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UniProtKB - Q9NQW5 (PRDM7_HUMAN)

Entry version 167 (25 May 2022)
Sequence version 2 (10 Feb 2009)
Previous versions | rss
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Protein

Histone-lysine N-methyltransferase PRDM7

Gene

PRDM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that selectively methylates 'Lys-4' of dimethylated histone H3 (H3K4me2) to produce trimethylated 'Lys-4' histone H3 (H3K4me3). May play a role in epigenetic regulation of gene expression by defining an active chromatin state.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 190 h(-1) with S-adenosyl-L-methionine as substrate. kcat is 9 h(-1) with H3K4me0 as substrate. kcat is 8 h(-1) with H3K4me1 as substrate. kcat is 190 h(-1) with H3K4me2 as substrate.1 Publication
  1. KM=900 µM for S-adenosyl-L-methionine1 Publication
  2. KM=0.8 µM for H3K4me01 Publication
  3. KM=0.7 µM for H3K4me11 Publication
  4. KM=3.5 µM for H3K4me21 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.1.1.354, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NQW5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NQW5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase PRDM7 (EC:2.1.1.-1 Publication)
Alternative name(s):
PR domain zinc finger protein 7
PR domain-containing protein 7
[histone H3]-lysine4 N-methyltransferase PRDM7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRDM71 PublicationImported
Synonyms:PFM4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9351, PRDM7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609759, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NQW5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000126856

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi289S → N: Gains the ability to sequentially mono-, di-, and tri-methylate both 'Lys-4' and 'Lys-36' of histone H3, albeit with lower efficiency when compared to PRDM9. 1 Publication1
Mutagenesisi312S → W: Gains the ability to sequentially mono-, di-, and tri-methylate both 'Lys-4' and 'Lys-36' of histone H3, albeit with lower efficiency when compared to PRDM9. 1 Publication1
Mutagenesisi357S → Y: Substantially increases histone-lysine N-methyltransferase activity. Gains the catalytic competency of PRDM9. Sequentially mono-, di-, and tri-methylates both 'Lys-4' and 'Lys-36' of histone H3. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		11105

Open Targets

More...OpenTargetsi		ENSG00000126856

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33719

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NQW5, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRDM7

Domain mapping of disease mutations (DMDM)

More...DMDMi		223590134

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000477631 – 492Histone-lysine N-methyltransferase PRDM7Add BLAST492

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NQW5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NQW5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NQW5

PeptideAtlas

More...PeptideAtlasi		Q9NQW5

PRoteomics IDEntifications database

More...PRIDEi		Q9NQW5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82207 [Q9NQW5-1]
82208 [Q9NQW5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NQW5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NQW5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000126856, Expressed in amniotic fluid and 64 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NQW5, baseline and differential

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000126856, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116286, 11 interactors

Protein interaction database and analysis system

More...IntActi		Q9NQW5, 9 interactors

Molecular INTeraction database

More...MINTi		Q9NQW5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000396732

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NQW5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9NQW5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NQW5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 86KRAB-relatedPROSITE-ProRule annotationAdd BLAST64
Domaini244 – 358SETPROSITE-ProRule annotationAdd BLAST115

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22
Regioni111 – 179DisorderedSequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi118 – 165Polar residuesSequence analysisAdd BLAST48

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2461, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158211

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_042879_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NQW5

Identification of Orthologs from Complete Genome Data

More...OMAi		EDCHELY

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NQW5

TreeFam database of animal gene trees

More...TreeFami		TF337915

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit
cd19193, PR-SET_PRDM7_9, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.170.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR003655, Krueppel-associated_box-rel
IPR044417, PRDM7_9_PR-SET
IPR001214, SET_dom
IPR046341, SET_dom_sf
IPR019041, SSXRD_motif

