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Entry version 135 (16 Oct 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Protein transport protein Sec31B

Gene

SEC31B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9NQW1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein transport protein Sec31B
Alternative name(s):
SEC31-like protein 2
SEC31-related protein B
SEC31B-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC31B
Synonyms:SEC31L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:23197 SEC31B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610258 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NQW1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000075826

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162402792

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NQW1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SEC31B

Domain mapping of disease mutations (DMDM)

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DMDMi
74762753

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002951531 – 1179Protein transport protein Sec31BAdd BLAST1179

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NQW1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NQW1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NQW1

PeptideAtlas

More...
PeptideAtlasi
Q9NQW1

PRoteomics IDEntifications database

More...
PRIDEi
Q9NQW1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82201 [Q9NQW1-1]
82202 [Q9NQW1-2]
82203 [Q9NQW1-3]
82204 [Q9NQW1-4]
82205 [Q9NQW1-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NQW1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NQW1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed at low levels with specific expression in thymus and testis. Expressed in testis by Sertoli cells, Leydig cells and spermatogonia and in cerebellum more prominently by Purkinje and granular cells (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000075826 Expressed in 142 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NQW1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NQW1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035882
HPA040819
HPA060052

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage.

Interacts (via WD 8) with SEC13 (By similarity).

Interacts with SEC31A.

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117447, 13 interactors

Protein interaction database and analysis system

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IntActi
Q9NQW1, 12 interactors

Molecular INTeraction database

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MINTi
Q9NQW1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359370

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati17 – 56WD 1Add BLAST40
Repeati67 – 110WD 2Add BLAST44
Repeati119 – 159WD 3Add BLAST41
Repeati166 – 206WD 4Add BLAST41
Repeati209 – 254WD 5Add BLAST46
Repeati258 – 298WD 6Add BLAST41
Repeati301 – 341WD 7Add BLAST41
Repeati391 – 422WD 8; interaction with SEC13PROSITE-ProRule annotationAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi821 – 1073Pro-richAdd BLAST253

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat SEC31 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0307 Eukaryota
ENOG410XQ1D LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000003175

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230582

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NQW1

KEGG Orthology (KO)

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KOi
K14005

Identification of Orthologs from Complete Genome Data

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OMAi
QGSRMQN

Database of Orthologous Groups

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OrthoDBi
100998at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NQW1

TreeFam database of animal gene trees

More...
TreeFami
TF313842

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040251 SEC31-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13923 PTHR13923, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00320 WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQW1-1) [UniParc]FASTAAdd to basket
Also known as: SEC31B-F

