ITM2C

Functionⁱ

Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).By similarity2 Publications

GO - Molecular functionⁱ

amyloid-beta binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19849849
ATP binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of amyloid precursor protein biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of neuron projection development
Source: UniProtKB
Inferred from direct assayⁱ
- 18452648
neuron differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 18452648
positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Integral membrane protein 2C Alternative name(s): Cerebral protein 14 Transmembrane protein BRI3 Cleaved into the following chain: CT-BRI3
Gene namesⁱ	Name:ITM2C Synonyms:BRI3 ORF Names:hucep-14, NPD018, PSEC0047
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000135916.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6175 ITM2C
MIMⁱ	609554 gene
neXtProtⁱ	NX_Q9NQX7

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	55 – 75	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Cell membrane, Lysosome, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	241 – 242	KR → AA: Completely abrogates proteolytic processing. 1 Publication		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	81618
Open Targets More...OpenTargetsⁱ	ENSG00000135916
PharmGKBⁱ	PA29972

Polymorphism and mutation databases

BioMutaⁱ	ITM2C
DMDMⁱ	12585259

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000154826	1 – 267	Integral membrane protein 2CAdd BLAST		267
PeptideⁱPRO_0000232645	243 – 267	CT-BRI3Add BLAST		25

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	37	PhosphothreonineBy similarity	1
Disulfide bondⁱ	163 ↔ 222	By similarity
Glycosylationⁱ	169	N-linked (GlcNAc...) asparagine1 Publication	1

Post-translational modificationⁱ

Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembanaire cleavage by SPPL2B.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	242 – 243	Cleavage; by furin		2

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9NQX7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NQX7
PaxDbⁱ	Q9NQX7
PeptideAtlas More...PeptideAtlasⁱ	Q9NQX7
PRIDEⁱ	Q9NQX7
ProteomicsDBⁱ	82226 82227 [Q9NQX7-2] 82228 [Q9NQX7-3]

PTM databases

iPTMnetⁱ	Q9NQX7
PhosphoSitePlusⁱ	Q9NQX7
SwissPalmⁱ	Q9NQX7

Expressionⁱ

Tissue specificityⁱ

High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000135916 Expressed in 228 organ(s), highest expression level in nucleus accumbens
CleanExⁱ	HS_BRI3 HS_ITM2C
ExpressionAtlasⁱ	Q9NQX7 baseline and differential
Genevisibleⁱ	Q9NQX7 HS

Interactionⁱ

Subunit structureⁱ

Interacts with BACE1. Interacts with APP. Interacts with STMN2.3 Publications

Protein-protein interaction databases

BioGridⁱ	123553, 7 interactors
IntActⁱ	Q9NQX7, 18 interactors
Molecular INTeraction database More...MINTⁱ	Q9NQX7
STRINGⁱ	9606.ENSP00000322730

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NQX7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	136 – 230	BRICHOSPROSITE-ProRule annotationAdd BLAST		95

Sequence similaritiesⁱ

Belongs to the ITM2 family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4681 Eukaryota ENOG410XRNN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005162
HOVERGENⁱ	HBG059373
InParanoidⁱ	Q9NQX7
KEGG Orthology (KO) More...KOⁱ	K18265
OMAⁱ	KKGTYLP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0E78
PhylomeDBⁱ	Q9NQX7
TreeFamⁱ	TF317770

Family and domain databases

InterProⁱ	View protein in InterPro IPR007084 BRICHOS_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04089 BRICHOS, 1 hit
SMARTⁱ	View protein in SMART SM01039 BRICHOS, 1 hit
PROSITEⁱ	View protein in PROSITE PS50869 BRICHOS, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NQX7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKISFQPAV AGIKGDKADK ASASAPAPAS ATEILLTPAR EEQPPQHRSK 
        60         70         80         90        100
RGGSVGGVCY LSMGMVVLLM GLVFASVYIY RYFFLAQLAR DNFFRCGVLY 
       110        120        130        140        150
EDSLSSQVRT QMELEEDVKI YLDENYERIN VPVPQFGGGD PADIIHDFQR 
       160        170        180        190        200
GLTAYHDISL DKCYVIELNT TIVLPPRNFW ELLMNVKRGT YLPQTYIIQE 
       210        220        230        240        250
EMVVTEHVSD KEALGSFIYH LCNGKDTYRL RRRATRRRIN KRGAKNCNAI 
       260 
RHFENTFVVE TLICGVV

Length:267

Mass (Da):30,224

Last modified:October 1, 2000 - v1

Checksum:ⁱ234DDB91B4F282E7

GO

Isoform 2 (identifier: Q9NQX7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
41-87: Missing.

