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UniProtKB - Q9NQZ5 (STAR7_HUMAN)
Protein
StAR-related lipid transfer protein 7, mitochondrial
Gene
STARD7
Organism
Homo sapiens (Human)
Status
Functioni
May play a protective role in mucosal tissues by preventing exaggerated allergic responses.
By similarityGO - Molecular functioni
- lipid binding Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q9NQZ5 |
Reactomei | R-HSA-1483191, Synthesis of PC |
SignaLinki | Q9NQZ5 |
Protein family/group databases
TCDBi | 8.A.120.1.1, the mitochondrial star-related lipid transfer protein (star) family |
Names & Taxonomyi
Protein namesi | Recommended name: StAR-related lipid transfer protein 7, mitochondrialAlternative name(s): Gestational trophoblastic tumor protein 1 START domain-containing protein 7 Short name: StARD7 |
Gene namesi | Name:STARD7 Synonyms:GTT1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18063, STARD7 |
MIMi | 616712, gene |
neXtProti | NX_Q9NQZ5 |
VEuPathDBi | HostDB:ENSG00000084090 |
Subcellular locationi
Mitochondrion
- Mitochondrion Curated
Mitochondrion
- mitochondrial outer membrane Source: Reactome
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 56910 |
MalaCardsi | STARD7 |
OpenTargetsi | ENSG00000084090 |
PharmGKBi | PA38285 |
Miscellaneous databases
Pharosi | Q9NQZ5, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3399912 |
Genetic variation databases
BioMutai | STARD7 |
DMDMi | 215273945 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 58 | MitochondrionSequence analysisAdd BLAST | 58 | |
ChainiPRO_0000220674 | 59 – 370 | StAR-related lipid transfer protein 7, mitochondrialAdd BLAST | 312 |
Proteomic databases
EPDi | Q9NQZ5 |
jPOSTi | Q9NQZ5 |
MassIVEi | Q9NQZ5 |
MaxQBi | Q9NQZ5 |
PaxDbi | Q9NQZ5 |
PeptideAtlasi | Q9NQZ5 |
PRIDEi | Q9NQZ5 |
ProteomicsDBi | 82233 |
PTM databases
iPTMneti | Q9NQZ5 |
PhosphoSitePlusi | Q9NQZ5 |
Expressioni
Tissue specificityi
Expressed in nasal epithelial cells. Down-regulated in nasal epithelial cells in patients experiencing an asthma exacerbation as compared to stable asthmatics and healthy controls.1 Publication
Gene expression databases
Bgeei | ENSG00000084090, Expressed in female gonad and 256 other tissues |
ExpressionAtlasi | Q9NQZ5, baseline and differential |
Genevisiblei | Q9NQZ5, HS |
Organism-specific databases
HPAi | ENSG00000084090, Low tissue specificity |
Interactioni
Binary interactionsi
Q9NQZ5
With | #Exp. | IntAct |
---|---|---|
HOGA1 [Q86XE5] | 2 | EBI-4402938,EBI-9658477 |
Protein-protein interaction databases
BioGRIDi | 121238, 29 interactors |
IntActi | Q9NQZ5, 28 interactors |
STRINGi | 9606.ENSP00000338030 |
Miscellaneous databases
RNActi | Q9NQZ5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 112 – 327 | STARTPROSITE-ProRule annotationAdd BLAST | 216 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 111 – 138 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 343 – 370 | DisorderedSequence analysisAdd BLAST | 28 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 86 – 111 | Sequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 344 – 359 | Polar residuesSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Coiled coil, Transit peptidePhylogenomic databases
eggNOGi | KOG2761, Eukaryota |
GeneTreei | ENSGT00940000157856 |
HOGENOMi | CLU_042209_0_0_1 |
InParanoidi | Q9NQZ5 |
OMAi | MFPRRPP |
OrthoDBi | 973910at2759 |
