PAK6

Functionⁱ

Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.2 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	436	ATPPROSITE-ProRule annotation		1
Active siteⁱ	526	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	413 – 421	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
Rac GTPase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of protein kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
apoptotic process
Source: UniProtKB
Traceable author statementⁱ
- 20070256
cytoskeleton organization
Source: UniProtKB
Traceable author statementⁱ
- 20070256
regulation of MAPK cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription, DNA-templated
Source: UniProtKB
Traceable author statementⁱ
- 20070256
signal transduction by protein phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
stress-activated protein kinase signaling cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-428540 Activation of RAC1
SignaLinkⁱ	Q9NQU5
SIGNORⁱ	Q9NQU5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase PAK 6 (EC:2.7.11.1) Alternative name(s): PAK-5 p21-activated kinase 6 Short name: PAK-6
Gene namesⁱ	Name:PAK6 Synonyms:PAK5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000137843.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16061 PAK6
MIMⁱ	608110 gene
neXtProtⁱ	NX_Q9NQU5

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	165	S → A: Almost complete loss of PAK6 activation by MAP2K6/MAPKK6; when associated with F-566. 1 Publication	1
Mutagenesisⁱ	560	S → A: Complete loss of PAK6 activation by MAP2K6/MAPKK6; when associated with A-165. 1 Publication	1
Mutagenesisⁱ	566	Y → F: Complete loss of PAK6 activation by MAP2K6/MAPKK6; when associated with A-165. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	106821730 56924
Open Targets More...OpenTargetsⁱ	ENSG00000137843 ENSG00000259288
PharmGKBⁱ	PA32921

Chemistry databases

ChEMBLⁱ	CHEMBL4311
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2137

Polymorphism and mutation databases

DMDMⁱ	23396789

DMDMⁱ

23396789

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086476	1 – 681	Serine/threonine-protein kinase PAK 6Add BLAST		681

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	560	Phosphoserine; by autocatalysisBy similarity		1

Post-translational modificationⁱ

Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation.2 Publications

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9NQU5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NQU5
PaxDbⁱ	Q9NQU5
PeptideAtlas More...PeptideAtlasⁱ	Q9NQU5
PRIDEⁱ	Q9NQU5
ProteomicsDBⁱ	82189

PTM databases

iPTMnetⁱ	Q9NQU5
PhosphoSitePlusⁱ	Q9NQU5

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000137843 Expressed in 91 organ(s), highest expression level in prefrontal cortex
CleanExⁱ	HS_PAK6
ExpressionAtlasⁱ	Q9NQU5 baseline and differential
Genevisibleⁱ	Q9NQU5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031124

HPAⁱ

HPA031124

Interactionⁱ

Subunit structureⁱ

Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1 (By similarity). Interacts with the androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LRRK2	Q5S007	2	EBI-1053685,EBI-5323863
RHOJ	Q9H4E5	3	EBI-1053685,EBI-6285694

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
Rac GTPase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121251, 24 interactors
IntActⁱ	Q9NQU5, 16 interactors
Molecular INTeraction database More...MINTⁱ	Q9NQU5
STRINGⁱ	9606.ENSP00000260404

Chemistry databases

BindingDBⁱ

Q9NQU5

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	16 – 27	Combined sources	12
Turnⁱ	28 – 31	Combined sources	4
Beta strandⁱ	32 – 35	Combined sources	4
Helixⁱ	38 – 44	Combined sources	7
Helixⁱ	387 – 395	Combined sources	9
Helixⁱ	404 – 406	Combined sources	3
Beta strandⁱ	407 – 416	Combined sources	10
Beta strandⁱ	419 – 426	Combined sources	8
Turnⁱ	427 – 429	Combined sources	3
Beta strandⁱ	432 – 439	Combined sources	8
Turnⁱ	440 – 442	Combined sources	3
Helixⁱ	446 – 448	Combined sources	3
Helixⁱ	449 – 458	Combined sources	10
Beta strandⁱ	467 – 473	Combined sources	7
Beta strandⁱ	476 – 481	Combined sources	6
Helixⁱ	489 – 493	Combined sources	5
Helixⁱ	500 – 519	Combined sources	20
Helixⁱ	529 – 531	Combined sources	3
Beta strandⁱ	532 – 534	Combined sources	3
Beta strandⁱ	540 – 542	Combined sources	3
Helixⁱ	545 – 547	Combined sources	3
Beta strandⁱ	553 – 555	Combined sources	3
Helixⁱ	565 – 567	Combined sources	3
Helixⁱ	570 – 573	Combined sources	4
Helixⁱ	581 – 596	Combined sources	16
Turnⁱ	600 – 603	Combined sources	4
Helixⁱ	606 – 615	Combined sources	10
Helixⁱ	624 – 626	Combined sources	3
Helixⁱ	629 – 638	Combined sources	10
Turnⁱ	643 – 645	Combined sources	3
Helixⁱ	649 – 653	Combined sources	5
Helixⁱ	656 – 660	Combined sources	5
Helixⁱ	664 – 670	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NQU5
SMRⁱ	Q9NQU5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9NQU5

