Kinesin-like protein KIF13B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• 14-3-3 protein binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.10

    "Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation."
    Yoshimura Y., Terabayashi T., Miki H.
    Mol. Cell. Biol. 30:2206-2219(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH 14-3-3, MUTAGENESIS OF SER-1381 AND SER-1410, PHOSPHORYLATION AT SER-1381 AND SER-1410.
• ATPase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• ATP binding Source: UniProtKB-KW
• microtubule binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• microtubule motor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.1

    "GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes."
    Hanada T., Lin L., Tibaldi E.V., Reinherz E.L., Chishti A.H.
    J. Biol. Chem. 275:28774-28784(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH DLG1 AND DLG4.
  • Ref.10

    "Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation."
    Yoshimura Y., Terabayashi T., Miki H.
    Mol. Cell. Biol. 30:2206-2219(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH 14-3-3, MUTAGENESIS OF SER-1381 AND SER-1410, PHOSPHORYLATION AT SER-1381 AND SER-1410.

GO - Biological processⁱ

• microtubule-based movement Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein targeting Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.1

    "GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes."
    Hanada T., Lin L., Tibaldi E.V., Reinherz E.L., Chishti A.H.
    J. Biol. Chem. 275:28774-28784(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH DLG1 AND DLG4.
• regulation of axonogenesis Source: UniProtKBInferred from direct assayⁱ
  • Ref.10

    "Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation."
    Yoshimura Y., Terabayashi T., Miki H.
    Mol. Cell. Biol. 30:2206-2219(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH 14-3-3, MUTAGENESIS OF SER-1381 AND SER-1410, PHOSPHORYLATION AT SER-1381 AND SER-1410.
• signal transduction Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • Ref.1

    "GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes."
    Hanada T., Lin L., Tibaldi E.V., Reinherz E.L., Chishti A.H.
    J. Biol. Chem. 275:28774-28784(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH DLG1 AND DLG4.
• T cell activation Source: UniProtKBNon-traceable author statementⁱ
  • "Direct interaction with a kinesin-related motor mediates transport of mammalian discs large tumor suppressor homologue in epithelial cells."
    Asaba N., Hanada T., Takeuchi A., Chishti A.H.
    J Biol Chem 278:8395-8400(2003) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• 14-3-3 protein binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.10

    "Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation."
    Yoshimura Y., Terabayashi T., Miki H.
    Mol. Cell. Biol. 30:2206-2219(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH 14-3-3, MUTAGENESIS OF SER-1381 AND SER-1410, PHOSPHORYLATION AT SER-1381 AND SER-1410.
• microtubule binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.1

    "GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes."
    Hanada T., Lin L., Tibaldi E.V., Reinherz E.L., Chishti A.H.
    J. Biol. Chem. 275:28774-28784(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH DLG1 AND DLG4.
  • Ref.10

    "Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation."
    Yoshimura Y., Terabayashi T., Miki H.
    Mol. Cell. Biol. 30:2206-2219(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH 14-3-3, MUTAGENESIS OF SER-1381 AND SER-1410, PHOSPHORYLATION AT SER-1381 AND SER-1410.

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MGDSKVKVAV RIRPMNRRET DLHTKCVVDV DANKVILNPV NTNLSKGDAR 
        60         70         80         90        100
GQPKVFAYDH CFWSMDESVK EKYAGQDIVF KCLGENILQN AFDGYNACIF 
       110        120        130        140        150
AYGQTGSGKS YTMMGTADQP GLIPRLCSGL FERTQKEENE EQSFKVEVSY 
       160        170        180        190        200
MEIYNEKVRD LLDPKGSRQT LKVREHSVLG PYVDGLSKLA VTSYKDIESL 
       210        220        230        240        250
MSEGNKSRTV AATNMNEESS RSHAVFKITL THTLYDVKSG TSGEKVGKLS 
       260        270        280        290        300
LVDLAGSERA TKTGAAGDRL KEGSNINKSL TTLGLVISAL ADQSAGKNKN 
       310        320        330        340        350
KFVPYRDSVL TWLLKDSLGG NSKTAMVATV SPAADNYDET LSTLRYADRA 
       360        370        380        390        400
KHIVNHAVVN EDPNARIIRD LREEVEKLRE QLTKAEAMKS PELKDRLEES 
       410        420        430        440        450
EKLIQEMTVT WEEKLRKTEE IAQERQKQLE SLGISLQSSG IKVGDDKCFL 
       460        470        480        490        500
VNLNADPALN ELLVYYLKEH TLIGSANSQD IQLCGMGILP EHCIIDITSE 
       510        520        530        540        550
GQVMLTPQKN TRTFVNGSSV SSPIQLHHGD RILWGNNHFF RLNLPKKKKK 
       560        570        580        590        600
AEREDEDQDP SMKNENSSEQ LDVDGDSSSE VSSEVNFNYE YAQMEVTMKA 
       610        620        630        640        650
LGSNDPMQSI LNSLEQQHEE EKRSALERQR LMYEHELEQL RRRLSPEKQN 
       660        670        680        690        700
CRSMDRFSFH SPSAQQRLRQ WAEEREATLN NSLMRLREQI VKANLLVREA 
       710        720        730        740        750
NYIAEELDKR TEYKVTLQIP ASSLDANRKR GSLLSEPAIQ VRRKGKGKQI 
       760        770        780        790        800
WSLEKLDNRL LDMRDLYQEW KECEEDNPVI RSYFKRADPF YDEQENHSLI 
       810        820        830        840        850
GVANVFLESL FYDVKLQYAV PIINQKGEVA GRLHVEVMRL SGDVGERIAG 
       860        870        880        890        900
GDEVAEVSFE KETQENKLVC MVKILQATGL PQHLSHFVFC KYSFWDQQEP 
       910        920        930        940        950
VIVAPEVDTS SSSVSKEPHC MVVFDHCNEF SVNITEDFIE HLSEGALAIE 
       960        970        980        990       1000
VYGHKINDPR KNPALWDLGI IQAKTRSLRD RWSEVTRKLE FWVQILEQNE 
      1010       1020       1030       1040       1050
NGEYCPVEVI SAKDVPTGGI FQLRQGQSRR VQVEVKSVQE SGTLPLMEEC 
      1060       1070       1080       1090       1100
ILSVGIGCVK VRPLRAPRTH ETFHEEEEDM DSYQDRDLER LRRKWLNALT 
      1110       1120       1130       1140       1150
KRQEYLDQQL QKLVSKRDKT EDDADREAQL LEMRLTLTEE RNAVMVPSAG 
      1160       1170       1180       1190       1200
SGIPGAPAEW TPVPGMETHI PVIFLDLNAD DFSSQDNLDD PEAGGWDATL 
      1210       1220       1230       1240       1250
TGEEEEEFFE LQIVKQHDGE VKAEASWDSA VHGCPQLSRG TPVDERLFLI 
      1260       1270       1280       1290       1300
VRVTVQLSHP ADMQLVLRKR ICVNVHGRQG FAQSLLKKMS HRSSIPGCGV 
      1310       1320       1330       1340       1350
TFEIVSNIPE DAQGVEEREA LARMAANVEN PASADSEAYI EKYLRSVLAV 
      1360       1370       1380       1390       1400
ENLLTLDRLR QEVAVKEQLT GKGKLSRRSI SSPNVNRLSG SRQDLIPSYS 
      1410       1420       1430       1440       1450
LGSNKGRWES QQDVSQTTVS RGIAPAPALS VSPQNNHSPD PGLSNLAASY 
      1460       1470       1480       1490       1500
LNPVKSFVPQ MPKLLKSLFP VRDEKRGKRP SPLAHQPVPR IMVQSASPDI 
      1510       1520       1530       1540       1550
RVTRMEEAQP EMGPDVLVQT MGAPALKICD KPAKVPSPPP VIAVTAVTPA 
      1560       1570       1580       1590       1600
PEAQDGPPSP LSEASSGYFS HSVSTATLSD ALGPGLDAAA PPGSMPTAPE 
      1610       1620       1630       1640       1650
AEPEAPISHP PPPTAVPAEE PPGPQQLVSP GRERPDLEAP APGSPFRVRR 
      1660       1670       1680       1690       1700
VRASELRSFS RMLAGDPGCS PGAEGNAPAP GAGGQALASD SEEADEVPEW 
      1710       1720       1730       1740       1750
LREGEFVTVG AHKTGVVRYV GPADFQEGTW VGVELDLPSG KNDGSIGGKQ 
      1760       1770       1780       1790       1800
YFRCNPGYGL LVRPSRVRRA TGPVRRRSTG LRLGAPEARR SATLSGSATN 
      1810       1820 
LASLTAALAK ADRSHKNPEN RKSWAS                           

        10         20         30         40         50
MPKLLKSLFP VRDEKRGKRP SPLAHQAQPE MGPDVLVQTM GAPALKICDK 
        60         70         80         90        100
PAKVPSPPPV IAVTAVTPAP EAQDGPPSPL SEASSGYFSH SVSTATLSDA 
       110        120        130        140        150
LGPGLDAAAP PGSMPTAPEA EPEAPISHPP PPTAVPAEEP PGPQQLVSPG 
       160        170        180        190        200
RERPDLEAPA PGSPFRVRRV RASELRSFSR MLAGDPGCSP GAEGNAPAPG 
       210        220        230        240        250
AGGQALASDS EEADEVPEWL REGEFVTVGA HKTGVVRYVG PADFQEGTWV 
       260        270        280        290        300
GVELDLPSGK NDGSIGGKQY FRCNPGYGLL VRPSRVRRAT GPVRRRSTGL 
       310        320        330        340 
RLGAPEARRS ATLSGSATNL ASLTAALAKA DRSHKNPENR KSWAS      

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. SIMILARITY comments
   Index of protein domains and families
5. Human chromosome 8
   Human chromosome 8: entries, gene names and cross-references to MIM
6. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations