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Entry version 156 (08 May 2019)
Sequence version 3 (09 Jan 2013)
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Protein

PR domain zinc finger protein 10

Gene

PRDM10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri355 – 377C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri560 – 582C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri588 – 610C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri616 – 639C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri644 – 666C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri672 – 695C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri727 – 750C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri772 – 795C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri834 – 857C2H2-type 10PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9NQV6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PR domain zinc finger protein 10 (EC:2.1.1.-)
Alternative name(s):
PR domain-containing protein 10
Tristanin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRDM10
Synonyms:KIAA1231, PFM7, TRIS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13995 PRDM10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618319 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NQV6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56980

Open Targets

More...
OpenTargetsi
ENSG00000170325

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33708

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRDM10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
442570289

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000477671 – 1147PR domain zinc finger protein 10Add BLAST1147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki380Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei424PhosphoserineCombined sources1
Modified residuei428PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NQV6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NQV6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NQV6

PeptideAtlas

More...
PeptideAtlasi
Q9NQV6

PRoteomics IDEntifications database

More...
PRIDEi
Q9NQV6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82192
82193 [Q9NQV6-1]
82194 [Q9NQV6-2]
82195 [Q9NQV6-4]
82196 [Q9NQV6-5]
82197 [Q9NQV6-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NQV6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NQV6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170325 Expressed in 205 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NQV6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NQV6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026997

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RELQ048643EBI-10312448,EBI-307352

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121298, 21 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NQV6, 4 interactors

Molecular INTeraction database

More...
MINTi
Q9NQV6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351686

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IHXX-ray2.50A/B/C/D188-339[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NQV6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NQV6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini208 – 326SETPROSITE-ProRule annotationAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi866 – 916Thr-richAdd BLAST51
Compositional biasi918 – 1031Gln-richAdd BLAST114
Compositional biasi1131 – 1134Poly-Thr4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SET domain is degenerated, suggesting that it has lost methyltransferase activity.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri355 – 377C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri560 – 582C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri588 – 610C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri616 – 639C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri644 – 666C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri672 – 695C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri727 – 750C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri772 – 795C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri834 – 857C2H2-type 10PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158740

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NQV6

Identification of Orthologs from Complete Genome Data

More...
OMAi
ECNRRFM

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

TreeFam database of animal gene trees

More...
TreeFami
TF350894

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001214 SET_dom
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 3 hits
PF12171 zf-C2H2_jaz, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q9NQV6-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSKDESSHV WPTSAEHEQN AAQVHFVPDT GTVAQIVYTD DQVRPPQQVV
60 70 80 90 100
YTADGASYTS VDGPEHTLVY IHPVEAAQTL FTDPGQVAYV QQDATAQQAS
110 120 130 140 150
LPVHNQVLPS IESVDGSDPL ATLQTPLGRL EAKEEEDEDE DEDTEEDEEE
160 170 180 190 200
DGEDTDLDDW EPDPPRPFDP HDLWCEECNN AHASVCPKHG PLHPIPNRPV
210 220 230 240 250
LTRARASLPL VLYIDRFLGG VFSKRRIPKR TQFGPVEGPL VRGSELKDCY
260 270 280 290 300
IHLKVSLDKG DRKERDLHED LWFELSDETL CNWMMFVRPA QNHLEQNLVA
310 320 330 340 350
YQYGHHVYYT TIKNVEPKQE LKVWYAASYA EFVNQKIHDI SEEERKVLRE
360 370 380 390 400
QEKNWPCYEC NRRFISSEQL QQHLNSHDEK LDVFSRTRGR GRGRGKRRFG
410 420 430 440 450
PGRRPGRPPK FIRLEITSEN GEKSDDGTQD LLHFPTKEQF DEAEPATLNG
460 470 480 490 500
LDQPEQTTIP IPQLPQETQS SLEHEPETHT LHLQPQHEES VVPTQSTLTA
510 520 530 540 550
DDMRRAKRIR LELQNAALQH LFIRKSFRPF KCLQCGKAFR EKDKLDQHLR
560 570 580 590 600
FHGREGNCPL TCDLCNKGFI SSTSLESHMK LHSDQKTYSC IFCPESFDRL
610 620 630 640 650
DLLKDHVAIH INDGYFTCPT CKKRFPDFIQ VKKHVRSFHS EKIYQCTECD
660 670 680 690 700
KAFCRPDKLR LHMLRHSDRK DFLCSTCGKQ FKRKDKLREH MQRMHNPERE
710 720 730 740 750
AKKADRISRS KTFKPRITST DYDSFTFKCR LCMMGFRRRG MLVNHLSKRH
760 770 780 790 800
PDMKIEEVPE LTLPIIKPNR DYFCQYCDKV YKSASKRKAH ILKNHPGAEL
810 820 830 840 850
PPSIRKLRPA GPGEPDPMLS THTQLTGTIA TPPVCCPHCS KQYSSKTKMV
860 870 880 890 900
QHIRKKHPEF AQLSNTIHTP LTTAVISATP AVLTTDSATG ETVVTTDLLT
910 920 930 940 950
QAMTELSQTL TTDYRTPQGD YQRIQYIPVS QSASGLQQPQ HIQLQVVQVA
960 970 980 990 1000
SATSPHQSQQ STVDVGQLHD PQPYPQHAIQ VQHIQVSGQP LSPSAQQAQQ
1010 1020 1030 1040 1050
GLSPSHIQGS SSTQGQALQQ QQQQQQNSSV QHTYLPSAWN SFRGYSSEIQ
1060 1070 1080 1090 1100
MMTLPPGQFV ITDSGVATPV TTGQVKAVTS GHYVLSESQS ELEEKQTSAL
1110 1120 1130 1140
SGGVQVEPPA HSDSLDPQTN SQQQTTQYII TTTTNGNGSS EVHITKP
Length:1,147
Mass (Da):130,136
Last modified:January 9, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE565CA8822CB2934
GO
Isoform 2 (identifier: Q9NQV6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA
     511-514: Missing.
     952-985: Missing.

