UniProtKB - Q9NQV5 (PRD11_HUMAN)
Protein
PR domain-containing protein 11
Gene
PRDM11
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcription regulation.1 Publication
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- histone methyltransferase activity Source: GO_Central
GO - Biological processi
- negative regulation of cell growth Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of fibroblast apoptotic process Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of cell cycle Source: UniProtKB
- regulation of gene expression Source: GO_Central
- regulation of MAPK cascade Source: UniProtKB
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Transcription, Transcription regulation |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
PathwayCommonsi | Q9NQV5 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PRDM11 Synonyms:PFM8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13996, PRDM11 |
MIMi | 616347, gene |
neXtProti | NX_Q9NQV5 |
VEuPathDBi | HostDB:ENSG00000019485.12 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 56981 |
OpenTargetsi | ENSG00000019485 |
PharmGKBi | PA33709 |
Miscellaneous databases
Pharosi | Q9NQV5, Tbio |
Genetic variation databases
BioMutai | PRDM11 |
DMDMi | 308153475 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047768 | 1 – 511 | PR domain-containing protein 11Add BLAST | 511 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 63 | PhosphoserineCombined sources | 1 | |
Cross-linki | 88 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 155 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 172 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 200 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 214 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q9NQV5 |
MassIVEi | Q9NQV5 |
MaxQBi | Q9NQV5 |
PaxDbi | Q9NQV5 |
PeptideAtlasi | Q9NQV5 |
PRIDEi | Q9NQV5 |
ProteomicsDBi | 82190 [Q9NQV5-1] 82191 [Q9NQV5-2] |
PTM databases
iPTMneti | Q9NQV5 |
PhosphoSitePlusi | Q9NQV5 |
Expressioni
Tissue specificityi
Highly expressed in lung, including bronchial epithelial cells and airway smooth muscle cells, as well as in peripheral blood mononuclear cells. In tonsils, expressed in B-cell types, including naive B-cells, centroblasts, centrocytes and memory B-cells (at protein level). In benign hyperplastic lymph nodes, expressed in germinal center cells in both the dark and light zones, as well as in scattered cells in the mantle zone and the interfollicular area (at protein level).2 Publications
Developmental stagei
Differential expressed during pseudoglandular and canalicular stages of lung development.1 Publication
Gene expression databases
Bgeei | ENSG00000019485, Expressed in stomach and 187 other tissues |
ExpressionAtlasi | Q9NQV5, baseline and differential |
Genevisiblei | Q9NQV5, HS |
Organism-specific databases
HPAi | ENSG00000019485, Low tissue specificity |
Interactioni
Binary interactionsi
Q9NQV5
With | #Exp. | IntAct |
---|---|---|
FHL2 [Q14192] | 3 | EBI-12941246,EBI-701903 |
Protein-protein interaction databases
BioGRIDi | 121299, 4 interactors |
IntActi | Q9NQV5, 11 interactors |
STRINGi | 9606.ENSP00000480626 |
Miscellaneous databases
RNActi | Q9NQV5, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9NQV5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 149 – 260 | SETPROSITE-ProRule annotationAdd BLAST | 112 |
Sequence similaritiesi
Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG2461, Eukaryota |
GeneTreei | ENSGT00940000159837 |
HOGENOMi | CLU_593911_0_0_1 |
InParanoidi | Q9NQV5 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9NQV5 |
TreeFami | TF316279 |
Family and domain databases
InterProi | View protein in InterPro IPR001214, SET_dom |
PROSITEi | View protein in PROSITE PS50280, SET, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NQV5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLKMAEPIAS LMIVECRACL RCSPLFLYQR EKDRMTENMK ECLAQTNAAV
60 70 80 90 100
GDMVTVVKTE VCSPLRDQEY GQPCSRRPDS SAMEVEPKKL KGKRDLIVPK
110 120 130 140 150
SFQQVDFWFC ESCQEYFVDE CPNHGPPVFV SDTPVPVGIP DRAALTIPQG
160 170 180 190 200
MEVVKDTSGE SDVRCVNEVI PKGHIFGPYE GQISTQDKSA GFFSWLIVDK
210 220 230 240 250
NNRYKSIDGS DETKANWMRY VVISREEREQ NLLAFQHSER IYFRACRDIR
260 270 280 290 300
PGEWLRVWYS EDYMKRLHSM SQETIHRNLA RGEKRLQREK SEQVLDNPED
310 320 330 340 350
LRGPIHLSVL RQGKSPYKRG FDEGDVHPQA KKKKIDLIFK DVLEASLESA
360 370 380 390 400
KVEAHQLALS TSLVIRKVPK YQDDAYSQCA TTMTHGVQNI GQTQGEGDWK
410 420 430 440 450
VPQGVSKEPG QLEDEEEEPS SFKADSPAEA SLASDPHELP TTSFCPNCIR
460 470 480 490 500
LKKKVRELQA ELDMLKSGKL PEPPVLPPQV LELPEFSDPA GKLVWMRLLS
510
EGRVRSGLCG G
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WWZ6 | A0A087WWZ6_HUMAN | PR domain-containing protein 11 | PRDM11 | 1,177 | Annotation score: | ||
H3BSZ2 | H3BSZ2_HUMAN | PR domain-containing protein 11 | PRDM11 | 480 | Annotation score: | ||
E9PJ09 | E9PJ09_HUMAN | PR domain-containing protein 11 | PRDM11 | 184 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 48 | A → V in BAC04425 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 58 – 67 | KTEVCSPLRD → NPS in AAF87244 (Ref. 1) Curated | 10 | |
Sequence conflicti | 214 | K → E in AAF87244 (Ref. 1) Curated | 1 |
Polymorphismi
A genome-wide association analysis shows PRDM11 association with forced vital capacity (FVC), a spirometric measure of pulmonary function, that reflects lung volume and is used to diagnose and monitor lung diseases.1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073689 | 200 | K → E in a patient with diffuse large B-cell lymphoma; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs111724149Ensembl. | 1 | |
Natural variantiVAR_073690 | 285 | R → S in a patient with diffuse large B-cell lymphoma; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs35090414Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039836 | 1 – 34 | Missing in isoform 2. 1 PublicationAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF275818 mRNA Translation: AAF87244.1 AK094792 mRNA Translation: BAC04425.1 AC103681 Genomic DNA No translation available. |
CCDSi | CCDS58130.1 [Q9NQV5-2] CCDS7912.1 [Q9NQV5-2] |
RefSeqi | NP_001243624.1, NM_001256695.1 NP_001243625.1, NM_001256696.1 [Q9NQV5-2] XP_011518533.1, XM_011520231.2 |
Genome annotation databases
Ensembli | ENST00000424263; ENSP00000394314; ENSG00000019485 [Q9NQV5-2] ENST00000530656; ENSP00000435976; ENSG00000019485 [Q9NQV5-1] |
GeneIDi | 56981 |
KEGGi | hsa:56981 |
UCSCi | uc031qaa.2, human [Q9NQV5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF275818 mRNA Translation: AAF87244.1 AK094792 mRNA Translation: BAC04425.1 AC103681 Genomic DNA No translation available. |
CCDSi | CCDS58130.1 [Q9NQV5-2] CCDS7912.1 [Q9NQV5-2] |
RefSeqi | NP_001243624.1, NM_001256695.1 NP_001243625.1, NM_001256696.1 [Q9NQV5-2] XP_011518533.1, XM_011520231.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3RAY | X-ray | 1.73 | A | 79-314 | [»] | |
SMRi | Q9NQV5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121299, 4 interactors |
IntActi | Q9NQV5, 11 interactors |
STRINGi | 9606.ENSP00000480626 |
PTM databases
iPTMneti | Q9NQV5 |
PhosphoSitePlusi | Q9NQV5 |
Genetic variation databases
BioMutai | PRDM11 |
DMDMi | 308153475 |
Proteomic databases
jPOSTi | Q9NQV5 |
MassIVEi | Q9NQV5 |
MaxQBi | Q9NQV5 |
PaxDbi | Q9NQV5 |
PeptideAtlasi | Q9NQV5 |
PRIDEi | Q9NQV5 |
ProteomicsDBi | 82190 [Q9NQV5-1] 82191 [Q9NQV5-2] |
Protocols and materials databases
ABCDi | Q9NQV5, 6 sequenced antibodies |
Antibodypediai | 26153, 136 antibodies |
DNASUi | 56981 |
Genome annotation databases
Ensembli | ENST00000424263; ENSP00000394314; ENSG00000019485 [Q9NQV5-2] ENST00000530656; ENSP00000435976; ENSG00000019485 [Q9NQV5-1] |
GeneIDi | 56981 |
KEGGi | hsa:56981 |
UCSCi | uc031qaa.2, human [Q9NQV5-1] |
Organism-specific databases
CTDi | 56981 |
DisGeNETi | 56981 |
GeneCardsi | PRDM11 |
HGNCi | HGNC:13996, PRDM11 |
HPAi | ENSG00000019485, Low tissue specificity |
MIMi | 616347, gene |
neXtProti | NX_Q9NQV5 |
OpenTargetsi | ENSG00000019485 |
PharmGKBi | PA33709 |
VEuPathDBi | HostDB:ENSG00000019485.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2461, Eukaryota |
GeneTreei | ENSGT00940000159837 |
HOGENOMi | CLU_593911_0_0_1 |
InParanoidi | Q9NQV5 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9NQV5 |
TreeFami | TF316279 |
Enzyme and pathway databases
PathwayCommonsi | Q9NQV5 |
Miscellaneous databases
BioGRID-ORCSi | 56981, 6 hits in 870 CRISPR screens |
ChiTaRSi | PRDM11, human |
GenomeRNAii | 56981 |
Pharosi | Q9NQV5, Tbio |
PROi | PR:Q9NQV5 |
RNActi | Q9NQV5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000019485, Expressed in stomach and 187 other tissues |
ExpressionAtlasi | Q9NQV5, baseline and differential |
Genevisiblei | Q9NQV5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001214, SET_dom |
PROSITEi | View protein in PROSITE PS50280, SET, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRD11_HUMAN | |
Accessioni | Q9NQV5Primary (citable) accession number: Q9NQV5 Secondary accession number(s): Q8N9F1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2002 |
Last sequence update: | October 5, 2010 | |
Last modified: | February 10, 2021 | |
This is version 136 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families