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	12 – 25	CRIBPROSITE-ProRule annotationAdd BLAST		14
Domainⁱ	407 – 658	Protein kinasePROSITE-ProRule annotationAdd BLAST		252

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	26 – 406	LinkerAdd BLAST		381

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0578 Eukaryota ENOG410XP4K LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150829
HOGENOMⁱ	HOG000234205
HOVERGENⁱ	HBG108518
InParanoidⁱ	Q9NQU5
KEGG Orthology (KO) More...KOⁱ	K05735
OMAⁱ	RPPQKDS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OT5
PhylomeDBⁱ	Q9NQU5
TreeFamⁱ	TF105352

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01093 CRIB_PAK_like, 1 hit
Gene3Dⁱ	3.90.810.10, 1 hit
InterProⁱ	View protein in InterPro IPR000095 CRIB_dom IPR036936 CRIB_dom_sf IPR011009 Kinase-like_dom_sf IPR035066 PAK6 IPR033923 PAK_BD IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS
PANTHERⁱ	PTHR24361:SF182 PTHR24361:SF182, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00786 PBD, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00285 PBD, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50108 CRIB, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NQU5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRKKKKKRP EISAPQNFQH RVHTSFDPKE GKFVGLPPQW QNILDTLRRP 
        60         70         80         90        100
KPVVDPSRIT RVQLQPMKTV VRGSAMPVDG YISGLLNDIQ KLSVISSNTL 
       110        120        130        140        150
RGRSPTSRRR AQSLGLLGDE HWATDPDMYL QSPQSERTDP HGLYLSCNGG 
       160        170        180        190        200
TPAGHKQMPW PEPQSPRVLP NGLAAKAQSL GPAEFQGASQ RCLQLGACLQ 
       210        220        230        240        250
SSPPGASPPT GTNRHGMKAA KHGSEEARPQ SCLVGSATGR PGGEGSPSPK 
       260        270        280        290        300
TRESSLKRRL FRSMFLSTAA TAPPSSSKPG PPPQSKPNSS FRPPQKDNPP 
       310        320        330        340        350
SLVAKAQSLP SDQPVGTFSP LTTSDTSSPQ KSLRTAPATG QLPGRSSPAG 
       360        370        380        390        400
SPRTWHAQIS TSNLYLPQDP TVAKGALAGE DTGVVTHEQF KAALRMVVDQ 
       410        420        430        440        450
GDPRLLLDSY VKIGEGSTGI VCLAREKHSG RQVAVKMMDL RKQQRRELLF 
       460        470        480        490        500
NEVVIMRDYQ HFNVVEMYKS YLVGEELWVL MEFLQGGALT DIVSQVRLNE 
       510        520        530        540        550
EQIATVCEAV LQALAYLHAQ GVIHRDIKSD SILLTLDGRV KLSDFGFCAQ 
       560        570        580        590        600
ISKDVPKRKS LVGTPYWMAP EVISRSLYAT EVDIWSLGIM VIEMVDGEPP 
       610        620        630        640        650
YFSDSPVQAM KRLRDSPPPK LKNSHKVSPV LRDFLERMLV RDPQERATAQ 
       660        670        680 
ELLDHPFLLQ TGLPECLVPL IQLYRKQTST C

Length:681

Mass (Da):74,869

Last modified:October 1, 2000 - v1

Checksum:ⁱF20A4FA257649BB9

GO

Isoform 2 (identifier: Q9NQU5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
583-627: Missing.