Show »
Length:1,023
Mass (Da):116,444
Checksum:iB5680EAEA32A4299
GO
Isoform 1 (identifier: Q9NQV6-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA

Show »
Length:1,061
Mass (Da):120,711
Checksum:iC712D4CDA514D995
GO
Isoform 4 (identifier: Q9NQV6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     511-514: Missing.
     984-984: I → IQVSEPTASAPSSA

Note: No experimental confirmation available.
Show »
Length:1,156
Mass (Da):130,865
Checksum:i0DF87B79FBAAE62C
GO
Isoform 5 (identifier: Q9NQV6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA
     984-984: I → IQVSEPTASAPSSA

Note: No experimental confirmation available.
Show »
Length:1,074
Mass (Da):121,924
Checksum:i7F7B76F86712D167
GO
Isoform 6 (identifier: Q9NQV6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     511-514: Missing.
     984-984: I → IQVSEPTASAPSSA
     1132-1147: TTTNGNGSSEVHITKP → AGSKVIQNEF...IVFKRISKRI

Note: No experimental confirmation available.
Show »
Length:1,214
Mass (Da):137,427
Checksum:i05D1A8B9136B7413
GO
Isoform 7 (identifier: Q9NQV6-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     984-984: I → IQVSEPTASAPSSA

Note: No experimental confirmation available.
Show »
Length:1,160
Mass (Da):131,349
Checksum:i1CCEC654DC42F464
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLV1E9PLV1_HUMAN
PR domain zinc finger protein 10
PRDM10
1,117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRS0E9PRS0_HUMAN
PR domain zinc finger protein 10
PRDM10
865Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS52E9PS52_HUMAN
PR domain zinc finger protein 10
PRDM10
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIB4E9PIB4_HUMAN
PR domain zinc finger protein 10
PRDM10
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91026 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46P → S in AAI12935 (Ref. 6) Curated1
Sequence conflicti387T → A in BAA91026 (PubMed:14702039).Curated1
Sequence conflicti569F → L in BX648944 (PubMed:17974005).Curated1
Sequence conflicti621C → Y in BX648944 (PubMed:17974005).Curated1
Sequence conflicti1112S → N in BX648944 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05441822A → T. Corresponds to variant dbSNP:rs11221912Ensembl.1
Natural variantiVAR_019984573T → A3 PublicationsCorresponds to variant dbSNP:rs2241571Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0363511 – 97MDSKD…DATAQ → MSAYSVPSTFA in isoform 1, isoform 2 and isoform 5. 4 PublicationsAdd BLAST97
Alternative sequenceiVSP_035655511 – 514Missing in isoform 2, isoform 4 and isoform 6. 3 Publications4
Alternative sequenceiVSP_035656952 – 985Missing in isoform 2. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_036352984I → IQVSEPTASAPSSA in isoform 4, isoform 5, isoform 6 and isoform 7. 3 Publications1
Alternative sequenceiVSP_0363531132 – 1147TTTNG…HITKP → AGSKVIQNEFTVGEECELET MTGEKVKTVVQLEGDNKLVT TFKNIKSVTELNGDIITNTM TLGDIVFKRISKRI in isoform 6. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF503171 mRNA Translation: AAP30847.1
AF275817 mRNA Translation: AAF87243.1
AB033057 mRNA Translation: BAA86545.2
BX648944 mRNA No translation available.
AP003041 Genomic DNA No translation available.
AP003326 Genomic DNA No translation available.
AP003327 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67761.1
BC112934 mRNA Translation: AAI12935.1
BC117415 mRNA Translation: AAI17416.1
BC143612 mRNA Translation: AAI43613.1
AK000234 mRNA Translation: BAA91026.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44771.1 [Q9NQV6-7]
CCDS44772.1 [Q9NQV6-1]
CCDS8484.1 [Q9NQV6-4]
CCDS8485.1 [Q9NQV6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_064613.2, NM_020228.2 [Q9NQV6-7]
NP_955469.1, NM_199437.1 [Q9NQV6-4]
NP_955470.1, NM_199438.1 [Q9NQV6-1]
NP_955471.1, NM_199439.1 [Q9NQV6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304538; ENSP00000302669; ENSG00000170325 [Q9NQV6-2]
ENST00000358825; ENSP00000351686; ENSG00000170325 [Q9NQV6-7]
ENST00000360871; ENSP00000354118; ENSG00000170325 [Q9NQV6-4]
ENST00000423662; ENSP00000398431; ENSG00000170325 [Q9NQV6-1]
ENST00000526082; ENSP00000432237; ENSG00000170325 [Q9NQV6-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56980

