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Protein

Transcriptional and immune response regulator

Gene

TCIM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711). Enhances the proliferation of follicular dendritic cells (PubMed:16730711). Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821). In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084). Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347). However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737).By similarityCurated8 Publications

GO - Molecular functioni

  • Notch binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional and immune response regulatorImported
Alternative name(s):
Thyroid cancer protein 1
Short name:
TC-1
Gene namesi
Name:TCIMImported
Synonyms:C8orf4, TC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000176907.4
HGNCiHGNC:1357 TCIM
MIMi607702 gene
neXtProtiNX_Q9NR00

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi74V → E: No effect on interaction with CBY1. 1 Publication1
Mutagenesisi86K → Q: Abolishes interaction with CBY1. Forms irregular perinuclear cytoplasmic aggregates. 1 Publication1
Mutagenesisi88T → K: Abolishes interaction with CBY1. 1 Publication1
Mutagenesisi96L → R: No effect on interaction with CBY1. Accumulates at nucleoli periphery. 1 Publication1

Organism-specific databases

DisGeNETi56892
OpenTargetsiENSG00000176907
PharmGKBiPA25962

Polymorphism and mutation databases

BioMutaiC8orf4
DMDMi296434443

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000896051 – 106Transcriptional and immune response regulatorAdd BLAST106

Proteomic databases

PaxDbiQ9NR00
PeptideAtlasiQ9NR00
PRIDEiQ9NR00
ProteomicsDBi82240

PTM databases

iPTMnetiQ9NR00
PhosphoSitePlusiQ9NR00

Expressioni

Tissue specificityi

Ubiquitous. Expressed in thyroid papillary carcinoma. Expressed in liver, expression levels decrease in hepatocellular carcinoma (PubMed:25985737). Slightly detected in normal lung, its expression is highly induced in lung cancer cells (at protein level) (PubMed:24941347).3 Publications

Inductioni

Induced by proinflammatory cytokines such as TNF and IL1B, via NF-kappaB signaling (PubMed:16730711, PubMed:19684084). Induced by cellular stresses such as heat shock, TPA, lipopolysaccahride and UV (PubMed:17603013). Induced by mitogens such as thrombin (PubMed:18959821).4 Publications

Gene expression databases

BgeeiENSG00000176907 Expressed in 206 organ(s), highest expression level in parotid gland
CleanExiHS_C8orf4
GenevisibleiQ9NR00 HS

Organism-specific databases

HPAiHPA027188

Interactioni

Subunit structurei

Monomer. Interacts with NOTCH2 (via ANK repeats), the interaction inhibits the nuclear translocation of NOTCH2 N2ICD (PubMed:25985737). Interacts (C-terminus) with CBY1 (C-terminus), TCIM competes with CTNNB1 for the interaction with CBY1 (PubMed:16424001).3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121222, 1 interactor
IntActiQ9NR00, 1 interactor
STRINGi9606.ENSP00000319914

Structurei

3D structure databases

DisProtiDP00372
ProteinModelPortaliQ9NR00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IXNR Eukaryota
ENOG410YPN0 LUCA
GeneTreeiENSGT00390000003458
HOGENOMiHOG000111608
HOVERGENiHBG054954
InParanoidiQ9NR00
OMAiSPSVHGY
OrthoDBiEOG091G0YFM
PhylomeDBiQ9NR00
TreeFamiTF338287

Family and domain databases

InterProiView protein in InterPro
IPR020282 Avpi1/C8orf4_dom
IPR039580 Tcim
PANTHERiPTHR32358 PTHR32358, 1 hit
PfamiView protein in Pfam
PF15063 TC1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD287216 Arg_vasopressin-induced_prot_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NR00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAKRSHQAV IMSTSLRVSP SIHGYHFDTA SRKKAVGNIF ENTDQESLER
60 70 80 90 100
LFRNSGDKKA EERAKIIFAI DQDVEEKTRA LMALKKRTKD KLFQFLKLRK

YSIKVH
Length:106
Mass (Da):12,337
Last modified:May 18, 2010 - v2
Checksum:i2D5C93B7E1E7AE09
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05081910V → I2 PublicationsCorresponds to variant dbSNP:rs6474226Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268037 mRNA Translation: AAF78961.1
AC022733 Genomic DNA No translation available.
BC020623 mRNA Translation: AAH20623.1
BC021672 mRNA Translation: AAH21672.1
CCDSiCCDS6115.1
RefSeqiNP_064515.1, NM_020130.4
UniGeneiHs.591849
Hs.745031

Genome annotation databases

EnsembliENST00000315792; ENSP00000319914; ENSG00000176907
GeneIDi56892
KEGGihsa:56892
UCSCiuc003xnq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268037 mRNA Translation: AAF78961.1
AC022733 Genomic DNA No translation available.
BC020623 mRNA Translation: AAH20623.1
BC021672 mRNA Translation: AAH21672.1
CCDSiCCDS6115.1
RefSeqiNP_064515.1, NM_020130.4
UniGeneiHs.591849
Hs.745031

3D structure databases

DisProtiDP00372
ProteinModelPortaliQ9NR00
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121222, 1 interactor
IntActiQ9NR00, 1 interactor
STRINGi9606.ENSP00000319914

PTM databases

iPTMnetiQ9NR00
PhosphoSitePlusiQ9NR00

Polymorphism and mutation databases

BioMutaiC8orf4
DMDMi296434443

Proteomic databases

PaxDbiQ9NR00
PeptideAtlasiQ9NR00
PRIDEiQ9NR00
ProteomicsDBi82240

Protocols and materials databases

DNASUi56892
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315792; ENSP00000319914; ENSG00000176907
GeneIDi56892
KEGGihsa:56892
UCSCiuc003xnq.3 human

Organism-specific databases

CTDi56892
DisGeNETi56892
EuPathDBiHostDB:ENSG00000176907.4
GeneCardsiTCIM
HGNCiHGNC:1357 TCIM
HPAiHPA027188
MIMi607702 gene
neXtProtiNX_Q9NR00
OpenTargetsiENSG00000176907
PharmGKBiPA25962
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXNR Eukaryota
ENOG410YPN0 LUCA
GeneTreeiENSGT00390000003458
HOGENOMiHOG000111608
HOVERGENiHBG054954
InParanoidiQ9NR00
OMAiSPSVHGY
OrthoDBiEOG091G0YFM
PhylomeDBiQ9NR00
TreeFamiTF338287

Miscellaneous databases

ChiTaRSiC8orf4 human
GeneWikiiC8orf4
GenomeRNAii56892
PROiPR:Q9NR00
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176907 Expressed in 206 organ(s), highest expression level in parotid gland
CleanExiHS_C8orf4
GenevisibleiQ9NR00 HS

Family and domain databases

InterProiView protein in InterPro
IPR020282 Avpi1/C8orf4_dom
IPR039580 Tcim
PANTHERiPTHR32358 PTHR32358, 1 hit
PfamiView protein in Pfam
PF15063 TC1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD287216 Arg_vasopressin-induced_prot_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCIM_HUMAN
AccessioniPrimary (citable) accession number: Q9NR00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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