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Protein

Unconventional myosin-Vc

Gene

MYO5C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi161 – 168ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Vc
Gene namesi
Name:MYO5C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000128833.12
HGNCiHGNC:7604 MYO5C
MIMi610022 gene
neXtProtiNX_Q9NQX4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi55930
OpenTargetsiENSG00000128833
PharmGKBiPA31409

Polymorphism and mutation databases

BioMutaiMYO5C
DMDMi294862453

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001234632 – 1742Unconventional myosin-VcAdd BLAST1741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NQX4
MaxQBiQ9NQX4
PaxDbiQ9NQX4
PeptideAtlasiQ9NQX4
PRIDEiQ9NQX4
ProteomicsDBi82223

PTM databases

iPTMnetiQ9NQX4
PhosphoSitePlusiQ9NQX4
SwissPalmiQ9NQX4

Expressioni

Tissue specificityi

Expressed chiefly in non-neuronal tissues. Particularly abundant in epithelial and glandular tissues including pancreas, prostate, mammary, stomach, colon and lung.1 Publication

Gene expression databases

BgeeiENSG00000128833 Expressed in 205 organ(s), highest expression level in oviduct epithelium
CleanExiHS_MYO5C
ExpressionAtlasiQ9NQX4 baseline and differential
GenevisibleiQ9NQX4 HS

Organism-specific databases

HPAiCAB020790
HPA032115
HPA032116

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121005, 109 interactors
IntActiQ9NQX4, 86 interactors
STRINGi9606.ENSP00000261839

Structurei

Secondary structure

11742
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NQX4
SMRiQ9NQX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 62Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST55
Domaini67 – 753Myosin motorPROSITE-ProRule annotationAdd BLAST687
Domaini756 – 779IQ 1PROSITE-ProRule annotationAdd BLAST24
Domaini780 – 806IQ 2PROSITE-ProRule annotationAdd BLAST27
Domaini807 – 829IQ 3PROSITE-ProRule annotationAdd BLAST23
Domaini830 – 854IQ 4PROSITE-ProRule annotationAdd BLAST25
Domaini855 – 884IQ 5PROSITE-ProRule annotationAdd BLAST30
Domaini1421 – 1697DilutePROSITE-ProRule annotationAdd BLAST277

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni632 – 654Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili884 – 1351Sequence analysisAdd BLAST468

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0160 Eukaryota
KOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
HOGENOMiHOG000171839
HOVERGENiHBG052556
InParanoidiQ9NQX4
KOiK10357
OMAiAESDMLQ
OrthoDBiEOG091G0G93
PhylomeDBiQ9NQX4
TreeFamiTF328771

Family and domain databases

CDDicd15476 Myo5c_CBD, 1 hit
cd01380 MYSc_Myo5, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR037991 Myo5c_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036103 MYSc_Myo5
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 4 hits
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 5 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 4 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVAELYTQY NRVWIPDPEE VWKSAEIAKD YRVGDKVLRL LLEDGTELDY
60 70 80 90 100
SVNPESLPPL RNPDILVGEN DLTALSYLHE PAVLHNLRIR FAESKLIYTY
110 120 130 140 150
SGIILVAMNP YKQLPIYGDA IIHAYSGQNM GDMDPHIFAV AEEAYKQMAR
160 170 180 190 200
NNRNQSIIVS GESGAGKTVS ARYAMRYFAT VSKSGSNAHV EDKVLASNPI
210 220 230 240 250
TEAVGNAKTT RNDNSSRFGK YTEISFDEQN QIIGANMSTY LLEKSRVVFQ
260 270 280 290 300
SENERNYHIF YQLCASAQQS EFKHLKLGSA EEFNYTRMGG NTVIEGVNDR
310 320 330 340 350
AEMVETQKTF TLLGFKEDFQ MDVFKILAAI LHLGNVQITA VGNERSSVSE
360 370 380 390 400
DDSHLKVFCE LLGLESGRVA QWLCNRKIVT SSETVVKPMT RPQAVNARDA
410 420 430 440 450
LAKKIYAHLF DFIVERINQA LQFSGKQHTF IGVLDIYGFE TFDVNSFEQF
460 470 480 490 500
CINYANEKLQ QQFNMHVFKL EQEEYMKEDI PWTLIDFYDN QPVIDLIEAK
510 520 530 540 550
MGILELLDEE CLLPHGTDEN WLQKLYNNFV NRNPLFEKPR MSNTSFVIQH
560 570 580 590 600
FADKVEYKCE GFLEKNRDTV YDMLVEILRA SKFHLCANFF QENPTPPSPF
610 620 630 640 650
GSMITVKSAK QVIKPNSKHF RTTVGSKFRS SLYLLMETLN ATTPHYVRCI
660 670 680 690 700
KPNDEKLPFE FDSKRIVQQL RACGVLETIR ISAQSYPSRW TYIEFYSRYG
710 720 730 740 750
ILMTKQELSF SDKKEVCKVV LHRLIQDSNQ YQFGKTKIFF RAGQVAYLEK
760 770 780 790 800
LRLDKLRQSC VMVQKHMRGW LQRKKFLRER RAALIIQQYF RGQQTVRKAI
810 820 830 840 850
TAVALKEAWA AIIIQKHCRG YLVRSLYQLI RMATITMQAY SRGFLARRRY
860 870 880 890 900
RKMLEEHKAV ILQKYARAWL ARRRFQSIRR FVLNIQLTYR VQRLQKKLED
910 920 930 940 950
QNKENHGLVE KLTSLAALRA GDVEKIQKLE AELEKAATHR RNYEEKGKRY
960 970 980 990 1000
RDAVEEKLAK LQKHNSELET QKEQIQLKLQ EKTEELKEKM DNLTKQLFDD
1010 1020 1030 1040 1050
VQKEERQRML LEKSFELKTQ DYEKQIQSLK EEIKALKDEK MQLQHLVEGE
1060 1070 1080 1090 1100
HVTSDGLKAE VARLSKQVKT ISEFEKEIEL LQAQKIDVEK HVQSQKREMR
1110 1120 1130 1140 1150
EKMSEITKQL LESYDIEDVR SRLSVEDLEH LNEDGELWFA YEGLKKATRV
1160 1170 1180 1190 1200
LESHFQSQKD CYEKEIEALN FKVVHLSQEI NHLQKLFREE NDINESIRHE
1210 1220 1230 1240 1250
VTRLTSENMM IPDFKQQISE LEKQKQDLEI RLNEQAEKMK GKLEELSNQL
1260 1270 1280 1290 1300
HRSQEEEGTQ RKALEAQNEI HTKEKEKLID KIQEMQEASD HLKKQFETES
1310 1320 1330 1340 1350
EVKCNFRQEA SRLTLENRDL EEELDMKDRV IKKLQDQVKT LSKTIGKAND
1360 1370 1380 1390 1400
VHSSSGPKEY LGMLQYKRED EAKLIQNLIL DLKPRGVVVN MIPGLPAHIL
1410 1420 1430 1440 1450
FMCVRYADSL NDANMLKSLM NSTINGIKQV VKEHLEDFEM LSFWLSNTCH
1460 1470 1480 1490 1500
FLNCLKQYSG EEEFMKHNSP QQNKNCLNNF DLSEYRQILS DVAIRIYHQF
1510 1520 1530 1540 1550
IIIMEKNIQP IIVPGMLEYE SLQGISGLKP TGFRKRSSSI DDTDGYTMTS
1560 1570 1580 1590 1600
VLQQLSYFYT TMCQNGLDPE LVRQAVKQLF FLIGAVTLNS LFLRKDMCSC
1610 1620 1630 1640 1650
RKGMQIRCNI SYLEEWLKDK NLQNSLAKET LEPLSQAAWL LQVKKTTDSD
1660 1670 1680 1690 1700
AKEIYERCTS LSAVQIIKIL NSYTPIDDFE KRVTPSFVRK VQALLNSRED
1710 1720 1730 1740
SSQLMLDTKY LFQVTFPFTP SPHALEMIQI PSSFKLGFLN RL
Length:1,742
Mass (Da):202,810
Last modified:April 20, 2010 - v2
Checksum:i790B1518098B9054
GO
Isoform 2 (identifier: Q9NQX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     425-430: GKQHTF → VLKPLM
     431-1742: Missing.

