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UniProtKB - Q9NQZ8 (ZNF71_HUMAN)
Protein
Endothelial zinc finger protein induced by tumor necrosis factor alpha
Gene
ZNF71
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 130 – 152 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 158 – 180 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 186 – 208 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 214 – 236 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 242 – 264 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 270 – 292 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 320 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 326 – 348 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 404 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 410 – 432 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 438 – 460 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 466 – 488 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9NQZ8 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q9NQZ8 |
Names & Taxonomyi
Protein namesi | Recommended name: Endothelial zinc finger protein induced by tumor necrosis factor alphaAlternative name(s): Zinc finger protein 71 |
Gene namesi | Name:ZNF71 Synonyms:EZFIT |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13141, ZNF71 |
MIMi | 194545, gene |
neXtProti | NX_Q9NQZ8 |
VEuPathDBi | HostDB:ENSG00000197951 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 58491 |
OpenTargetsi | ENSG00000197951 |
PharmGKBi | PA37715 |
Miscellaneous databases
Pharosi | Q9NQZ8, Tdark |
Genetic variation databases
BioMutai | ZNF71 |
DMDMi | 21263627 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047381 | 1 – 489 | Endothelial zinc finger protein induced by tumor necrosis factor alphaAdd BLAST | 489 |
Proteomic databases
EPDi | Q9NQZ8 |
MassIVEi | Q9NQZ8 |
MaxQBi | Q9NQZ8 |
PaxDbi | Q9NQZ8 |
PeptideAtlasi | Q9NQZ8 |
PRIDEi | Q9NQZ8 |
ProteomicsDBi | 82239 |
PTM databases
iPTMneti | Q9NQZ8 |
PhosphoSitePlusi | Q9NQZ8 |
Expressioni
Tissue specificityi
Highly expressed in placenta, followed by brain, testis, pancreas, heart, small intestine, muscle, uterus, prostate and peripheral blood leukocytes. Not detected in liver, lung, colon, stomach, salivary and thyroid gland.
Inductioni
By TNF.
Gene expression databases
Bgeei | ENSG00000197951, Expressed in cortical plate and 148 other tissues |
ExpressionAtlasi | Q9NQZ8, baseline and differential |
Genevisiblei | Q9NQZ8, HS |
Organism-specific databases
HPAi | ENSG00000197951, Low tissue specificity |
Interactioni
Binary interactionsi
Q9NQZ8
Protein-protein interaction databases
BioGRIDi | 121821, 77 interactors |
IntActi | Q9NQZ8, 58 interactors |
MINTi | Q9NQZ8 |
STRINGi | 9606.ENSP00000328245 |
Miscellaneous databases
RNActi | Q9NQZ8, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 61 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 98 – 122 | DisorderedSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 130 – 152 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 158 – 180 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 186 – 208 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 214 – 236 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 242 – 264 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 270 – 292 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 320 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 326 – 348 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 404 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 410 – 432 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 438 – 460 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 466 – 488 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163774 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q9NQZ8 |
OMAi | CVEKKTY |
PhylomeDBi | Q9NQZ8 |
TreeFami | TF350858 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 13 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9NQZ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKELDPKNDI SEDKLSVVGE ATGGPTRNGA RGPGSEGVWE PGSWPERPRG
60 70 80 90 100
DAGAEWEPLG IPQGNKLLGG SVPACHELKA FANQGCVLVP PRLDDPTEKG
