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Protein

Ectonucleoside triphosphate diphosphohydrolase 7

Gene

ENTPD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP.

Cofactori

Ca2+1 Publication, Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei217Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.1.5 2681
ReactomeiR-HSA-8850843 Phosphate bond hydrolysis by NTPDase proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 7 (EC:3.6.1.-)
Short name:
NTPDase 7
Alternative name(s):
Lysosomal apyrase-like protein 1
Gene namesi
Name:ENTPD7
Synonyms:LALP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000198018.6
HGNCiHGNC:19745 ENTPD7
MIMi616753 gene
neXtProtiNX_Q9NQZ7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 546VesicularSequence analysisAdd BLAST497
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Topological domaini568 – 604CytoplasmicSequence analysisAdd BLAST37

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57089
OpenTargetsiENSG00000198018
PharmGKBiPA134993462

Polymorphism and mutation databases

BioMutaiENTPD7
DMDMi74752912

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002744191 – 604Ectonucleoside triphosphate diphosphohydrolase 7Add BLAST604

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi448 ↔ 477By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9NQZ7
MaxQBiQ9NQZ7
PaxDbiQ9NQZ7
PeptideAtlasiQ9NQZ7
PRIDEiQ9NQZ7
ProteomicsDBi82238

PTM databases

iPTMnetiQ9NQZ7
PhosphoSitePlusiQ9NQZ7

Expressioni

Gene expression databases

BgeeiENSG00000198018
CleanExiHS_ENTPD7
ExpressionAtlasiQ9NQZ7 baseline and differential
GenevisibleiQ9NQZ7 HS

Organism-specific databases

HPAiHPA014351

Interactioni

Protein-protein interaction databases

BioGridi121358, 25 interactors
STRINGi9606.ENSP00000359520

Structurei

3D structure databases

ProteinModelPortaliQ9NQZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1386 Eukaryota
COG5371 LUCA
GeneTreeiENSGT00550000074435
HOGENOMiHOG000090205
HOVERGENiHBG006789
InParanoidiQ9NQZ7
KOiK14643
OMAiSAWMYQV
OrthoDBiEOG091G04IV
PhylomeDBiQ9NQZ7
TreeFamiTF354343

Family and domain databases

InterProiView protein in InterPro
IPR000407 GDA1_CD39_NTPase
PANTHERiPTHR11782 PTHR11782, 1 hit
PfamiView protein in Pfam
PF01150 GDA1_CD39, 1 hit
PROSITEiView protein in PROSITE
PS01238 GDA1_CD39_NTPASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NQZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARISFSYLC PASWYFTVPT VSPFLRQRVA FLGLFFISCL LLLMLIIDFR
60 70 80 90 100
HWSASLPRDR QYERYLARVG ELEATDTEDP NLNYGLVVDC GSSGSRIFVY
110 120 130 140 150
FWPRHNGNPH DLLDIKQMRD RNSQPVVKKI KPGISAMADT PEHASDYLRP
160 170 180 190 200
LLSFAAAHVP VKKHKETPLY ILCTAGMRLL PERKQLAILA DLVKDLPLEF
210 220 230 240 250
DFLFSQSQAE VISGKQEGVY AWIGINFVLG RFDHEDESDA EATQELAAGR
260 270 280 290 300
RRTVGILDMG GASLQIAYEV PTSTSVLPAK QEEAAKILLA EFNLGCDVQH
310 320 330 340 350
TEHVYRVYVT TFLGFGGNFA RQRYEDLVLN ETLNKNRLLG QKTGLSPDNP
360 370 380 390 400
FLDPCLPVGL TDVVERNSQV LHVRGRGDWV SCGAMLSPLL ARSNTSQASL
410 420 430 440 450
NGIYQSPIDF NNSEFYGFSE FFYCTEDVLR IGGRYHGPTF AKAAQDYCGM
460 470 480 490 500
AWSVLTQRFK NGLFSSHADE HRLKYQCFKS AWMYQVLHEG FHFPYDYPNL
510 520 530 540 550
RTAQLVYDRE VQWTLGAILY KTRFLPLRDL RQEGVRQAHG SWFRLSFVYN
560 570 580 590 600
HYLFFACILV VLLAIFLYLL RLRRIHHRQT RASAPLDLLW LEEVVPMMGV

QVGP
Length:604
Mass (Da):68,960
Last modified:October 1, 2000 - v1
Checksum:i6B73997A8AB318D8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030287276V → A1 PublicationCorresponds to variant dbSNP:rs11190245Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269255 mRNA Translation: AAF90135.1
AK055540 mRNA Translation: BAG51533.1
AK314542 mRNA Translation: BAG37130.1
AL133353 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49861.1
BC119008 mRNA Translation: AAI19009.1
BC122857 mRNA Translation: AAI22858.1
CCDSiCCDS7480.1
RefSeqiNP_065087.1, NM_020354.3
UniGeneiHs.28326
Hs.744948

Genome annotation databases

EnsembliENST00000370489; ENSP00000359520; ENSG00000198018
GeneIDi57089
KEGGihsa:57089
UCSCiuc001kqa.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiENTP7_HUMAN
AccessioniPrimary (citable) accession number: Q9NQZ7
Secondary accession number(s): B2RB83, B3KP21, D3DR64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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