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF09514, SSXRD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50806, KRAB_RELATED, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQW5-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSPERSQEES PEGDTERTER KPMVKDAFKD ISIYFTKEEW AEMGDWEKTR 
        60         70         80         90        100
YRNVKMNYNA LITVGLRATR PAFMCHRRQA IKLQVDDTED SDEEWTPRQQ 
       110        120        130        140        150
VKPPWMAFRG EQSKHQKGMP KASFNNESSL RELSGTPNLL NTSDSEQAQK 
       160        170        180        190        200
PVSPPGEAST SGQHSRLKLE LRRKETEGKM YSLRERKGHA YKEISEPQDD 
       210        220        230        240        250
DYLYCEMCQN FFIDSCAAHG PPTFVKDSAV DKGHPNRSAL SLPPGLRIGP 
       260        270        280        290        300
SGIPQAGLGV WNEASDLPLG LHFGPYEGRI TEDEEAANSG YSWLITKGRN 
       310        320        330        340        350
CYEYVDGKDK SSANWMRYVN CARDDEEQNL VAFQYHRQIF YRTCRVIRPG 
       360        370        380        390        400
CELLVWSGDE YGQELGIRSS IEPAESLGQA VNCWSGMGMS MARNWASSGA 
       410        420        430        440        450
ASGRKSSWQG ENQSQRSIHV PHAVWPFQVK NFSVNMWNAI TPLRTSQDHL 
       460        470        480        490 
QENFSNQRIP AQGIRIRSGN ILIHAAVMTK PKVKRSKKGP NS
Length:492
Mass (Da):55,777
Last modified:February 10, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C80D8DE8BA65DC5
GO
Isoform 2 (identifier: Q9NQW5-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-206: Missing.
     318-377: YVNCARDDEE...RSSIEPAESL → TKARDPSMSL...RGSESGAAIF
     378-492: Missing.

Show »
Length:171
Mass (Da):18,442
Checksum:iF4F63783520C0072
GO
Isoform 3 (identifier: Q9NQW5-1) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-206: Missing.
     368-492: RSSIEPAESL...VKRSKKGPNS → KWGSKWKKEL...GEAPVCRKDE

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:407
Mass (Da):45,890
Checksum:iD09E7D983CFA4426
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A4Q9G9A4Q9G9_HUMAN
Histone-lysine N-methyltransferase ...
PRDM7 PRDM7_V2
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUJ3H3BUJ3_HUMAN
Histone-lysine N-methyltransferase ...
PRDM7
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti357S → Y in AAF78084 (PubMed:10668202).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05746190D → E1 PublicationCorresponds to variant dbSNP:rs12925933Ensembl.1
Natural variantiVAR_057462131R → K. Corresponds to variant dbSNP:rs2078478Ensembl.1
Natural variantiVAR_057463435N → K. Corresponds to variant dbSNP:rs7206111Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0363491 – 206Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST206
Alternative sequenceiVSP_006930318 – 377YVNCA…PAESL → TKARDPSMSLMLSGLFKSKI SQSTCGTQSLLSELPRTICK KTSPTRESLPRGSESGAAIF in isoform 2. 2 PublicationsAdd BLAST60
Alternative sequenceiVSP_036350368 – 492RSSIE…KGPNS → KWGSKWKKELMAGREPKPEI HPCPSCCLAFSSQKFLSQHV ERNHSSQNFPGPSARKLLQP ENPCPGDQNQERQYSDPRCC NDKTKGQEIKERSKLLNKRT WQREISRAFSSPPKGQMGSS RVGERMMEEESRTGQKVNPG NTGKLFVGVGISRIAKVKYG ECGQGFSDKSDVITHQRTHT GGKPYVCRECGEGFSRKSDL LSHQRTHTGEKPYVCRECER GFSRKSVLLIHQRTHRGEAP VCRKDE in isoform 3. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_006931378 – 492Missing in isoform 2. 2 PublicationsAdd BLAST115

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AM690991 mRNA Translation: CAM84449.1
AF274347 mRNA Translation: AAF78084.1
AF274348 mRNA Translation: AAF78085.1
CH471184 Genomic DNA Translation: EAW66654.1
BC107033 mRNA Translation: AAI07034.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45557.1 [Q9NQW5-3]

