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Protein

Protein transport protein Sec31B

Gene

SEC31B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum.1 Publication

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

SignaLinkiQ9NQW1

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec31B
Alternative name(s):
SEC31-like protein 2
SEC31-related protein B
SEC31B-1
Gene namesi
Name:SEC31B
Synonyms:SEC31L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000075826.16
HGNCiHGNC:23197 SEC31B
MIMi610258 gene
neXtProtiNX_Q9NQW1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000075826
PharmGKBiPA162402792

Polymorphism and mutation databases

BioMutaiSEC31B
DMDMi74762753

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951531 – 1179Protein transport protein Sec31BAdd BLAST1179

Post-translational modificationi

Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9NQW1
PeptideAtlasiQ9NQW1
PRIDEiQ9NQW1
ProteomicsDBi82201
82202 [Q9NQW1-2]
82203 [Q9NQW1-3]
82204 [Q9NQW1-4]
82205 [Q9NQW1-5]

PTM databases

iPTMnetiQ9NQW1
PhosphoSitePlusiQ9NQW1

Expressioni

Tissue specificityi

Ubiquitously expressed at low levels with specific expression in thymus and testis. Expressed in testis by Sertoli cells, Leydig cells and spermatogonia and in cerebellum more prominently by Purkinje and granular cells (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000075826 Expressed in 142 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_SEC31B
ExpressionAtlasiQ9NQW1 baseline and differential
GenevisibleiQ9NQW1 HS

Organism-specific databases

HPAiHPA035882
HPA040819
HPA060052

Interactioni

Subunit structurei

COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). Interacts with SEC31A.By similarity1 Publication

Protein-protein interaction databases

BioGridi117447, 13 interactors
IntActiQ9NQW1, 4 interactors
MINTiQ9NQW1
STRINGi9606.ENSP00000359370

Structurei

3D structure databases

ProteinModelPortaliQ9NQW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati17 – 56WD 1Add BLAST40
Repeati67 – 110WD 2Add BLAST44
Repeati119 – 159WD 3Add BLAST41
Repeati166 – 206WD 4Add BLAST41
Repeati209 – 254WD 5Add BLAST46
Repeati258 – 298WD 6Add BLAST41
Repeati301 – 341WD 7Add BLAST41
Repeati391 – 422WD 8; interaction with SEC13PROSITE-ProRule annotationAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi821 – 1073Pro-richAdd BLAST253

Sequence similaritiesi

Belongs to the WD repeat SEC31 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0307 Eukaryota
ENOG410XQ1D LUCA
GeneTreeiENSGT00390000003175
HOGENOMiHOG000230582
HOVERGENiHBG055626
InParanoidiQ9NQW1
KOiK14005
OMAiVSWSQAD
OrthoDBiEOG091G01VB
PhylomeDBiQ9NQW1
TreeFamiTF313842

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9NQW1-1) [UniParc]FASTAAdd to basket
Also known as: SEC31B-F