PhylomeDBi | Q9NQZ5 |
TreeFami | TF320705 |
Family and domain databases
CDDi | cd08911, START_STARD7-like, 1 hit |
Gene3Di | 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR023393, START-like_dom_sf IPR002913, START_lipid-bd_dom IPR041949, START_STARD7 |
Pfami | View protein in Pfam PF01852, START, 1 hit |
SMARTi | View protein in SMART SM00234, START, 1 hit |
PROSITEi | View protein in PROSITE PS50848, START, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9NQZ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPRRLLAAW LAGTRGGGLL ALLANQCRFV TGLRVRRAQQ IAQLYGRLYS
60 70 80 90 100
ESSRRVLLGR LWRRLHGRPG HASALMAALA GVFVWDEERI QEEELQRSIN
110 120 130 140 150
EMKRLEEMSN MFQSSGVQHH PPEPKAQTEG NEDSEGKEQR WEMVMDKKHF
160 170 180 190 200
KLWRRPITGT HLYQYRVFGT YTDVTPRQFF NVQLDTEYRK KWDALVIKLE
210 220 230 240 250
VIERDVVSGS EVLHWVTHFP YPMYSRDYVY VRRYSVDQEN NMMVLVSRAV
260 270 280 290 300
EHPSVPESPE FVRVRSYESQ MVIRPHKSFD ENGFDYLLTY SDNPQTVFPR
310 320 330 340 350
YCVSWMVSSG MPDFLEKLHM ATLKAKNMEI KVKDYISAKP LEMSSEAKAT
360 370
SQSSERKNEG SCGPARIEYA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JTD3 | C9JTD3_HUMAN | StAR-related lipid transfer protein... | STARD7 | 147 | Annotation score: |
Sequence cautioni
The sequence AAF81750 differs from that shown. Reason: Frameshift.Curated
The sequence AAH07894 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH08894 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH09998 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH12774 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH12793 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH13279 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH14076 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH14274 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH32106 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 72 – 73 | Missing in AAF81750 (PubMed:15013637).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020345 | 140 | R → P1 PublicationCorresponds to variant dbSNP:rs2276650Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF270647 mRNA Translation: AAF81750.1 Frameshift. AC012307 Genomic DNA Translation: AAY24223.1 CH471207 Genomic DNA Translation: EAW71382.1 CH471207 Genomic DNA Translation: EAW71383.1 BC007894 mRNA Translation: AAH07894.1 Different initiation. BC008894 mRNA Translation: AAH08894.1 Different initiation. BC009998 mRNA Translation: AAH09998.1 Different initiation. BC012774 mRNA Translation: AAH12774.1 Different initiation. BC012793 mRNA Translation: AAH12793.1 Different initiation. BC013279 mRNA Translation: AAH13279.1 Different initiation. BC014076 mRNA Translation: AAH14076.1 Different initiation. BC014274 mRNA Translation: AAH14274.3 Different initiation. BC032106 mRNA Translation: AAH32106.1 Different initiation. |
CCDSi | CCDS2017.2 |
RefSeqi | NP_064536.2, NM_020151.3 |
Genome annotation databases
Ensembli | ENST00000337288; ENSP00000338030; ENSG00000084090 |
GeneIDi | 56910 |
KEGGi | hsa:56910 |
MANE-Selecti | ENST00000337288.10; ENSP00000338030.5; NM_020151.4; NP_064536.2 |