« Hide

        10         20         30         40         50
MFRKKKKKRP EISAPQNFQH RVHTSFDPKE GKFVGLPPQW QNILDTLRRP 
        60         70         80         90        100
KPVVDPSRIT RVQLQPMKTV VRGSAMPVDG YISGLLNDIQ KLSVISSNTL 
       110        120        130        140        150
RGRSPTSRRR AQSLGLLGDE HWATDPDMYL QSPQSERTDP HGLYLSCNGG 
       160        170        180        190        200
TPAGHKQMPW PEPQSPRVLP NGLAAKAQSL GPAEFQGASQ RCLQLGACLQ 
       210        220        230        240        250
SSPPGASPPT GTNRHGMKAA KHGSEEARPQ SCLVGSATGR PGGEGSPSPK 
       260        270        280        290        300
TRESSLKRRL FRSMFLSTAA TAPPSSSKPG PPPQSKPNSS FRPPQKDNPP 
       310        320        330        340        350
SLVAKAQSLP SDQPVGTFSP LTTSDTSSPQ KSLRTAPATG QLPGRSSPAG 
       360        370        380        390        400
SPRTWHAQIS TSNLYLPQDP TVAKGALAGE DTGVVTHEQF KAALRMVVDQ 
       410        420        430        440        450
GDPRLLLDSY VKIGEGSTGI VCLAREKHSG RQVAVKMMDL RKQQRRELLF 
       460        470        480        490        500
NEVVIMRDYQ HFNVVEMYKS YLVGEELWVL MEFLQGGALT DIVSQVRLNE 
       510        520        530        540        550
EQIATVCEAV LQALAYLHAQ GVIHRDIKSD SILLTLDGRV KLSDFGFCAQ 
       560        570        580        590        600
ISKDVPKRKS LVGTPYWMAP EVISRSLYAT EVSPVLRDFL ERMLVRDPQE 
       610        620        630 
RATAQELLDH PFLLQTGLPE CLVPLIQLYR KQTSTC

Show »

Length:636

Mass (Da):69,777

Checksum:ⁱ3CA588AAB5B8E522

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YL16	H0YL16_HUMAN	Serine/threonine-protein kinase PAK... Serine/threonine-protein kinase PAK 6	PAK6	284	Annotation score:
H0YK38	H0YK38_HUMAN	Serine/threonine-protein kinase PAK... Serine/threonine-protein kinase PAK 6	PAK6	74	Annotation score:
H0YK91	H0YK91_HUMAN	Serine/threonine-protein kinase PAK... Serine/threonine-protein kinase PAK 6	PAK6	112	Annotation score:
H0YM99	H0YM99_HUMAN	Serine/threonine-protein kinase PAK... Serine/threonine-protein kinase PAK 6	PAK6	104	Annotation score:
H0YL47	H0YL47_HUMAN	Serine/threonine-protein kinase PAK... Serine/threonine-protein kinase PAK 6	PAK6	71	Annotation score:
H0YMS4	H0YMS4_HUMAN	Serine/threonine-protein kinase PAK... Serine/threonine-protein kinase PAK 6	PAK6	123	Annotation score:
H0YLZ9	H0YLZ9_HUMAN	Serine/threonine-protein kinase PAK... Serine/threonine-protein kinase PAK 6	PAK6	122	Annotation score:
H0YKB6	H0YKB6_HUMAN	Serine/threonine-protein kinase PAK... Serine/threonine-protein kinase PAK 6	PAK6	57	Annotation score:
H0YK74	H0YK74_HUMAN	Serine/threonine-protein kinase PAK... Serine/threonine-protein kinase PAK 6	PAK6	109	Annotation score:
H0YL02	H0YL02_HUMAN	Serine/threonine-protein kinase PAK... Serine/threonine-protein kinase PAK 6	PAK6	20	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	60	T → A in BAG54772 (PubMed:14702039).Curated		1
Sequence conflictⁱ	381	D → G in BAG54772 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_035631	3	R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs201346085Ensembl.	1
Natural variantⁱVAR_019993	76	M → V1 PublicationCorresponds to variant dbSNP:rs2412504Ensembl.	1
Natural variantⁱVAR_051655	103	R → C. Corresponds to variant dbSNP:rs36081263Ensembl.	1
Natural variantⁱVAR_051656	151	T → I. Corresponds to variant dbSNP:rs35593179Ensembl.	1
Natural variantⁱVAR_040972	184	E → K1 PublicationCorresponds to variant dbSNP:rs56349744Ensembl.	1
Natural variantⁱVAR_040973	205	G → E1 PublicationCorresponds to variant dbSNP:rs55920845Ensembl.	1
Natural variantⁱVAR_040974	208	P → T1 PublicationCorresponds to variant dbSNP:rs35501648Ensembl.	1
Natural variantⁱVAR_040975	210	T → M1 PublicationCorresponds to variant dbSNP:rs34869667Ensembl.	1
Natural variantⁱVAR_019994	215	H → R1 PublicationCorresponds to variant dbSNP:rs3743135Ensembl.	1
Natural variantⁱVAR_019995	337	P → L1 PublicationCorresponds to variant dbSNP:rs3743137Ensembl.	1
Natural variantⁱVAR_040976	376	A → V1 PublicationCorresponds to variant dbSNP:rs55806501Ensembl.	1
Natural variantⁱVAR_051657	475	E → K. Corresponds to variant dbSNP:rs34445577Ensembl.	1
Natural variantⁱVAR_040977	514	L → R in a lung small cell carcinoma sample; somatic mutation. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056733	583 – 627	Missing in isoform 2. 1 PublicationAdd BLAST		45

