DYRK4

Functionⁱ

Possible non-essential role in spermiogenesis.By similarity

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Cofactorⁱ

Mg²⁺By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	133	ATP		1
Active siteⁱ	230	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	110 – 118	ATPPROSITE-ProRule annotation		9
Nucleotide bindingⁱ	183 – 186	ATPPROSITE-ProRule annotation		4

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
protein serine/threonine kinase activity Source: UniProtKB-KW
protein tyrosine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q9NR20

SignaLinkⁱ

Q9NR20

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC:2.7.12.1)
Gene namesⁱ	Name:DYRK4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000010219.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3095 DYRK4
MIMⁱ	609181 gene
neXtProtⁱ	NX_Q9NR20

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	133	K → R: Loss of kinase activity. 1 Publication		1
Mutagenesisⁱ	264	Y → F: Abolishes kinase activity. 1 Publication		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000010219
PharmGKBⁱ	PA27552

Chemistry databases

ChEMBLⁱ	CHEMBL1075115
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2013

Polymorphism and mutation databases

BioMutaⁱ	DYRK4
DMDMⁱ	68566308

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000085940	1 – 520	Dual specificity tyrosine-phosphorylation-regulated kinase 4Add BLAST		520

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	264	Phosphotyrosine; by autocatalysis1 Publication		1

Post-translational modificationⁱ

Autophosphorylation on Tyr-264 in the activation loop is required for kinase activity.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9NR20
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NR20
PaxDbⁱ	Q9NR20
PeptideAtlas More...PeptideAtlasⁱ	Q9NR20
PRIDEⁱ	Q9NR20
ProteomicsDBⁱ	82254 82255 [Q9NR20-2]

PTM databases

iPTMnetⁱ	Q9NR20
PhosphoSitePlusⁱ	Q9NR20

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000010219 Expressed in 201 organ(s), highest expression level in left testis
CleanExⁱ	HS_DYRK4
ExpressionAtlasⁱ	Q9NR20 baseline and differential
Genevisibleⁱ	Q9NR20 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028065 HPA056073

HPAⁱ

HPA028065
HPA056073

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DYRK2	Q92630	3	EBI-3914009,EBI-749432
MID1	O15344	3	EBI-3914009,EBI-2340316

Protein-protein interaction databases

BioGridⁱ	114326, 16 interactors
IntActⁱ	Q9NR20, 13 interactors
STRINGⁱ	9606.ENSP00000010132

Chemistry databases

BindingDBⁱ

Q9NR20

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NR20
SMRⁱ	Q9NR20
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	104 – 400	Protein kinasePROSITE-ProRule annotationAdd BLAST		297

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0667 Eukaryota ENOG410XPET LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119032
HOGENOMⁱ	HOG000220863
HOVERGENⁱ	HBG051426
InParanoidⁱ	Q9NR20
KEGG Orthology (KO) More...KOⁱ	K18669
PhylomeDBⁱ	Q9NR20
TreeFamⁱ	TF314624

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NR20-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS 
        60         70         80         90        100
PYEQSEILGY AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI 
       110        120        130        140        150
AYRYEVLETI GKGSFGQVAK CLDHKNNELV ALKIIRNKKR FHQQALMELK 
       160        170        180        190        200
ILEALRKKDK DNTYNVVHMK DFFYFRNHFC ITFELLGINL YELMKNNNFQ 
       210        220        230        240        250
GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ KGQASVKVID 
       260        270        280        290        300
FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 
       310        320        330        340        350
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN 
       360        370        380        390        400
RGKKRYPDSK DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI 
       410        420        430        440        450
HQSRNLKPQP RPQTLRKSNS FFPSETRKDK VQGCHHSSRK ADEITKETTE 
       460        470        480        490        500
KTKDSPTKHV QHSGDQQDCL QHGADTVQLP QLVDAPKKSE AAVGAEVSMT 
       510        520
SPGQSKNFSL KNTNVLPPIV

Note: May be due to a competing acceptor splice site. No experimental confirmation available.

Length:520

Mass (Da):59,608

Last modified:May 10, 2005 - v2

Checksum:ⁱ33FECD8249DDB223

GO

Isoform 2 (identifier: Q9NR20-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
441-441: Missing.

« Hide

        10         20         30         40         50
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS 
        60         70         80         90        100
PYEQSEILGY AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI 
       110        120        130        140        150
AYRYEVLETI GKGSFGQVAK CLDHKNNELV ALKIIRNKKR FHQQALMELK 
       160        170        180        190        200
ILEALRKKDK DNTYNVVHMK DFFYFRNHFC ITFELLGINL YELMKNNNFQ 
       210        220        230        240        250
GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ KGQASVKVID 
       260        270        280        290        300
FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 
       310        320        330        340        350
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN 
       360        370        380        390        400
RGKKRYPDSK DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI 
       410        420        430        440        450
HQSRNLKPQP RPQTLRKSNS FFPSETRKDK VQGCHHSSRK DEITKETTEK 
       460        470        480        490        500
TKDSPTKHVQ HSGDQQDCLQ HGADTVQLPQ LVDAPKKSEA AVGAEVSMTS 
       510 
PGQSKNFSLK NTNVLPPIV

Show »

Length:519

Mass (Da):59,537

Checksum:ⁱ2ACD1BC87AA1591B

GO

Isoform 3 (identifier: Q9NR20-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MQLLPPPIRT...YQENQAHNQM

« Hide

        10         20         30         40         50
MQLLPPPIRT GTKTQMDAKK PRKCDLTPFL VLKARKKQKF TSAKVGSKLS 
        60         70         80         90        100
VQIQKPPSNI KNSRMTQVFH KNTSVTSLPF VDTKGKKNTV SFPHISKKVL 
       110        120        130        140        150
LKSSLLYQEN QAHNQMPASE LKASEIPFHP SIKTQDPKAE EKSPKKQKVT 
       160        170        180        190        200
LTAAEALKLF KNQLSPYEQS EILGYAELWF LGLEAKKLDT APEKFSKTSF 
       210        220        230        240        250
DDEHGFYLKV LHDHIAYRYE VLETIGKGSF GQVAKCLDHK NNELVALKII 
       260        270        280        290        300
RNKKRFHQQA LMELKILEAL RKKDKDNTYN VVHMKDFFYF RNHFCITFEL 
       310        320        330        340        350
LGINLYELMK NNNFQGFSLS IVRRFTLSVL KCLQMLSVEK IIHCDLKPEN 
       360        370        380        390        400
IVLYQKGQAS VKVIDFGSSC YEHQKVYTYI QSRFYRSPEV ILGHPYDVAI 
       410        420        430        440        450
DMWSLGCITA ELYTGYPLFP GENEVEQLAC IMEVLGLPPA GFIQTASRRQ 
       460        470        480        490        500
TFFDSKGFPK NITNNRGKKR YPDSKDLTMV LKTYDTSFLD FLRRCLVWEP 
       510        520        530        540        550
SLRMTPDQAL KHAWIHQSRN LKPQPRPQTL RKSNSFFPSE TRKDKVQGCH 
       560        570        580        590        600
HSSRKADEIT KETTEKTKDS PTKHVQHSGD QQDCLQHGAD TVQLPQLVDA 
       610        620        630 
PKKSEAAVGA EVSMTSPGQS KNFSLKNTNV LPPIV

Note: No experimental confirmation available.

