UniProtKB - Q9NR19 (ACSA_HUMAN)

BLAST

>sp|Q9NR19|ACSA_HUMAN Acetyl-coenzyme A synthetase, cytoplasmic OS=Homo sapiens OX=9606 GN=ACSS2 PE=1 SV=1
MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE
FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK
VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC
ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK
GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC
EPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIG
WITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFG
DEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG
ATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTY
FKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVV
GHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSG
KIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ

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History
Entry version 152 (12 Sep 2018)
Sequence version 1 (01 Oct 2000)
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Protein

Acetyl-coenzyme A synthetase, cytoplasmic

Gene

ACSS2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Activates acetate so that it can be used for lipid synthesis or for energy generation.

Catalytic activityⁱ

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	363	Coenzyme ABy similarity	1
Binding siteⁱ	552	ATPBy similarity	1
Binding siteⁱ	567	ATPBy similarity	1
Binding siteⁱ	575	Coenzyme A; via carbonyl oxygenBy similarity	1
Binding siteⁱ	636	Coenzyme ABy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	439 – 441	ATPBy similarity		3
Nucleotide bindingⁱ	463 – 468	ATPBy similarity		6

GO - Molecular functionⁱ

acetate-CoA ligase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10843999
AMP binding
Source: UniProtKB
Inferred by curatorⁱ
- 10843999
ATP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acetate biosynthetic process Source: Ensembl
acetyl-CoA biosynthetic process from acetate Source: InterPro
ethanol oxidation Source: Reactome
lipid biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10843999
propionate biosynthetic process Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ligase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS05484-MONOMER
BRENDAⁱ	6.2.1.1 2681
Reactomeⁱ	R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis R-HSA-71384 Ethanol oxidation

Chemistry databases

SwissLipidsⁱ	SLP:000001167

SwissLipidsⁱ

SLP:000001167

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Acetyl-coenzyme A synthetase, cytoplasmic (EC:6.2.1.1) Alternative name(s): Acetate--CoA ligase Acetyl-CoA synthetase Short name: ACS Short name: AceCS Acyl-CoA synthetase short-chain family member 2 Acyl-activating enzyme
Gene namesⁱ	Name:ACSS2 Synonyms:ACAS2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131069.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15814 ACSS2
MIMⁱ	605832 gene
neXtProtⁱ	NX_Q9NR19

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55902
Open Targets More...OpenTargetsⁱ	ENSG00000131069
PharmGKBⁱ	PA24429

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00131 Adenosine monophosphate DB00171 Adenosine triphosphate DB09395 Sodium acetate

DrugBankⁱ

DB00131 Adenosine monophosphate
DB00171 Adenosine triphosphate
DB09395 Sodium acetate

Polymorphism and mutation databases

BioMutaⁱ	ACSS2
DMDMⁱ	20137525

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000208423	1 – 701	Acetyl-coenzyme A synthetase, cytoplasmicAdd BLAST		701

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	28	PhosphoserineCombined sources	1
Modified residueⁱ	30	PhosphoserineCombined sources	1
Modified residueⁱ	36	PhosphoserineCombined sources	1
Modified residueⁱ	263	PhosphoserineBy similarity	1
Modified residueⁱ	265	PhosphoserineBy similarity	1
Modified residueⁱ	267	PhosphoserineCombined sources	1
Modified residueⁱ	418	N6-acetyllysineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9NR19
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NR19
PaxDbⁱ	Q9NR19
PeptideAtlas More...PeptideAtlasⁱ	Q9NR19
PRIDEⁱ	Q9NR19
ProteomicsDBⁱ	82253

PTM databases

iPTMnetⁱ	Q9NR19
PhosphoSitePlusⁱ	Q9NR19

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000131069 Expressed in 200 organ(s), highest expression level in liver
CleanExⁱ	HS_ACSS2
ExpressionAtlasⁱ	Q9NR19 baseline and differential
Genevisibleⁱ	Q9NR19 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA004141

HPAⁱ

HPA004141

Interactionⁱ

Subunit structureⁱ

Monomer.

