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UniProtKB - Q9NQT8 (KI13B_HUMAN)

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Protein

Kinesin-like protein KIF13B

Gene

KIF13B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi103 – 110ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • 14-3-3 protein binding Source: UniProtKB
  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule binding Source: InterPro
  • microtubule motor activity Source: GO_Central
  • protein kinase binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cytoskeleton-dependent intracellular transport Source: GO_Central
  • microtubule-based movement Source: UniProtKB
  • protein targeting Source: UniProtKB
  • regulation of axonogenesis Source: UniProtKB
  • signal transduction Source: UniProtKB
  • T cell activation Source: UniProtKB
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF13B
Alternative name(s):
Kinesin-like protein GAKIN
Gene namesi
Name:KIF13B
Synonyms:GAKIN, KIAA0639
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000197892.12
HGNCiHGNC:14405 KIF13B
MIMi607350 gene
neXtProtiNX_Q9NQT8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1381S → A: Abolishes phosphorylation by MARK2; when associated with A-1410. 1 Publication1
Mutagenesisi1410S → A: Abolishes phosphorylation by MARK2; when associated with A-1389. 1 Publication1

Organism-specific databases

DisGeNETi23303
OpenTargetsiENSG00000197892
PharmGKBiPA30099

Polymorphism and mutation databases

BioMutaiKIF13B
DMDMi519668668

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254481 – 1826Kinesin-like protein KIF13BAdd BLAST1826

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei661PhosphoserineCombined sources1
Modified residuei1379PhosphoserineCombined sources1
Modified residuei1381Phosphoserine; by MARK2Combined sources1 Publication1
Modified residuei1382PhosphoserineCombined sources1
Modified residuei1391PhosphoserineCombined sources1
Modified residuei1410Phosphoserine; by MARK2Combined sources1 Publication1
Modified residuei1432PhosphoserineCombined sources1
Modified residuei1438PhosphoserineCombined sources1
Modified residuei1537PhosphoserineCombined sources1
Modified residuei1545PhosphothreonineCombined sources1
Modified residuei1559PhosphoserineCombined sources1
Modified residuei1644PhosphoserineCombined sources1
Modified residuei1797PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated at Ser-1381 and Ser-1410 by MARK2, promoting interaction with 14-3-3 and inhibiting microtubule-dependent accumulation and formation of axons.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NQT8
MaxQBiQ9NQT8
PaxDbiQ9NQT8
PeptideAtlasiQ9NQT8
PRIDEiQ9NQT8
ProteomicsDBi82187

PTM databases

iPTMnetiQ9NQT8
PhosphoSitePlusiQ9NQT8
SwissPalmiQ9NQT8

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000197892
CleanExiHS_KIF13B
ExpressionAtlasiQ9NQT8 baseline and differential
GenevisibleiQ9NQT8 HS

Organism-specific databases

HPAiHPA025023
HPA049655

Interactioni

Subunit structurei

Binds to DLG1 and DLG4. Interacts (when phosphorylated at Ser-1381 and Ser-1410) with 14-3-3.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • 14-3-3 protein binding Source: UniProtKB
  • microtubule binding Source: InterPro
  • protein kinase binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi116895, 101 interactors
DIPiDIP-34586N
IntActiQ9NQT8, 95 interactors
STRINGi9606.ENSP00000427900

Structurei

Secondary structure

11826
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 12Combined sources7
Helixi17 – 22Combined sources6
Beta strandi28 – 31Combined sources4
Beta strandi34 – 37Combined sources4
Beta strandi54 – 57Combined sources4
Beta strandi59 – 63Combined sources5
Turni70 – 72Combined sources3
Helixi76 – 92Combined sources17
Beta strandi97 – 103Combined sources7
Helixi109 – 113Combined sources5
Beta strandi117 – 120Combined sources4
Helixi122 – 137Combined sources16
Beta strandi142 – 154Combined sources13
Beta strandi157 – 160Combined sources4
Beta strandi189 – 191Combined sources3
Helixi194 – 206Combined sources13
Beta strandi222 – 235Combined sources14
Beta strandi241 – 253Combined sources13
Helixi272 – 292Combined sources21
Helixi305 – 307Combined sources3
Helixi309 – 313Combined sources5
Helixi315 – 318Combined sources4
Beta strandi323 – 330Combined sources8
Helixi334 – 336Combined sources3
Helixi337 – 350Combined sources14
Beta strandi449 – 452Combined sources4
Turni457 – 460Combined sources4
Beta strandi464 – 466Combined sources3
Beta strandi469 – 476Combined sources8
Beta strandi480 – 482Combined sources3
Beta strandi493 – 497Combined sources5
Beta strandi503 – 507Combined sources5
Beta strandi513 – 515Combined sources3
Beta strandi524 – 526Combined sources3
Beta strandi531 – 534Combined sources4
Turni535 – 537Combined sources3
Beta strandi538 – 543Combined sources6
Beta strandi1706 – 1708Combined sources3
Beta strandi1710 – 1712Combined sources3
Beta strandi1714 – 1721Combined sources8
Beta strandi1724 – 1728Combined sources5
Beta strandi1730 – 1734Combined sources5
Beta strandi1736 – 1738Combined sources3
Beta strandi1743 – 1746Combined sources4
Beta strandi1760 – 1762Combined sources3
Helixi1764 – 1766Combined sources3

