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Entry version 168 (12 Aug 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Zinc finger protein 331

Gene

ZNF331

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation. May play a role in spermatogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri131 – 153C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NQX6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 331
Alternative name(s):
C2H2-like zinc finger protein rearranged in thyroid adenomas
Zinc finger protein 361
Zinc finger protein 463
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF331
Synonyms:RITA, ZNF361, ZNF463
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000130844.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15489, ZNF331

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606043, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NQX6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55422

Open Targets

More...
OpenTargetsi
ENSG00000130844

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134866703

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NQX6, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF331

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34925661

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475351 – 463Zinc finger protein 331Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NQX6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NQX6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NQX6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NQX6

PeptideAtlas

More...
PeptideAtlasi
Q9NQX6

PRoteomics IDEntifications database

More...
PRIDEi
Q9NQX6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82225

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NQX6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NQX6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130844, Expressed in adenohypophysis and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NQX6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NQX6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000130844, Tissue enhanced (adrenal gland, ovary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
120663, 63 interactors

Protein interaction database and analysis system

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IntActi
Q9NQX6, 60 interactors

Molecular INTeraction database

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MINTi
Q9NQX6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000253144

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NQX6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NQX6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 78KRABPROSITE-ProRule annotationAdd BLAST73

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 153C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161267

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NQX6

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
WACLDST

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NQX6

TreeFam database of animal gene trees

More...
TreeFami
TF341817

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q9NQX6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQGLVTFAD VAIDFSQEEW ACLNSAQRDL YWDVMLENYS NLVSLDLESA
60 70 80 90 100
YENKSLPTEK NIHEIRASKR NSDRRSKSLG RNWICEGTLE RPQRSRGRYV
110 120 130 140 150
NQMIINYVKR PATREGTPPR THQRHHKENS FECKDCGKAF SRGYQLSQHQ
160 170 180 190 200
KIHTGEKPYE CKECKKAFRW GNQLTQHQKI HTGEKPYECK DCGKAFRWGS
210 220 230 240 250
SLVIHKRIHT GEKPYECKDC GKAFRRGDEL TQHQRFHTGE KDYECKDCGK
260 270 280 290 300
TFSRVYKLIQ HKRIHSGEKP YECKDCGKAF ICGSSLIQHK RIHTGEKPYE
310 320 330 340 350
CQECGKAFTR VNYLTQHQKI HTGEKPHECK ECGKAFRWGS SLVKHERIHT
360 370 380 390 400
GEKPYKCTEC GKAFNCGYHL TQHERIHTGE TPYKCKECGK AFIYGSSLVK
410 420 430 440 450
HERIHTGVKP YGCTECGKSF SHGHQLTQHQ KTHSGAKSYE CKECGKACNH
460
LNHLREHQRI HNS
Length:463
Mass (Da):53,739
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9DB42D0870A7767
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ETJ5E7ETJ5_HUMAN
Zinc finger protein 331
ZNF331
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q71QC5Q71QC5_HUMAN
KRAB zinc finger protein
ZNF331
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RH27D6RH27_HUMAN
Zinc finger protein 331
ZNF331
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPG5E7EPG5_HUMAN
Zinc finger protein 331
ZNF331
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPT0E7EPT0_HUMAN
Zinc finger protein 331
ZNF331
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EV14E7EV14_HUMAN
Zinc finger protein 331
ZNF331
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWU7E7EWU7_HUMAN
Zinc finger protein 331
ZNF331
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q71QC9Q71QC9_HUMAN
KRAB zinc finger protein
ZNF331
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti59E → K in AAH09433 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF272148 mRNA Translation: AAF78075.1
AF251515 mRNA Translation: AAF70179.2
BC009433 mRNA Translation: AAH09433.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33102.1

NCBI Reference Sequences

More...
RefSeqi
NP_001073375.1, NM_001079906.1
NP_001073376.1, NM_001079907.1
NP_001240727.1, NM_001253798.1
NP_001240728.1, NM_001253799.1
NP_001240729.1, NM_001253800.1
NP_001240730.1, NM_001253801.2
NP_001304042.1, NM_001317113.1
NP_001304043.1, NM_001317114.1
NP_001304044.1, NM_001317115.1
NP_001304045.1, NM_001317116.1
NP_001304046.1, NM_001317117.1
NP_001304047.1, NM_001317118.1
NP_001304048.1, NM_001317119.1
NP_001304049.1, NM_001317120.1
NP_001304050.1, NM_001317121.1
NP_061025.5, NM_018555.5
XP_011525378.1, XM_011527076.2
XP_011525380.1, XM_011527078.2
XP_016882425.1, XM_017026936.1
XP_016882426.1, XM_017026937.1
XP_016882427.1, XM_017026938.1
XP_016882428.1, XM_017026939.1
XP_016882429.1, XM_017026940.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000253144; ENSP00000253144; ENSG00000130844
ENST00000411977; ENSP00000393336; ENSG00000130844
ENST00000449416; ENSP00000393817; ENSG00000130844
ENST00000504493; ENSP00000425517; ENSG00000130844
ENST00000511154; ENSP00000421014; ENSG00000130844
ENST00000511593; ENSP00000427439; ENSG00000130844
ENST00000512387; ENSP00000421728; ENSG00000130844
ENST00000513999; ENSP00000423156; ENSG00000130844
ENST00000648122; ENSP00000496977; ENSG00000130844
ENST00000648236; ENSP00000497263; ENSG00000130844
ENST00000648397; ENSP00000497726; ENSG00000130844
ENST00000648511; ENSP00000497652; ENSG00000130844
ENST00000649326; ENSP00000498006; ENSG00000130844