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF276893 mRNA Translation: AAF82800.1 AJ236915 mRNA Translation: CAC18720.1 AK131522 mRNA Translation: BAG54772.1 AK290227 mRNA Translation: BAF82916.1 AK315813 mRNA Translation: BAF98704.1 AK315817 mRNA Translation: BAF98708.1 AC020658 Genomic DNA No translation available. AC025429 Genomic DNA No translation available. CH471125 Genomic DNA Translation: EAW92395.1 CH471125 Genomic DNA Translation: EAW92401.1 BC035596 mRNA Translation: AAH35596.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10054.1 [Q9NQU5-1] CCDS61590.1 [Q9NQU5-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001122100.1, NM_001128628.2 [Q9NQU5-1] NP_001122101.1, NM_001128629.2 [Q9NQU5-1] NP_001263646.1, NM_001276717.1 [Q9NQU5-1] NP_001263647.1, NM_001276718.1 [Q9NQU5-2] NP_064553.1, NM_020168.5 [Q9NQU5-1]
UniGeneⁱ	Hs.732375 Hs.745440

Genome annotation databases

Ensemblⁱ	ENST00000260404; ENSP00000260404; ENSG00000137843 [Q9NQU5-1] ENST00000455577; ENSP00000409465; ENSG00000137843 [Q9NQU5-2] ENST00000542403; ENSP00000439597; ENSG00000137843 [Q9NQU5-1] ENST00000560346; ENSP00000453858; ENSG00000137843 [Q9NQU5-1]
GeneIDⁱ	106821730 56924
KEGGⁱ	hsa:106821730 hsa:56924
UCSC genome browser More...UCSCⁱ	uc001zky.5 human [Q9NQU5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NQU5	Non-specific serine/threonine protein kinase		HUMAN		681	UniRef100_Q9NQU5
Serine/threonine-protein kinase PAK 6 (Fragment)		HUMAN		284
Serine/threonine-protein kinase PAK 6 (Fragment)		HUMAN		123
Serine/threonine-protein kinase PAK 6 (Fragment)		HUMAN		104
Serine/threonine-protein kinase PAK 6 (Fragment)		HUMAN		109
+2

Protein	Similar proteins		Species	Score	Length	Source
Q9NQU5	Serine/threonine-protein kinase PAK 6		MOUSE		682	UniRef90_Q9NQU5
Serine/threonine-protein kinase PAK 6		PONAB		681
Non-specific serine/threonine protein kinase		HUMAN		681
Non-specific serine/threonine protein kinase		CEREH		692
Non-specific serine/threonine protein kinase		MUSPF		688
+121
Q9NQU5-2	Non-specific serine/threonine protein kinase		SAIBB		706	UniRef90_Q9NQU5-2
Non-specific serine/threonine protein kinase		RHIRO		636
Non-specific serine/threonine protein kinase		PANPA		636
Non-specific serine/threonine protein kinase		CALJA		636
Non-specific serine/threonine protein kinase		MACNE		636
+10

Protein	Similar proteins		Species	Score	Length	Source
Q9NQU5	Serine/threonine-protein kinase PAK 6		MOUSE		682	UniRef50_Q9NQU5
Serine/threonine-protein kinase PAK 6		PONAB		681
Non-specific serine/threonine protein kinase		HUMAN		681
Non-specific serine/threonine protein kinase		CEREH		692
Non-specific serine/threonine protein kinase		MUSPF		688
+241

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF276893 mRNA Translation: AAF82800.1 AJ236915 mRNA Translation: CAC18720.1 AK131522 mRNA Translation: BAG54772.1 AK290227 mRNA Translation: BAF82916.1 AK315813 mRNA Translation: BAF98704.1 AK315817 mRNA Translation: BAF98708.1 AC020658 Genomic DNA No translation available. AC025429 Genomic DNA No translation available. CH471125 Genomic DNA Translation: EAW92395.1 CH471125 Genomic DNA Translation: EAW92401.1 BC035596 mRNA Translation: AAH35596.1
CCDSⁱ	CCDS10054.1 [Q9NQU5-1] CCDS61590.1 [Q9NQU5-2]
RefSeqⁱ	NP_001122100.1, NM_001128628.2 [Q9NQU5-1] NP_001122101.1, NM_001128629.2 [Q9NQU5-1] NP_001263646.1, NM_001276717.1 [Q9NQU5-1] NP_001263647.1, NM_001276718.1 [Q9NQU5-2] NP_064553.1, NM_020168.5 [Q9NQU5-1]
UniGeneⁱ	Hs.732375 Hs.745440

