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Protein

Neural proliferation differentiation and control protein 1

Gene

NPDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Neural proliferation differentiation and control protein 1
Short name:
NPDC-1
Gene namesi
Name:NPDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000107281.9
HGNCiHGNC:7899 NPDC1
MIMi605798 gene
neXtProtiNX_Q9NQX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56654
OpenTargetsiENSG00000107281
PharmGKBiPA31701

Polymorphism and mutation databases

BioMutaiNPDC1
DMDMi22261810

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000002183035 – 325Neural proliferation differentiation and control protein 1Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NQX5
MaxQBiQ9NQX5
PaxDbiQ9NQX5
PeptideAtlasiQ9NQX5
PRIDEiQ9NQX5
ProteomicsDBi82224

PTM databases

iPTMnetiQ9NQX5
PhosphoSitePlusiQ9NQX5

Expressioni

Tissue specificityi

Strongly expressed in adult brain; especially in hippocampus, frontal lobe and temporal lobe.

Gene expression databases

BgeeiENSG00000107281 Expressed in 93 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_NPDC1
ExpressionAtlasiQ9NQX5 baseline and differential
GenevisibleiQ9NQX5 HS

Organism-specific databases

HPAiHPA008189

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi121167, 30 interactors
IntActiQ9NQX5, 28 interactors
STRINGi9606.ENSP00000360660

Structurei

3D structure databases

ProteinModelPortaliQ9NQX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi145 – 167Pro/Ser/Thr-richAdd BLAST23
Compositional biasi227 – 237Pro/Ser/Thr-richAdd BLAST11

Sequence similaritiesi

Belongs to the NPDC1/cab-1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3884 Eukaryota
ENOG4111QDP LUCA
GeneTreeiENSGT00440000038604
HOGENOMiHOG000231546
HOVERGENiHBG052657
InParanoidiQ9NQX5
OMAiEPVHMSP
PhylomeDBiQ9NQX5
TreeFamiTF318443

Family and domain databases

InterProiView protein in InterPro
IPR009635 NPDC1
PANTHERiPTHR23352 PTHR23352, 1 hit
PfamiView protein in Pfam
PF06809 NPDC1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9NQX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATPLPPPSP RHLRLLRLLL SGLVLGAALR GAAAGHPDVA ACPGSLDCAL
60 70 80 90 100
KRRARCPPGA HACGPCLQPF QEDQQGLCVP RMRRPPGGGR PQPRLEDEID
110 120 130 140 150
FLAQELARKE SGHSTPPLPK DRQRLPEPAT LGFSARGQGL ELGLPSTPGT
160 170 180 190 200
PTPTPHTSLG SPVSSDPVHM SPLEPRGGQG DGLALVLILA FCVAGAAALS
210 220 230 240 250
VASLCWCRLQ REIRLTQKAD YATAKAPGSP AAPRISPGDQ RLAQSAEMYH
260 270 280 290 300
YQHQRQQMLC LERHKEPPKE LDTASSDEEN EDGDFTVYEC PGLAPTGEME
310 320
VRNPLFDHAA LSAPLPAPSS PPALP
Length:325
Mass (Da):34,516
Last modified:August 13, 2002 - v2
Checksum:i21D6512AD345A575
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SPY9Q5SPY9_HUMAN
Neural proliferation differentiatio...
NPDC1
403Annotation score:
A0A087WYK7A0A087WYK7_HUMAN
Neural proliferation differentiatio...
NPDC1
28Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113H → Q in AAF76225 (Ref. 1) Curated1
Sequence conflicti159L → M in AAK27328 (PubMed:11245976).Curated1
Sequence conflicti210Q → H in AAK27328 (PubMed:11245976).Curated1
Sequence conflicti218 – 226KADYATAKA → EGRLRHCEG in CAB43321 (PubMed:17974005).Curated9
Sequence conflicti289E → D in AAF82603 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272357 mRNA Translation: AAF76225.1
AF285836 mRNA Translation: AAK27328.1
AL807752 Genomic DNA No translation available.
BC004217 mRNA Translation: AAH04217.1
AF283247 mRNA Translation: AAF82603.1
AL050221 mRNA Translation: CAB43321.1
CCDSiCCDS7024.1
PIRiT08809
RefSeqiNP_056207.3, NM_015392.3
UniGeneiHs.719906

Genome annotation databases

EnsembliENST00000371601; ENSP00000360660; ENSG00000107281
GeneIDi56654
KEGGihsa:56654
UCSCiuc004ckt.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272357 mRNA Translation: AAF76225.1
AF285836 mRNA Translation: AAK27328.1
AL807752 Genomic DNA No translation available.
BC004217 mRNA Translation: AAH04217.1
AF283247 mRNA Translation: AAF82603.1
AL050221 mRNA Translation: CAB43321.1
CCDSiCCDS7024.1
PIRiT08809
RefSeqiNP_056207.3, NM_015392.3
UniGeneiHs.719906

3D structure databases

ProteinModelPortaliQ9NQX5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121167, 30 interactors
IntActiQ9NQX5, 28 interactors
STRINGi9606.ENSP00000360660

PTM databases

iPTMnetiQ9NQX5
PhosphoSitePlusiQ9NQX5

Polymorphism and mutation databases

BioMutaiNPDC1
DMDMi22261810

Proteomic databases

EPDiQ9NQX5
MaxQBiQ9NQX5
PaxDbiQ9NQX5
PeptideAtlasiQ9NQX5
PRIDEiQ9NQX5
ProteomicsDBi82224

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371601; ENSP00000360660; ENSG00000107281
GeneIDi56654
KEGGihsa:56654
UCSCiuc004ckt.3 human

Organism-specific databases

CTDi56654
DisGeNETi56654
EuPathDBiHostDB:ENSG00000107281.9
GeneCardsiNPDC1
HGNCiHGNC:7899 NPDC1
HPAiHPA008189
MIMi605798 gene
neXtProtiNX_Q9NQX5
OpenTargetsiENSG00000107281
PharmGKBiPA31701
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3884 Eukaryota
ENOG4111QDP LUCA
GeneTreeiENSGT00440000038604
HOGENOMiHOG000231546
HOVERGENiHBG052657
InParanoidiQ9NQX5
OMAiEPVHMSP
PhylomeDBiQ9NQX5
TreeFamiTF318443

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRSiNPDC1 human
GeneWikiiNPDC1
GenomeRNAii56654
PROiPR:Q9NQX5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107281 Expressed in 93 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_NPDC1
ExpressionAtlasiQ9NQX5 baseline and differential
GenevisibleiQ9NQX5 HS

Family and domain databases

InterProiView protein in InterPro
IPR009635 NPDC1
PANTHERiPTHR23352 PTHR23352, 1 hit
PfamiView protein in Pfam
PF06809 NPDC1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPDC1_HUMAN
AccessioniPrimary (citable) accession number: Q9NQX5
Secondary accession number(s): Q5SPY8
, Q9BTD6, Q9BXT3, Q9NQS2, Q9Y434
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: August 13, 2002
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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