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Entry version 181 (07 Oct 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Exosome complex component RRP46

Gene

EXOSC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.2 Publications

Caution

The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processrRNA processing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9NQT4

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-429958, mRNA decay by 3' to 5' exoribonuclease
R-HSA-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-450604, KSRP (KHSRP) binds and destabilizes mRNA
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9NQT4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exosome complex component RRP46
Alternative name(s):
Chronic myelogenous leukemia tumor antigen 28
Exosome component 5
Ribosomal RNA-processing protein 46
p12B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EXOSC5
Synonyms:CML28, RRP46
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000077348.8

Human Gene Nomenclature Database

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HGNCi
HGNC:24662, EXOSC5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606492, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9NQT4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Exosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56915

Open Targets

More...
OpenTargetsi
ENSG00000077348

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134890468

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9NQT4, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EXOSC5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
14285757

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001399751 – 235Exosome complex component RRP46Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei20PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NQT4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NQT4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NQT4

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NQT4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NQT4

PeptideAtlas

More...
PeptideAtlasi
Q9NQT4

PRoteomics IDEntifications database

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PRIDEi
Q9NQT4

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
82183

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NQT4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NQT4

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9NQT4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000077348, Expressed in monocyte and 174 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NQT4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NQT4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000077348, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA exosome complex (PubMed:29906447). Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure.

Interacts with EXOSC1.

Interacts with GTPBP1.

Interacts with ZC3HAV1.

Interacts with DDX17 only in the presence of ZC3HAV1 in an RNA-independent manner.

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9NQT4
With#Exp.IntAct
ACOT11 - isoform 2 [Q8WXI4-2]3EBI-371876,EBI-17721098
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-371876,EBI-10173507
BIRC2 [Q13490]6EBI-371876,EBI-514538
BORCS6 [Q96GS4]3EBI-371876,EBI-10193358
CALCOCO2 [Q13137]3EBI-371876,EBI-739580
CCDC88B [A6NC98]3EBI-371876,EBI-347573
DDIT4L [Q96D03]3EBI-371876,EBI-742054
DOCK8 - isoform 2 [Q8NF50-2]3EBI-371876,EBI-10174653
EFHC2 [Q5JST6]3EBI-371876,EBI-2349927
EXOSC1 [Q9Y3B2]32EBI-371876,EBI-371892
EXOSC10 [Q01780]3EBI-371876,EBI-358236
EXOSC3 [Q9NQT5]9EBI-371876,EBI-371866
EXOSC8 [Q96B26]21EBI-371876,EBI-371922
FCHO1 [A0A0C3SFZ9]3EBI-371876,EBI-11977403
FCHO1 [O14526]4EBI-371876,EBI-719823
FH [P07954]3EBI-371876,EBI-1050358
GOLGA2 [Q08379]3EBI-371876,EBI-618309
HOXC4 [P09017]3EBI-371876,EBI-3923226
IKZF3 [Q9UKT9]7EBI-371876,EBI-747204
KCTD13 [Q8WZ19]3EBI-371876,EBI-742916
KRT13 [A1A4E9]3EBI-371876,EBI-10171552
KRT27 [Q7Z3Y8]3EBI-371876,EBI-3044087
KRT31 [Q15323]3EBI-371876,EBI-948001
KRT34 [O76011]3EBI-371876,EBI-1047093
KRT35 [Q92764]3EBI-371876,EBI-1058674
LCA5L [O95447]3EBI-371876,EBI-8473670
LRMDA [A0A087WWI0]3EBI-371876,EBI-18393842
LZTS2 [Q9BRK4]3EBI-371876,EBI-741037
MEOX2 [Q6FHY5]3EBI-371876,EBI-16439278
MTMR3 [Q13615]3EBI-371876,EBI-371938
MYLIP [Q8WY64]3EBI-371876,EBI-6952711
NKAPD1 [Q6ZUT1]3EBI-371876,EBI-3920396
PEG10 - isoform 2 [Q86TG7-2]3EBI-371876,EBI-6259410
PICK1 [Q9NRD5]3EBI-371876,EBI-79165
PIH1D2 [Q8WWB5]3EBI-371876,EBI-10232538
PRDM6 [Q9NQX0]3EBI-371876,EBI-11320284
REL [Q04864]3EBI-371876,EBI-307352
REL - isoform 2 [Q04864-2]3EBI-371876,EBI-10829018
SHISA6 [Q6ZSJ9]3EBI-371876,EBI-12037847
SNW1 [Q13573]3EBI-371876,EBI-632715
SPTA1 [P02549]3EBI-371876,EBI-375617
TFIP11 [Q9UBB9]3EBI-371876,EBI-1105213
TLE5 - isoform 2 [Q08117-2]3EBI-371876,EBI-11741437
TNFAIP1 [Q13829]6EBI-371876,EBI-2505861
TRIB3 [Q96RU7]3EBI-371876,EBI-492476
TRIM54 [Q9BYV2]6EBI-371876,EBI-2130429
TRIM62 [Q9BVG3]3EBI-371876,EBI-6929619
ZFP90 [Q8TF47]3EBI-371876,EBI-11419867
ZNF420 [Q8TAQ5]3EBI-371876,EBI-3923307
ZNF620 [Q6ZNG0]3EBI-371876,EBI-4395669
ZNF655 [Q8N720]5EBI-371876,EBI-625509
ZNF792 [Q3KQV3]3EBI-371876,EBI-10240849
Zc3hav1 [Q8K3Y6] from Rattus norvegicus.6EBI-371876,EBI-8860250

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121243, 125 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-476, Nuclear exosome complex, DIS3-EXOSC10 variant
CPX-591, Nucleolar exosome complex, EXOSC10 variant
CPX-592, Cytoplasmic exosome complex, DIS3L variant
CPX-593, Exosome complex, DIS3 variant
CPX-600, Cytoplasmic exosome complex, DIS3L-EXOSC10 variant

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9NQT4

Database of interacting proteins

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DIPi
DIP-29846N

Protein interaction database and analysis system

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IntActi
Q9NQT4, 99 interactors

Molecular INTeraction database

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MINTi
Q9NQT4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000221233

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NQT4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NQT4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NQT4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNase PH family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1069, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000153348

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_063514_2_3_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NQT4

KEGG Orthology (KO)

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KOi
K12590

Identification of Orthologs from Complete Genome Data

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OMAi
CNYRPKA

Database of Orthologous Groups

More...
OrthoDBi
1129417at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NQT4

TreeFam database of animal gene trees

More...
TreeFami
TF315920

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.230.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001247, ExoRNase_PH_dom1
IPR015847, ExoRNase_PH_dom2
IPR036345, ExoRNase_PH_dom2_sf
IPR027408, PNPase/RNase_PH_dom_sf
IPR020568, Ribosomal_S5_D2-typ_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01138, RNase_PH, 1 hit
PF03725, RNase_PH_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54211, SSF54211, 1 hit
SSF55666, SSF55666, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9NQT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEETHTDAK IRAENGTGSS PRGPGCSLRH FACEQNLLSR PDGSASFLQG
60 70 80 90 100
DTSVLAGVYG PAEVKVSKEI FNKATLEVIL RPKIGLPGVA EKSRERLIRN
110 120 130 140 150
TCEAVVLGTL HPRTSITVVL QVVSDAGSLL ACCLNAACMA LVDAGVPMRA
160 170 180 190 200
LFCGVACALD SDGTLVLDPT SKQEKEARAV LTFALDSVER KLLMSSTKGL
210 220 230
YSDTELQQCL AAAQAASQHV FRFYRESLQR RYSKS
Length:235
Mass (Da):25,249
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3C1FCB39D85B1EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R102M0R102_HUMAN
Exosome complex component RRP46
EXOSC5
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R050M0R050_HUMAN
Exosome complex component RRP46
EXOSC5
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R289M0R289_HUMAN
Exosome complex component RRP46
EXOSC5
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM75154 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0307885T → M1 PublicationCorresponds to variant dbSNP:rs10853751Ensembl.1
Natural variantiVAR_05186833C → W. Corresponds to variant dbSNP:rs34500671Ensembl.1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF281134 mRNA Translation: AAF82135.1
AF285785 mRNA Translation: AAM75154.1 Different initiation.
AC011462 Genomic DNA No translation available.
BC007742 mRNA Translation: AAH07742.1
BC107696 mRNA Translation: AAI07697.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12580.1

NCBI Reference Sequences

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RefSeqi
NP_064543.3, NM_020158.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000221233; ENSP00000221233; ENSG00000077348

Database of genes from NCBI RefSeq genomes

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GeneIDi
56915

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:56915

UCSC genome browser

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UCSCi
uc002oqo.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281134 mRNA Translation: AAF82135.1
AF285785 mRNA Translation: AAM75154.1 Different initiation.
AC011462 Genomic DNA No translation available.
BC007742 mRNA Translation: AAH07742.1
BC107696 mRNA Translation: AAI07697.1
CCDSiCCDS12580.1
RefSeqiNP_064543.3, NM_020158.3

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NN6X-ray3.35D1-235[»]
6D6Qelectron microscopy3.45D1-235[»]
6D6Relectron microscopy3.45D1-235[»]
6H25electron microscopy3.80D1-235[»]
SMRiQ9NQT4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121243, 125 interactors
ComplexPortaliCPX-476, Nuclear exosome complex, DIS3-EXOSC10 variant
CPX-591, Nucleolar exosome complex, EXOSC10 variant
CPX-592, Cytoplasmic exosome complex, DIS3L variant
CPX-593, Exosome complex, DIS3 variant
CPX-600, Cytoplasmic exosome complex, DIS3L-EXOSC10 variant
CORUMiQ9NQT4
DIPiDIP-29846N
IntActiQ9NQT4, 99 interactors
MINTiQ9NQT4
STRINGi9606.ENSP00000221233

PTM databases

iPTMnetiQ9NQT4
PhosphoSitePlusiQ9NQT4
SwissPalmiQ9NQT4

Polymorphism and mutation databases

BioMutaiEXOSC5
DMDMi14285757

Proteomic databases

EPDiQ9NQT4
jPOSTiQ9NQT4
MassIVEiQ9NQT4
MaxQBiQ9NQT4
PaxDbiQ9NQT4
PeptideAtlasiQ9NQT4
PRIDEiQ9NQT4
ProteomicsDBi82183

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30775, 189 antibodies

The DNASU plasmid repository

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DNASUi
56915

Genome annotation databases

EnsembliENST00000221233; ENSP00000221233; ENSG00000077348
GeneIDi56915
KEGGihsa:56915
UCSCiuc002oqo.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
56915
DisGeNETi56915
EuPathDBiHostDB:ENSG00000077348.8

GeneCards: human genes, protein and diseases

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GeneCardsi
EXOSC5
HGNCiHGNC:24662, EXOSC5
HPAiENSG00000077348, Low tissue specificity
MIMi606492, gene
neXtProtiNX_Q9NQT4
OpenTargetsiENSG00000077348
PharmGKBiPA134890468

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1069, Eukaryota
GeneTreeiENSGT00940000153348
HOGENOMiCLU_063514_2_3_1
InParanoidiQ9NQT4
KOiK12590
OMAiCNYRPKA
OrthoDBi1129417at2759
PhylomeDBiQ9NQT4
TreeFamiTF315920

Enzyme and pathway databases

PathwayCommonsiQ9NQT4
ReactomeiR-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-429958, mRNA decay by 3' to 5' exoribonuclease
R-HSA-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-450604, KSRP (KHSRP) binds and destabilizes mRNA
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
SIGNORiQ9NQT4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
56915, 630 hits in 881 CRISPR screens
EvolutionaryTraceiQ9NQT4

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Exosome_component_5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56915
PharosiQ9NQT4, Tbio

Protein Ontology

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PROi
PR:Q9NQT4
RNActiQ9NQT4, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000077348, Expressed in monocyte and 174 other tissues
ExpressionAtlasiQ9NQT4, baseline and differential
GenevisibleiQ9NQT4, HS

Family and domain databases

Gene3Di3.30.230.70, 1 hit
InterProiView protein in InterPro
IPR001247, ExoRNase_PH_dom1
IPR015847, ExoRNase_PH_dom2
IPR036345, ExoRNase_PH_dom2_sf
IPR027408, PNPase/RNase_PH_dom_sf
IPR020568, Ribosomal_S5_D2-typ_fold
PfamiView protein in Pfam
PF01138, RNase_PH, 1 hit
PF03725, RNase_PH_C, 1 hit
SUPFAMiSSF54211, SSF54211, 1 hit
SSF55666, SSF55666, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXOS5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQT4
Secondary accession number(s): Q32Q81, Q8NG16, Q96I89
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: October 7, 2020
This is version 181 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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