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UniProtKB - Q9NR11 (ZN302_HUMAN)
Protein
Zinc finger protein 302
Gene
ZNF302
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 280 – 302 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 308 – 330 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 336 – 358 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 364 – 386 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 414 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 420 – 442 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 448 – 470 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9NR11 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q9NR11 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 302Alternative name(s): Zinc finger protein 135-like Zinc finger protein 140-like Zinc finger protein 327 |
Gene namesi | Name:ZNF302 Synonyms:ZNF135L, ZNF140L, ZNF327 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13848, ZNF302 |
neXtProti | NX_Q9NR11 |
VEuPathDBi | HostDB:ENSG00000089335 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55900 |
OpenTargetsi | ENSG00000089335 |
PharmGKBi | PA37820 |
Miscellaneous databases
Pharosi | Q9NR11, Tdark |
Genetic variation databases
BioMutai | ZNF302 |
DMDMi | 23397010 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047522 | 1 – 478 | Zinc finger protein 302Add BLAST | 478 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 183 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q9NR11 |
MassIVEi | Q9NR11 |
MaxQBi | Q9NR11 |
PaxDbi | Q9NR11 |
PeptideAtlasi | Q9NR11 |
PRIDEi | Q9NR11 |
ProteomicsDBi | 82242 [Q9NR11-1] 82243 [Q9NR11-2] |
PTM databases
iPTMneti | Q9NR11 |
PhosphoSitePlusi | Q9NR11 |
Expressioni
Gene expression databases
Bgeei | ENSG00000089335, Expressed in sural nerve and 233 other tissues |
ExpressionAtlasi | Q9NR11, baseline and differential |
Genevisiblei | Q9NR11, HS |
Organism-specific databases
HPAi | ENSG00000089335, Tissue enhanced (brain, choroid plexus) |
Interactioni
Binary interactionsi
Q9NR11
With | #Exp. | IntAct |
---|---|---|
CEP70 [Q8NHQ1] | 4 | EBI-3916142,EBI-739624 |
Isoform 2 [Q9NR11-2]
Protein-protein interaction databases
BioGRIDi | 120987, 20 interactors |
IntActi | Q9NR11, 22 interactors |
MINTi | Q9NR11 |
Miscellaneous databases
RNActi | Q9NR11, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 75 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 280 – 302 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 308 – 330 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 336 – 358 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 364 – 386 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 414 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 420 – 442 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 448 – 470 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161431 |
InParanoidi | Q9NR11 |
OMAi | NHICEKS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9NR11 |
TreeFami | TF337055 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 7 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NR11-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSQVTFSDVA IDFSHEEWAC LDSAQRDLYK DVMVQNYENL VSVGLSVTKP
60 70 80 90 100
YVIMLLEDGK EPWMMEKKLS KAYPFPLSHS VPASVNFGFS ALFEHCSEVT
110 120 130 140 150
EIFELSELCV FWVLHFLSNS PNSTVEAFSR SKKKKKKKKK RQCFAFLIYF
160 170 180 190 200
RLGIKMGKQG IINKEGYLYE DSPQPVTMEK VVKQSYEFSN SNKNLEYTEC
210 220 230 240 250
DTFRSTFHSK STLSEPQNNS AEGNSHKYDI LKKNLSKKSV IKSERINGGK
260 270 280 290 300
KLLNSNKSGA AFNQSKSLTL PQTCNREKIY TCSECGKAFG KQSILSRHWR
310 320 330 340 350
IHTGEKPYEC RECGKTFSHG SSLTRHQISH SGEKPYKCIE CGKAFSHGSS
360 370 380 390 400
LTNHQSTHTG EKPYECMNCG KSFSRVSLLI QHLRIHTQEK RYECRICGKA
410 420 430 440 450
FIHSSSLIHH QKSHTGEKPY ECRECGKAFC CSSHLTQHQR IHSMKKKYEC
460 470
NKCLKVFSSF SFLVQHQSIH TEEKPFEV
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EVR1 | E7EVR1_HUMAN | Zinc finger protein 302 | ZNF302 | 443 | Annotation score: | ||
A0A087WYF4 | A0A087WYF4_HUMAN | Zinc finger protein 302 | ZNF302 | 400 | Annotation score: | ||
D6R9Q0 | D6R9Q0_HUMAN | Zinc finger protein 302 | ZNF302 | 131 | Annotation score: | ||
B4DMN2 | B4DMN2_HUMAN | Zinc finger protein 302 | ZNF302 | 132 | Annotation score: | ||
D6RAM0 | D6RAM0_HUMAN | Zinc finger protein 302 | ZNF302 | 142 | Annotation score: | ||
D6RA23 | D6RA23_HUMAN | Zinc finger protein 302 | ZNF302 | 120 | Annotation score: | ||
V9GYY2 | V9GYY2_HUMAN | Zinc finger protein 302 | ZNF302 | 28 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 451 | N → H in AAF67475 (Ref. 3) Curated | 1 | |
Sequence conflicti | 456 | V → G in AAF67475 (Ref. 3) Curated | 1 | |
Sequence conflicti | 464 | V → G in AAF67475 (Ref. 3) Curated | 1 | |