Show »

Length:635

Mass (Da):72,577

Checksum:ⁱ42F432C350F65F2D

GO

Isoform 4 (identifier: Q9NR20-4) [UniParc]FASTA Add to basket

Also known as: DYRK4-L

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MQLLPPPIRT...YQENQAHNQM

« Hide

        10         20         30         40         50
MQLLPPPIRT GTKTQMDAKK PRKCDLTPFL VLKARKKQKF TSAKGPTLSE 
        60         70         80         90        100
IYMVGSKLSV QIQKPPSNIK NSRMTQVFHK NTSVTSLPFV DTKGKKNTVS 
       110        120        130        140        150
FPHISKKVLL KSSLLYQENQ AHNQMPASEL KASEIPFHPS IKTQDPKAEE 
       160        170        180        190        200
KSPKKQKVTL TAAEALKLFK NQLSPYEQSE ILGYAELWFL GLEAKKLDTA 
       210        220        230        240        250
PEKFSKTSFD DEHGFYLKVL HDHIAYRYEV LETIGKGSFG QVAKCLDHKN 
       260        270        280        290        300
NELVALKIIR NKKRFHQQAL MELKILEALR KKDKDNTYNV VHMKDFFYFR 
       310        320        330        340        350
NHFCITFELL GINLYELMKN NNFQGFSLSI VRRFTLSVLK CLQMLSVEKI 
       360        370        380        390        400
IHCDLKPENI VLYQKGQASV KVIDFGSSCY EHQKVYTYIQ SRFYRSPEVI 
       410        420        430        440        450
LGHPYDVAID MWSLGCITAE LYTGYPLFPG ENEVEQLACI MEVLGLPPAG 
       460        470        480        490        500
FIQTASRRQT FFDSKGFPKN ITNNRGKKRY PDSKDLTMVL KTYDTSFLDF 
       510        520        530        540        550
LRRCLVWEPS LRMTPDQALK HAWIHQSRNL KPQPRPQTLR KSNSFFPSET 
       560        570        580        590        600
RKDKVQGCHH SSRKADEITK ETTEKTKDSP TKHVQHSGDQ QDCLQHGADT 
       610        620        630        640 
VQLPQLVDAP KKSEAAVGAE VSMTSPGQSK NFSLKNTNVL PPIV

Note: Contains a bipartite nuclear localization signal at positions 19-37.1 Publication

Show »

Length:644

Mass (Da):73,569

Checksum:ⁱ688041E86A28626C

GO

Isoform 5 (identifier: Q9NR20-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
380-382: Missing.

« Hide

        10         20         30         40         50
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS 
        60         70         80         90        100
PYEQSEILGY AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI 
       110        120        130        140        150
AYRYEVLETI GKGSFGQVAK CLDHKNNELV ALKIIRNKKR FHQQALMELK 
       160        170        180        190        200
ILEALRKKDK DNTYNVVHMK DFFYFRNHFC ITFELLGINL YELMKNNNFQ 
       210        220        230        240        250
GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ KGQASVKVID 
       260        270        280        290        300
FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 
       310        320        330        340        350
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN 
       360        370        380        390        400
RGKKRYPDSK DLTMVLKTYD TSFLDFLRRW EPSLRMTPDQ ALKHAWIHQS 
       410        420        430        440        450
RNLKPQPRPQ TLRKSNSFFP SETRKDKVQG CHHSSRKADE ITKETTEKTK 
       460        470        480        490        500
DSPTKHVQHS GDQQDCLQHG ADTVQLPQLV DAPKKSEAAV GAEVSMTSPG 
       510 
QSKNFSLKNT NVLPPIV

Note: Due to an alternative splicing donor site in exon 19. Markedly reduced enzymatic activity.1 Publication

Show »

Length:517

Mass (Da):59,293

Checksum:ⁱ0C076681A026AC27

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0A0MTH5	A0A0A0MTH5_HUMAN	Dual-specificity tyrosine-phosphory... Dual-specificity tyrosine-phosphorylation-regulated kinase 4	DYRK4	634	Annotation score:
H0YFI4	H0YFI4_HUMAN	Dual-specificity tyrosine-phosphory... Dual-specificity tyrosine-phosphorylation-regulated kinase 4	DYRK4	120	Annotation score:
F5H4X6	F5H4X6_HUMAN	Dual-specificity tyrosine-phosphory... Dual-specificity tyrosine-phosphorylation-regulated kinase 4	DYRK4	59	Annotation score:
F5H3D3	F5H3D3_HUMAN	Dual-specificity tyrosine-phosphory... Dual-specificity tyrosine-phosphorylation-regulated kinase 4	DYRK4	43	Annotation score:
F5GWS4	F5GWS4_HUMAN	Dual-specificity tyrosine-phosphory... Dual-specificity tyrosine-phosphorylation-regulated kinase 4	DYRK4	68	Annotation score:

Sequence cautionⁱ

The sequence AAF91393 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AK308260 differs from that shown. Reason: Frameshift at position 470.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	165	N → I in BAF85011 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_033900	61	A → T. Corresponds to variant dbSNP:rs12306130Ensembl.	1
Natural variantⁱVAR_040465	70	A → S1 Publication	1
Natural variantⁱVAR_010721	95	V → I1 PublicationCorresponds to variant dbSNP:rs746486416Ensembl.	1
Natural variantⁱVAR_010722	189	N → S1 PublicationCorresponds to variant dbSNP:rs3741927Ensembl.	1
Natural variantⁱVAR_014948	454	D → V. Corresponds to variant dbSNP:rs1801016Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_057132	1	M → MQLLPPPIRTGTKTQMDAKK PRKCDLTPFLVLKARKKQKF TSAKVGSKLSVQIQKPPSNI KNSRMTQVFHKNTSVTSLPF VDTKGKKNTVSFPHISKKVL LKSSLLYQENQAHNQM in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_057133	1	M → MQLLPPPIRTGTKTQMDAKK PRKCDLTPFLVLKARKKQKF TSAKGPTLSEIYMVGSKLSV QIQKPPSNIKNSRMTQVFHK NTSVTSLPFVDTKGKKNTVS FPHISKKVLLKSSLLYQENQ AHNQM in isoform 4. 1 Publication	1
Alternative sequenceⁱVSP_057134	380 – 382	Missing in isoform 5. 1 Publication	3
Alternative sequenceⁱVSP_013745	441	Missing in isoform 2. 2 Publications	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF263541 mRNA Translation: AAF91393.1 Different initiation. AK292322 mRNA Translation: BAF85011.1 AK308260 mRNA No translation available. BC031244 mRNA Translation: AAH31244.1 Y09305 mRNA Translation: CAA70488.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8530.1 [Q9NR20-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_003836.1, NM_003845.2 [Q9NR20-1]
UniGeneⁱ	Hs.439530

Genome annotation databases

Ensemblⁱ	ENST00000010132; ENSP00000010132; ENSG00000010219 [Q9NR20-1] ENST00000540757; ENSP00000441755; ENSG00000010219 [Q9NR20-1]
GeneIDⁱ	8798
KEGGⁱ	hsa:8798
UCSC genome browser More...UCSCⁱ	uc001qmx.5 human [Q9NR20-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NR20	Isoform 4 of Dual specificity tyrosine-phosphorylation-regulated kinase 4		HUMAN		644	UniRef100_Q9NR20
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 (Fragment)		HUMAN		254
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 (Fragment)		HUMAN		247
cDNA FLJ60811, highly similar to Dual specificitytyrosine-phosphorylation-regulated kinase 4		HUMAN		157
UPI00038F238B		HUMAN		234
Q9NR20-2	Dual-specificity tyrosine-phosphorylation-regulated kinase 4		HUMAN		634	UniRef100_A0A0A0MTH5
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 (Fragment)		HUMAN		178
cDNA FLJ61032, highly similar to Dual specific itytyrosine-phosphorylation-regulated kinase 4		HUMAN		233

Protein	Similar proteins		Species	Score	Length	Source
Q9NR20	Isoform 4 of Dual specificity tyrosine-phosphorylation-regulated kinase 4		HUMAN		644	UniRef90_Q9NR20
DYRK4 isoform 1		PONAB		634
Dual specificity tyrosine phosphorylation regulated kinase 4		PANTR		634
Uncharacterized protein		GORGO		634
Uncharacterized protein		PANPA		547
+40

Protein	Similar proteins		Species	Score	Length	Source
Q9NR20	Isoform 4 of Dual specificity tyrosine-phosphorylation-regulated kinase 4		HUMAN		644	UniRef50_Q9NR20
DYRK4 isoform 1		PONAB		634
Uncharacterized protein		GORGO		634
Dual specificity tyrosine phosphorylation regulated kinase 4		PANTR		634
Uncharacterized protein		PANPA		547
+239

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF263541 mRNA Translation: AAF91393.1 Different initiation. AK292322 mRNA Translation: BAF85011.1 AK308260 mRNA No translation available. BC031244 mRNA Translation: AAH31244.1 Y09305 mRNA Translation: CAA70488.1
CCDSⁱ	CCDS8530.1 [Q9NR20-1]
RefSeqⁱ	NP_003836.1, NM_003845.2 [Q9NR20-1]
UniGeneⁱ	Hs.439530

3D structure databases

ProteinModelPortalⁱ	Q9NR20
SMRⁱ	Q9NR20
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114326, 16 interactors
IntActⁱ	Q9NR20, 13 interactors
STRINGⁱ	9606.ENSP00000010132

Chemistry databases

BindingDBⁱ	Q9NR20
ChEMBLⁱ	CHEMBL1075115
GuidetoPHARMACOLOGYⁱ	2013

PTM databases

iPTMnetⁱ	Q9NR20
PhosphoSitePlusⁱ	Q9NR20

Polymorphism and mutation databases

BioMutaⁱ	DYRK4
DMDMⁱ	68566308

Proteomic databases

EPDⁱ	Q9NR20
MaxQBⁱ	Q9NR20
PaxDbⁱ	Q9NR20
PeptideAtlasⁱ	Q9NR20
PRIDEⁱ	Q9NR20
ProteomicsDBⁱ	82254 82255 [Q9NR20-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8798
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000010132; ENSP00000010132; ENSG00000010219 [Q9NR20-1] ENST00000540757; ENSP00000441755; ENSG00000010219 [Q9NR20-1]
GeneIDⁱ	8798
KEGGⁱ	hsa:8798
UCSCⁱ	uc001qmx.5 human [Q9NR20-1]

Organism-specific databases

CTDⁱ	8798
EuPathDBⁱ	HostDB:ENSG00000010219.13
GeneCardsⁱ	DYRK4
HGNCⁱ	HGNC:3095 DYRK4
HPAⁱ	HPA028065 HPA056073
MIMⁱ	609181 gene
neXtProtⁱ	NX_Q9NR20
OpenTargetsⁱ	ENSG00000010219
PharmGKBⁱ	PA27552
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0667 Eukaryota ENOG410XPET LUCA
GeneTreeⁱ	ENSGT00760000119032
HOGENOMⁱ	HOG000220863
HOVERGENⁱ	HBG051426
InParanoidⁱ	Q9NR20
KOⁱ	K18669
PhylomeDBⁱ	Q9NR20
TreeFamⁱ	TF314624

Enzyme and pathway databases

SignaLinkⁱ	Q9NR20

SignaLinkⁱ

Q9NR20

Miscellaneous databases

GenomeRNAiⁱ	8798
Protein Ontology More...PROⁱ	PR:Q9NR20
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000010219 Expressed in 201 organ(s), highest expression level in left testis
CleanExⁱ	HS_DYRK4
ExpressionAtlasⁱ	Q9NR20 baseline and differential
Genevisibleⁱ	Q9NR20 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DYRK4_HUMAN
Accessionⁱ	Q9NR20Primary (citable) accession number: Q9NR20 Secondary accession number(s): A8K8F7, Q8NEF2, Q92631
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	May 10, 2005
	Last modified:	September 12, 2018
	This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9NR20 (DYRK4_HUMAN)

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Dual specificity tyrosine-phosphorylation-regulated kinase 4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