Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 144 (13 Feb 2019)
Sequence version 2 (21 Mar 2006)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Anillin

Gene

ANLN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636).7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: MGI
  • cadherin binding Source: BHF-UCL
  • GTP-Rho binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processCell cycle, Cell division, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anillin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANLN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000011426.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14082 ANLN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616027 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NQW6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Focal segmental glomerulosclerosis 8 (FSGS8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
See also OMIM:616032
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072418431R → C in FSGS8; results in decreased interaction with CD2AP. 1 PublicationCorresponds to variant dbSNP:rs587777741EnsemblClinVar.1
Natural variantiVAR_072419618G → C in FSGS8. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi32R → A: Abrogates interaction with CD2AP. 1 Publication1
Mutagenesisi41R → A: Abrogates ubiquitin-mediated proteolysis; when associated with A-44. 1 Publication1
Mutagenesisi44L → A: Abrogates ubiquitin-mediated proteolysis; when associated with A-41. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
54443

MalaCards human disease database

More...
MalaCardsi
ANLN
MIMi616032 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000011426

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93213 Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24809

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANLN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90111962

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002279651 – 1124AnillinAdd BLAST1124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei54PhosphoserineCombined sources1
Modified residuei72PhosphoserineCombined sources1
Modified residuei97PhosphoserineBy similarity1
Modified residuei102PhosphoserineCombined sources1
Modified residuei172PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei194PhosphothreonineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei252PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei261PhosphoserineBy similarity1
Modified residuei320PhosphothreonineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei364PhosphothreonineCombined sources1
Modified residuei371N6-acetyllysineCombined sources1
Modified residuei397PhosphothreonineCombined sources1
Modified residuei401PhosphothreonineCombined sources1
Modified residuei417PhosphoserineCombined sources1
Modified residuei419PhosphoserineCombined sources1
Modified residuei449PhosphoserineCombined sources1
Modified residuei485PhosphoserineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei553PhosphoserineCombined sources1
Modified residuei561PhosphoserineCombined sources1
Modified residuei637PhosphoserineCombined sources1
Modified residuei642PhosphoserineCombined sources1
Modified residuei658PhosphoserineCombined sources1
Modified residuei661PhosphoserineCombined sources1
Modified residuei664PhosphoserineCombined sources1
Modified residuei671PhosphotyrosineBy similarity1
Modified residuei678PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1
Modified residuei792PhosphoserineCombined sources1
Modified residuei927PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated during mitosis.2 Publications
Ubiquitinated, and this requires FZR1/CDH1.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NQW6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NQW6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NQW6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NQW6

PeptideAtlas

More...
PeptideAtlasi
Q9NQW6

PRoteomics IDEntifications database

More...
PRIDEi
Q9NQW6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82209
82210 [Q9NQW6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NQW6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NQW6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and thymus. In dividing cells expression increases during S and G2 phases, peaks at mitosis and subsequently drops as cells enter G1 phase.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000011426 Expressed in 165 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NQW6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NQW6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB033902
CAB062547
CAB068175
HPA005680
HPA050556

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with F-actin (PubMed:10931866). Interacts with CD2AP (PubMed:15800069). May interact with RHOA (PubMed:16357138). Interacts with FZR1/CDH1 during mitotic exit (PubMed:16040610).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MARCH10Q8NA823EBI-10312488,EBI-2341554

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119959, 148 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NQW6, 142 interactors

Molecular INTeraction database

More...
MINTi
Q9NQW6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265748

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Y7BX-ray1.90A980-1113[»]
4XH3X-ray2.10A712-1124[»]
4XOIX-ray2.09B/D712-981[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NQW6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NQW6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini983 – 1107PHPROSITE-ProRule annotationAdd BLAST125

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 230Nuclear localizationAdd BLAST230
Regioni1 – 155Interaction with CD2AP1 PublicationAdd BLAST155
Regioni1 – 45Required for ubiquitinationAdd BLAST45
Regioni231 – 676Interaction with F-actinAdd BLAST446
Regioni730 – 1124Localization to the cleavage furrowAdd BLAST395

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili569 – 604Sequence analysisAdd BLAST36

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3640 Eukaryota
ENOG4110J5Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008749

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033950

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG059477

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NQW6

KEGG Orthology (KO)

More...
KOi
K18621

Identification of Orthologs from Complete Genome Data

More...
OMAi
GAGIKPF

Database of Orthologous Groups

More...
OrthoDBi
130192at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NQW6