Note: No experimental confirmation available.
Show »
Length:430
Mass (Da):48,392
Checksum:i5EC9C554382216F1
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMK3H0YMK3_HUMAN
Unconventional myosin-Vc
MYO5C
269Annotation score:
H0YM93H0YM93_HUMAN
Unconventional myosin-Vc
MYO5C
106Annotation score:
H0YM96H0YM96_HUMAN
Unconventional myosin-Vc
MYO5C
153Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061365172R → C. Corresponds to variant dbSNP:rs55686434Ensembl.1
Natural variantiVAR_010646522L → P1 Publication1
Natural variantiVAR_010647634L → S. 1
Natural variantiVAR_0245441075E → K. Corresponds to variant dbSNP:rs3825801Ensembl.1
Natural variantiVAR_0561861396P → L. Corresponds to variant dbSNP:rs17650440Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056592425 – 430GKQHTF → VLKPLM in isoform 2. 1 Publication6
Alternative sequenceiVSP_056593431 – 1742Missing in isoform 2. 1 PublicationAdd BLAST1312

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272390 mRNA Translation: AAF78783.1
AC010674 Genomic DNA No translation available.
BC064841 mRNA Translation: AAH64841.1
CCDSiCCDS42036.1 [Q9NQX4-1]
RefSeqiNP_061198.2, NM_018728.3 [Q9NQX4-1]
UniGeneiHs.487036

Genome annotation databases

EnsembliENST00000261839; ENSP00000261839; ENSG00000128833 [Q9NQX4-1]
ENST00000559459; ENSP00000454064; ENSG00000128833 [Q9NQX4-2]
GeneIDi55930
KEGGihsa:55930
UCSCiuc010bff.4 human [Q9NQX4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272390 mRNA Translation: AAF78783.1
AC010674 Genomic DNA No translation available.
BC064841 mRNA Translation: AAH64841.1
CCDSiCCDS42036.1 [Q9NQX4-1]
RefSeqiNP_061198.2, NM_018728.3 [Q9NQX4-1]
UniGeneiHs.487036

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4L8TX-ray2.95A1319-1742[»]
4ZG4X-ray2.36B/E1-755[»]
5HMPX-ray2.40A/B5-754[»]
ProteinModelPortaliQ9NQX4
SMRiQ9NQX4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121005, 109 interactors
IntActiQ9NQX4, 86 interactors
STRINGi9606.ENSP00000261839

PTM databases

iPTMnetiQ9NQX4
PhosphoSitePlusiQ9NQX4
SwissPalmiQ9NQX4

Polymorphism and mutation databases

BioMutaiMYO5C
DMDMi294862453

Proteomic databases

EPDiQ9NQX4
MaxQBiQ9NQX4
PaxDbiQ9NQX4
PeptideAtlasiQ9NQX4
PRIDEiQ9NQX4
ProteomicsDBi82223

Protocols and materials databases

DNASUi55930
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261839; ENSP00000261839; ENSG00000128833 [Q9NQX4-1]
ENST00000559459; ENSP00000454064; ENSG00000128833 [Q9NQX4-2]
GeneIDi55930
KEGGihsa:55930
UCSCiuc010bff.4 human [Q9NQX4-1]

Organism-specific databases

CTDi55930
DisGeNETi55930
EuPathDBiHostDB:ENSG00000128833.12
GeneCardsiMYO5C
H-InvDBiHIX0038194
HIX0202185
HGNCiHGNC:7604 MYO5C
HPAiCAB020790
HPA032115
HPA032116
MIMi610022 gene
neXtProtiNX_Q9NQX4
OpenTargetsiENSG00000128833
PharmGKBiPA31409
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0160 Eukaryota
KOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
HOGENOMiHOG000171839
HOVERGENiHBG052556
InParanoidiQ9NQX4
KOiK10357
OMAiAESDMLQ
OrthoDBiEOG091G0G93
PhylomeDBiQ9NQX4
TreeFamiTF328771

Miscellaneous databases

ChiTaRSiMYO5C human
GenomeRNAii55930
PROiPR:Q9NQX4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128833 Expressed in 205 organ(s), highest expression level in oviduct epithelium
CleanExiHS_MYO5C
ExpressionAtlasiQ9NQX4 baseline and differential
GenevisibleiQ9NQX4 HS

Family and domain databases

CDDicd15476 Myo5c_CBD, 1 hit
cd01380 MYSc_Myo5, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR037991 Myo5c_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036103 MYSc_Myo5
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 4 hits
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 5 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 4 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYO5C_HUMAN
AccessioniPrimary (citable) accession number: Q9NQX4
Secondary accession number(s): Q6P1W8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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