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLKELERPA VQAWSPASQY PLYLATGTSA QQLDSSFSTN GTLEIFEVDF
60 70 80 90 100
RDPSLDLKHR GVLSALSRFH KLVWGSFGSG LLESSGVIVG GGDNGMLILY
110 120 130 140 150
NVTHILSSGK EPVIAQKQKH TGAVRALDLN PFQGNLLASG ASDSEIFIWD
160 170 180 190 200
LNNLNVPMTL GSKSQQPPED IKALSWNRQA QHILSSAHPS GKAVVWDLRK
210 220 230 240 250
NEPIIKVSDH SNRMHCSGLA WHPDIATQLV LCSEDDRLPV IQLWDLRFAS
260 270 280 290 300
SPLKVLESHS RGILSVSWSQ ADAELLLTSA KDSQILCRNL GSSEVVYKLP
310 320 330 340 350
TQSSWCFDVQ WCPRDPSVFS AASFNGWISL YSVMGRSWEV QHMRQADKIS
360 370 380 390 400
SSFSKGQPLP PLQVPEQVAQ APLIPPLKKP PKWIRRPTGV SFAFGGKLVT
410 420 430 440 450
FGLPSTPAHL VPQPCPRLVF ISQVTTESEF LMRSAELQEA LGSGNLLNYC
460 470 480 490 500
QNKSQQALLQ SEKMLWQFLK VTLEQDSRMK FLKLLGYSKD ELQKKVATWL
510 520 530 540 550
KSDVGLGESP QPKGNDLNSD RQQAFCSQAS KHTTKEASAS SAFFDELVPQ
560 570 580 590 600
NMTPWEIPIT KDIDGLLSQA LLLGELGPAV ELCLKEERFA DAIILAQAGG
610 620 630 640 650
TDLLKQTQER YLAKKKTKIS SLLACVVQKN WKDVVCTCSL KNWREALALL
660 670 680 690 700
LTYSGTEKFP ELCDMLGTRM EQEGSRALTS EARLCYVCSG SVERLVECWA
710 720 730 740 750
KCHQALSPMA LQDLMEKVMV LNRSLEQLRG PHGVSPGPAT TYRVTQYANL
760 770 780 790 800
LAAQGSLATA MSFLPRDCAQ PPVQQLRDRL FHAQGSAVLG QQSPPFPFPR
810 820 830 840 850
IVVGATLHSK ETSSYRLGSQ PSHQVPTPSP RPRVFTPQSS PAMPLAPSHP
860 870 880 890 900
SPYQGPRTQN ISDYRAPGPQ AIQPLPLSPG VRPASSQPQL LGGQRVQVPN
910 920 930 940 950
PVGFPGTWPL PGSPLPMACP GIMRPGSTSL PETPRLFPLL PLRPLGPGRM
960 970 980 990 1000
VSHTPAPPAS FPVPYLPGDP GAPCSSVLPT TGILTPHPGP QDSWKEAPAP
1010 1020 1030 1040 1050
RGNLQRNKLP ETFMPPAPIT APVMSLTPEL QGILPSQPPV SSVSHAPPGV
1060 1070 1080 1090 1100
PGELSLQLQH LPPEKMERKE LPPEHQSLKS SFEALLQRCS LSATDLKTKR
1110 1120 1130 1140 1150
KLEEAAQRLE YLYEKLCEGT LSPHVVAGLH EVARCVDAGS FEQGLAVHAQ
1160 1170
VAGCSSFSEV SSFMPILKAV LIIAHKLLV
Length:1,179
Mass (Da):128,697
Last modified:October 1, 2000 - v1
Checksum:i88C591B060643A5D
GO
Isoform 2 (identifier: Q9NQW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-165: Missing.
     349-349: I → V
     350-1179: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:348
Mass (Da):38,450
Checksum:iBD8A60259743B860
GO
Isoform 3 (identifier: Q9NQW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-85: FHKLVWGSFGSGLLESS → ATSWLQGPAILKSSLGI
     86-1179: Missing.

Show »
Length:85
Mass (Da):9,294
Checksum:i1CA9C2A4C9F56411
GO
Isoform 4 (identifier: Q9NQW1-4) [UniParc]FASTAAdd to basket
Also known as: SEC31B-t

The sequence of this isoform differs from the canonical sequence as follows:
     470-482: KVTLEQDSRMKFL → KPARDSSGARR
     483-1179: Missing.

Show »
Length:480
Mass (Da):52,984
Checksum:iA91F37DAA6824103
GO
Isoform 5 (identifier: Q9NQW1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-165: Missing.

Note: No experimental confirmation available.
Show »
Length:1,178
Mass (Da):128,569
Checksum:i102AA849D41A1D65
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKR7E9PKR7_HUMAN
Protein transport protein Sec31B
SEC31B
349Annotation score:
F6TTE0F6TTE0_HUMAN
Protein transport protein Sec31B
SEC31B
85Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti805A → V in CAB45735 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03322889V → A1 PublicationCorresponds to variant dbSNP:rs3763695Ensembl.1
Natural variantiVAR_033229100Y → C. Corresponds to variant dbSNP:rs7074707Ensembl.1
Natural variantiVAR_033230129L → F1 PublicationCorresponds to variant dbSNP:rs3793706Ensembl.1
Natural variantiVAR_033231332S → A1 PublicationCorresponds to variant dbSNP:rs2295774Ensembl.1
Natural variantiVAR_033232372P → S. Corresponds to variant dbSNP:rs2295772Ensembl.1
Natural variantiVAR_053415433R → Q. Corresponds to variant dbSNP:rs2295771Ensembl.1
Natural variantiVAR_053416478R → T. Corresponds to variant dbSNP:rs11819496Ensembl.1
Natural variantiVAR_033233527S → R. Corresponds to variant dbSNP:rs17113157Ensembl.1
Natural variantiVAR_0332341169A → S. Corresponds to variant dbSNP:rs2298075Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02675769 – 85FHKLV…LLESS → ATSWLQGPAILKSSLGI in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_02675886 – 1179Missing in isoform 3. 1 PublicationAdd BLAST1094
Alternative sequenceiVSP_026759165Missing in isoform 2 and isoform 5. 1 Publication1
Alternative sequenceiVSP_026760349I → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_026761350 – 1179Missing in isoform 2. 1 PublicationAdd BLAST830
Alternative sequenceiVSP_026762470 – 482KVTLE…RMKFL → KPARDSSGARR in isoform 4. CuratedAdd BLAST13
Alternative sequenceiVSP_026763483 – 1179Missing in isoform 4. CuratedAdd BLAST697

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274863 mRNA Translation: AAF78243.1
AL080141 mRNA Translation: CAB45735.1
BX640914 mRNA Translation: CAE45955.1
AL133352 Genomic DNA No translation available.
BC034946 mRNA Translation: AAH34946.1
BC044569 mRNA No translation available.
BC144313 mRNA Translation: AAI44314.1
CCDSiCCDS7495.1 [Q9NQW1-1]
PIRiT12526
RefSeqiNP_056305.1, NM_015490.3 [Q9NQW1-1]
UniGeneiHs.18889

Genome annotation databases

EnsembliENST00000370345; ENSP00000359370; ENSG00000075826 [Q9NQW1-1]
ENST00000462434; ENSP00000474124; ENSG00000075826 [Q9NQW1-2]
GeneIDi25956
KEGGihsa:25956
UCSCiuc001krc.2 human [Q9NQW1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274863 mRNA Translation: AAF78243.1
AL080141 mRNA Translation: CAB45735.1
BX640914 mRNA Translation: CAE45955.1
AL133352 Genomic DNA No translation available.
BC034946 mRNA Translation: AAH34946.1
BC044569 mRNA No translation available.
BC144313 mRNA Translation: AAI44314.1
CCDSiCCDS7495.1 [Q9NQW1-1]
PIRiT12526
RefSeqiNP_056305.1, NM_015490.3 [Q9NQW1-1]
UniGeneiHs.18889

3D structure databases

ProteinModelPortaliQ9NQW1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117447, 13 interactors
IntActiQ9NQW1, 4 interactors
MINTiQ9NQW1
STRINGi9606.ENSP00000359370

PTM databases

iPTMnetiQ9NQW1
PhosphoSitePlusiQ9NQW1

Polymorphism and mutation databases

BioMutaiSEC31B
DMDMi74762753

Proteomic databases

PaxDbiQ9NQW1
PeptideAtlasiQ9NQW1
PRIDEiQ9NQW1
ProteomicsDBi82201
82202 [Q9NQW1-2]
82203 [Q9NQW1-3]
82204 [Q9NQW1-4]
82205 [Q9NQW1-5]

Protocols and materials databases

DNASUi25956
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370345; ENSP00000359370; ENSG00000075826 [Q9NQW1-1]
ENST00000462434; ENSP00000474124; ENSG00000075826 [Q9NQW1-2]
GeneIDi25956
KEGGihsa:25956
UCSCiuc001krc.2 human [Q9NQW1-1]

Organism-specific databases

CTDi25956
EuPathDBiHostDB:ENSG00000075826.16
GeneCardsiSEC31B
HGNCiHGNC:23197 SEC31B
HPAiHPA035882
HPA040819
HPA060052
MIMi610258 gene
neXtProtiNX_Q9NQW1
OpenTargetsiENSG00000075826
PharmGKBiPA162402792
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0307 Eukaryota
ENOG410XQ1D LUCA
GeneTreeiENSGT00390000003175
HOGENOMiHOG000230582
HOVERGENiHBG055626
InParanoidiQ9NQW1
KOiK14005
OMAiVSWSQAD
OrthoDBiEOG091G01VB
PhylomeDBiQ9NQW1
TreeFamiTF313842

Enzyme and pathway databases

SignaLinkiQ9NQW1

Miscellaneous databases

ChiTaRSiSEC31B human
GenomeRNAii25956
PROiPR:Q9NQW1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075826 Expressed in 142 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_SEC31B
ExpressionAtlasiQ9NQW1 baseline and differential
GenevisibleiQ9NQW1 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC31B_HUMAN
AccessioniPrimary (citable) accession number: Q9NQW1
Secondary accession number(s): B7ZM75
, Q6MZS3, Q86UF0, Q9Y4Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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