NR20 |
SIGNORi | Q9NR20 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DYRK4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3095, DYRK4 |
MIMi | 609181, gene |
neXtProti | NX_Q9NR20 |
VEuPathDBi | HostDB:ENSG00000010219 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytoskeleton
- cytoskeleton Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 133 | K → R: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 264 | Y → F: Abolishes kinase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8798 |
OpenTargetsi | ENSG00000010219 |
PharmGKBi | PA27552 |
Miscellaneous databases
Pharosi | Q9NR20, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1075115 |
GuidetoPHARMACOLOGYi | 2013 |
Genetic variation databases
BioMutai | DYRK4 |
DMDMi | 68566308 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085940 | 1 – 520 | Dual specificity tyrosine-phosphorylation-regulated kinase 4Add BLAST | 520 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 264 | Phosphotyrosine; by autocatalysis1 Publication | 1 |
Post-translational modificationi
Autophosphorylation on Tyr-264 in the activation loop is required for kinase activity.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NR20 |
jPOSTi | Q9NR20 |
MassIVEi | Q9NR20 |
MaxQBi | Q9NR20 |
PaxDbi | Q9NR20 |
PeptideAtlasi | Q9NR20 |
PRIDEi | Q9NR20 |
ProteomicsDBi | 82254 [Q9NR20-1] 82255 [Q9NR20-2] |
PTM databases
iPTMneti | Q9NR20 |
PhosphoSitePlusi | Q9NR20 |
Expressioni
Gene expression databases
Bgeei | ENSG00000010219, Expressed in left testis and 214 other tissues |
ExpressionAtlasi | Q9NR20, baseline and differential |
Genevisiblei | Q9NR20, HS |
Organism-specific databases
HPAi | ENSG00000010219, Tissue enhanced (testis) |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 114326, 16 interactors |
IntActi | Q9NR20, 14 interactors |
STRINGi | 9606.ENSP00000441755 |
Chemistry databases
BindingDBi | Q9NR20 |
Miscellaneous databases
RNActi | Q9NR20, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 104 – 400 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 297 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 32 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 404 – 467 | DisorderedSequence analysisAdd BLAST | 64 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 4 (identifier: Q9NR20-4) | |||||
Motifi | 19 – 37 | Bipartite nuclear localization signal1 PublicationAdd BLAST | 19 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 406 – 421 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 422 – 461 | Basic and acidic residuesSequence analysisAdd BLAST | 40 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0667, Eukaryota |
GeneTreei | ENSGT00940000159401 |
HOGENOMi | CLU_000288_5_9_1 |
InParanoidi | Q9NR20 |
OrthoDBi | 870358at2759 |
PhylomeDBi | Q9NR20 |
TreeFami | TF314624 |
Family and domain databases
Gene3Di | 3.30.10.30, 1 hit |
InterProi | View protein in InterPro IPR042521, DYRK IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NR20-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS
60 70 80 90 100
PYEQSEILGY AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI
110 120 130 140 150
AYRYEVLETI GKGSFGQVAK CLDHKNNELV ALKIIRNKKR FHQQALMELK
160 170 180 190 200
ILEALRKKDK DNTYNVVHMK DFFYFRNHFC ITFELLGINL YELMKNNNFQ
210 220 230 240 250
GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ KGQASVKVID
260 270 280 290 300
FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG
310 320 330 340 350
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN
360 370 380 390 400
RGKKRYPDSK DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI
410 420 430 440 450
HQSRNLKPQP RPQTLRKSNS FFPSETRKDK VQGCHHSSRK ADEITKETTE
460 470 480 490 500
KTKDSPTKHV QHSGDQQDCL QHGADTVQLP QLVDAPKKSE AAVGAEVSMT
510 520
SPGQSKNFSL KNTNVLPPIV
Note: May be due to a competing acceptor splice site.
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MTH5 | A0A0A0MTH5_HUMAN | Dual-specificity kinase | DYRK4 | 634 | Annotation score: | ||
H0YFI4 | H0YFI4_HUMAN | Dual-specificity tyrosine-phosphory... | DYRK4 | 120 | Annotation score: | ||
F5GWS4 | F5GWS4_HUMAN | Dual-specificity tyrosine-phosphory... | DYRK4 | 68 | Annotation score: | ||
F5H4X6 | F5H4X6_HUMAN | Dual-specificity tyrosine-phosphory... | DYRK4 | 59 | Annotation score: | ||
F5H3D3 | F5H3D3_HUMAN | Dual-specificity tyrosine-phosphory... | DYRK4 | 43 | Annotation score: |
Sequence cautioni
The sequence AAF91393 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK308260 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 165 | N → I in BAF85011 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033900 | 61 | A → T. Corresponds to variant dbSNP:rs12306130Ensembl. | 1 | |
Natural variantiVAR_040465 | 70 | A → S1 Publication | 1 | |
Natural variantiVAR_010721 | 95 | V → I1 PublicationCorresponds to variant dbSNP:rs746486416Ensembl. | 1 | |
Natural variantiVAR_010722 | 189 | N → S1 PublicationCorresponds to variant dbSNP:rs3741927Ensembl. | 1 | |
Natural variantiVAR_014948 | 454 | D → V. Corresponds to variant dbSNP:rs1801016Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057132 | 1 | M → MQLLPPPIRTGTKTQMDAKK PRKCDLTPFLVLKARKKQKF TSAKVGSKLSVQIQKPPSNI KNSRMTQVFHKNTSVTSLPF VDTKGKKNTVSFPHISKKVL LKSSLLYQENQAHNQM in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_057133 | 1 | M → MQLLPPPIRTGTKTQMDAKK PRKCDLTPFLVLKARKKQKF TSAKGPTLSEIYMVGSKLSV QIQKPPSNIKNSRMTQVFHK NTSVTSLPFVDTKGKKNTVS FPHISKKVLLKSSLLYQENQ AHNQM in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_057134 | 380 – 382 | Missing in isoform 5. 1 Publication | 3 | |
Alternative sequenceiVSP_013745 | 441 | Missing in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF263541 mRNA Translation: AAF91393.1 Different initiation. AK292322 mRNA Translation: BAF85011.1 AK308260 mRNA No translation available. BC031244 mRNA Translation: AAH31244.1 Y09305 mRNA Translation: CAA70488.1 |
CCDSi | CCDS8530.1 [Q9NR20-1] |
RefSeqi | NP_003836.1, NM_003845.2 [Q9NR20-1] |
Genome annotation databases
Ensembli | ENST00000010132; ENSP00000010132; ENSG00000010219 ENST00000540757; ENSP00000441755; ENSG00000010219 |
GeneIDi | 8798 |
KEGGi | hsa:8798 |
UCSCi | uc001qmx.5, human [Q9NR20-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF263541 mRNA Translation: AAF91393.1 Different initiation. AK292322 mRNA Translation: BAF85011.1 AK308260 mRNA No translation available. BC031244 mRNA Translation: AAH31244.1 Y09305 mRNA Translation: CAA70488.1 |
CCDSi | CCDS8530.1 [Q9NR20-1] |
RefSeqi | NP_003836.1, NM_003845.2 [Q9NR20-1] |
3D structure databases
SMRi | Q9NR20 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114326, 16 interactors |
IntActi | Q9NR20, 14 interactors |
STRINGi | 9606.ENSP00000441755 |
Chemistry databases
BindingDBi | Q9NR20 |
ChEMBLi | CHEMBL1075115 |
GuidetoPHARMACOLOGYi | 2013 |
PTM databases
iPTMneti | Q9NR20 |
PhosphoSitePlusi | Q9NR20 |
Genetic variation databases
BioMutai | DYRK4 |
DMDMi | 68566308 |
Proteomic databases
EPDi | Q9NR20 |
jPOSTi | Q9NR20 |
MassIVEi | Q9NR20 |
MaxQBi | Q9NR20 |
PaxDbi | Q9NR20 |
PeptideAtlasi | Q9NR20 |
PRIDEi | Q9NR20 |
ProteomicsDBi | 82254 [Q9NR20-1] 82255 [Q9NR20-2] |
Protocols and materials databases
Antibodypediai | 22291, 293 antibodies from 28 providers |
DNASUi | 8798 |
Genome annotation databases
Ensembli | ENST00000010132; ENSP00000010132; ENSG00000010219 ENST00000540757; ENSP00000441755; ENSG00000010219 |
GeneIDi | 8798 |
KEGGi | hsa:8798 |
UCSCi | uc001qmx.5, human [Q9NR20-1] |
Organism-specific databases
CTDi | 8798 |
DisGeNETi | 8798 |
GeneCardsi | DYRK4 |
HGNCi | HGNC:3095, DYRK4 |
HPAi | ENSG00000010219, Tissue enhanced (testis) |
MIMi | 609181, gene |
neXtProti | NX_Q9NR20 |
OpenTargetsi | ENSG00000010219 |
PharmGKBi | PA27552 |
VEuPathDBi | HostDB:ENSG00000010219 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0667, Eukaryota |
GeneTreei | ENSGT00940000159401 |
HOGENOMi | CLU_000288_5_9_1 |
InParanoidi | Q9NR20 |
OrthoDBi | 870358at2759 |
PhylomeDBi | Q9NR20 |
TreeFami | TF314624 |
Enzyme and pathway databases
BRENDAi | 2.7.12.1, 2681 |
PathwayCommonsi | Q9NR20 |
SignaLinki | Q9NR20 |
SIGNORi | Q9NR20 |
Miscellaneous databases
BioGRID-ORCSi | 8798, 4 hits in 1077 CRISPR screens |
ChiTaRSi | DYRK4, human |
GenomeRNAii | 8798 |
Pharosi | Q9NR20, Tchem |
PROi | PR:Q9NR20 |
RNActi | Q9NR20, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000010219, Expressed in left testis and 214 other tissues |
ExpressionAtlasi | Q9NR20, baseline and differential |
Genevisiblei | Q9NR20, HS |
Family and domain databases
Gene3Di | 3.30.10.30, 1 hit |
InterProi | View protein in InterPro IPR042521, DYRK IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DYRK4_HUMAN | |
Accessioni | Q9NR20Primary (citable) accession number: Q9NR20 Secondary accession number(s): A8K8F7, Q8NEF2, Q92631 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 23, 2022 | |
This is version 180 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families