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLKELERPA VQAWSPASQY PLYLATGTSA QQLDSSFSTN GTLEIFEVDF
60 70 80 90 100
RDPSLDLKHR GVLSALSRFH KLVWGSFGSG LLESSGVIVG GGDNGMLILY
110 120 130 140 150
NVTHILSSGK EPVIAQKQKH TGAVRALDLN PFQGNLLASG ASDSEIFIWD
160 170 180 190 200
LNNLNVPMTL GSKSQQPPED IKALSWNRQA QHILSSAHPS GKAVVWDLRK
210 220 230 240 250
NEPIIKVSDH SNRMHCSGLA WHPDIATQLV LCSEDDRLPV IQLWDLRFAS
260 270 280 290 300
SPLKVLESHS RGILSVSWSQ ADAELLLTSA KDSQILCRNL GSSEVVYKLP
310 320 330 340 350
TQSSWCFDVQ WCPRDPSVFS AASFNGWISL YSVMGRSWEV QHMRQADKIS
360 370 380 390 400
SSFSKGQPLP PLQVPEQVAQ APLIPPLKKP PKWIRRPTGV SFAFGGKLVT
410 420 430 440 450
FGLPSTPAHL VPQPCPRLVF ISQVTTESEF LMRSAELQEA LGSGNLLNYC
460 470 480 490 500
QNKSQQALLQ SEKMLWQFLK VTLEQDSRMK FLKLLGYSKD ELQKKVATWL
510 520 530 540 550
KSDVGLGESP QPKGNDLNSD RQQAFCSQAS KHTTKEASAS SAFFDELVPQ
560 570 580 590 600
NMTPWEIPIT KDIDGLLSQA LLLGELGPAV ELCLKEERFA DAIILAQAGG
610 620 630 640 650
TDLLKQTQER YLAKKKTKIS SLLACVVQKN WKDVVCTCSL KNWREALALL
660 670 680 690 700
LTYSGTEKFP ELCDMLGTRM EQEGSRALTS EARLCYVCSG SVERLVECWA
710 720 730 740 750
KCHQALSPMA LQDLMEKVMV LNRSLEQLRG PHGVSPGPAT TYRVTQYANL
760 770 780 790 800
LAAQGSLATA MSFLPRDCAQ PPVQQLRDRL FHAQGSAVLG QQSPPFPFPR
810 820 830 840 850
IVVGATLHSK ETSSYRLGSQ PSHQVPTPSP RPRVFTPQSS PAMPLAPSHP
860 870 880 890 900
SPYQGPRTQN ISDYRAPGPQ AIQPLPLSPG VRPASSQPQL LGGQRVQVPN
910 920 930 940 950
PVGFPGTWPL PGSPLPMACP GIMRPGSTSL PETPRLFPLL PLRPLGPGRM
960 970 980 990 1000
VSHTPAPPAS FPVPYLPGDP GAPCSSVLPT TGILTPHPGP QDSWKEAPAP
1010 1020 1030 1040 1050
RGNLQRNKLP ETFMPPAPIT APVMSLTPEL QGILPSQPPV SSVSHAPPGV
1060 1070 1080 1090 1100
PGELSLQLQH LPPEKMERKE LPPEHQSLKS SFEALLQRCS LSATDLKTKR
1110 1120 1130 1140 1150
KLEEAAQRLE YLYEKLCEGT LSPHVVAGLH EVARCVDAGS FEQGLAVHAQ
1160 1170
VAGCSSFSEV SSFMPILKAV LIIAHKLLV
Length:1,179
Mass (Da):128,697
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88C591B060643A5D
GO
Isoform 2 (identifier: Q9NQW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-165: Missing.
     349-349: I → V
     350-1179: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:348
Mass (Da):38,450
Checksum:iBD8A60259743B860
GO
Isoform 3 (identifier: Q9NQW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-85: FHKLVWGSFGSGLLESS → ATSWLQGPAILKSSLGI
     86-1179: Missing.

Show »
Length:85
Mass (Da):9,294
Checksum:i1CA9C2A4C9F56411
GO
Isoform 4 (identifier: Q9NQW1-4) [UniParc]FASTAAdd to basket
Also known as: SEC31B-t

The sequence of this isoform differs from the canonical sequence as follows:
     470-482: KVTLEQDSRMKFL → KPARDSSGARR
     483-1179: Missing.

Show »
Length:480
Mass (Da):52,984
Checksum:iA91F37DAA6824103
GO
Isoform 5 (identifier: Q9NQW1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-165: Missing.

Note: No experimental confirmation available.
Show »
Length:1,178
Mass (Da):128,569
Checksum:i102AA849D41A1D65
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKR7E9PKR7_HUMAN
Protein transport protein Sec31B
SEC31B
349Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TTE0F6TTE0_HUMAN
Protein transport protein Sec31B
SEC31B
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti805A → V in CAB45735 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03322889V → A1 PublicationCorresponds to variant dbSNP:rs3763695Ensembl.1
Natural variantiVAR_033229100Y → C. Corresponds to variant dbSNP:rs7074707Ensembl.1
Natural variantiVAR_033230129L → F1 PublicationCorresponds to variant dbSNP:rs3793706Ensembl.1
Natural variantiVAR_033231332S → A1 PublicationCorresponds to variant dbSNP:rs2295774Ensembl.1
Natural variantiVAR_033232372P → S. Corresponds to variant dbSNP:rs2295772Ensembl.1
Natural variantiVAR_053415433R → Q. Corresponds to variant dbSNP:rs2295771Ensembl.1
Natural variantiVAR_053416478R → T. Corresponds to variant dbSNP:rs11819496Ensembl.1
Natural variantiVAR_033233527S → R. Corresponds to variant dbSNP:rs17113157Ensembl.1
Natural variantiVAR_0332341169A → S. Corresponds to variant dbSNP:rs2298075Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02675769 – 85FHKLV…LLESS → ATSWLQGPAILKSSLGI in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_02675886 – 1179Missing in isoform 3. 1 PublicationAdd BLAST1094
Alternative sequenceiVSP_026759165Missing in isoform 2 and isoform 5. 1 Publication1
Alternative sequenceiVSP_026760349I → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_026761350 – 1179Missing in isoform 2. 1 PublicationAdd BLAST830
Alternative sequenceiVSP_026762470 – 482KVTLE…RMKFL → KPARDSSGARR in isoform 4. CuratedAdd BLAST13
Alternative sequenceiVSP_026763483 – 1179Missing in isoform 4. CuratedAdd BLAST697

