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Entry version 170 (22 Apr 2020)
Sequence version 2 (20 Apr 2010)
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Protein

Unconventional myosin-Vc

Gene

MYO5C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi161 – 168ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin-Vc
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYO5C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7604 MYO5C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610022 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NQX4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55930

Open Targets

More...
OpenTargetsi
ENSG00000128833

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31409

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NQX4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYO5C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
294862453

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234632 – 1742Unconventional myosin-VcAdd BLAST1741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NQX4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NQX4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NQX4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NQX4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NQX4

PeptideAtlas

More...
PeptideAtlasi
Q9NQX4

PRoteomics IDEntifications database

More...
PRIDEi
Q9NQX4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66876
82223 [Q9NQX4-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NQX4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NQX4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NQX4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed chiefly in non-neuronal tissues. Particularly abundant in epithelial and glandular tissues including pancreas, prostate, mammary, stomach, colon and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000128833 Expressed in oviduct epithelium and 204 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NQX4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NQX4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000128833 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121005, 112 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NQX4, 110 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261839

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NQX4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11742
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NQX4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 62Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST55
Domaini67 – 753Myosin motorPROSITE-ProRule annotationAdd BLAST687
Domaini756 – 779IQ 1PROSITE-ProRule annotationAdd BLAST24
Domaini780 – 806IQ 2PROSITE-ProRule annotationAdd BLAST27
Domaini807 – 829IQ 3PROSITE-ProRule annotationAdd BLAST23
Domaini830 – 854IQ 4PROSITE-ProRule annotationAdd BLAST25
Domaini855 – 884IQ 5PROSITE-ProRule annotationAdd BLAST30
Domaini1421 – 1697DilutePROSITE-ProRule annotationAdd BLAST277

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni632 – 654Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili884 – 1351Sequence analysisAdd BLAST468

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0160 Eukaryota
KOG0161 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157971

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000192_9_4_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NQX4

KEGG Orthology (KO)

More...
KOi
K10357

Identification of Orthologs from Complete Genome Data

More...
OMAi
KWTVKKQ

Database of Orthologous Groups

More...
OrthoDBi
311886at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NQX4

