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Protein

Zinc finger protein 331

Gene

ZNF331

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation. May play a role in spermatogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 153C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 331
Alternative name(s):
C2H2-like zinc finger protein rearranged in thyroid adenomas
Zinc finger protein 361
Zinc finger protein 463
Gene namesi
Name:ZNF331
Synonyms:RITA, ZNF361, ZNF463
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130844.16
HGNCiHGNC:15489 ZNF331
MIMi606043 gene
neXtProtiNX_Q9NQX6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55422
OpenTargetsiENSG00000130844
PharmGKBiPA134866703

Polymorphism and mutation databases

BioMutaiZNF331
DMDMi34925661

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475351 – 463Zinc finger protein 331Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9NQX6
PaxDbiQ9NQX6
PeptideAtlasiQ9NQX6
PRIDEiQ9NQX6
ProteomicsDBi82225

PTM databases

iPTMnetiQ9NQX6
PhosphoSitePlusiQ9NQX6

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiENSG00000130844 Expressed in 230 organ(s), highest expression level in adenohypophysis
CleanExiHS_ZNF331
ExpressionAtlasiQ9NQX6 baseline and differential
GenevisibleiQ9NQX6 HS

Organism-specific databases

HPAiHPA063157

Interactioni

Protein-protein interaction databases

BioGridi120663, 63 interactors
IntActiQ9NQX6, 10 interactors
MINTiQ9NQX6
STRINGi9606.ENSP00000253144

Structurei

3D structure databases

ProteinModelPortaliQ9NQX6
SMRiQ9NQX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 78KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 153C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9NQX6
KOiK09228
OMAiKAFSHGH
OrthoDBiEOG091G02KC
PhylomeDBiQ9NQX6
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

Q9NQX6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQGLVTFAD VAIDFSQEEW ACLNSAQRDL YWDVMLENYS NLVSLDLESA
60 70 80 90 100
YENKSLPTEK NIHEIRASKR NSDRRSKSLG RNWICEGTLE RPQRSRGRYV
110 120 130 140 150
NQMIINYVKR PATREGTPPR THQRHHKENS FECKDCGKAF SRGYQLSQHQ
160 170 180 190 200
KIHTGEKPYE CKECKKAFRW GNQLTQHQKI HTGEKPYECK DCGKAFRWGS
210 220 230 240 250
SLVIHKRIHT GEKPYECKDC GKAFRRGDEL TQHQRFHTGE KDYECKDCGK
260 270 280 290 300
TFSRVYKLIQ HKRIHSGEKP YECKDCGKAF ICGSSLIQHK RIHTGEKPYE
310 320 330 340 350
CQECGKAFTR VNYLTQHQKI HTGEKPHECK ECGKAFRWGS SLVKHERIHT
360 370 380 390 400
GEKPYKCTEC GKAFNCGYHL TQHERIHTGE TPYKCKECGK AFIYGSSLVK
410 420 430 440 450
HERIHTGVKP YGCTECGKSF SHGHQLTQHQ KTHSGAKSYE CKECGKACNH
460
LNHLREHQRI HNS
Length:463
Mass (Da):53,739
Last modified:October 1, 2000 - v1
Checksum:iA9DB42D0870A7767
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ERM8E7ERM8_HUMAN
Zinc finger protein 331
ZNF331
166Annotation score:
E7ETJ5E7ETJ5_HUMAN
Zinc finger protein 331
ZNF331
177Annotation score:
Q71QC5Q71QC5_HUMAN
KRAB zinc finger protein
ZNF331
85Annotation score:
Q71QC6Q71QC6_HUMAN
KRAB zinc finger protein
ZNF331
66Annotation score:
Q71QC9Q71QC9_HUMAN
KRAB zinc finger protein
ZNF331
64Annotation score:
E7EWU7E7EWU7_HUMAN
Zinc finger protein 331
ZNF331
99Annotation score:
E7ENR0E7ENR0_HUMAN
Zinc finger protein 331
ZNF331
86Annotation score:
E7EPT0E7EPT0_HUMAN
Zinc finger protein 331
ZNF331
105Annotation score:
E7EPG5E7EPG5_HUMAN
Zinc finger protein 331
ZNF331
98Annotation score:
E7EV14E7EV14_HUMAN
Zinc finger protein 331
ZNF331
63Annotation score:
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59E → K in AAH09433 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272148 mRNA Translation: AAF78075.1
AF251515 mRNA Translation: AAF70179.2
BC009433 mRNA Translation: AAH09433.1
CCDSiCCDS33102.1
RefSeqiNP_001073375.1, NM_001079906.1
NP_001073376.1, NM_001079907.1
NP_001240727.1, NM_001253798.1
NP_001240728.1, NM_001253799.1
NP_001240729.1, NM_001253800.1
NP_001240730.1, NM_001253801.2
NP_001304042.1, NM_001317113.1
NP_001304043.1, NM_001317114.1
NP_001304044.1, NM_001317115.1
NP_001304045.1, NM_001317116.1
NP_001304046.1, NM_001317117.1
NP_001304047.1, NM_001317118.1
NP_001304048.1, NM_001317119.1
NP_001304049.1, NM_001317120.1
NP_001304050.1, NM_001317121.1
NP_061025.5, NM_018555.5
XP_011525378.1, XM_011527076.2
XP_011525380.1, XM_011527078.2
XP_016882425.1, XM_017026936.1
XP_016882426.1, XM_017026937.1
XP_016882427.1, XM_017026938.1
XP_016882428.1, XM_017026939.1
XP_016882429.1, XM_017026940.1
UniGeneiHs.185674