Protein-protein interaction databases

BioGridⁱ	120989, 6 interactors
IntActⁱ	Q9NR19, 5 interactors
STRINGⁱ	9606.ENSP00000253382

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NR19
SMRⁱ	Q9NR19
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	219 – 222	Coenzyme A bindingBy similarity		4

Sequence similaritiesⁱ

Belongs to the ATP-dependent AMP-binding enzyme family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1175 Eukaryota COG0365 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119178
HOGENOMⁱ	HOG000229981
HOVERGENⁱ	HBG014401
InParanoidⁱ	Q9NR19
KEGG Orthology (KO) More...KOⁱ	K01895
OMAⁱ	DHWWHDL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G039C
PhylomeDBⁱ	Q9NR19
TreeFamⁱ	TF300417

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05966 ACS, 1 hit
InterProⁱ	View protein in InterPro IPR011904 Ac_CoA_lig IPR032387 ACAS_N IPR025110 AMP-bd_C IPR020845 AMP-binding_CS IPR000873 AMP-dep_Synth/Lig
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16177 ACAS_N, 1 hit PF00501 AMP-binding, 1 hit PF13193 AMP-binding_C, 1 hit
TIGRFAMsⁱ	TIGR02188 Ac_CoA_lig_AcsA, 1 hit
PROSITEⁱ	View protein in PROSITE PS00455 AMP_BINDING, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NR19-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLPEERVRS GSGSRGQEEA GAGGRARSWS PPPEVSRSAH VPSLQRYREL 
        60         70         80         90        100
HRRSVEEPRE FWGDIAKEFY WKTPCPGPFL RYNFDVTKGK IFIEWMKGAT 
       110        120        130        140        150
TNICYNVLDR NVHEKKLGDK VAFYWEGNEP GETTQITYHQ LLVQVCQFSN 
       160        170        180        190        200
VLRKQGIQKG DRVAIYMPMI PELVVAMLAC ARIGALHSIV FAGFSSESLC 
       210        220        230        240        250
ERILDSSCSL LITTDAFYRG EKLVNLKELA DEALQKCQEK GFPVRCCIVV 
       260        270        280        290        300
KHLGRAELGM GDSTSQSPPI KRSCPDVQIS WNQGIDLWWH ELMQEAGDEC 
       310        320        330        340        350
EPEWCDAEDP LFILYTSGST GKPKGVVHTV GGYMLYVATT FKYVFDFHAE 
       360        370        380        390        400
DVFWCTADIG WITGHSYVTY GPLANGATSV LFEGIPTYPD VNRLWSIVDK 
       410        420        430        440        450
YKVTKFYTAP TAIRLLMKFG DEPVTKHSRA SLQVLGTVGE PINPEAWLWY 
       460        470        480        490        500
HRVVGAQRCP IVDTFWQTET GGHMLTPLPG ATPMKPGSAT FPFFGVAPAI 
       510        520        530        540        550
LNESGEELEG EAEGYLVFKQ PWPGIMRTVY GNHERFETTY FKKFPGYYVT 
       560        570        580        590        600
GDGCQRDQDG YYWITGRIDD MLNVSGHLLS TAEVESALVE HEAVAEAAVV 
       610        620        630        640        650
GHPHPVKGEC LYCFVTLCDG HTFSPKLTEE LKKQIREKIG PIATPDYIQN 
       660        670        680        690        700
APGLPKTRSG KIMRRVLRKI AQNDHDLGDM STVADPSVIS HLFSHRCLTI 

Q

Length:701

Mass (Da):78,580

Last modified:October 1, 2000 - v1

Checksum:ⁱ833580B41B73A8B4

Isoform 2 (identifier: Q9NR19-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
277-277: V → VQGKLKEKSKRVQP

« Hide

        10         20         30         40         50
MGLPEERVRS GSGSRGQEEA GAGGRARSWS PPPEVSRSAH VPSLQRYREL 
        60         70         80         90        100
HRRSVEEPRE FWGDIAKEFY WKTPCPGPFL RYNFDVTKGK IFIEWMKGAT 
       110        120        130        140        150
TNICYNVLDR NVHEKKLGDK VAFYWEGNEP GETTQITYHQ LLVQVCQFSN 
       160        170        180        190        200
VLRKQGIQKG DRVAIYMPMI PELVVAMLAC ARIGALHSIV FAGFSSESLC 
       210        220        230        240        250
ERILDSSCSL LITTDAFYRG EKLVNLKELA DEALQKCQEK GFPVRCCIVV 
       260        270        280        290        300
KHLGRAELGM GDSTSQSPPI KRSCPDVQGK LKEKSKRVQP QISWNQGIDL 
       310        320        330        340        350
WWHELMQEAG DECEPEWCDA EDPLFILYTS GSTGKPKGVV HTVGGYMLYV 
       360        370        380        390        400
ATTFKYVFDF HAEDVFWCTA DIGWITGHSY VTYGPLANGA TSVLFEGIPT 
       410        420        430        440        450
YPDVNRLWSI VDKYKVTKFY TAPTAIRLLM KFGDEPVTKH SRASLQVLGT 
       460        470        480        490        500
VGEPINPEAW LWYHRVVGAQ RCPIVDTFWQ TETGGHMLTP LPGATPMKPG 
       510        520        530        540        550
SATFPFFGVA PAILNESGEE LEGEAEGYLV FKQPWPGIMR TVYGNHERFE 
       560        570        580        590        600
TTYFKKFPGY YVTGDGCQRD QDGYYWITGR IDDMLNVSGH LLSTAEVESA 
       610        620        630        640        650
LVEHEAVAEA AVVGHPHPVK GECLYCFVTL CDGHTFSPKL TEELKKQIRE 
       660        670        680        690        700
KIGPIATPDY IQNAPGLPKT RSGKIMRRVL RKIAQNDHDL GDMSTVADPS 
       710 
VISHLFSHRC LTIQ