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56980

UCSC genome browser

More...
UCSCi
uc001qfj.4 human [Q9NQV6-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503171 mRNA Translation: AAP30847.1
AF275817 mRNA Translation: AAF87243.1
AB033057 mRNA Translation: BAA86545.2
BX648944 mRNA No translation available.
AP003041 Genomic DNA No translation available.
AP003326 Genomic DNA No translation available.
AP003327 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67761.1
BC112934 mRNA Translation: AAI12935.1
BC117415 mRNA Translation: AAI17416.1
BC143612 mRNA Translation: AAI43613.1
AK000234 mRNA Translation: BAA91026.1 Different initiation.
CCDSiCCDS44771.1 [Q9NQV6-7]
CCDS44772.1 [Q9NQV6-1]
CCDS8484.1 [Q9NQV6-4]
CCDS8485.1 [Q9NQV6-2]
RefSeqiNP_064613.2, NM_020228.2 [Q9NQV6-7]
NP_955469.1, NM_199437.1 [Q9NQV6-4]
NP_955470.1, NM_199438.1 [Q9NQV6-1]
NP_955471.1, NM_199439.1 [Q9NQV6-2]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IHXX-ray2.50A/B/C/D188-339[»]
SMRiQ9NQV6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121298, 21 interactors
IntActiQ9NQV6, 4 interactors
MINTiQ9NQV6
STRINGi9606.ENSP00000351686

PTM databases

iPTMnetiQ9NQV6
PhosphoSitePlusiQ9NQV6

Polymorphism and mutation databases

BioMutaiPRDM10
DMDMi442570289

Proteomic databases

jPOSTiQ9NQV6
MaxQBiQ9NQV6
PaxDbiQ9NQV6
PeptideAtlasiQ9NQV6
PRIDEiQ9NQV6
ProteomicsDBi82192
82193 [Q9NQV6-1]
82194 [Q9NQV6-2]
82195 [Q9NQV6-4]
82196 [Q9NQV6-5]
82197 [Q9NQV6-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304538; ENSP00000302669; ENSG00000170325 [Q9NQV6-2]
ENST00000358825; ENSP00000351686; ENSG00000170325 [Q9NQV6-7]
ENST00000360871; ENSP00000354118; ENSG00000170325 [Q9NQV6-4]
ENST00000423662; ENSP00000398431; ENSG00000170325 [Q9NQV6-1]
ENST00000526082; ENSP00000432237; ENSG00000170325 [Q9NQV6-5]
GeneIDi56980
KEGGihsa:56980
UCSCiuc001qfj.4 human [Q9NQV6-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56980
DisGeNETi56980

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRDM10
HGNCiHGNC:13995 PRDM10
HPAiHPA026997
MIMi618319 gene
neXtProtiNX_Q9NQV6
OpenTargetsiENSG00000170325
PharmGKBiPA33708

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000158740
InParanoidiQ9NQV6
OMAiECNRRFM
OrthoDBi1318335at2759
TreeFamiTF350894

Enzyme and pathway databases

SignaLinkiQ9NQV6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PRDM10 human
EvolutionaryTraceiQ9NQV6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56980

Protein Ontology

More...
PROi
PR:Q9NQV6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170325 Expressed in 205 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ9NQV6 baseline and differential
GenevisibleiQ9NQV6 HS

Family and domain databases

InterProiView protein in InterPro
IPR001214 SET_dom
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
PF12171 zf-C2H2_jaz, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRD10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQV6
Secondary accession number(s): B7ZL71
, G3XAE5, J3KP23, Q17R90, Q2KHR4, Q863Z2, Q9NXI4, Q9ULI9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: January 9, 2013
Last modified: May 8, 2019
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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