« Hide

        10         20         30         40         50
MVKISFQPAV AGIKGDKADK ASASAPAPAS ATEILLTPAR LARDNFFRCG 
        60         70         80         90        100
VLYEDSLSSQ VRTQMELEED VKIYLDENYE RINVPVPQFG GGDPADIIHD 
       110        120        130        140        150
FQRGLTAYHD ISLDKCYVIE LNTTIVLPPR NFWELLMNVK RGTYLPQTYI 
       160        170        180        190        200
IQEEMVVTEH VSDKEALGSF IYHLCNGKDT YRLRRRATRR RINKRGAKNC 
       210        220
NAIRHFENTF VVETLICGVV

Show »

Length:220

Mass (Da):24,956

Checksum:ⁱ9C16C85BD37BA9CC

GO

Isoform 3 (identifier: Q9NQX7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
151-187: Missing.

« Hide

        10         20         30         40         50
MVKISFQPAV AGIKGDKADK ASASAPAPAS ATEILLTPAR EEQPPQHRSK 
        60         70         80         90        100
RGGSVGGVCY LSMGMVVLLM GLVFASVYIY RYFFLAQLAR DNFFRCGVLY 
       110        120        130        140        150
EDSLSSQVRT QMELEEDVKI YLDENYERIN VPVPQFGGGD PADIIHDFQR 
       160        170        180        190        200
RGTYLPQTYI IQEEMVVTEH VSDKEALGSF IYHLCNGKDT YRLRRRATRR 
       210        220        230
RINKRGAKNC NAIRHFENTF VVETLICGVV

Note: No experimental confirmation available.

Show »

Length:230

Mass (Da):25,921

Checksum:ⁱ6C8BF583B61C58D0

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JG41	C9JG41_HUMAN	Integral membrane protein 2C Integral membrane protein 2C	ITM2C	180	Annotation score:
Q96JS4	Q96JS4_HUMAN	Cerebral protein-3 Cerebral protein-3 (Integral membrane protein 2C, isoform CRA_d)	ITM2C hucep-3, hCG_34338	166	Annotation score:
B8ZZM6	B8ZZM6_HUMAN	Integral membrane protein 2C Integral membrane protein 2C	ITM2C	205	Annotation score:
F5H4I5	F5H4I5_HUMAN	Integral membrane protein 2C Integral membrane protein 2C	ITM2C	122	Annotation score:
E7EUS6	E7EUS6_HUMAN	Integral membrane protein 2C Integral membrane protein 2C	ITM2C	125	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	22 – 39	Missing in BAC03562 (PubMed:14702039).CuratedAdd BLAST	18
Sequence conflictⁱ	133	V → A in BAD96417 (Ref. 8) Curated	1
Sequence conflictⁱ	205	T → A in CAG33489 (Ref. 7) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_022111	53	G → S5 PublicationsCorresponds to variant dbSNP:rs2289235Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_013471	41 – 87	Missing in isoform 2. 2 PublicationsAdd BLAST		47
Alternative sequenceⁱVSP_013472	151 – 187	Missing in isoform 3. 1 PublicationAdd BLAST		37

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB003629 mRNA Translation: BAB46927.1 AF272043 mRNA Translation: AAF89492.1 AY049777 mRNA Translation: AAL15434.1 AF271781 mRNA Translation: AAG44792.1 AL136603 mRNA Translation: CAB66538.1 AK056321 mRNA Translation: BAG51676.1 AK090975 mRNA Translation: BAC03562.1 CR457208 mRNA Translation: CAG33489.1 AK222697 mRNA Translation: BAD96417.1 AK075361 mRNA Translation: BAC11570.1 AL713651 mRNA Translation: CAD28460.1 CH471063 Genomic DNA Translation: EAW70936.1 BC002424 mRNA Translation: AAH02424.1 BC025742 mRNA Translation: AAH25742.1 BC050668 mRNA Translation: AAH50668.1 BC098563 mRNA Translation: AAH98563.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2479.1 [Q9NQX7-1] CCDS33395.1 [Q9NQX7-3] CCDS33396.1 [Q9NQX7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001012532.1, NM_001012514.2 [Q9NQX7-2] NP_001012534.1, NM_001012516.2 [Q9NQX7-3] NP_001274169.1, NM_001287240.1 NP_001274170.1, NM_001287241.1 [Q9NQX7-1] NP_112188.1, NM_030926.5 [Q9NQX7-1]
UniGeneⁱ	Hs.111577

Genome annotation databases

Ensemblⁱ	ENST00000326407; ENSP00000322100; ENSG00000135916 [Q9NQX7-3] ENST00000326427; ENSP00000322730; ENSG00000135916 [Q9NQX7-1] ENST00000335005; ENSP00000335121; ENSG00000135916 [Q9NQX7-2]
GeneIDⁱ	81618
KEGGⁱ	hsa:81618
UCSC genome browser More...UCSCⁱ	uc002vqz.5 human [Q9NQX7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NQX7	Integral membrane protein 2C, isoform CRA_a		HUMAN		267	UniRef100_Q9NQX7
Integral membrane protein 2C		PANTR		267
Integral membrane protein 2C		GORGO		267
Integral membrane protein 2C (Fragment)		HUMAN		180
ITM2C isoform 10 (Fragment)		PANTR		180
Q9NQX7-2	ITM2C isoform 5		PONAB		220	UniRef100_A0A2J8TQE5
Integral membrane protein 2C		PANTR		220
Integral membrane protein 2C		GORGO		220
Q9NQX7-3	Integral membrane protein 2C		PANTR		230	UniRef100_A0A2I3RXM4
Integral membrane protein 2C		GORGO		230

Protein	Similar proteins		Species	Score	Length	Source
Q9NQX7	Integral membrane protein 2C		PONAB		267	UniRef90_Q9NQX7
Integral membrane protein 2C		MACFA		267
Integral membrane protein 2C, isoform CRA_a		HUMAN		267
Integral membrane protein 2C		PANTR		267
Integral membrane protein 2C		GORGO		267
+45
Q9NQX7-2	Integral membrane protein 2C		LOXAF		180	UniRef90_G3UJF7
Uncharacterized protein		PROCO		222
Uncharacterized protein		FELCA		222
Integral membrane protein 2C isoform 3		CALJA		220
Integral membrane protein 2C		SAIBB		220
+24
Q9NQX7-3	Integral membrane protein 2C		MOUSE		232	UniRef90_A0A087WRM2
Uncharacterized protein		PROCO		232
Uncharacterized protein		FELCA		232
Uncharacterized protein		ICTTR		231
Integral membrane protein 2C		SAIBB		230
+22

Protein	Similar proteins		Species	Score	Length	Source
Q9NQX7	Integral membrane protein 2C		MACFA		267	UniRef50_Q9NQX7
Integral membrane protein 2C		PONAB		267
Integral membrane protein 2C		BOVIN		271
Integral membrane protein 2C		PIG		269
Integral membrane protein 2C		MOUSE		269
+268
Q9NQX7-2	Uncharacterized protein		RABIT		243	UniRef50_G1T160
Integral membrane protein 2C		FUKDA		245
integral membrane protein 2C		Florida manatee		205
Integral membrane protein 2C		TUPCH		251
ITM2C		CEREH		209
+64
Q9NQX7-3	Uncharacterized protein		SHEEP		238	UniRef50_W5QHL6
integral membrane protein 2C isoform X3		ERIEU		230
Uncharacterized protein		RHIRO		226
Uncharacterized protein		CAVPO		230
Uncharacterized protein		PROCO		232
+41