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF274863 mRNA Translation: AAF78243.1
AL080141 mRNA Translation: CAB45735.1
BX640914 mRNA Translation: CAE45955.1
AL133352 Genomic DNA No translation available.
BC034946 mRNA Translation: AAH34946.1
BC044569 mRNA No translation available.
BC144313 mRNA Translation: AAI44314.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7495.1 [Q9NQW1-1]

Protein sequence database of the Protein Information Resource

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PIRi
T12526

NCBI Reference Sequences

More...
RefSeqi
NP_056305.1, NM_015490.3 [Q9NQW1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000370345; ENSP00000359370; ENSG00000075826 [Q9NQW1-1]
ENST00000462434; ENSP00000474124; ENSG00000075826 [Q9NQW1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25956

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:25956

UCSC genome browser

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UCSCi
uc001krc.2 human [Q9NQW1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274863 mRNA Translation: AAF78243.1
AL080141 mRNA Translation: CAB45735.1
BX640914 mRNA Translation: CAE45955.1
AL133352 Genomic DNA No translation available.
BC034946 mRNA Translation: AAH34946.1
BC044569 mRNA No translation available.
BC144313 mRNA Translation: AAI44314.1
CCDSiCCDS7495.1 [Q9NQW1-1]
PIRiT12526
RefSeqiNP_056305.1, NM_015490.3 [Q9NQW1-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi117447, 13 interactors
IntActiQ9NQW1, 12 interactors
MINTiQ9NQW1
STRINGi9606.ENSP00000359370

PTM databases

iPTMnetiQ9NQW1
PhosphoSitePlusiQ9NQW1

Polymorphism and mutation databases

BioMutaiSEC31B
DMDMi74762753

Proteomic databases

jPOSTiQ9NQW1
MassIVEiQ9NQW1
PaxDbiQ9NQW1
PeptideAtlasiQ9NQW1
PRIDEiQ9NQW1
ProteomicsDBi82201 [Q9NQW1-1]
82202 [Q9NQW1-2]
82203 [Q9NQW1-3]
82204 [Q9NQW1-4]
82205 [Q9NQW1-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
25956

Genome annotation databases

EnsembliENST00000370345; ENSP00000359370; ENSG00000075826 [Q9NQW1-1]
ENST00000462434; ENSP00000474124; ENSG00000075826 [Q9NQW1-2]
GeneIDi25956
KEGGihsa:25956
UCSCiuc001krc.2 human [Q9NQW1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25956

GeneCards: human genes, protein and diseases

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GeneCardsi
SEC31B
HGNCiHGNC:23197 SEC31B
HPAiHPA035882
HPA040819
HPA060052
MIMi610258 gene
neXtProtiNX_Q9NQW1
OpenTargetsiENSG00000075826
PharmGKBiPA162402792

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0307 Eukaryota
ENOG410XQ1D LUCA
GeneTreeiENSGT00390000003175
HOGENOMiHOG000230582
InParanoidiQ9NQW1
KOiK14005
OMAiQGSRMQN
OrthoDBi100998at2759
PhylomeDBiQ9NQW1
TreeFamiTF313842

Enzyme and pathway databases

SignaLinkiQ9NQW1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SEC31B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25956
PharosiQ9NQW1

Protein Ontology

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PROi
PR:Q9NQW1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000075826 Expressed in 142 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ9NQW1 baseline and differential
GenevisibleiQ9NQW1 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR040251 SEC31-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13923 PTHR13923, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC31B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQW1
Secondary accession number(s): B7ZM75
, Q6MZS3, Q86UF0, Q9Y4Q8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2000
Last modified: October 16, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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