Genome annotation databases

EnsembliENST00000253144; ENSP00000253144; ENSG00000130844
ENST00000411977; ENSP00000393336; ENSG00000130844
ENST00000449416; ENSP00000393817; ENSG00000130844
ENST00000511154; ENSP00000421014; ENSG00000130844
ENST00000511593; ENSP00000427439; ENSG00000130844
ENST00000512387; ENSP00000421728; ENSG00000130844
ENST00000513999; ENSP00000423156; ENSG00000130844
GeneIDi55422
KEGGihsa:55422
UCSCiuc002qbx.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272148 mRNA Translation: AAF78075.1
AF251515 mRNA Translation: AAF70179.2
BC009433 mRNA Translation: AAH09433.1
CCDSiCCDS33102.1
RefSeqiNP_001073375.1, NM_001079906.1
NP_001073376.1, NM_001079907.1
NP_001240727.1, NM_001253798.1
NP_001240728.1, NM_001253799.1
NP_001240729.1, NM_001253800.1
NP_001240730.1, NM_001253801.2
NP_001304042.1, NM_001317113.1
NP_001304043.1, NM_001317114.1
NP_001304044.1, NM_001317115.1
NP_001304045.1, NM_001317116.1
NP_001304046.1, NM_001317117.1
NP_001304047.1, NM_001317118.1
NP_001304048.1, NM_001317119.1
NP_001304049.1, NM_001317120.1
NP_001304050.1, NM_001317121.1
NP_061025.5, NM_018555.5
XP_011525378.1, XM_011527076.2
XP_011525380.1, XM_011527078.2
XP_016882425.1, XM_017026936.1
XP_016882426.1, XM_017026937.1
XP_016882427.1, XM_017026938.1
XP_016882428.1, XM_017026939.1
XP_016882429.1, XM_017026940.1
UniGeneiHs.185674

3D structure databases

ProteinModelPortaliQ9NQX6
SMRiQ9NQX6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120663, 63 interactors
IntActiQ9NQX6, 10 interactors
MINTiQ9NQX6
STRINGi9606.ENSP00000253144

PTM databases

iPTMnetiQ9NQX6
PhosphoSitePlusiQ9NQX6

Polymorphism and mutation databases

BioMutaiZNF331
DMDMi34925661

Proteomic databases

EPDiQ9NQX6
PaxDbiQ9NQX6
PeptideAtlasiQ9NQX6
PRIDEiQ9NQX6
ProteomicsDBi82225

Protocols and materials databases

DNASUi55422
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253144; ENSP00000253144; ENSG00000130844
ENST00000411977; ENSP00000393336; ENSG00000130844
ENST00000449416; ENSP00000393817; ENSG00000130844
ENST00000511154; ENSP00000421014; ENSG00000130844
ENST00000511593; ENSP00000427439; ENSG00000130844
ENST00000512387; ENSP00000421728; ENSG00000130844
ENST00000513999; ENSP00000423156; ENSG00000130844
GeneIDi55422
KEGGihsa:55422
UCSCiuc002qbx.2 human

Organism-specific databases

CTDi55422
DisGeNETi55422
EuPathDBiHostDB:ENSG00000130844.16
GeneCardsiZNF331
HGNCiHGNC:15489 ZNF331
HPAiHPA063157
MIMi606043 gene
neXtProtiNX_Q9NQX6
OpenTargetsiENSG00000130844
PharmGKBiPA134866703
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9NQX6
KOiK09228
OMAiKAFSHGH
OrthoDBiEOG091G02KC
PhylomeDBiQ9NQX6
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF331 human
GeneWikiiZNF331
GenomeRNAii55422
PROiPR:Q9NQX6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130844 Expressed in 230 organ(s), highest expression level in adenohypophysis
CleanExiHS_ZNF331
ExpressionAtlasiQ9NQX6 baseline and differential
GenevisibleiQ9NQX6 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN331_HUMAN
AccessioniPrimary (citable) accession number: Q9NQX6
Secondary accession number(s): Q96GJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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