3D structure databases

ProteinModelPortaliQ9NQT8
SMRiQ9NQT8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NQT8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 353Kinesin motorPROSITE-ProRule annotationAdd BLAST349
Domaini471 – 535FHAAdd BLAST65
Domaini1721 – 1763CAP-GlyPROSITE-ProRule annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili364 – 439Sequence analysisAdd BLAST76
Coiled coili607 – 710Sequence analysisAdd BLAST104
Coiled coili752 – 772Sequence analysisAdd BLAST21
Coiled coili1096 – 1143Sequence analysisAdd BLAST48

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0245 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00890000139327
HOGENOMiHOG000230729
HOVERGENiHBG052244
InParanoidiQ9NQT8
KOiK17914
OMAiSWDSAVH
OrthoDBiEOG091G0091
PhylomeDBiQ9NQT8
TreeFamiTF105221

Family and domain databases

CDDicd00060 FHA, 1 hit
Gene3Di2.30.30.190, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR000253 FHA_dom
IPR036978 KIF13B
IPR022164 Kinesin-like
IPR027640 Kinesin-like_fam
IPR022140 Kinesin-like_KIF1-typ
IPR032405 Kinesin_assoc
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR24115 PTHR24115, 1 hit
PTHR24115:SF746 PTHR24115:SF746, 1 hit
PfamiView protein in Pfam
PF01302 CAP_GLY, 1 hit
PF12473 DUF3694, 1 hit
PF00498 FHA, 1 hit
PF12423 KIF1B, 1 hit
PF00225 Kinesin, 1 hit
PF16183 Kinesin_assoc, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM01052 CAP_GLY, 1 hit
SM00129 KISc, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit
SSF74924 SSF74924, 1 hit
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 1 hit
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDSKVKVAV RIRPMNRRET DLHTKCVVDV DANKVILNPV NTNLSKGDAR 
        60         70         80         90        100
GQPKVFAYDH CFWSMDESVK EKYAGQDIVF KCLGENILQN AFDGYNACIF 
       110        120        130        140        150
AYGQTGSGKS YTMMGTADQP GLIPRLCSGL FERTQKEENE EQSFKVEVSY 
       160        170        180        190        200
MEIYNEKVRD LLDPKGSRQT LKVREHSVLG PYVDGLSKLA VTSYKDIESL 
       210        220        230        240        250
MSEGNKSRTV AATNMNEESS RSHAVFKITL THTLYDVKSG TSGEKVGKLS 
       260        270        280        290        300
LVDLAGSERA TKTGAAGDRL KEGSNINKSL TTLGLVISAL ADQSAGKNKN 
       310        320        330        340        350
KFVPYRDSVL TWLLKDSLGG NSKTAMVATV SPAADNYDET LSTLRYADRA 
       360        370        380        390        400
KHIVNHAVVN EDPNARIIRD LREEVEKLRE QLTKAEAMKS PELKDRLEES 
       410        420        430        440        450
EKLIQEMTVT WEEKLRKTEE IAQERQKQLE SLGISLQSSG IKVGDDKCFL 
       460        470        480        490        500
VNLNADPALN ELLVYYLKEH TLIGSANSQD IQLCGMGILP EHCIIDITSE 
       510        520        530        540        550
GQVMLTPQKN TRTFVNGSSV SSPIQLHHGD RILWGNNHFF RLNLPKKKKK 
       560        570        580        590        600
AEREDEDQDP SMKNENSSEQ LDVDGDSSSE VSSEVNFNYE YAQMEVTMKA 
       610        620        630        640        650
LGSNDPMQSI LNSLEQQHEE EKRSALERQR LMYEHELEQL RRRLSPEKQN 
       660        670        680        690        700
CRSMDRFSFH SPSAQQRLRQ WAEEREATLN NSLMRLREQI VKANLLVREA 
       710        720        730        740        750
NYIAEELDKR TEYKVTLQIP ASSLDANRKR GSLLSEPAIQ VRRKGKGKQI 
       760        770        780        790        800
WSLEKLDNRL LDMRDLYQEW KECEEDNPVI RSYFKRADPF YDEQENHSLI 
       810        820        830        840        850
GVANVFLESL FYDVKLQYAV PIINQKGEVA GRLHVEVMRL SGDVGERIAG 
       860        870        880        890        900
GDEVAEVSFE KETQENKLVC MVKILQATGL PQHLSHFVFC KYSFWDQQEP 
       910        920        930        940        950
VIVAPEVDTS SSSVSKEPHC MVVFDHCNEF SVNITEDFIE HLSEGALAIE 
       960        970        980        990       1000
VYGHKINDPR KNPALWDLGI IQAKTRSLRD RWSEVTRKLE FWVQILEQNE 
      1010       1020       1030       1040       1050
NGEYCPVEVI SAKDVPTGGI FQLRQGQSRR VQVEVKSVQE SGTLPLMEEC 
      1060       1070       1080       1090       1100
ILSVGIGCVK VRPLRAPRTH ETFHEEEEDM DSYQDRDLER LRRKWLNALT 
      1110       1120       1130       1140       1150
KRQEYLDQQL QKLVSKRDKT EDDADREAQL LEMRLTLTEE RNAVMVPSAG 
      1160       1170       1180       1190       1200
SGIPGAPAEW TPVPGMETHI PVIFLDLNAD DFSSQDNLDD PEAGGWDATL 
      1210       1220       1230       1240       1250
TGEEEEEFFE LQIVKQHDGE VKAEASWDSA VHGCPQLSRG TPVDERLFLI 
      1260       1270       1280       1290       1300
VRVTVQLSHP ADMQLVLRKR ICVNVHGRQG FAQSLLKKMS HRSSIPGCGV 
      1310       1320       1330       1340       1350
TFEIVSNIPE DAQGVEEREA LARMAANVEN PASADSEAYI EKYLRSVLAV 
      1360       1370       1380       1390       1400
ENLLTLDRLR QEVAVKEQLT GKGKLSRRSI SSPNVNRLSG SRQDLIPSYS 
      1410       1420       1430       1440       1450
LGSNKGRWES QQDVSQTTVS RGIAPAPALS VSPQNNHSPD PGLSNLAASY 
      1460       1470       1480       1490       1500
LNPVKSFVPQ MPKLLKSLFP VRDEKRGKRP SPLAHQPVPR IMVQSASPDI 
      1510       1520       1530       1540       1550
RVTRMEEAQP EMGPDVLVQT MGAPALKICD KPAKVPSPPP VIAVTAVTPA 
      1560       1570       1580       1590       1600
PEAQDGPPSP LSEASSGYFS HSVSTATLSD ALGPGLDAAA PPGSMPTAPE 
      1610       1620       1630       1640       1650
AEPEAPISHP PPPTAVPAEE PPGPQQLVSP GRERPDLEAP APGSPFRVRR 
      1660       1670       1680       1690       1700
VRASELRSFS RMLAGDPGCS PGAEGNAPAP GAGGQALASD SEEADEVPEW 
      1710       1720       1730       1740       1750
LREGEFVTVG AHKTGVVRYV GPADFQEGTW VGVELDLPSG KNDGSIGGKQ 
      1760       1770       1780       1790       1800
YFRCNPGYGL LVRPSRVRRA TGPVRRRSTG LRLGAPEARR SATLSGSATN 
      1810       1820 
LASLTAALAK ADRSHKNPEN RKSWAS
Length:1,826
Mass (Da):202,789
Last modified:June 26, 2013 - v2
Checksum:i7A336B3C5BDA21E6
GO
Isoform 2 (identifier: Q9NQT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1460: Missing.
     1487-1507: Missing.