110 120 130 140 150
ACPPVRRGKN FSSTSDLSKP PMPCEEKKTY DCSECGKAFS RSSSLIKHQR
160 170 180 190 200
IHTGEKPFEC DTCGKHFIER SSLTIHQRVH TGEKPYACGD CGKAFSQRMN
210 220 230 240 250
LTVHQRTHTG EKPYVCDVCG KAFRKTSSLT QHERIHTGEK PYACGDCGKA
260 270 280 290 300
FSQNMHLIVH QRTHTGEKPY VCPECGRAFS QNMHLTEHQR THTGEKPYAC
310 320 330 340 350
KECGKAFNKS SSLTLHQRNH TGEKPYVCGE CGKAFSQSSY LIQHQRFHIG
360 370 380 390 400
VKPFECSECG KAFSKNSSLT QHQRIHTGEK PYECYICKKH FTGRSSLIVH
410 420 430 440 450
QIVHTGEKPY VCGECGKAFS QSAYLIEHQR IHTGEKPYRC GQCGKSFIKN
460 470 480
SSLTVHQRIH TGEKPYRCGE CGKTFSRNTN LTRHLRIHT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0R0C0 | M0R0C0_HUMAN | Endothelial zinc finger protein-ind... | ZNF71 hCG_91980 | 549 | Annotation score: |
Sequence cautioni
The sequence AAD23608 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052762 | 27 | R → G. Corresponds to variant dbSNP:rs10405299Ensembl. | 1 | |
Natural variantiVAR_024196 | 105 | V → I. Corresponds to variant dbSNP:rs2072501Ensembl. | 1 | |
Natural variantiVAR_052763 | 121 | P → L. Corresponds to variant dbSNP:rs35392779Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF269249 mRNA Translation: AAF88036.1 AC007228 Genomic DNA Translation: AAD23608.1 Different initiation. BC014280 mRNA Translation: AAH14280.1 X60074 Genomic DNA Translation: CAC16174.1 M88357 Genomic DNA Translation: AAA61315.1 |
CCDSi | CCDS12947.1 |
PIRi | A42825 A43284 |
RefSeqi | NP_067039.1, NM_021216.4 XP_016882569.1, XM_017027080.1 |
Genome annotation databases
Ensembli | ENST00000328070; ENSP00000328245; ENSG00000197951 |
GeneIDi | 58491 |
KEGGi | hsa:58491 |
UCSCi | uc002qnm.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF269249 mRNA Translation: AAF88036.1 AC007228 Genomic DNA Translation: AAD23608.1 Different initiation. BC014280 mRNA Translation: AAH14280.1 X60074 Genomic DNA Translation: CAC16174.1 M88357 Genomic DNA Translation: AAA61315.1 |
CCDSi | CCDS12947.1 |
PIRi | A42825 A43284 |
RefSeqi | NP_067039.1, NM_021216.4 XP_016882569.1, XM_017027080.1 |
3D structure databases
SMRi | Q9NQZ8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121821, 77 interactors |
IntActi | Q9NQZ8, 58 interactors |
MINTi | Q9NQZ8 |
STRINGi | 9606.ENSP00000328245 |
PTM databases
iPTMneti | Q9NQZ8 |
PhosphoSitePlusi | Q9NQZ8 |
Genetic variation databases
BioMutai | ZNF71 |
DMDMi | 21263627 |
Proteomic databases
EPDi | Q9NQZ8 |
MassIVEi | Q9NQZ8 |
MaxQBi | Q9NQZ8 |
PaxDbi | Q9NQZ8 |
PeptideAtlasi | Q9NQZ8 |
PRIDEi | Q9NQZ8 |
ProteomicsDBi | 82239 |
Protocols and materials databases
Antibodypediai | 19623, 170 antibodies from 29 providers |
DNASUi | 58491 |
Genome annotation databases
Ensembli | ENST00000328070; ENSP00000328245; ENSG00000197951 |
GeneIDi | 58491 |
KEGGi | hsa:58491 |
UCSCi | uc002qnm.5, human |
Organism-specific databases
CTDi | 58491 |
DisGeNETi | 58491 |
GeneCardsi | ZNF71 |
HGNCi | HGNC:13141, ZNF71 |
HPAi | ENSG00000197951, Low tissue specificity |
MIMi | 194545, gene |
neXtProti | NX_Q9NQZ8 |
OpenTargetsi | ENSG00000197951 |
PharmGKBi | PA37715 |
VEuPathDBi | HostDB:ENSG00000197951 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163774 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q9NQZ8 |
OMAi | CVEKKTY |
PhylomeDBi | Q9NQZ8 |
TreeFami | TF350858 |
Enzyme and pathway databases
PathwayCommonsi | Q9NQZ8 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q9NQZ8 |
Miscellaneous databases
BioGRID-ORCSi | 58491, 8 hits in 1064 CRISPR screens |
ChiTaRSi | ZNF71, human |
GeneWikii | ZNF71 |
GenomeRNAii | 58491 |
Pharosi | Q9NQZ8, Tdark |
PROi | PR:Q9NQZ8 |
RNActi | Q9NQZ8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197951, Expressed in cortical plate and 148 other tissues |
ExpressionAtlasi | Q9NQZ8, baseline and differential |
Genevisiblei | Q9NQZ8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 13 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZNF71_HUMAN | |
Accessioni | Q9NQZ8Primary (citable) accession number: Q9NQZ8 Secondary accession number(s): Q15919, Q9UC09, Q9UQD3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 27, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families