Sequence conflicti | 472 | E → G in AAF67475 (Ref. 3) Curated | 1 | |
Sequence conflicti | 476 – 478 | FEV → LKFRNAGNPSTSLNH in AAF67475 (Ref. 3) Curated | 3 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006914 | 72 – 169 | AYPFP…EGYLY → DWESRWENKELSTKKDIYD in isoform 2. 4 PublicationsAdd BLAST | 98 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF265236 mRNA Translation: AAF74775.1 AF326206 mRNA Translation: AAK11224.1 AF155656 mRNA Translation: AAF67475.1 AL834318 mRNA Translation: CAD38987.1 BC024176 mRNA Translation: AAH24176.1 |
CCDSi | CCDS46042.1 [Q9NR11-2] |
RefSeqi | NP_001012320.1, NM_001012320.2 [Q9NR11-2] NP_001276110.1, NM_001289181.1 NP_001276111.1, NM_001289182.1 NP_001276112.1, NM_001289183.1 [Q9NR11-2] NP_001276113.1, NM_001289184.1 NP_001276114.1, NM_001289185.1 NP_001276115.1, NM_001289186.1 [Q9NR11-2] NP_001276116.1, NM_001289187.1 [Q9NR11-2] NP_001276117.1, NM_001289188.1 NP_001276118.1, NM_001289189.1 NP_001276119.1, NM_001289190.1 NP_001276120.1, NM_001289191.1 NP_001276121.1, NM_001289192.1 NP_060913.2, NM_018443.3 [Q9NR11-2] NP_061145.2, NM_018675.2 |
Genome annotation databases
Ensembli | ENST00000423823.6; ENSP00000405219.2; ENSG00000089335.22 [Q9NR11-2] ENST00000457781.6; ENSP00000391067.2; ENSG00000089335.22 [Q9NR11-2] ENST00000505242.6; ENSP00000421028.1; ENSG00000089335.22 [Q9NR11-2] |
GeneIDi | 55900 |
KEGGi | hsa:55900 |
MANE-Selecti | ENST00000505242.6; ENSP00000421028.1; NM_001289187.2; NP_001276116.1 [Q9NR11-2] |
UCSCi | uc002nvp.3, human [Q9NR11-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF265236 mRNA Translation: AAF74775.1 AF326206 mRNA Translation: AAK11224.1 AF155656 mRNA Translation: AAF67475.1 AL834318 mRNA Translation: CAD38987.1 BC024176 mRNA Translation: AAH24176.1 |
CCDSi | CCDS46042.1 [Q9NR11-2] |
RefSeqi | NP_001012320.1, NM_001012320.2 [Q9NR11-2] NP_001276110.1, NM_001289181.1 NP_001276111.1, NM_001289182.1 NP_001276112.1, NM_001289183.1 [Q9NR11-2] NP_001276113.1, NM_001289184.1 NP_001276114.1, NM_001289185.1 NP_001276115.1, NM_001289186.1 [Q9NR11-2] NP_001276116.1, NM_001289187.1 [Q9NR11-2] NP_001276117.1, NM_001289188.1 NP_001276118.1, NM_001289189.1 NP_001276119.1, NM_001289190.1 NP_001276120.1, NM_001289191.1 NP_001276121.1, NM_001289192.1 NP_060913.2, NM_018443.3 [Q9NR11-2] NP_061145.2, NM_018675.2 |
3D structure databases
AlphaFoldDBi | Q9NR11 |
SMRi | Q9NR11 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120987, 20 interactors |
IntActi | Q9NR11, 22 interactors |
MINTi | Q9NR11 |
PTM databases
iPTMneti | Q9NR11 |
PhosphoSitePlusi | Q9NR11 |
Genetic variation databases
BioMutai | ZNF302 |
DMDMi | 23397010 |
Proteomic databases
EPDi | Q9NR11 |
MassIVEi | Q9NR11 |
MaxQBi | Q9NR11 |
PaxDbi | Q9NR11 |
PeptideAtlasi | Q9NR11 |
PRIDEi | Q9NR11 |
ProteomicsDBi | 82242 [Q9NR11-1] 82243 [Q9NR11-2] |
Protocols and materials databases
Antibodypediai | 29194, 107 antibodies from 16 providers |
DNASUi | 55900 |
Genome annotation databases
Ensembli | ENST00000423823.6; ENSP00000405219.2; ENSG00000089335.22 [Q9NR11-2] ENST00000457781.6; ENSP00000391067.2; ENSG00000089335.22 [Q9NR11-2] ENST00000505242.6; ENSP00000421028.1; ENSG00000089335.22 [Q9NR11-2] |
GeneIDi | 55900 |
KEGGi | hsa:55900 |
MANE-Selecti | ENST00000505242.6; ENSP00000421028.1; NM_001289187.2; NP_001276116.1 [Q9NR11-2] |
UCSCi | uc002nvp.3, human [Q9NR11-1] |
Organism-specific databases
CTDi | 55900 |
DisGeNETi | 55900 |
GeneCardsi | ZNF302 |
HGNCi | HGNC:13848, ZNF302 |
HPAi | ENSG00000089335, Tissue enhanced (brain, choroid plexus) |
neXtProti | NX_Q9NR11 |
OpenTargetsi | ENSG00000089335 |
PharmGKBi | PA37820 |
VEuPathDBi | HostDB:ENSG00000089335 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161431 |
InParanoidi | Q9NR11 |
OMAi | NHICEKS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9NR11 |
TreeFami | TF337055 |
Enzyme and pathway databases
PathwayCommonsi | Q9NR11 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q9NR11 |
Miscellaneous databases
BioGRID-ORCSi | 55900, 11 hits in 1019 CRISPR screens |
ChiTaRSi | ZNF302, human |
GenomeRNAii | 55900 |
Pharosi | Q9NR11, Tdark |
PROi | PR:Q9NR11 |
RNActi | Q9NR11, protein |
Gene expression databases
Bgeei | ENSG00000089335, Expressed in sural nerve and 233 other tissues |
ExpressionAtlasi | Q9NR11, baseline and differential |
Genevisiblei | Q9NR11, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 7 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN302_HUMAN | |
Accessioni | Q9NR11Primary (citable) accession number: Q9NR11 Secondary accession number(s): Q658J3, Q9BZD8, Q9P0J4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 181 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families