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):35,860
Checksum:i54A705E9CBB2F535
GO

Sequence cautioni

The sequence BAA31614 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55V → C in AAF81263 (PubMed:10859302).Curated1
Sequence conflicti191V → A in AAF81263 (PubMed:10859302).Curated1
Sequence conflicti226F → L in AAF81263 (PubMed:10859302).Curated1
Sequence conflicti237V → A in AAF81263 (PubMed:10859302).Curated1
Sequence conflicti278K → E in AAF81263 (PubMed:10859302).Curated1
Sequence conflicti356H → N in AAF81263 (PubMed:10859302).Curated1
Sequence conflicti797H → L in AAF81263 (PubMed:10859302).Curated1
Sequence conflicti858S → P in AAF81263 (PubMed:10859302).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0559821471V → I. Corresponds to variant dbSNP:rs17526980Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563601 – 1460Missing in isoform 2. 1 PublicationAdd BLAST1460
Alternative sequenceiVSP_0563611487 – 1507Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279865 mRNA Translation: AAF81263.1
AB014539 mRNA Translation: BAA31614.3 Different initiation.
AK294837 mRNA Translation: BAG57946.1
AC084262 Genomic DNA No translation available.
AC103830 Genomic DNA No translation available.
AC108449 Genomic DNA No translation available.
AL583912 mRNA Translation: CAC29496.1
CCDSiCCDS55217.1 [Q9NQT8-1]
RefSeqiNP_056069.2, NM_015254.3 [Q9NQT8-1]
UniGeneiHs.444767

Genome annotation databases

EnsembliENST00000524189; ENSP00000427900; ENSG00000197892 [Q9NQT8-1]
GeneIDi23303
KEGGihsa:23303
UCSCiuc003xhh.5 human [Q9NQT8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKI13B_HUMAN
AccessioniPrimary (citable) accession number: Q9NQT8
Secondary accession number(s): B4DGY5
, B5MC45, F8VPJ2, O75134, Q9BYJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 26, 2013
Last modified: July 18, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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