NCBI Reference Sequences

More...RefSeqi		NP_001091643.1, NM_001098173.1 [Q9NQW5-3]
XP_005256331.1, XM_005256274.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000449207.8; ENSP00000396732.2; ENSG00000126856.16

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11105

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11105

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000449207.8; ENSP00000396732.2; NM_001098173.2; NP_001091643.1

UCSC genome browser

More...UCSCi		uc010cje.4, human [Q9NQW5-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM690991 mRNA Translation: CAM84449.1
AF274347 mRNA Translation: AAF78084.1
AF274348 mRNA Translation: AAF78085.1
CH471184 Genomic DNA Translation: EAW66654.1
BC107033 mRNA Translation: AAI07034.1
CCDSiCCDS45557.1 [Q9NQW5-3]
RefSeqiNP_001091643.1, NM_001098173.1 [Q9NQW5-3]
XP_005256331.1, XM_005256274.3

3D structure databases

AlphaFoldDBiQ9NQW5
SMRiQ9NQW5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116286, 11 interactors
IntActiQ9NQW5, 9 interactors
MINTiQ9NQW5
STRINGi9606.ENSP00000396732

PTM databases

iPTMnetiQ9NQW5
PhosphoSitePlusiQ9NQW5

Genetic variation databases

BioMutaiPRDM7
DMDMi223590134

Proteomic databases

jPOSTiQ9NQW5
MassIVEiQ9NQW5
PaxDbiQ9NQW5
PeptideAtlasiQ9NQW5
PRIDEiQ9NQW5
ProteomicsDBi82207 [Q9NQW5-1]
82208 [Q9NQW5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		67566, 64 antibodies from 16 providers

The DNASU plasmid repository

More...DNASUi		11105

Genome annotation databases

EnsembliENST00000449207.8; ENSP00000396732.2; ENSG00000126856.16
GeneIDi11105
KEGGihsa:11105
MANE-SelectiENST00000449207.8; ENSP00000396732.2; NM_001098173.2; NP_001091643.1
UCSCiuc010cje.4, human [Q9NQW5-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11105
DisGeNETi11105

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRDM7
HGNCiHGNC:9351, PRDM7
HPAiENSG00000126856, Tissue enriched (testis)
MIMi609759, gene
neXtProtiNX_Q9NQW5
OpenTargetsiENSG00000126856
PharmGKBiPA33719
VEuPathDBiHostDB:ENSG00000126856

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2461, Eukaryota
GeneTreeiENSGT00940000158211
HOGENOMiCLU_042879_1_0_1
InParanoidiQ9NQW5
OMAiEDCHELY
OrthoDBi1318335at2759
PhylomeDBiQ9NQW5
TreeFamiTF337915

Enzyme and pathway databases

BRENDAi2.1.1.354, 2681
PathwayCommonsiQ9NQW5
ReactomeiR-HSA-212436, Generic Transcription Pathway
SignaLinkiQ9NQW5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11105, 13 hits in 1030 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11105
PharosiQ9NQW5, Tdark

Protein Ontology

More...PROi		PR:Q9NQW5
RNActiQ9NQW5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000126856, Expressed in amniotic fluid and 64 other tissues
ExpressionAtlasiQ9NQW5, baseline and differential

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
cd19193, PR-SET_PRDM7_9, 1 hit
Gene3Di2.170.270.10, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR003655, Krueppel-associated_box-rel
IPR044417, PRDM7_9_PR-SET
IPR001214, SET_dom
IPR046341, SET_dom_sf
IPR019041, SSXRD_motif
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF09514, SSXRD, 1 hit
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SUPFAMiSSF109640, SSF109640, 1 hit
PROSITEiView protein in PROSITE
PS50806, KRAB_RELATED, 1 hit
PS50280, SET, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRDM7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQW5
Secondary accession number(s): A4Q9G8, Q08EM4, Q9NQW4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: February 10, 2009
Last modified: May 25, 2022
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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