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Protein

Fascin-3

Gene

FSCN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as an actin bundling protein.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fascin-3
Alternative name(s):
Testis fascin
Gene namesi
Name:FSCN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106328.9
HGNCiHGNC:3961 FSCN3
MIMi615800 gene
neXtProtiNX_Q9NQT6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi29999
OpenTargetsiENSG00000106328
PharmGKBiPA28379

Polymorphism and mutation databases

BioMutaiFSCN3
DMDMi18203315

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193831 – 498Fascin-3Add BLAST498

Proteomic databases

PaxDbiQ9NQT6
PeptideAtlasiQ9NQT6
PRIDEiQ9NQT6
ProteomicsDBi82186

PTM databases

iPTMnetiQ9NQT6
PhosphoSitePlusiQ9NQT6

Expressioni

Tissue specificityi

Expressed in testis.

Gene expression databases

BgeeiENSG00000106328 Expressed in 80 organ(s), highest expression level in testis
CleanExiHS_FSCN3
ExpressionAtlasiQ9NQT6 baseline and differential
GenevisibleiQ9NQT6 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119023, 4 interactors
STRINGi9606.ENSP00000265825

Structurei

3D structure databases

ProteinModelPortaliQ9NQT6
SMRiQ9NQT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fascin family.Curated

Phylogenomic databases

eggNOGiENOG410IF4E Eukaryota
ENOG410XPHV LUCA
GeneTreeiENSGT00530000063373
HOGENOMiHOG000029285
HOVERGENiHBG051663
InParanoidiQ9NQT6
KOiK17456
OMAiCIHLLPC
OrthoDBiEOG091G0C6S
PhylomeDBiQ9NQT6
TreeFamiTF323992

Family and domain databases

CDDicd00257 Fascin, 3 hits
InterProiView protein in InterPro
IPR008999 Actin-crosslinking
IPR010431 Fascin
IPR022768 Fascin-domain
IPR024703 Fascin_metazoans
IPR030143 FSCN3
PANTHERiPTHR10551 PTHR10551, 1 hit
PTHR10551:SF1 PTHR10551:SF1, 1 hit
PfamiView protein in Pfam
PF06268 Fascin, 2 hits
PIRSFiPIRSF005682 Fascin, 1 hit
SUPFAMiSSF50405 SSF50405, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQT6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDETEWIHRH PKAEDLRVGL ISWAGTYLTF EACKNTVTAT AKSLGRRQTW
60 70 80 90 100
EILVSNEHET QAVVRLKSVQ GLYLLCECDG TVCYGRPRTS HHGCFLLRFH
110 120 130 140 150
RNSKWTLQCL ISGRYLESNG KDVFCTSHVL SAYHMWTPRP ALHVHVILYS
160 170 180 190 200
PIHRCYARAD PTMGRIWVDA AVPCLEECGF LLHFRDGCYH LETSTHHFLS
210 220 230 240 250
HVDRLFSQPS SQTAFHMQVR PGGLVALCDG EGGMLYPQGT HLLLGMGCNP
260 270 280 290 300
MRGEEWFILQ HCPTWVSLRS KTGRFISVIY DGEVRAASER LNRMSLFQFE
310 320 330 340 350
CDSESPTVQL RSANGYYLSQ RRHRAVMADG HPLESDTFFR MHWNCGRIIL
360 370 380 390 400
QSCRGRFLGI APNSLLMANV ILPGPNEEFG ILFANRSFLV LRGRYGYVGS
410 420 430 440 450
SSGHDLIQCN QDQPDRIHLL PCRPGIYHFQ AQGGSFWSIT SFGTFRPWGK
460 470 480 490
FALNFCIELQ GSNLLTVLAP NGFYMRADQS GTLLADSEDI TRECIWEF
Length:498
Mass (Da):56,624
Last modified:October 1, 2000 - v1
Checksum:iFF9A1BE44F7D4354
GO
Isoform 2 (identifier: Q9NQT6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.
     431-485: AQGGSFWSIT...RADQSGTLLA → GGILLVNNIL...RPKWHPVGRQ
     486-498: Missing.

Note: No experimental confirmation available.
Show »
Length:351
Mass (Da):39,835
Checksum:i6AB08C1B8994E916
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GN86R4GN86_HUMAN
Fascin-3
FSCN3
147Annotation score:
F8WDZ8F8WDZ8_HUMAN
Fascin-3
FSCN3
79Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02202124A → S. Corresponds to variant dbSNP:rs3779536Ensembl.1
Natural variantiVAR_033939428H → L. Corresponds to variant dbSNP:rs34394613Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0570011 – 134Missing in isoform 2. 1 PublicationAdd BLAST134
Alternative sequenceiVSP_057002431 – 485AQGGS…GTLLA → GGILLVNNILWHLSPLGQVC PQLLYRASGEQLTHCTGPQW LLHASRPKWHPVGRQ in isoform 2. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_057003486 – 498Missing in isoform 2. Add BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281049 mRNA Translation: AAF91439.1
AK300518 mRNA Translation: BAG62230.1
AK314050 mRNA Translation: BAG36759.1
AC000357 Genomic DNA No translation available.
AC073934 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24319.1
CH471070 Genomic DNA Translation: EAW83632.1
BC035606 mRNA Translation: AAH35606.1
CCDSiCCDS34746.1 [Q9NQT6-1]
RefSeqiNP_065102.1, NM_020369.2 [Q9NQT6-1]
UniGeneiHs.712692

Genome annotation databases

EnsembliENST00000265825; ENSP00000265825; ENSG00000106328 [Q9NQT6-1]
GeneIDi29999
KEGGihsa:29999
UCSCiuc003vmd.3 human [Q9NQT6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281049 mRNA Translation: AAF91439.1
AK300518 mRNA Translation: BAG62230.1
AK314050 mRNA Translation: BAG36759.1
AC000357 Genomic DNA No translation available.
AC073934 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24319.1
CH471070 Genomic DNA Translation: EAW83632.1
BC035606 mRNA Translation: AAH35606.1
CCDSiCCDS34746.1 [Q9NQT6-1]
RefSeqiNP_065102.1, NM_020369.2 [Q9NQT6-1]
UniGeneiHs.712692

3D structure databases

ProteinModelPortaliQ9NQT6
SMRiQ9NQT6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119023, 4 interactors
STRINGi9606.ENSP00000265825

PTM databases

iPTMnetiQ9NQT6
PhosphoSitePlusiQ9NQT6

Polymorphism and mutation databases

BioMutaiFSCN3
DMDMi18203315

Proteomic databases

PaxDbiQ9NQT6
PeptideAtlasiQ9NQT6
PRIDEiQ9NQT6
ProteomicsDBi82186

Protocols and materials databases

DNASUi29999
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265825; ENSP00000265825; ENSG00000106328 [Q9NQT6-1]
GeneIDi29999
KEGGihsa:29999
UCSCiuc003vmd.3 human [Q9NQT6-1]

Organism-specific databases

CTDi29999
DisGeNETi29999
EuPathDBiHostDB:ENSG00000106328.9
GeneCardsiFSCN3
HGNCiHGNC:3961 FSCN3
MIMi615800 gene
neXtProtiNX_Q9NQT6
OpenTargetsiENSG00000106328
PharmGKBiPA28379
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF4E Eukaryota
ENOG410XPHV LUCA
GeneTreeiENSGT00530000063373
HOGENOMiHOG000029285
HOVERGENiHBG051663
InParanoidiQ9NQT6
KOiK17456
OMAiCIHLLPC
OrthoDBiEOG091G0C6S
PhylomeDBiQ9NQT6
TreeFamiTF323992

Miscellaneous databases

GeneWikiiFSCN3
GenomeRNAii29999
PROiPR:Q9NQT6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106328 Expressed in 80 organ(s), highest expression level in testis
CleanExiHS_FSCN3
ExpressionAtlasiQ9NQT6 baseline and differential
GenevisibleiQ9NQT6 HS

Family and domain databases

CDDicd00257 Fascin, 3 hits
InterProiView protein in InterPro
IPR008999 Actin-crosslinking
IPR010431 Fascin
IPR022768 Fascin-domain
IPR024703 Fascin_metazoans
IPR030143 FSCN3
PANTHERiPTHR10551 PTHR10551, 1 hit
PTHR10551:SF1 PTHR10551:SF1, 1 hit
PfamiView protein in Pfam
PF06268 Fascin, 2 hits
PIRSFiPIRSF005682 Fascin, 1 hit
SUPFAMiSSF50405 SSF50405, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFSCN3_HUMAN
AccessioniPrimary (citable) accession number: Q9NQT6
Secondary accession number(s): A4D0Z2
, A6NLL7, B2RA62, B4DU68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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