TreeFam database of animal gene trees

More...
TreeFami
TF106494

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01263 PH_anillin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012966 AHD
IPR031970 Anillin_N
IPR011993 PH-like_dom_sf
IPR037840 PH_Anillin
IPR001849 PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08174 Anillin, 1 hit
PF16018 Anillin_N, 2 hits
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQW6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPFTEKLLE RTRARRENLQ RKMAERPTAA PRSMTHAKRA RQPLSEASNQ
60 70 80 90 100
QPLSGGEEKS CTKPSPSKKR CSDNTEVEVS NLENKQPVES TSAKSCSPSP
110 120 130 140 150
VSPQVQPQAA DTISDSVAVP ASLLGMRRGL NSRLEATAAS SVKTRMQKLA
160 170 180 190 200
EQRRRWDNDD MTDDIPESSL FSPMPSEEKA ASPPRPLLSN ASATPVGRRG
210 220 230 240 250
RLANLAATIC SWEDDVNHSF AKQNSVQEQP GTACLSKFSS ASGASARINS
260 270 280 290 300
SSVKQEATFC SQRDGDASLN KALSSSADDA SLVNASISSS VKATSPVKST
310 320 330 340 350
TSITDAKSCE GQNPELLPKT PISPLKTGVS KPIVKSTLSQ TVPSKGELSR
360 370 380 390 400
EICLQSQSKD KSTTPGGTGI KPFLERFGER CQEHSKESPA RSTPHRTPII
410 420 430 440 450
TPNTKAIQER LFKQDTSSST THLAQQLKQE RQKELACLRG RFDKGNIWSA
460 470 480 490 500
EKGGNSKSKQ LETKQETHCQ STPLKKHQGV SKTQSLPVTE KVTENQIPAK
510 520 530 540 550
NSSTEPKGFT ECEMTKSSPL KITLFLEEDK SLKVTSDPKV EQKIEVIREI
560 570 580 590 600
EMSVDDDDIN SSKVINDLFS DVLEEGELDM EKSQEEMDQA LAESSEEQED
610 620 630 640 650
ALNISSMSLL APLAQTVGVV SPESLVSTPR LELKDTSRSD ESPKPGKFQR
660 670 680 690 700
TRVPRAESGD SLGSEDRDLL YSIDAYRSQR FKETERPSIK QVIVRKEDVT
710 720 730 740 750
SKLDEKNNAF PCQVNIKQKM QELNNEINMQ QTVIYQASQA LNCCVDEEHG
760 770 780 790 800
KGSLEEAEAE RLLLIATGKR TLLIDELNKL KNEGPQRKNK ASPQSEFMPS
810 820 830 840 850
KGSVTLSEIR LPLKADFVCS TVQKPDAANY YYLIILKAGA ENMVATPLAS
860 870 880 890 900
TSNSLNGDAL TFTTTFTLQD VSNDFEINIE VYSLVQKKDP SGLDKKKKTS
910 920 930 940 950
KSKAITPKRL LTSITTKSNI HSSVMASPGG LSAVRTSNFA LVGSYTLSLS
960 970 980 990 1000
SVGNTKFVLD KVPFLSSLEG HIYLKIKCQV NSSVEERGFL TIFEDVSGFG
1010 1020 1030 1040 1050
AWHRRWCVLS GNCISYWTYP DDEKRKNPIG RINLANCTSR QIEPANREFC
1060 1070 1080 1090 1100
ARRNTFELIT VRPQREDDRE TLVSQCRDTL CVTKNWLSAD TKEERDLWMQ
1110 1120
KLNQVLVDIR LWQPDACYKP IGKP
Length:1,124
Mass (Da):124,199
Last modified:March 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79A8CC25C950DB2D
GO
Isoform 2 (identifier: Q9NQW6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     508-544: Missing.

Show »
Length:1,087
Mass (Da):120,016
Checksum:i5B45A0FFA334747F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3S1H7C3S1_HUMAN
Anillin
ANLN
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1C2H7C1C2_HUMAN
Anillin
ANLN
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJT6C9JJT6_HUMAN
Anillin
ANLN
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1K5H7C1K5_HUMAN
Anillin
ANLN
276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0Y6H7C0Y6_HUMAN
Anillin
ANLN
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C167H7C167_HUMAN
Anillin
ANLN
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0G4C9J0G4_HUMAN
Anillin
ANLN
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3R2H7C3R2_HUMAN
Anillin
ANLN
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH34692 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91710 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91711 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53L → F in AAF75796 (PubMed:10931866).Curated1
Sequence conflicti62T → S in AAF75796 (PubMed:10931866).Curated1
Sequence conflicti294T → TS (PubMed:10931866).Curated1
Sequence conflicti294T → TS (PubMed:17974005).Curated1
Sequence conflicti410R → K in AAH70066 (PubMed:15489334).Curated1
Sequence conflicti625L → S in BAA91711 (PubMed:14702039).Curated1
Sequence conflicti1035A → V in CAI56788 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02566165S → W. Corresponds to variant dbSNP:rs3735400Ensembl.1
Natural variantiVAR_025662185R → KCombined sources1 PublicationCorresponds to variant dbSNP:rs197367EnsemblClinVar.1
Natural variantiVAR_072418431R → C in FSGS8; results in decreased interaction with CD2AP. 1 PublicationCorresponds to variant dbSNP:rs587777741EnsemblClinVar.1
Natural variantiVAR_072419618G → C in FSGS8. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017617508 – 544Missing in isoform 2. 2 PublicationsAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF273437 mRNA Translation: AAF75796.1
BC034692 mRNA Translation: AAH34692.1 Different initiation.
BC070066 mRNA Translation: AAH70066.1
CR936650 mRNA Translation: CAI56788.1
AK001468 mRNA Translation: BAA91710.1 Different initiation.
AK001472 mRNA Translation: BAA91711.1 Different initiation.
AK023208 mRNA Translation: BAB14463.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5447.1 [Q9NQW6-1]
CCDS64628.1 [Q9NQW6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001271230.1, NM_001284301.2 [Q9NQW6-2]
NP_001271231.1, NM_001284302.2
NP_061155.2, NM_018685.4 [Q9NQW6-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.62180

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265748; ENSP00000265748; ENSG00000011426 [Q9NQW6-1]
ENST00000396068; ENSP00000379380; ENSG00000011426 [Q9NQW6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54443

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54443

UCSC genome browser

More...
UCSCi
uc003tff.4 human [Q9NQW6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273437 mRNA Translation: AAF75796.1
BC034692 mRNA Translation: AAH34692.1 Different initiation.
BC070066 mRNA Translation: AAH70066.1
CR936650 mRNA Translation: CAI56788.1
AK001468 mRNA Translation: BAA91710.1 Different initiation.
AK001472 mRNA Translation: BAA91711.1 Different initiation.
AK023208 mRNA Translation: BAB14463.1
CCDSiCCDS5447.1 [Q9NQW6-1]
CCDS64628.1 [Q9NQW6-2]
RefSeqiNP_001271230.1, NM_001284301.2 [Q9NQW6-2]
NP_001271231.1, NM_001284302.2
NP_061155.2, NM_018685.4 [Q9NQW6-1]
UniGeneiHs.62180

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Y7BX-ray1.90A980-1113[»]
4XH3X-ray2.10A712-1124[»]
4XOIX-ray2.09B/D712-981[»]
ProteinModelPortaliQ9NQW6
SMRiQ9NQW6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119959, 148 interactors
IntActiQ9NQW6, 142 interactors
MINTiQ9NQW6
STRINGi9606.ENSP00000265748

PTM databases

iPTMnetiQ9NQW6
PhosphoSitePlusiQ9NQW6

Polymorphism and mutation databases

BioMutaiANLN
DMDMi90111962

Proteomic databases

EPDiQ9NQW6
jPOSTiQ9NQW6
MaxQBiQ9NQW6
PaxDbiQ9NQW6
PeptideAtlasiQ9NQW6
PRIDEiQ9NQW6
ProteomicsDBi82209
82210 [Q9NQW6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265748; ENSP00000265748; ENSG00000011426 [Q9NQW6-1]
ENST00000396068; ENSP00000379380; ENSG00000011426 [Q9NQW6-2]
GeneIDi54443
KEGGihsa:54443
UCSCiuc003tff.4 human [Q9NQW6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54443
DisGeNETi54443
EuPathDBiHostDB:ENSG00000011426.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ANLN

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0006603
HGNCiHGNC:14082 ANLN
HPAiCAB033902
CAB062547
CAB068175
HPA005680
HPA050556
MalaCardsiANLN
MIMi616027 gene
616032 phenotype
neXtProtiNX_Q9NQW6
OpenTargetsiENSG00000011426
Orphaneti93213 Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis
PharmGKBiPA24809

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3640 Eukaryota
ENOG4110J5Z LUCA
GeneTreeiENSGT00390000008749
HOGENOMiHOG000033950
HOVERGENiHBG059477
InParanoidiQ9NQW6
KOiK18621
OMAiGAGIKPF
OrthoDBi130192at2759
PhylomeDBiQ9NQW6
TreeFamiTF106494

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ANLN human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ANLN

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54443

Protein Ontology

More...
PROi
PR:Q9NQW6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000011426 Expressed in 165 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9NQW6 baseline and differential
GenevisibleiQ9NQW6 HS

Family and domain databases

CDDicd01263 PH_anillin, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR012966 AHD
IPR031970 Anillin_N
IPR011993 PH-like_dom_sf
IPR037840 PH_Anillin
IPR001849 PH_domain
PfamiView protein in Pfam
PF08174 Anillin, 1 hit
PF16018 Anillin_N, 2 hits
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANLN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQW6
Secondary accession number(s): Q5CZ78
, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: February 13, 2019
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again