TreeFam database of animal gene trees

More...
TreeFami
TF328771

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15476 Myo5c_CBD, 1 hit
cd01380 MYSc_Myo5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR037991 Myo5c_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036103 MYSc_Myo5
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 4 hits
PF00063 Myosin_head, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 5 hits
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 4 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVAELYTQY NRVWIPDPEE VWKSAEIAKD YRVGDKVLRL LLEDGTELDY
60 70 80 90 100
SVNPESLPPL RNPDILVGEN DLTALSYLHE PAVLHNLRIR FAESKLIYTY
110 120 130 140 150
SGIILVAMNP YKQLPIYGDA IIHAYSGQNM GDMDPHIFAV AEEAYKQMAR
160 170 180 190 200
NNRNQSIIVS GESGAGKTVS ARYAMRYFAT VSKSGSNAHV EDKVLASNPI
210 220 230 240 250
TEAVGNAKTT RNDNSSRFGK YTEISFDEQN QIIGANMSTY LLEKSRVVFQ
260 270 280 290 300
SENERNYHIF YQLCASAQQS EFKHLKLGSA EEFNYTRMGG NTVIEGVNDR
310 320 330 340 350
AEMVETQKTF TLLGFKEDFQ MDVFKILAAI LHLGNVQITA VGNERSSVSE
360 370 380 390 400
DDSHLKVFCE LLGLESGRVA QWLCNRKIVT SSETVVKPMT RPQAVNARDA
410 420 430 440 450
LAKKIYAHLF DFIVERINQA LQFSGKQHTF IGVLDIYGFE TFDVNSFEQF
460 470 480 490 500
CINYANEKLQ QQFNMHVFKL EQEEYMKEDI PWTLIDFYDN QPVIDLIEAK
510 520 530 540 550
MGILELLDEE CLLPHGTDEN WLQKLYNNFV NRNPLFEKPR MSNTSFVIQH
560 570 580 590 600
FADKVEYKCE GFLEKNRDTV YDMLVEILRA SKFHLCANFF QENPTPPSPF
610 620 630 640 650
GSMITVKSAK QVIKPNSKHF RTTVGSKFRS SLYLLMETLN ATTPHYVRCI
660 670 680 690 700
KPNDEKLPFE FDSKRIVQQL RACGVLETIR ISAQSYPSRW TYIEFYSRYG
710 720 730 740 750
ILMTKQELSF SDKKEVCKVV LHRLIQDSNQ YQFGKTKIFF RAGQVAYLEK
760 770 780 790 800
LRLDKLRQSC VMVQKHMRGW LQRKKFLRER RAALIIQQYF RGQQTVRKAI
810 820 830 840 850
TAVALKEAWA AIIIQKHCRG YLVRSLYQLI RMATITMQAY SRGFLARRRY
860 870 880 890 900
RKMLEEHKAV ILQKYARAWL ARRRFQSIRR FVLNIQLTYR VQRLQKKLED
910 920 930 940 950
QNKENHGLVE KLTSLAALRA GDVEKIQKLE AELEKAATHR RNYEEKGKRY
960 970 980 990 1000
RDAVEEKLAK LQKHNSELET QKEQIQLKLQ EKTEELKEKM DNLTKQLFDD
1010 1020 1030 1040 1050
VQKEERQRML LEKSFELKTQ DYEKQIQSLK EEIKALKDEK MQLQHLVEGE
1060 1070 1080 1090 1100
HVTSDGLKAE VARLSKQVKT ISEFEKEIEL LQAQKIDVEK HVQSQKREMR
1110 1120 1130 1140 1150
EKMSEITKQL LESYDIEDVR SRLSVEDLEH LNEDGELWFA YEGLKKATRV
1160 1170 1180 1190 1200
LESHFQSQKD CYEKEIEALN FKVVHLSQEI NHLQKLFREE NDINESIRHE
1210 1220 1230 1240 1250
VTRLTSENMM IPDFKQQISE LEKQKQDLEI RLNEQAEKMK GKLEELSNQL
1260 1270 1280 1290 1300
HRSQEEEGTQ RKALEAQNEI HTKEKEKLID KIQEMQEASD HLKKQFETES
1310 1320 1330 1340 1350
EVKCNFRQEA SRLTLENRDL EEELDMKDRV IKKLQDQVKT LSKTIGKAND
1360 1370 1380 1390 1400
VHSSSGPKEY LGMLQYKRED EAKLIQNLIL DLKPRGVVVN MIPGLPAHIL
1410 1420 1430 1440 1450
FMCVRYADSL NDANMLKSLM NSTINGIKQV VKEHLEDFEM LSFWLSNTCH
1460 1470 1480 1490 1500
FLNCLKQYSG EEEFMKHNSP QQNKNCLNNF DLSEYRQILS DVAIRIYHQF
1510 1520 1530 1540 1550
IIIMEKNIQP IIVPGMLEYE SLQGISGLKP TGFRKRSSSI DDTDGYTMTS
1560 1570 1580 1590 1600
VLQQLSYFYT TMCQNGLDPE LVRQAVKQLF FLIGAVTLNS LFLRKDMCSC
1610 1620 1630 1640 1650
RKGMQIRCNI SYLEEWLKDK NLQNSLAKET LEPLSQAAWL LQVKKTTDSD
1660 1670 1680 1690 1700
AKEIYERCTS LSAVQIIKIL NSYTPIDDFE KRVTPSFVRK VQALLNSRED
1710 1720 1730 1740
SSQLMLDTKY LFQVTFPFTP SPHALEMIQI PSSFKLGFLN RL
Length:1,742
Mass (Da):202,810
Last modified:April 20, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i790B1518098B9054
GO
Isoform 2 (identifier: Q9NQX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     425-430: GKQHTF → VLKPLM
     431-1742: Missing.

