ZNF71

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	130 – 152	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	158 – 180	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	186 – 208	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	214 – 236	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	242 – 264	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	270 – 292	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	298 – 320	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	326 – 348	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	354 – 376	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	382 – 404	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	410 – 432	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	438 – 460	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	466 – 488	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW
sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Endothelial zinc finger protein induced by tumor necrosis factor alpha Alternative name(s): Zinc finger protein 71
Gene namesⁱ	Name:ZNF71 Synonyms:EZFIT
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197951.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13141 ZNF71
MIMⁱ	194545 gene
neXtProtⁱ	NX_Q9NQZ8

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	58491
Open Targets More...OpenTargetsⁱ	ENSG00000197951
PharmGKBⁱ	PA37715

Polymorphism and mutation databases

BioMutaⁱ	ZNF71
DMDMⁱ	21263627

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047381	1 – 489	Endothelial zinc finger protein induced by tumor necrosis factor alphaAdd BLAST		489

Proteomic databases

EPDⁱ	Q9NQZ8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NQZ8
PaxDbⁱ	Q9NQZ8
PeptideAtlas More...PeptideAtlasⁱ	Q9NQZ8
PRIDEⁱ	Q9NQZ8
ProteomicsDBⁱ	82239

PTM databases

iPTMnetⁱ	Q9NQZ8
PhosphoSitePlusⁱ	Q9NQZ8

Expressionⁱ

Tissue specificityⁱ

Highly expressed in placenta, followed by brain, testis, pancreas, heart, small intestine, muscle, uterus, prostate and peripheral blood leukocytes. Not detected in liver, lung, colon, stomach, salivary and thyroid gland.

Inductionⁱ

By TNF.

Gene expression databases

Bgeeⁱ	ENSG00000197951 Expressed in 129 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_ZNF71
ExpressionAtlasⁱ	Q9NQZ8 baseline and differential
Genevisibleⁱ	Q9NQZ8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018124

HPAⁱ

HPA018124

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TRIM41	Q8WV44	4	EBI-7138235,EBI-725997

With

Entry

#Exp.

IntAct

Notes

TRIM41

Q8WV44

4

EBI-7138235,EBI-725997

Protein-protein interaction databases

BioGridⁱ	121821, 42 interactors
IntActⁱ	Q9NQZ8, 25 interactors
Molecular INTeraction database More...MINTⁱ	Q9NQZ8
STRINGⁱ	9606.ENSP00000328245

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NQZ8
SMRⁱ	Q9NQZ8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	130 – 152	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	158 – 180	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	186 – 208	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	214 – 236	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	242 – 264	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	270 – 292	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	298 – 320	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	326 – 348	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	354 – 376	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	382 – 404	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	410 – 432	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	438 – 460	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	466 – 488	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150844
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q9NQZ8
OMAⁱ	CHELKAF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q9NQZ8
TreeFamⁱ	TF350858

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 13 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9NQZ8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKELDPKNDI SEDKLSVVGE ATGGPTRNGA RGPGSEGVWE PGSWPERPRG 
        60         70         80         90        100
DAGAEWEPLG IPQGNKLLGG SVPACHELKA FANQGCVLVP PRLDDPTEKG 
       110        120        130        140        150
ACPPVRRGKN FSSTSDLSKP PMPCEEKKTY DCSECGKAFS RSSSLIKHQR 
       160        170        180        190        200
IHTGEKPFEC DTCGKHFIER SSLTIHQRVH TGEKPYACGD CGKAFSQRMN 
       210        220        230        240        250
LTVHQRTHTG EKPYVCDVCG KAFRKTSSLT QHERIHTGEK PYACGDCGKA 
       260        270        280        290        300
FSQNMHLIVH QRTHTGEKPY VCPECGRAFS QNMHLTEHQR THTGEKPYAC 
       310        320        330        340        350
KECGKAFNKS SSLTLHQRNH TGEKPYVCGE CGKAFSQSSY LIQHQRFHIG 
       360        370        380        390        400
VKPFECSECG KAFSKNSSLT QHQRIHTGEK PYECYICKKH FTGRSSLIVH 
       410        420        430        440        450
QIVHTGEKPY VCGECGKAFS QSAYLIEHQR IHTGEKPYRC GQCGKSFIKN 
       460        470        480 
SSLTVHQRIH TGEKPYRCGE CGKTFSRNTN LTRHLRIHT

Length:489

Mass (Da):54,498

Last modified:October 1, 2000 - v1

Checksum:ⁱ6B1156D21FF9295C

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	M0R0C0	M0R0C0_HUMAN		Endothelial zinc finger protein-ind... Endothelial zinc finger protein-induced by tumor necrosis factor alpha	ZNF71	128	Annotation score:

Sequence cautionⁱ

The sequence AAD23608 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_052762	27	R → G. Corresponds to variant dbSNP:rs10405299Ensembl.	1
Natural variantⁱVAR_024196	105	V → I. Corresponds to variant dbSNP:rs2072501Ensembl.	1
Natural variantⁱVAR_052763	121	P → L. Corresponds to variant dbSNP:rs35392779Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF269249 mRNA Translation: AAF88036.1 AC007228 Genomic DNA Translation: AAD23608.1 Different initiation. BC014280 mRNA Translation: AAH14280.1 X60074 Genomic DNA Translation: CAC16174.1 M88357 Genomic DNA Translation: AAA61315.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12947.1
PIRⁱ	A42825 A43284
NCBI Reference Sequences More...RefSeqⁱ	NP_067039.1, NM_021216.4 XP_016882569.1, XM_017027080.1
UniGeneⁱ	Hs.301431 Hs.600391

Genome annotation databases

Ensemblⁱ	ENST00000328070; ENSP00000328245; ENSG00000197951
GeneIDⁱ	58491
KEGGⁱ	hsa:58491
UCSC genome browser More...UCSCⁱ	uc002qnm.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NQZ8	Endothelial zinc finger protein-induced by tumor necrosis factor alpha (Fragment)		HUMAN		128	UniRef100_Q9NQZ8
UPI0000202CFF		HUMAN		549

Protein	Similar proteins		Species	Score	Length	Source
Q9NQZ8	Endothelial zinc finger protein-induced by tumor necrosis factor alpha (Fragment)		HUMAN		128	UniRef90_Q9NQZ8
Uncharacterized protein		PONAB		610
Uncharacterized protein		MACNE		549
Uncharacterized protein		PAPAN		549
Uncharacterized protein		MACFA		549
+45

Protein	Similar proteins		Species	Score	Length	Source
Q9NQZ8	Zinc finger protein 2 homolog		HUMAN		461	UniRef50_Q9NQZ8
Uncharacterized protein		PONAB		610
Uncharacterized protein		CERAT		549
Uncharacterized protein		MACMU		549
Uncharacterized protein		PAPAN		549
+137

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF269249 mRNA Translation: AAF88036.1 AC007228 Genomic DNA Translation: AAD23608.1 Different initiation. BC014280 mRNA Translation: AAH14280.1 X60074 Genomic DNA Translation: CAC16174.1 M88357 Genomic DNA Translation: AAA61315.1
CCDSⁱ	CCDS12947.1
PIRⁱ	A42825 A43284
RefSeqⁱ	NP_067039.1, NM_021216.4 XP_016882569.1, XM_017027080.1
UniGeneⁱ	Hs.301431 Hs.600391

3D structure databases

ProteinModelPortalⁱ	Q9NQZ8
SMRⁱ	Q9NQZ8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121821, 42 interactors
IntActⁱ	Q9NQZ8, 25 interactors
MINTⁱ	Q9NQZ8
STRINGⁱ	9606.ENSP00000328245

PTM databases

iPTMnetⁱ	Q9NQZ8
PhosphoSitePlusⁱ	Q9NQZ8

Polymorphism and mutation databases

BioMutaⁱ	ZNF71
DMDMⁱ	21263627

Proteomic databases

EPDⁱ	Q9NQZ8
MaxQBⁱ	Q9NQZ8
PaxDbⁱ	Q9NQZ8
PeptideAtlasⁱ	Q9NQZ8
PRIDEⁱ	Q9NQZ8
ProteomicsDBⁱ	82239

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000328070; ENSP00000328245; ENSG00000197951
GeneIDⁱ	58491
KEGGⁱ	hsa:58491
UCSCⁱ	uc002qnm.5 human

Organism-specific databases

CTDⁱ	58491
DisGeNETⁱ	58491
EuPathDBⁱ	HostDB:ENSG00000197951.8
GeneCardsⁱ	ZNF71
HGNCⁱ	HGNC:13141 ZNF71
HPAⁱ	HPA018124
MIMⁱ	194545 gene
neXtProtⁱ	NX_Q9NQZ8
OpenTargetsⁱ	ENSG00000197951
PharmGKBⁱ	PA37715
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00930000150844
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q9NQZ8
OMAⁱ	CHELKAF
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q9NQZ8
TreeFamⁱ	TF350858

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSⁱ	ZNF71 human
GeneWikiⁱ	ZNF71
GenomeRNAiⁱ	58491
Protein Ontology More...PROⁱ	PR:Q9NQZ8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000197951 Expressed in 129 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_ZNF71
ExpressionAtlasⁱ	Q9NQZ8 baseline and differential
Genevisibleⁱ	Q9NQZ8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 13 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZNF71_HUMAN
Accessionⁱ	Q9NQZ8Primary (citable) accession number: Q9NQZ8 Secondary accession number(s): Q15919, Q9UC09, Q9UQD3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniProtKB - Q9NQZ8 (ZNF71_HUMAN)

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Endothelial zinc finger protein induced by tumor necrosis factor alpha

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