UCSCi | uc002svm.6, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF270647 mRNA Translation: AAF81750.1 Frameshift. AC012307 Genomic DNA Translation: AAY24223.1 CH471207 Genomic DNA Translation: EAW71382.1 CH471207 Genomic DNA Translation: EAW71383.1 BC007894 mRNA Translation: AAH07894.1 Different initiation. BC008894 mRNA Translation: AAH08894.1 Different initiation. BC009998 mRNA Translation: AAH09998.1 Different initiation. BC012774 mRNA Translation: AAH12774.1 Different initiation. BC012793 mRNA Translation: AAH12793.1 Different initiation. BC013279 mRNA Translation: AAH13279.1 Different initiation. BC014076 mRNA Translation: AAH14076.1 Different initiation. BC014274 mRNA Translation: AAH14274.3 Different initiation. BC032106 mRNA Translation: AAH32106.1 Different initiation. |
CCDSi | CCDS2017.2 |
RefSeqi | NP_064536.2, NM_020151.3 |
3D structure databases
SMRi | Q9NQZ5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121238, 29 interactors |
IntActi | Q9NQZ5, 28 interactors |
STRINGi | 9606.ENSP00000338030 |
Chemistry databases
ChEMBLi | CHEMBL3399912 |
Protein family/group databases
TCDBi | 8.A.120.1.1, the mitochondrial star-related lipid transfer protein (star) family |
PTM databases
iPTMneti | Q9NQZ5 |
PhosphoSitePlusi | Q9NQZ5 |
Genetic variation databases
BioMutai | STARD7 |
DMDMi | 215273945 |
Proteomic databases
EPDi | Q9NQZ5 |
jPOSTi | Q9NQZ5 |
MassIVEi | Q9NQZ5 |
MaxQBi | Q9NQZ5 |
PaxDbi | Q9NQZ5 |
PeptideAtlasi | Q9NQZ5 |
PRIDEi | Q9NQZ5 |
ProteomicsDBi | 82233 |
Protocols and materials databases
Antibodypediai | 32404, 153 antibodies from 23 providers |
DNASUi | 56910 |
Genome annotation databases
Ensembli | ENST00000337288; ENSP00000338030; ENSG00000084090 |
GeneIDi | 56910 |
KEGGi | hsa:56910 |
MANE-Selecti | ENST00000337288.10; ENSP00000338030.5; NM_020151.4; NP_064536.2 |
UCSCi | uc002svm.6, human |
Organism-specific databases
CTDi | 56910 |
DisGeNETi | 56910 |
GeneCardsi | STARD7 |
HGNCi | HGNC:18063, STARD7 |
HPAi | ENSG00000084090, Low tissue specificity |
MalaCardsi | STARD7 |
MIMi | 616712, gene |
neXtProti | NX_Q9NQZ5 |
OpenTargetsi | ENSG00000084090 |
PharmGKBi | PA38285 |
VEuPathDBi | HostDB:ENSG00000084090 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2761, Eukaryota |
GeneTreei | ENSGT00940000157856 |
HOGENOMi | CLU_042209_0_0_1 |
InParanoidi | Q9NQZ5 |
OMAi | MFPRRPP |
OrthoDBi | 973910at2759 |
PhylomeDBi | Q9NQZ5 |
TreeFami | TF320705 |
Enzyme and pathway databases
PathwayCommonsi | Q9NQZ5 |
Reactomei | R-HSA-1483191, Synthesis of PC |
SignaLinki | Q9NQZ5 |
Miscellaneous databases
BioGRID-ORCSi | 56910, 254 hits in 1048 CRISPR screens |
ChiTaRSi | STARD7, human |
GeneWikii | STARD7 |
GenomeRNAii | 56910 |
Pharosi | Q9NQZ5, Tbio |
PROi | PR:Q9NQZ5 |
RNActi | Q9NQZ5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000084090, Expressed in female gonad and 256 other tissues |
ExpressionAtlasi | Q9NQZ5, baseline and differential |
Genevisiblei | Q9NQZ5, HS |
Family and domain databases
CDDi | cd08911, START_STARD7-like, 1 hit |
Gene3Di | 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR023393, START-like_dom_sf IPR002913, START_lipid-bd_dom IPR041949, START_STARD7 |
Pfami | View protein in Pfam PF01852, START, 1 hit |
SMARTi | View protein in SMART SM00234, START, 1 hit |
PROSITEi | View protein in PROSITE PS50848, START, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STAR7_HUMAN | |
Accessioni | Q9NQZ5Primary (citable) accession number: Q9NQZ5 Secondary accession number(s): D3DXG9 Q969M6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 15, 2002 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 23, 2022 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot