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Entry version 145 (25 May 2022)
Sequence version 1 (01 Oct 2000)
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Protein

Glucose-6-phosphatase 2

Gene

G6PC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.45 mM for glucose-6-phosphate (at pH 6.5)

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei79SubstrateSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei115Proton donorSequence analysis1
Binding sitei168SubstrateSequence analysis1
Active sitei174NucleophileBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processGluconeogenesis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.9, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NQR9

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-70263, Gluconeogenesis

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9NQR9

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NQR9

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00138

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucose-6-phosphatase 2 (EC:3.1.3.9)
Short name:
G-6-Pase 2
Short name:
G6Pase 2
Alternative name(s):
Islet-specific glucose-6-phosphatase catalytic subunit-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:G6PC2
Synonyms:IGRP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28906, G6PC2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608058, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NQR9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000152254

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 24LumenalSequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 56CytoplasmicSequence analysisAdd BLAST11
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 115LumenalSequence analysisAdd BLAST38
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 146CytoplasmicSequence analysis10
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168LumenalSequence analysis1
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 211CytoplasmicSequence analysisAdd BLAST22
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 261LumenalSequence analysisAdd BLAST29
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 293CytoplasmicSequence analysisAdd BLAST11
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 318LumenalSequence analysis4
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Topological domaini340 – 355CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi50N → A: No effect on N-glycosylation. 1 Publication1
Mutagenesisi92N → A: Loss of N-glycosylation. 1 Publication1
Mutagenesisi287N → A: No effect on N-glycosylation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
57818
MIMi612108, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000152254

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134944773

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NQR9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
G6PC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74725272

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003345091 – 355Glucose-6-phosphatase 2Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi92N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated; the non-glycosylated form is more unstable and is degraded through the proteasome.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NQR9

PRoteomics IDEntifications database

More...
PRIDEi
Q9NQR9

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
G6PC2

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9NQR9, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NQR9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NQR9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152254, Expressed in islet of Langerhans and 68 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NQR9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NQR9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000152254, Group enriched (pancreas, retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121777, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364512

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NQR9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q9NQR9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NQR9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi352 – 355Prevents secretion from ERSequence analysis4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glucose-6-phosphatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QS9B, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183150

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_052517_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NQR9

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKAKKWC

Database of Orthologous Groups

More...
OrthoDBi
743717at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NQR9

TreeFam database of animal gene trees

More...
TreeFami
TF324388

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016275, Glucose-6-phosphatase
IPR036938, P_Acid_Pase_2/haloperoxi_sf
IPR000326, P_Acid_Pase_2/haloperoxidase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01569, PAP2, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000905, Glucose-6-phosphatase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00014, acidPPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48317, SSF48317, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFLHRNGVL IIQHLQKDYR AYYTFLNFMS NVGDPRNIFF IYFPLCFQFN
60 70 80 90 100
QTVGTKMIWV AVIGDWLNLI FKWILFGHRP YWWVQETQIY PNHSSPCLEQ
110 120 130 140 150
FPTTCETGPG SPSGHAMGAS CVWYVMVTAA LSHTVCGMDK FSITLHRLTW
160 170 180 190 200
SFLWSVFWLI QISVCISRVF IATHFPHQVI LGVIGGMLVA EAFEHTPGIQ
210 220 230 240 250
TASLGTYLKT NLFLFLFAVG FYLLLRVLNI DLLWSVPIAK KWCANPDWIH
260 270 280 290 300
IDTTPFAGLV RNLGVLFGLG FAINSEMFLL SCRGGNNYTL SFRLLCALTS
310 320 330 340 350
LTILQLYHFL QIPTHEEHLF YVLSFCKSAS IPLTVVAFIP YSVHMLMKQS

GKKSQ
Length:355
Mass (Da):40,580
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD642C37496B6C4EB
GO
Isoform 2 (identifier: Q9NQR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-102: ILFGHRPYWWVQETQIYPNHSSPCLEQFP → KSIWPCNGRILCLVCHGNRCPEPHCLWDG
     103-355: Missing.

Show »
Length:102
Mass (Da):12,160
Checksum:i45E36A48F44C0C93
GO
Isoform 3 (identifier: Q9NQR9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-154: LTWSFLW → HAGGRGL
     155-355: Missing.

Show »
Length:154
Mass (Da):17,757
Checksum:i7203B17AA6D4CF40
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IYU7C9IYU7_HUMAN
Glucose-6-phosphatase 2
G6PC2
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in G6PC2 define the fasting plasma glucose levels quantitative trait locus 1 (FGQTL1) [MIMi:612108]. The normal fasting plasma glucose level in the plasma is defined as less than 100 mg per deciliter (5.55 mmol per liter). Higher fasting plasma glucose levels predict type 2 diabetes in young adults and increases the risk of mortality.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043372171I → V. Corresponds to variant dbSNP:rs2232322Ensembl.1
Natural variantiVAR_043373207Y → S. Corresponds to variant dbSNP:rs2232323Ensembl.1
Natural variantiVAR_043374219V → L. Corresponds to variant dbSNP:rs492594Ensembl.1
Natural variantiVAR_043375324S → P. Corresponds to variant dbSNP:rs2232326Ensembl.1
Natural variantiVAR_043376340P → L. Corresponds to variant dbSNP:rs2232327Ensembl.1
Natural variantiVAR_043377342S → C. Corresponds to variant dbSNP:rs2232328Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03364874 – 102ILFGH…LEQFP → KSIWPCNGRILCLVCHGNRC PEPHCLWDG in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_033649103 – 355Missing in isoform 2. 1 PublicationAdd BLAST253
Alternative sequenceiVSP_046180148 – 154LTWSFLW → HAGGRGL in isoform 3. 1 Publication7
Alternative sequenceiVSP_046181155 – 355Missing in isoform 3. 1 PublicationAdd BLAST201

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF283835 Genomic DNA Translation: AAF82810.1
BQ777188 mRNA No translation available.
CR627438 mRNA Translation: CAH10524.1
AC069137 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11291.1
BC104778 mRNA Translation: AAI04779.1
BC113376 mRNA Translation: AAI13377.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2230.1 [Q9NQR9-1]
CCDS46443.1 [Q9NQR9-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001075155.1, NM_001081686.1 [Q9NQR9-3]
NP_066999.1, NM_021176.2 [Q9NQR9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282075.5; ENSP00000282075.4; ENSG00000152254.11 [Q9NQR9-2]
ENST00000375363.8; ENSP00000364512.3; ENSG00000152254.11
ENST00000429379.2; ENSP00000396939.2; ENSG00000152254.11 [Q9NQR9-3]
ENST00000612807.1; ENSP00000481098.1; ENSG00000278373.4 [Q9NQR9-3]
ENST00000617403.1; ENSP00000483899.1; ENSG00000278373.4 [Q9NQR9-2]
ENST00000622133.4; ENSP00000482583.1; ENSG00000278373.4

Database of genes from NCBI RefSeq genomes

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GeneIDi
57818

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57818

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

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MANE-Selecti
ENST00000375363.8; ENSP00000364512.3; NM_021176.3; NP_066999.1

UCSC genome browser

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UCSCi
uc002uem.4, human [Q9NQR9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283835 Genomic DNA Translation: AAF82810.1
BQ777188 mRNA No translation available.
CR627438 mRNA Translation: CAH10524.1
AC069137 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11291.1
BC104778 mRNA Translation: AAI04779.1
BC113376 mRNA Translation: AAI13377.1
CCDSiCCDS2230.1 [Q9NQR9-1]
CCDS46443.1 [Q9NQR9-3]
RefSeqiNP_001075155.1, NM_001081686.1 [Q9NQR9-3]
NP_066999.1, NM_021176.2 [Q9NQR9-1]

3D structure databases

AlphaFoldDBiQ9NQR9
SMRiQ9NQR9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121777, 1 interactor
STRINGi9606.ENSP00000364512

PTM databases

DEPODiG6PC2
GlyGeniQ9NQR9, 1 site
iPTMnetiQ9NQR9
PhosphoSitePlusiQ9NQR9

Genetic variation databases

BioMutaiG6PC2
DMDMi74725272

Proteomic databases

PaxDbiQ9NQR9
PRIDEiQ9NQR9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
53147, 71 antibodies from 12 providers

The DNASU plasmid repository

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DNASUi
57818

Genome annotation databases

EnsembliENST00000282075.5; ENSP00000282075.4; ENSG00000152254.11 [Q9NQR9-2]
ENST00000375363.8; ENSP00000364512.3; ENSG00000152254.11
ENST00000429379.2; ENSP00000396939.2; ENSG00000152254.11 [Q9NQR9-3]
ENST00000612807.1; ENSP00000481098.1; ENSG00000278373.4 [Q9NQR9-3]
ENST00000617403.1; ENSP00000483899.1; ENSG00000278373.4 [Q9NQR9-2]
ENST00000622133.4; ENSP00000482583.1; ENSG00000278373.4
GeneIDi57818
KEGGihsa:57818
MANE-SelectiENST00000375363.8; ENSP00000364512.3; NM_021176.3; NP_066999.1
UCSCiuc002uem.4, human [Q9NQR9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57818
DisGeNETi57818

GeneCards: human genes, protein and diseases

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GeneCardsi
G6PC2
HGNCiHGNC:28906, G6PC2
HPAiENSG00000152254, Group enriched (pancreas, retina)
MIMi608058, gene
612108, phenotype
neXtProtiNX_Q9NQR9
OpenTargetsiENSG00000152254
PharmGKBiPA134944773
VEuPathDBiHostDB:ENSG00000152254

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QS9B, Eukaryota
GeneTreeiENSGT00950000183150
HOGENOMiCLU_052517_0_0_1
InParanoidiQ9NQR9
OMAiPKAKKWC
OrthoDBi743717at2759
PhylomeDBiQ9NQR9
TreeFamiTF324388

Enzyme and pathway databases

UniPathwayiUPA00138
BRENDAi3.1.3.9, 2681
PathwayCommonsiQ9NQR9
ReactomeiR-HSA-70263, Gluconeogenesis
SABIO-RKiQ9NQR9
SIGNORiQ9NQR9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
57818, 12 hits in 1073 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
G6PC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57818
PharosiQ9NQR9, Tbio

Protein Ontology

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PROi
PR:Q9NQR9
RNActiQ9NQR9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152254, Expressed in islet of Langerhans and 68 other tissues
ExpressionAtlasiQ9NQR9, baseline and differential
GenevisibleiQ9NQR9, HS

Family and domain databases

InterProiView protein in InterPro
IPR016275, Glucose-6-phosphatase
IPR036938, P_Acid_Pase_2/haloperoxi_sf
IPR000326, P_Acid_Pase_2/haloperoxidase
PfamiView protein in Pfam
PF01569, PAP2, 1 hit
PIRSFiPIRSF000905, Glucose-6-phosphatase, 1 hit
SMARTiView protein in SMART
SM00014, acidPPc, 1 hit
SUPFAMiSSF48317, SSF48317, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG6PC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQR9
Secondary accession number(s): E9PAX2, Q6AHZ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2000
Last modified: May 25, 2022
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
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