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Protein

Acetyl-coenzyme A synthetase, cytoplasmic

Gene

ACSS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates acetate so that it can be used for lipid synthesis or for energy generation.

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei363Coenzyme ABy similarity1
Binding sitei552ATPBy similarity1
Binding sitei567ATPBy similarity1
Binding sitei575Coenzyme A; via carbonyl oxygenBy similarity1
Binding sitei636Coenzyme ABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi439 – 441ATPBy similarity3
Nucleotide bindingi463 – 468ATPBy similarity6

GO - Molecular functioni

  • acetate-CoA ligase activity Source: UniProtKB
  • AMP binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS05484-MONOMER
BRENDAi6.2.1.1 2681
ReactomeiR-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-71384 Ethanol oxidation

Chemistry databases

SwissLipidsiSLP:000001167

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetase, cytoplasmic (EC:6.2.1.1)
Alternative name(s):
Acetate--CoA ligase
Acetyl-CoA synthetase
Short name:
ACS
Short name:
AceCS
Acyl-CoA synthetase short-chain family member 2
Acyl-activating enzyme
Gene namesi
Name:ACSS2
Synonyms:ACAS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000131069.19
HGNCiHGNC:15814 ACSS2
MIMi605832 gene
neXtProtiNX_Q9NR19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55902
OpenTargetsiENSG00000131069
PharmGKBiPA24429

Chemistry databases

DrugBankiDB00131 Adenosine monophosphate
DB00171 Adenosine triphosphate
DB09395 Sodium acetate

Polymorphism and mutation databases

BioMutaiACSS2
DMDMi20137525

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002084231 – 701Acetyl-coenzyme A synthetase, cytoplasmicAdd BLAST701

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei263PhosphoserineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei267PhosphoserineCombined sources1
Modified residuei418N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NR19
MaxQBiQ9NR19
PaxDbiQ9NR19
PeptideAtlasiQ9NR19
PRIDEiQ9NR19
ProteomicsDBi82253

PTM databases

iPTMnetiQ9NR19
PhosphoSitePlusiQ9NR19

Expressioni

Gene expression databases

BgeeiENSG00000131069
CleanExiHS_ACSS2
ExpressionAtlasiQ9NR19 baseline and differential
GenevisibleiQ9NR19 HS

Organism-specific databases

HPAiHPA004141

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi120989, 6 interactors
IntActiQ9NR19, 5 interactors
STRINGi9606.ENSP00000253382

Structurei

3D structure databases

ProteinModelPortaliQ9NR19
SMRiQ9NR19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 222Coenzyme A bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1175 Eukaryota
COG0365 LUCA
GeneTreeiENSGT00760000119178
HOGENOMiHOG000229981
HOVERGENiHBG014401
InParanoidiQ9NR19
KOiK01895
OMAiDHWWHDL
OrthoDBiEOG091G039C
PhylomeDBiQ9NR19
TreeFamiTF300417

Family and domain databases

CDDicd05966 ACS, 1 hit
InterProiView protein in InterPro
IPR011904 Ac_CoA_lig
IPR032387 ACAS_N
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF16177 ACAS_N, 1 hit
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
TIGRFAMsiTIGR02188 Ac_CoA_lig_AcsA, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NR19-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLPEERVRS GSGSRGQEEA GAGGRARSWS PPPEVSRSAH VPSLQRYREL
60 70 80 90 100
HRRSVEEPRE FWGDIAKEFY WKTPCPGPFL RYNFDVTKGK IFIEWMKGAT
110 120 130 140 150
TNICYNVLDR NVHEKKLGDK VAFYWEGNEP GETTQITYHQ LLVQVCQFSN
160 170 180 190 200
VLRKQGIQKG DRVAIYMPMI PELVVAMLAC ARIGALHSIV FAGFSSESLC
210 220 230 240 250
ERILDSSCSL LITTDAFYRG EKLVNLKELA DEALQKCQEK GFPVRCCIVV
260 270 280 290 300
KHLGRAELGM GDSTSQSPPI KRSCPDVQIS WNQGIDLWWH ELMQEAGDEC
310 320 330 340 350
EPEWCDAEDP LFILYTSGST GKPKGVVHTV GGYMLYVATT FKYVFDFHAE
360 370 380 390 400
DVFWCTADIG WITGHSYVTY GPLANGATSV LFEGIPTYPD VNRLWSIVDK
410 420 430 440 450
YKVTKFYTAP TAIRLLMKFG DEPVTKHSRA SLQVLGTVGE PINPEAWLWY
460 470 480 490 500
HRVVGAQRCP IVDTFWQTET GGHMLTPLPG ATPMKPGSAT FPFFGVAPAI
510 520 530 540 550
LNESGEELEG EAEGYLVFKQ PWPGIMRTVY GNHERFETTY FKKFPGYYVT
560 570 580 590 600
GDGCQRDQDG YYWITGRIDD MLNVSGHLLS TAEVESALVE HEAVAEAAVV
610 620 630 640 650
GHPHPVKGEC LYCFVTLCDG HTFSPKLTEE LKKQIREKIG PIATPDYIQN
660 670 680 690 700
APGLPKTRSG KIMRRVLRKI AQNDHDLGDM STVADPSVIS HLFSHRCLTI

Q
Length:701
Mass (Da):78,580
Last modified:October 1, 2000 - v1
Checksum:i833580B41B73A8B4
GO
Isoform 2 (identifier: Q9NR19-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     277-277: V → VQGKLKEKSKRVQP

Note: No experimental confirmation available.
Show »
Length:714
Mass (Da):80,087
Checksum:i820E84E62A72E214
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79F → L in BAC03849 (PubMed:14702039).Curated1
Sequence conflicti615V → F in AAH12172 (PubMed:15489334).Curated1
Sequence conflicti680M → L in BAC03849 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046376277V → VQGKLKEKSKRVQP in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263614 mRNA Translation: AAF75064.1
AK092281 mRNA Translation: BAC03849.1
AL133324 Genomic DNA No translation available.
AL049709 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76248.1
BC012172 mRNA Translation: AAH12172.1
CCDSiCCDS13243.1 [Q9NR19-1]
CCDS42868.2 [Q9NR19-2]
RefSeqiNP_001070020.2, NM_001076552.2 [Q9NR19-2]
NP_061147.1, NM_018677.3 [Q9NR19-1]
UniGeneiHs.517034

Genome annotation databases

EnsembliENST00000253382; ENSP00000253382; ENSG00000131069 [Q9NR19-2]
ENST00000360596; ENSP00000353804; ENSG00000131069 [Q9NR19-1]
GeneIDi55902
KEGGihsa:55902
UCSCiuc002xbd.3 human [Q9NR19-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiACSA_HUMAN
AccessioniPrimary (citable) accession number: Q9NR19
Secondary accession number(s): A6NE90
, Q5QPH2, Q5QPH3, Q8N238, Q96EL0, Q9NQP7, Q9UJ15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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