Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PR domain zinc finger protein 5

Gene

PRDM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri167 – 190C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri199 – 221C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 287C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri295 – 317C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 455C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri461 – 483C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 625C2H2-type 16PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Methyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q9NQX1 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PR domain zinc finger protein 5 (EC:2.1.1.-)
Alternative name(s):
PR domain-containing protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRDM5
Synonyms:PFM2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138738.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9349 PRDM5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614161 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NQX1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Brittle cornea syndrome 2 (BCS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by extreme corneal thinning resulting in corneal rupture after minor trauma, blue sclerae, keratoconus or keratoglobus, hyperelasticity of the skin, and hypermobile joints.
See also OMIM:614170
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_066393107Y → C in BCS2. 1 PublicationCorresponds to variant dbSNP:rs387907111EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
11107

MalaCards human disease database

More...
MalaCardsi
PRDM5
MIMi614170 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000138738

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90354 Brittle cornea syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33717

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRDM5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212276458

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000477611 – 630PR domain zinc finger protein 5Add BLAST630

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NQX1

PeptideAtlas

More...
PeptideAtlasi
Q9NQX1

PRoteomics IDEntifications database

More...
PRIDEi
Q9NQX1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82218
82219 [Q9NQX1-2]
82220 [Q9NQX1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NQX1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NQX1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138738 Expressed in 145 organ(s), highest expression level in stomach

CleanEx database of gene expression profiles

More...
CleanExi
HS_PRDM5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NQX1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NQX1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051406

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EHMT2/G9A, GFI1 and HDAC1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116287, 43 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NQX1, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264808

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NQX1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NQX1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 124SETPROSITE-ProRule annotationAdd BLAST117

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri167 – 190C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri199 – 221C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 287C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri295 – 317C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 455C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri461 – 483C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 625C2H2-type 16PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
KOG2461 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158340

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG098380

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NQX1

KEGG Orthology (KO)

More...
KOi
K22534

Identification of Orthologs from Complete Genome Data

More...
OMAi
MDNIHGE

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NQX1

TreeFam database of animal gene trees

More...
TreeFami
TF106478

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
IPR017125 Znf_PRDM5-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 10 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037162 PRDM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00317 SET, 1 hit
SM00355 ZnF_C2H2, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGMYVPDRF SLKSSRVQDG MGLYTARRVR KGEKFGPFAG EKRMPEDLDE
60 70 80 90 100
NMDYRLMWEV RGSKGEVLYI LDATNPRHSN WLRFVHEAPS QEQKNLAAIQ
110 120 130 140 150
EGENIFYLAV EDIETDTELL IGYLDSDMEA EEEEQQIMTV IKEGEVENSR
160 170 180 190 200
RQSTAGRKDR LGCKEDYACP QCESSFTSED ILAEHLQTLH QKPTEEKEFK
210 220 230 240 250
CKNCGKKFPV KQALQRHVLQ CTAKSSLKES SRSFQCSVCN SSFSSASSFE
260 270 280 290 300
QHQETCRGDA RFVCKADSCG KRLKSKDALK RHQENVHTGD PKKKLICSVC
310 320 330 340 350
NKKCSSASSL QEHRKIHEIF DCQECMKKFI SANQLKRHMI THSEKRPYNC
360 370 380 390 400
EICNKSFKRL DQVGAHKVIH SEDKPYKCKL CGKGFAHRNV YKNHKKTHSE
410 420 430 440 450
ERPFQCEECK ALFRTPFSLQ RHLLIHNSER TFKCHHCDAT FKRKDTLNVH
460 470 480 490 500
VQVVHERHKK YRCELCNKAF VTPSVLRSHK KTHTGEKEKI CPYCGQKFAS
510 520 530 540 550
SGTLRVHIRS HTGERPYQCP YCEKGFSKND GLKMHIRTHT REKPYKCSEC
560 570 580 590 600
SKAFSQKRGL DEHKRTHTGE KPFQCDVCDL AFSLKKMLIR HKMTHNPNRP
610 620 630
LAECQFCHKK FTRNDYLKVH MDNIHGVADS
Length:630
Mass (Da):73,090
Last modified:November 4, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD16AF81AB5A34398
GO
Isoform 2 (identifier: Q9NQX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     218-248: Missing.

Show »
Length:599
Mass (Da):69,862
Checksum:i567E937469373B58
GO
Isoform 3 (identifier: Q9NQX1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-111: EGENIFYLAVE → DKNLGPAEWRG
     112-630: Missing.

Show »
Length:111
Mass (Da):12,874
Checksum:iF0568A1C8495EC01
GO
Isoform 4 (identifier: Q9NQX1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     218-248: Missing.
     515-532: RPYQCPYCEKGFSKNDGL → AVQVLRVQQGLQPEARPG
     533-630: Missing.

Note: No experimental confirmation available.
Show »
Length:501
Mass (Da):58,124
Checksum:i5560F041B4F4B3E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9S1H0Y9S1_HUMAN
PR domain zinc finger protein 5
PRDM5
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti261R → K in AAF78077 (PubMed:15077163).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066393107Y → C in BCS2. 1 PublicationCorresponds to variant dbSNP:rs387907111EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_035652101 – 111EGENIFYLAVE → DKNLGPAEWRG in isoform 3. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_035653112 – 630Missing in isoform 3. 2 PublicationsAdd BLAST519
Alternative sequenceiVSP_035654218 – 248Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_054395515 – 532RPYQC…KNDGL → AVQVLRVQQGLQPEARPG in isoform 4. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_054396533 – 630Missing in isoform 4. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF272897 mRNA Translation: AAF78077.1
AK056352 mRNA Translation: BAG51686.1
AC025741 Genomic DNA No translation available.
AC104068 Genomic DNA No translation available.
AC104795 Genomic DNA No translation available.
BC066942 mRNA Translation: AAH66942.1
BC121037 mRNA Translation: AAI21038.1
BC121038 mRNA Translation: AAI21039.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3716.1 [Q9NQX1-1]
CCDS75187.1 [Q9NQX1-4]
CCDS75188.1 [Q9NQX1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001287752.1, NM_001300823.1 [Q9NQX1-2]
NP_001287753.1, NM_001300824.1 [Q9NQX1-4]
NP_061169.2, NM_018699.3 [Q9NQX1-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.666782

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264808; ENSP00000264808; ENSG00000138738 [Q9NQX1-1]
ENST00000394435; ENSP00000377955; ENSG00000138738 [Q9NQX1-3]
ENST00000428209; ENSP00000404832; ENSG00000138738 [Q9NQX1-2]
ENST00000515109; ENSP00000422309; ENSG00000138738 [Q9NQX1-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11107

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11107

UCSC genome browser

More...
UCSCi
uc003idn.4 human [Q9NQX1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272897 mRNA Translation: AAF78077.1
AK056352 mRNA Translation: BAG51686.1
AC025741 Genomic DNA No translation available.
AC104068 Genomic DNA No translation available.
AC104795 Genomic DNA No translation available.
BC066942 mRNA Translation: AAH66942.1
BC121037 mRNA Translation: AAI21038.1
BC121038 mRNA Translation: AAI21039.1
CCDSiCCDS3716.1 [Q9NQX1-1]
CCDS75187.1 [Q9NQX1-4]
CCDS75188.1 [Q9NQX1-2]
RefSeqiNP_001287752.1, NM_001300823.1 [Q9NQX1-2]
NP_001287753.1, NM_001300824.1 [Q9NQX1-4]
NP_061169.2, NM_018699.3 [Q9NQX1-1]
UniGeneiHs.666782

3D structure databases

ProteinModelPortaliQ9NQX1
SMRiQ9NQX1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116287, 43 interactors
IntActiQ9NQX1, 11 interactors
STRINGi9606.ENSP00000264808

Protein family/group databases

MoonDBiQ9NQX1 Predicted

PTM databases

iPTMnetiQ9NQX1
PhosphoSitePlusiQ9NQX1

Polymorphism and mutation databases

BioMutaiPRDM5
DMDMi212276458

Proteomic databases

PaxDbiQ9NQX1
PeptideAtlasiQ9NQX1
PRIDEiQ9NQX1
ProteomicsDBi82218
82219 [Q9NQX1-2]
82220 [Q9NQX1-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264808; ENSP00000264808; ENSG00000138738 [Q9NQX1-1]
ENST00000394435; ENSP00000377955; ENSG00000138738 [Q9NQX1-3]
ENST00000428209; ENSP00000404832; ENSG00000138738 [Q9NQX1-2]
ENST00000515109; ENSP00000422309; ENSG00000138738 [Q9NQX1-4]
GeneIDi11107
KEGGihsa:11107
UCSCiuc003idn.4 human [Q9NQX1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11107
DisGeNETi11107
EuPathDBiHostDB:ENSG00000138738.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRDM5
HGNCiHGNC:9349 PRDM5
HPAiHPA051406
MalaCardsiPRDM5
MIMi614161 gene
614170 phenotype
neXtProtiNX_Q9NQX1
OpenTargetsiENSG00000138738
Orphaneti90354 Brittle cornea syndrome
PharmGKBiPA33717

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
KOG2461 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000158340
HOGENOMiHOG000234617
HOVERGENiHBG098380
InParanoidiQ9NQX1
KOiK22534
OMAiMDNIHGE
OrthoDBi1318335at2759
PhylomeDBiQ9NQX1
TreeFamiTF106478

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PRDM5 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11107

Protein Ontology

More...
PROi
PR:Q9NQX1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138738 Expressed in 145 organ(s), highest expression level in stomach
CleanExiHS_PRDM5
ExpressionAtlasiQ9NQX1 baseline and differential
GenevisibleiQ9NQX1 HS

Family and domain databases

InterProiView protein in InterPro
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
IPR017125 Znf_PRDM5-like
PfamiView protein in Pfam
PF00096 zf-C2H2, 10 hits
PIRSFiPIRSF037162 PRDM, 1 hit
SMARTiView protein in SMART
SM00317 SET, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRDM5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQX1
Secondary accession number(s): Q0VAI9, Q0VAJ0, Q6NXQ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 4, 2008
Last modified: January 16, 2019
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again