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UniProtKB - Q9NR20 (DYRK4_HUMAN)

Entry version 177 (07 Apr 2021)
Sequence version 2 (10 May 2005)
Previous versions | rss
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Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 4

Gene

DYRK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possible non-essential role in spermiogenesis.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei133ATP1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei230Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi110 – 118ATPPROSITE-ProRule annotation9
Nucleotide bindingi183 – 186ATPPROSITE-ProRule annotation4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NR20

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NR20

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NR20

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC:2.7.12.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DYRK4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3095, DYRK4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609181, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NR20

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000010219.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi133K → R: Loss of kinase activity. 1 Publication1
Mutagenesisi264Y → F: Abolishes kinase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		8798

Open Targets

More...OpenTargetsi		ENSG00000010219

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27552

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NR20, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1075115

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2013

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DYRK4

Domain mapping of disease mutations (DMDM)

More...DMDMi		68566308

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000859401 – 520Dual specificity tyrosine-phosphorylation-regulated kinase 4Add BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei264Phosphotyrosine; by autocatalysis1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylation on Tyr-264 in the activation loop is required for kinase activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NR20

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NR20

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NR20

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NR20

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NR20

PeptideAtlas

More...PeptideAtlasi		Q9NR20

PRoteomics IDEntifications database

More...PRIDEi		Q9NR20

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82254 [Q9NR20-1]
82255 [Q9NR20-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NR20

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NR20

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000010219, Expressed in left testis and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NR20, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NR20, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000010219, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114326, 16 interactors

Protein interaction database and analysis system

More...IntActi		Q9NR20, 14 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000441755

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NR20

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NR20, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NR20

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini104 – 400Protein kinasePROSITE-ProRule annotationAdd BLAST297

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 4 (identifier: Q9NR20-4)
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi19 – 37Bipartite nuclear localization signal1 PublicationAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0667, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159401

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_5_9_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NR20

Identification of Orthologs from Complete Genome Data

More...OMAi		THNVVHM

Database of Orthologous Groups

More...OrthoDBi		870358at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NR20

TreeFam database of animal gene trees

More...TreeFami		TF314624

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.8.980, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR042521, DYRK
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NR20-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS 
        60         70         80         90        100
PYEQSEILGY AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI 
       110        120        130        140        150
AYRYEVLETI GKGSFGQVAK CLDHKNNELV ALKIIRNKKR FHQQALMELK 
       160        170        180        190        200
ILEALRKKDK DNTYNVVHMK DFFYFRNHFC ITFELLGINL YELMKNNNFQ 
       210        220        230        240        250
GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ KGQASVKVID 
       260        270        280        290        300
FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 
       310        320        330        340        350
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN 
       360        370        380        390        400
RGKKRYPDSK DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI 
       410        420        430        440        450
HQSRNLKPQP RPQTLRKSNS FFPSETRKDK VQGCHHSSRK ADEITKETTE 
       460        470        480        490        500
KTKDSPTKHV QHSGDQQDCL QHGADTVQLP QLVDAPKKSE AAVGAEVSMT 
       510        520
SPGQSKNFSL KNTNVLPPIV
Note: May be due to a competing acceptor splice site.
Length:520
Mass (Da):59,608
Last modified:May 10, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33FECD8249DDB223
GO
Isoform 2 (identifier: Q9NR20-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     441-441: Missing.

Show »
Length:519
Mass (Da):59,537
Checksum:i2ACD1BC87AA1591B
GO
Isoform 3 (identifier: Q9NR20-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQLLPPPIRT...YQENQAHNQM

Show »
Length:635
Mass (Da):72,577
Checksum:i42F432C350F65F2D
GO
Isoform 4 (identifier: Q9NR20-4) [UniParc]FASTAAdd to basket
Also known as: DYRK4-L

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQLLPPPIRT...YQENQAHNQM

Show »
Length:644
Mass (Da):73,569
Checksum:i688041E86A28626C
GO
Isoform 5 (identifier: Q9NR20-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-382: Missing.

Note: Due to an alternative splicing donor site in exon 19. Markedly reduced enzymatic activity.1 Publication
Show »
Length:517
Mass (Da):59,293
Checksum:i0C076681A026AC27
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MTH5A0A0A0MTH5_HUMAN
Dual-specificity kinase
DYRK4
634Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFI4H0YFI4_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK4
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWS4F5GWS4_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK4
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H4X6F5H4X6_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK4
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H3D3F5H3D3_HUMAN
Dual-specificity tyrosine-phosphory...
DYRK4
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF91393 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK308260 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti165N → I in BAF85011 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03390061A → T. Corresponds to variant dbSNP:rs12306130Ensembl.1
Natural variantiVAR_04046570A → S1 Publication1
Natural variantiVAR_01072195V → I1 PublicationCorresponds to variant dbSNP:rs746486416Ensembl.1
Natural variantiVAR_010722189N → S1 PublicationCorresponds to variant dbSNP:rs3741927Ensembl.1
Natural variantiVAR_014948454D → V. Corresponds to variant dbSNP:rs1801016Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0571321M → MQLLPPPIRTGTKTQMDAKK PRKCDLTPFLVLKARKKQKF TSAKVGSKLSVQIQKPPSNI KNSRMTQVFHKNTSVTSLPF VDTKGKKNTVSFPHISKKVL LKSSLLYQENQAHNQM in isoform 3. 1 Publication1
Alternative sequenceiVSP_0571331M → MQLLPPPIRTGTKTQMDAKK PRKCDLTPFLVLKARKKQKF TSAKGPTLSEIYMVGSKLSV QIQKPPSNIKNSRMTQVFHK NTSVTSLPFVDTKGKKNTVS FPHISKKVLLKSSLLYQENQ AHNQM in isoform 4. 1 Publication1
Alternative sequenceiVSP_057134380 – 382Missing in isoform 5. 1 Publication3
Alternative sequenceiVSP_013745441Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF263541 mRNA Translation: AAF91393.1 Different initiation.
AK292322 mRNA Translation: BAF85011.1
AK308260 mRNA No translation available.
BC031244 mRNA Translation: AAH31244.1
Y09305 mRNA Translation: CAA70488.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8530.1 [Q9NR20-1]

NCBI Reference Sequences

More...RefSeqi		NP_003836.1, NM_003845.2 [Q9NR20-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000010132; ENSP00000010132; ENSG00000010219 [Q9NR20-1]
ENST00000540757; ENSP00000441755; ENSG00000010219 [Q9NR20-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8798

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8798

UCSC genome browser

More...UCSCi		uc001qmx.5, human [Q9NR20-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263541 mRNA Translation: AAF91393.1 Different initiation.
AK292322 mRNA Translation: BAF85011.1
AK308260 mRNA No translation available.
BC031244 mRNA Translation: AAH31244.1
Y09305 mRNA Translation: CAA70488.1
CCDSiCCDS8530.1 [Q9NR20-1]
RefSeqiNP_003836.1, NM_003845.2 [Q9NR20-1]

3D structure databases

SMRiQ9NR20
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114326, 16 interactors
IntActiQ9NR20, 14 interactors
STRINGi9606.ENSP00000441755

Chemistry databases

BindingDBiQ9NR20
ChEMBLiCHEMBL1075115
GuidetoPHARMACOLOGYi2013

PTM databases

iPTMnetiQ9NR20
PhosphoSitePlusiQ9NR20

Genetic variation databases

BioMutaiDYRK4
DMDMi68566308

Proteomic databases

EPDiQ9NR20
jPOSTiQ9NR20
MassIVEiQ9NR20
MaxQBiQ9NR20
PaxDbiQ9NR20
PeptideAtlasiQ9NR20
PRIDEiQ9NR20
ProteomicsDBi82254 [Q9NR20-1]
82255 [Q9NR20-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22291, 285 antibodies

The DNASU plasmid repository

More...DNASUi		8798

Genome annotation databases

EnsembliENST00000010132; ENSP00000010132; ENSG00000010219 [Q9NR20-1]
ENST00000540757; ENSP00000441755; ENSG00000010219 [Q9NR20-1]
GeneIDi8798
KEGGihsa:8798
UCSCiuc001qmx.5, human [Q9NR20-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8798
DisGeNETi8798

GeneCards: human genes, protein and diseases

More...GeneCardsi		DYRK4
HGNCiHGNC:3095, DYRK4
HPAiENSG00000010219, Tissue enriched (testis)
MIMi609181, gene
neXtProtiNX_Q9NR20
OpenTargetsiENSG00000010219
PharmGKBiPA27552
VEuPathDBiHostDB:ENSG00000010219.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0667, Eukaryota
GeneTreeiENSGT00940000159401
HOGENOMiCLU_000288_5_9_1
InParanoidiQ9NR20
OMAiTHNVVHM
OrthoDBi870358at2759
PhylomeDBiQ9NR20
TreeFamiTF314624

Enzyme and pathway databases

PathwayCommonsiQ9NR20
SignaLinkiQ9NR20
SIGNORiQ9NR20

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8798, 4 hits in 1024 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DYRK4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8798
PharosiQ9NR20, Tchem

Protein Ontology

More...PROi		PR:Q9NR20
RNActiQ9NR20, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000010219, Expressed in left testis and 214 other tissues
ExpressionAtlasiQ9NR20, baseline and differential
GenevisibleiQ9NR20, HS

Family and domain databases

Gene3Di1.10.8.980, 1 hit
InterProiView protein in InterPro
IPR042521, DYRK
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYRK4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NR20
Secondary accession number(s): A8K8F7, Q8NEF2, Q92631
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 10, 2005
Last modified: April 7, 2021
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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