Database of genes from NCBI RefSeq genomes

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GeneIDi
55422

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55422

UCSC genome browser

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UCSCi
uc002qbx.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272148 mRNA Translation: AAF78075.1
AF251515 mRNA Translation: AAF70179.2
BC009433 mRNA Translation: AAH09433.1
CCDSiCCDS33102.1
RefSeqiNP_001073375.1, NM_001079906.1
NP_001073376.1, NM_001079907.1
NP_001240727.1, NM_001253798.1
NP_001240728.1, NM_001253799.1
NP_001240729.1, NM_001253800.1
NP_001240730.1, NM_001253801.2
NP_001304042.1, NM_001317113.1
NP_001304043.1, NM_001317114.1
NP_001304044.1, NM_001317115.1
NP_001304045.1, NM_001317116.1
NP_001304046.1, NM_001317117.1
NP_001304047.1, NM_001317118.1
NP_001304048.1, NM_001317119.1
NP_001304049.1, NM_001317120.1
NP_001304050.1, NM_001317121.1
NP_061025.5, NM_018555.5
XP_011525378.1, XM_011527076.2
XP_011525380.1, XM_011527078.2
XP_016882425.1, XM_017026936.1
XP_016882426.1, XM_017026937.1
XP_016882427.1, XM_017026938.1
XP_016882428.1, XM_017026939.1
XP_016882429.1, XM_017026940.1

3D structure databases

SMRiQ9NQX6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120663, 63 interactors
IntActiQ9NQX6, 60 interactors
MINTiQ9NQX6
STRINGi9606.ENSP00000253144

PTM databases

iPTMnetiQ9NQX6
PhosphoSitePlusiQ9NQX6

Polymorphism and mutation databases

BioMutaiZNF331
DMDMi34925661

Proteomic databases

EPDiQ9NQX6
jPOSTiQ9NQX6
MassIVEiQ9NQX6
PaxDbiQ9NQX6
PeptideAtlasiQ9NQX6
PRIDEiQ9NQX6
ProteomicsDBi82225

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32728, 110 antibodies

The DNASU plasmid repository

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DNASUi
55422

Genome annotation databases

EnsembliENST00000253144; ENSP00000253144; ENSG00000130844
ENST00000411977; ENSP00000393336; ENSG00000130844
ENST00000449416; ENSP00000393817; ENSG00000130844
ENST00000504493; ENSP00000425517; ENSG00000130844
ENST00000511154; ENSP00000421014; ENSG00000130844
ENST00000511593; ENSP00000427439; ENSG00000130844
ENST00000512387; ENSP00000421728; ENSG00000130844
ENST00000513999; ENSP00000423156; ENSG00000130844
ENST00000648122; ENSP00000496977; ENSG00000130844
ENST00000648236; ENSP00000497263; ENSG00000130844
ENST00000648397; ENSP00000497726; ENSG00000130844
ENST00000648511; ENSP00000497652; ENSG00000130844
ENST00000649326; ENSP00000498006; ENSG00000130844
GeneIDi55422
KEGGihsa:55422
UCSCiuc002qbx.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55422
DisGeNETi55422
EuPathDBiHostDB:ENSG00000130844.16

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF331
HGNCiHGNC:15489, ZNF331
HPAiENSG00000130844, Tissue enhanced (adrenal gland, ovary)
MIMi606043, gene
neXtProtiNX_Q9NQX6
OpenTargetsiENSG00000130844
PharmGKBiPA134866703

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161267
HOGENOMiCLU_002678_44_0_1
InParanoidiQ9NQX6
KOiK09228
OMAiWACLDST
OrthoDBi1318335at2759
PhylomeDBiQ9NQX6
TreeFamiTF341817

Enzyme and pathway databases

PathwayCommonsiQ9NQX6
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55422, 3 hits in 892 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF331, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZNF331

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55422
PharosiQ9NQX6, Tbio

Protein Ontology

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PROi
PR:Q9NQX6
RNActiQ9NQX6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130844, Expressed in adenohypophysis and 240 other tissues
ExpressionAtlasiQ9NQX6, baseline and differential
GenevisibleiQ9NQX6, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 12 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN331_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQX6
Secondary accession number(s): Q96GJ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2000
Last modified: August 12, 2020
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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