Note: No experimental confirmation available.

Show »

Length:714

Mass (Da):80,087

Checksum:ⁱ820E84E62A72E214

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JY31	C9JY31_HUMAN	Acetyl-coenzyme A synthetase, cytop... Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	203	Annotation score:
C9IYL0	C9IYL0_HUMAN	Acetyl-coenzyme A synthetase, cytop... Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	182	Annotation score:
C9J7L5	C9J7L5_HUMAN	Acetyl-coenzyme A synthetase, cytop... Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	163	Annotation score:
B4DEH9	B4DEH9_HUMAN	cDNA FLJ53719, highly similar to Ac... cDNA FLJ53719, highly similar to Acetyl-coenzyme A synthetase, cytoplasmic (EC6.2.1.1)	ACSS2	187	Annotation score:
F8WCJ4	F8WCJ4_HUMAN	Acetyl-coenzyme A synthetase, cytop... Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	124	Annotation score:
F8WDJ9	F8WDJ9_HUMAN	Acetyl-coenzyme A synthetase, cytop... Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	74	Annotation score:
C9JXD9	C9JXD9_HUMAN	Acetyl-coenzyme A synthetase, cytop... Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	147	Annotation score:
F8WC73	F8WC73_HUMAN	Acetyl-coenzyme A synthetase, cytop... Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	60	Annotation score:
F8WBQ7	F8WBQ7_HUMAN	Acetyl-coenzyme A synthetase, cytop... Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	37	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	79	F → L in BAC03849 (PubMed:14702039).Curated	1
Sequence conflictⁱ	615	V → F in AAH12172 (PubMed:15489334).Curated	1
Sequence conflictⁱ	680	M → L in BAC03849 (PubMed:14702039).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046376	277	V → VQGKLKEKSKRVQP in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF263614 mRNA Translation: AAF75064.1 AK092281 mRNA Translation: BAC03849.1 AL133324 Genomic DNA No translation available. AL049709 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76248.1 BC012172 mRNA Translation: AAH12172.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13243.1 [Q9NR19-1] CCDS42868.2 [Q9NR19-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001070020.2, NM_001076552.2 [Q9NR19-2] NP_061147.1, NM_018677.3 [Q9NR19-1]
UniGeneⁱ	Hs.517034

Genome annotation databases

Ensemblⁱ	ENST00000253382; ENSP00000253382; ENSG00000131069 [Q9NR19-2] ENST00000360596; ENSP00000353804; ENSG00000131069 [Q9NR19-1]
GeneIDⁱ	55902
KEGGⁱ	hsa:55902
UCSC genome browser More...UCSCⁱ	uc002xbd.3 human [Q9NR19-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NR19	Acetyl-coenzyme A synthetase		HUMAN		606	UniRef100_Q9NR19
Acetyl-coenzyme A synthetase (Fragment)		HUMAN		662

Protein	Similar proteins		Species	Score	Length	Source
Q9NR19	Acetyl-coenzyme A synthetase, cytoplasmic		MOUSE		701	UniRef90_Q9NR19
Acetyl-coenzyme A synthetase		HUMAN		606
ACSS2 isoform 13		PONAB		719
ACSS2 isoform 12		PANTR		719
Acetyl-coenzyme A synthetase, cytoplasmic		MACMU		716
+249

Protein	Similar proteins		Species	Score	Length	Source
Q9NR19	Acetyl-coenzyme A synthetase, cytoplasmic		MOUSE		701	UniRef50_Q9NR19
Acetyl-coenzyme A synthetase		HUMAN		606
ACSS2 isoform 13		PONAB		719
ACSS2 isoform 12		PANTR		719
Acetyl-coenzyme A synthetase, cytoplasmic		MACMU		716
+820

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF263614 mRNA Translation: AAF75064.1 AK092281 mRNA Translation: BAC03849.1 AL133324 Genomic DNA No translation available. AL049709 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76248.1 BC012172 mRNA Translation: AAH12172.1
CCDSⁱ	CCDS13243.1 [Q9NR19-1] CCDS42868.2 [Q9NR19-2]
RefSeqⁱ	NP_001070020.2, NM_001076552.2 [Q9NR19-2] NP_061147.1, NM_018677.3 [Q9NR19-1]
UniGeneⁱ	Hs.517034

3D structure databases

ProteinModelPortalⁱ	Q9NR19
SMRⁱ	Q9NR19
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120989, 6 interactors
IntActⁱ	Q9NR19, 5 interactors
STRINGⁱ	9606.ENSP00000253382

Chemistry databases

DrugBankⁱ	DB00131 Adenosine monophosphate DB00171 Adenosine triphosphate DB09395 Sodium acetate
SwissLipidsⁱ	SLP:000001167

PTM databases

iPTMnetⁱ	Q9NR19
PhosphoSitePlusⁱ	Q9NR19

Polymorphism and mutation databases

BioMutaⁱ	ACSS2
DMDMⁱ	20137525

Proteomic databases

EPDⁱ	Q9NR19
MaxQBⁱ	Q9NR19
PaxDbⁱ	Q9NR19
PeptideAtlasⁱ	Q9NR19
PRIDEⁱ	Q9NR19
ProteomicsDBⁱ	82253

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000253382; ENSP00000253382; ENSG00000131069 [Q9NR19-2] ENST00000360596; ENSP00000353804; ENSG00000131069 [Q9NR19-1]
GeneIDⁱ	55902
KEGGⁱ	hsa:55902
UCSCⁱ	uc002xbd.3 human [Q9NR19-1]

Organism-specific databases

CTDⁱ	55902
DisGeNETⁱ	55902
EuPathDBⁱ	HostDB:ENSG00000131069.19
GeneCardsⁱ	ACSS2
HGNCⁱ	HGNC:15814 ACSS2
HPAⁱ	HPA004141
MIMⁱ	605832 gene
neXtProtⁱ	NX_Q9NR19
OpenTargetsⁱ	ENSG00000131069
PharmGKBⁱ	PA24429
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1175 Eukaryota COG0365 LUCA
GeneTreeⁱ	ENSGT00760000119178
HOGENOMⁱ	HOG000229981
HOVERGENⁱ	HBG014401
InParanoidⁱ	Q9NR19
KOⁱ	K01895
OMAⁱ	DHWWHDL
OrthoDBⁱ	EOG091G039C
PhylomeDBⁱ	Q9NR19
TreeFamⁱ	TF300417

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS05484-MONOMER
BRENDAⁱ	6.2.1.1 2681
Reactomeⁱ	R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis R-HSA-71384 Ethanol oxidation

Miscellaneous databases

ChiTaRSⁱ	ACSS2 human
GeneWikiⁱ	ACSS2
GenomeRNAiⁱ	55902
Protein Ontology More...PROⁱ	PR:Q9NR19
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000131069 Expressed in 200 organ(s), highest expression level in liver
CleanExⁱ	HS_ACSS2
ExpressionAtlasⁱ	Q9NR19 baseline and differential
Genevisibleⁱ	Q9NR19 HS

Family and domain databases

CDDⁱ	cd05966 ACS, 1 hit
InterProⁱ	View protein in InterPro IPR011904 Ac_CoA_lig IPR032387 ACAS_N IPR025110 AMP-bd_C IPR020845 AMP-binding_CS IPR000873 AMP-dep_Synth/Lig
Pfamⁱ	View protein in Pfam PF16177 ACAS_N, 1 hit PF00501 AMP-binding, 1 hit PF13193 AMP-binding_C, 1 hit
TIGRFAMsⁱ	TIGR02188 Ac_CoA_lig_AcsA, 1 hit
PROSITEⁱ	View protein in PROSITE PS00455 AMP_BINDING, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACSA_HUMAN
Accessionⁱ	Q9NR19Primary (citable) accession number: Q9NR19 Secondary accession number(s): A6NE90 Q9UJ15
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 3, 2002
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NR19 (ACSA_HUMAN)

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Acetyl-coenzyme A synthetase, cytoplasmic

ACSS2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Mitochondrion

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