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2C30	X-ray	1.60	A	383-681	[»]
	2ODB	X-ray	2.40	B	11-45	[»]
	4KS7	X-ray	1.40	A	385-674	[»]
	4KS8	X-ray	1.95	A	385-674	[»]
ProteinModelPortalⁱ	Q9NQU5
SMRⁱ	Q9NQU5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121251, 24 interactors
IntActⁱ	Q9NQU5, 16 interactors
MINTⁱ	Q9NQU5
STRINGⁱ	9606.ENSP00000260404

Chemistry databases

BindingDBⁱ	Q9NQU5
ChEMBLⁱ	CHEMBL4311
GuidetoPHARMACOLOGYⁱ	2137

PTM databases

iPTMnetⁱ	Q9NQU5
PhosphoSitePlusⁱ	Q9NQU5

Polymorphism and mutation databases

DMDMⁱ	23396789

DMDMⁱ

23396789

Proteomic databases

EPDⁱ	Q9NQU5
MaxQBⁱ	Q9NQU5
PaxDbⁱ	Q9NQU5
PeptideAtlasⁱ	Q9NQU5
PRIDEⁱ	Q9NQU5
ProteomicsDBⁱ	82189

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	56924
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000260404; ENSP00000260404; ENSG00000137843 [Q9NQU5-1] ENST00000455577; ENSP00000409465; ENSG00000137843 [Q9NQU5-2] ENST00000542403; ENSP00000439597; ENSG00000137843 [Q9NQU5-1] ENST00000560346; ENSP00000453858; ENSG00000137843 [Q9NQU5-1]
GeneIDⁱ	106821730 56924
KEGGⁱ	hsa:106821730 hsa:56924
UCSCⁱ	uc001zky.5 human [Q9NQU5-1]

Organism-specific databases

CTDⁱ	106821730 56924
DisGeNETⁱ	106821730 56924
EuPathDBⁱ	HostDB:ENSG00000137843.11
GeneCardsⁱ	PAK6
HGNCⁱ	HGNC:16061 PAK6
HPAⁱ	HPA031124
MIMⁱ	608110 gene
neXtProtⁱ	NX_Q9NQU5
OpenTargetsⁱ	ENSG00000137843 ENSG00000259288
PharmGKBⁱ	PA32921
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0578 Eukaryota ENOG410XP4K LUCA
GeneTreeⁱ	ENSGT00930000150829
HOGENOMⁱ	HOG000234205
HOVERGENⁱ	HBG108518
InParanoidⁱ	Q9NQU5
KOⁱ	K05735
OMAⁱ	RPPQKDS
OrthoDBⁱ	EOG091G0OT5
PhylomeDBⁱ	Q9NQU5
TreeFamⁱ	TF105352

Enzyme and pathway databases

Reactomeⁱ	R-HSA-428540 Activation of RAC1
SignaLinkⁱ	Q9NQU5
SIGNORⁱ	Q9NQU5

Miscellaneous databases

EvolutionaryTraceⁱ	Q9NQU5
GeneWikiⁱ	PAK6
GenomeRNAiⁱ	56924
Protein Ontology More...PROⁱ	PR:Q9NQU5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000137843 Expressed in 91 organ(s), highest expression level in prefrontal cortex
CleanExⁱ	HS_PAK6
ExpressionAtlasⁱ	Q9NQU5 baseline and differential
Genevisibleⁱ	Q9NQU5 HS

Family and domain databases

CDDⁱ	cd01093 CRIB_PAK_like, 1 hit
Gene3Dⁱ	3.90.810.10, 1 hit
InterProⁱ	View protein in InterPro IPR000095 CRIB_dom IPR036936 CRIB_dom_sf IPR011009 Kinase-like_dom_sf IPR035066 PAK6 IPR033923 PAK_BD IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS
PANTHERⁱ	PTHR24361:SF182 PTHR24361:SF182, 1 hit
Pfamⁱ	View protein in Pfam PF00786 PBD, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00285 PBD, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50108 CRIB, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PAK6_HUMAN
Accessionⁱ	Q9NQU5Primary (citable) accession number: Q9NQU5 Secondary accession number(s): A8K2G2, B3KYB0, G5E9R2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NQU5 (PAK6_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Serine/threonine-protein kinase PAK 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