Show »
Length:430
Mass (Da):48,392
Checksum:i5EC9C554382216F1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YM93H0YM93_HUMAN
Unconventional myosin-Vc
MYO5C
106Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMK3H0YMK3_HUMAN
Unconventional myosin-Vc
MYO5C
269Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YM96H0YM96_HUMAN
Unconventional myosin-Vc
MYO5C
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061365172R → C. Corresponds to variant dbSNP:rs55686434Ensembl.1
Natural variantiVAR_010646522L → P1 Publication1
Natural variantiVAR_010647634L → S. 1
Natural variantiVAR_0245441075E → K. Corresponds to variant dbSNP:rs3825801Ensembl.1
Natural variantiVAR_0561861396P → L. Corresponds to variant dbSNP:rs17650440Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056592425 – 430GKQHTF → VLKPLM in isoform 2. 1 Publication6
Alternative sequenceiVSP_056593431 – 1742Missing in isoform 2. 1 PublicationAdd BLAST1312

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF272390 mRNA Translation: AAF78783.1
AC010674 Genomic DNA No translation available.
BC064841 mRNA Translation: AAH64841.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42036.1 [Q9NQX4-1]

NCBI Reference Sequences

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RefSeqi
NP_061198.2, NM_018728.3 [Q9NQX4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000261839; ENSP00000261839; ENSG00000128833 [Q9NQX4-1]
ENST00000559459; ENSP00000454064; ENSG00000128833 [Q9NQX4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55930

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55930

UCSC genome browser

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UCSCi
uc010bff.4 human [Q9NQX4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272390 mRNA Translation: AAF78783.1
AC010674 Genomic DNA No translation available.
BC064841 mRNA Translation: AAH64841.1
CCDSiCCDS42036.1 [Q9NQX4-1]
RefSeqiNP_061198.2, NM_018728.3 [Q9NQX4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4L8TX-ray2.95A1319-1742[»]
4ZG4X-ray2.36B/E1-755[»]
5HMPX-ray2.40A/B5-754[»]
SMRiQ9NQX4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi121005, 112 interactors
IntActiQ9NQX4, 110 interactors
STRINGi9606.ENSP00000261839

PTM databases

iPTMnetiQ9NQX4
PhosphoSitePlusiQ9NQX4
SwissPalmiQ9NQX4

Polymorphism and mutation databases

BioMutaiMYO5C
DMDMi294862453

Proteomic databases

EPDiQ9NQX4
jPOSTiQ9NQX4
MassIVEiQ9NQX4
MaxQBiQ9NQX4
PaxDbiQ9NQX4
PeptideAtlasiQ9NQX4
PRIDEiQ9NQX4
ProteomicsDBi66876
82223 [Q9NQX4-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
24945 56 antibodies

The DNASU plasmid repository

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DNASUi
55930

Genome annotation databases

EnsembliENST00000261839; ENSP00000261839; ENSG00000128833 [Q9NQX4-1]
ENST00000559459; ENSP00000454064; ENSG00000128833 [Q9NQX4-2]
GeneIDi55930
KEGGihsa:55930
UCSCiuc010bff.4 human [Q9NQX4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55930
DisGeNETi55930

GeneCards: human genes, protein and diseases

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GeneCardsi
MYO5C
HGNCiHGNC:7604 MYO5C
HPAiENSG00000128833 Low tissue specificity
MIMi610022 gene
neXtProtiNX_Q9NQX4
OpenTargetsiENSG00000128833
PharmGKBiPA31409

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0160 Eukaryota
KOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000157971
HOGENOMiCLU_000192_9_4_1
InParanoidiQ9NQX4
KOiK10357
OMAiKWTVKKQ
OrthoDBi311886at2759
PhylomeDBiQ9NQX4
TreeFamiTF328771

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MYO5C human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55930
PharosiQ9NQX4 Tbio

Protein Ontology

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PROi
PR:Q9NQX4
RNActiQ9NQX4 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000128833 Expressed in oviduct epithelium and 204 other tissues
ExpressionAtlasiQ9NQX4 baseline and differential
GenevisibleiQ9NQX4 HS

Family and domain databases

CDDicd15476 Myo5c_CBD, 1 hit
cd01380 MYSc_Myo5, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR037991 Myo5c_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036103 MYSc_Myo5
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 4 hits
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 5 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 4 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYO5C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQX4
Secondary accession number(s): Q6P1W8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 20, 2010
Last modified: April 22, 2020
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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