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB003629 mRNA Translation: BAB46927.1 AF272043 mRNA Translation: AAF89492.1 AY049777 mRNA Translation: AAL15434.1 AF271781 mRNA Translation: AAG44792.1 AL136603 mRNA Translation: CAB66538.1 AK056321 mRNA Translation: BAG51676.1 AK090975 mRNA Translation: BAC03562.1 CR457208 mRNA Translation: CAG33489.1 AK222697 mRNA Translation: BAD96417.1 AK075361 mRNA Translation: BAC11570.1 AL713651 mRNA Translation: CAD28460.1 CH471063 Genomic DNA Translation: EAW70936.1 BC002424 mRNA Translation: AAH02424.1 BC025742 mRNA Translation: AAH25742.1 BC050668 mRNA Translation: AAH50668.1 BC098563 mRNA Translation: AAH98563.1
CCDSⁱ	CCDS2479.1 [Q9NQX7-1] CCDS33395.1 [Q9NQX7-3] CCDS33396.1 [Q9NQX7-2]
RefSeqⁱ	NP_001012532.1, NM_001012514.2 [Q9NQX7-2] NP_001012534.1, NM_001012516.2 [Q9NQX7-3] NP_001274169.1, NM_001287240.1 NP_001274170.1, NM_001287241.1 [Q9NQX7-1] NP_112188.1, NM_030926.5 [Q9NQX7-1]
UniGeneⁱ	Hs.111577

3D structure databases

ProteinModelPortalⁱ	Q9NQX7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123553, 7 interactors
IntActⁱ	Q9NQX7, 18 interactors
MINTⁱ	Q9NQX7
STRINGⁱ	9606.ENSP00000322730

PTM databases

iPTMnetⁱ	Q9NQX7
PhosphoSitePlusⁱ	Q9NQX7
SwissPalmⁱ	Q9NQX7

Polymorphism and mutation databases

BioMutaⁱ	ITM2C
DMDMⁱ	12585259

Proteomic databases

EPDⁱ	Q9NQX7
MaxQBⁱ	Q9NQX7
PaxDbⁱ	Q9NQX7
PeptideAtlasⁱ	Q9NQX7
PRIDEⁱ	Q9NQX7
ProteomicsDBⁱ	82226 82227 [Q9NQX7-2] 82228 [Q9NQX7-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	81618
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000326407; ENSP00000322100; ENSG00000135916 [Q9NQX7-3] ENST00000326427; ENSP00000322730; ENSG00000135916 [Q9NQX7-1] ENST00000335005; ENSP00000335121; ENSG00000135916 [Q9NQX7-2]
GeneIDⁱ	81618
KEGGⁱ	hsa:81618
UCSCⁱ	uc002vqz.5 human [Q9NQX7-1]

Organism-specific databases

CTDⁱ	81618
DisGeNETⁱ	81618
EuPathDBⁱ	HostDB:ENSG00000135916.15
GeneCardsⁱ	ITM2C
HGNCⁱ	HGNC:6175 ITM2C
MIMⁱ	609554 gene
neXtProtⁱ	NX_Q9NQX7
OpenTargetsⁱ	ENSG00000135916
PharmGKBⁱ	PA29972
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4681 Eukaryota ENOG410XRNN LUCA
GeneTreeⁱ	ENSGT00390000005162
HOVERGENⁱ	HBG059373
InParanoidⁱ	Q9NQX7
KOⁱ	K18265
OMAⁱ	KKGTYLP
OrthoDBⁱ	EOG091G0E78
PhylomeDBⁱ	Q9NQX7
TreeFamⁱ	TF317770

Miscellaneous databases

ChiTaRSⁱ	ITM2C human
GeneWikiⁱ	ITM2C
GenomeRNAiⁱ	81618
Protein Ontology More...PROⁱ	PR:Q9NQX7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135916 Expressed in 228 organ(s), highest expression level in nucleus accumbens
CleanExⁱ	HS_BRI3 HS_ITM2C
ExpressionAtlasⁱ	Q9NQX7 baseline and differential
Genevisibleⁱ	Q9NQX7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007084 BRICHOS_dom
Pfamⁱ	View protein in Pfam PF04089 BRICHOS, 1 hit
SMARTⁱ	View protein in SMART SM01039 BRICHOS, 1 hit
PROSITEⁱ	View protein in PROSITE PS50869 BRICHOS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ITM2C_HUMAN
Accessionⁱ	Q9NQX7Primary (citable) accession number: Q9NQX7 Secondary accession number(s): B3KPG4 Q9BUP8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9NQX7 (ITM2C_HUMAN)

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Integral membrane protein 2C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Lysosome

Extracellular region or secreted

Golgi apparatus

Lysosome

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