Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9NQV5 (PRD11_HUMAN)

(max 400 entries)x

Your basket is currently empty. i

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

PR domain-containing protein 11

Gene

PRDM11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcription regulation.1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
PR domain-containing protein 11 (EC:2.1.1.-)
Gene namesi
Name:PRDM11
Synonyms:PFM8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000019485.12
HGNCiHGNC:13996 PRDM11
MIMi616347 gene
neXtProtiNX_Q9NQV5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56981
OpenTargetsiENSG00000019485
PharmGKBiPA33709

Polymorphism and mutation databases

DMDMi308153475

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477681 – 511PR domain-containing protein 11Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphoserineCombined sources1
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki155Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki172Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki200Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NQV5
MaxQBiQ9NQV5
PaxDbiQ9NQV5
PeptideAtlasiQ9NQV5
PRIDEiQ9NQV5
ProteomicsDBi82190
82191 [Q9NQV5-2]

PTM databases

iPTMnetiQ9NQV5
PhosphoSitePlusiQ9NQV5

Expressioni

Tissue specificityi

Highly expressed in lung, including bronchial epithelial cells and airway smooth muscle cells, as well as in peripheral blood mononuclear cells. In tonsils, expressed in B-cell types, including naive B-cells, centroblasts, centrocytes and memory B-cells (at protein level). In benign hyperplastic lymph nodes, expressed in germinal center cells in both the dark and light zones, as well as in scattered cells in the mantle zone and the interfollicular area (at protein level).2 Publications

Developmental stagei

Differential expressed during pseudoglandular and canalicular stages of lung development.1 Publication

Gene expression databases

BgeeiENSG00000019485
CleanExiHS_PRDM11
ExpressionAtlasiQ9NQV5 baseline and differential
GenevisibleiQ9NQV5 HS

Organism-specific databases

HPAiHPA057072

Interactioni

Protein-protein interaction databases

IntActiQ9NQV5, 1 interactor
STRINGi9606.ENSP00000263765

Structurei

Secondary structure

1511
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi108 – 110Combined sources3
Turni111 – 114Combined sources4
Beta strandi115 – 121Combined sources7
Turni122 – 124Combined sources3
Beta strandi128 – 130Combined sources3
Helixi142 – 145Combined sources4
Beta strandi151 – 155Combined sources5
Beta strandi161 – 165Combined sources5
Beta strandi174 – 176Combined sources3
Beta strandi181 – 184Combined sources4
Beta strandi194 – 198Combined sources5
Beta strandi204 – 208Combined sources5
Turni212 – 214Combined sources3
Helixi217 – 220Combined sources4
Turni227 – 229Combined sources3
Beta strandi232 – 237Combined sources6
Beta strandi240 – 247Combined sources8
Beta strandi256 – 259Combined sources4
Helixi261 – 267Combined sources7

3D structure databases

ProteinModelPortaliQ9NQV5
SMRiQ9NQV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 260SETPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IN44 Eukaryota
ENOG410ZHQ1 LUCA
GeneTreeiENSGT00920000149076
HOGENOMiHOG000231445
HOVERGENiHBG053665
InParanoidiQ9NQV5
OMAiGEGDWKI
PhylomeDBiQ9NQV5
TreeFamiTF316279

Family and domain databases

InterProiView protein in InterPro
IPR001214 SET_dom
PfamiView protein in Pfam
PF00856 SET, 1 hit
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKMAEPIAS LMIVECRACL RCSPLFLYQR EKDRMTENMK ECLAQTNAAV 
        60         70         80         90        100
GDMVTVVKTE VCSPLRDQEY GQPCSRRPDS SAMEVEPKKL KGKRDLIVPK 
       110        120        130        140        150
SFQQVDFWFC ESCQEYFVDE CPNHGPPVFV SDTPVPVGIP DRAALTIPQG 
       160        170        180        190        200
MEVVKDTSGE SDVRCVNEVI PKGHIFGPYE GQISTQDKSA GFFSWLIVDK 
       210        220        230        240        250
NNRYKSIDGS DETKANWMRY VVISREEREQ NLLAFQHSER IYFRACRDIR 
       260        270        280        290        300
PGEWLRVWYS EDYMKRLHSM SQETIHRNLA RGEKRLQREK SEQVLDNPED 
       310        320        330        340        350
LRGPIHLSVL RQGKSPYKRG FDEGDVHPQA KKKKIDLIFK DVLEASLESA 
       360        370        380        390        400
KVEAHQLALS TSLVIRKVPK YQDDAYSQCA TTMTHGVQNI GQTQGEGDWK 
       410        420        430        440        450
VPQGVSKEPG QLEDEEEEPS SFKADSPAEA SLASDPHELP TTSFCPNCIR 
       460        470        480        490        500
LKKKVRELQA ELDMLKSGKL PEPPVLPPQV LELPEFSDPA GKLVWMRLLS 
       510 
EGRVRSGLCG G
Length:511
Mass (Da):57,863
Last modified:October 5, 2010 - v2
Checksum:i81DCAA502315EA5B
GO
Isoform 2 (identifier: Q9NQV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Note: No experimental confirmation available.
Show »
Length:477
Mass (Da):53,865
Checksum:i70133F1E616A817D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48A → V in BAC04425 (PubMed:14702039).Curated1
Sequence conflicti58 – 67KTEVCSPLRD → NPS in AAF87244 (Ref. 1) Curated10
Sequence conflicti214K → E in AAF87244 (Ref. 1) Curated1

Polymorphismi

A genome-wide association analysis shows PRDM11 association with forced vital capacity (FVC), a spirometric measure of pulmonary function, that reflects lung volume and is used to diagnose and monitor lung diseases.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073689200K → E in a patient with diffuse large B-cell lymphoma; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs111724149Ensembl.1
Natural variantiVAR_073690285R → S in a patient with diffuse large B-cell lymphoma; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs35090414Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0398361 – 34Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275818 mRNA Translation: AAF87244.1
AK094792 mRNA Translation: BAC04425.1
AC103681 Genomic DNA No translation available.
CCDSiCCDS58130.1 [Q9NQV5-2]
RefSeqiNP_001243624.1, NM_001256695.1
NP_001243625.1, NM_001256696.1 [Q9NQV5-2]
XP_011518533.1, XM_011520231.2 [Q9NQV5-2]
UniGeneiHs.178715

Genome annotation databases

EnsembliENST00000424263; ENSP00000394314; ENSG00000019485 [Q9NQV5-2]
ENST00000530656; ENSP00000435976; ENSG00000019485 [Q9NQV5-1]
GeneIDi56981
KEGGihsa:56981
UCSCiuc031qaa.2 human [Q9NQV5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRD11_HUMAN
AccessioniPrimary (citable) accession number: Q9NQV5
Secondary accession number(s): Q8N9F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 5, 2010
Last modified: July 18, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health