Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 132 (31 Jul 2019)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Glucose-6-phosphatase 2

Gene

G6PC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.45 mM for glucose-6-phosphate (at pH 6.5)

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

    This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
    View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei79SubstrateSequence analysis1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei115Proton donorSequence analysis1
    Binding sitei168SubstrateSequence analysis1
    Active sitei174NucleophileBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processGluconeogenesis

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS14422-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.1.3.9 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-70263 Gluconeogenesis

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q9NQR9

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00138

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Glucose-6-phosphatase 2 (EC:3.1.3.9)
    Short name:
    G-6-Pase 2
    Short name:
    G6Pase 2
    Alternative name(s):
    Islet-specific glucose-6-phosphatase catalytic subunit-related protein
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:G6PC2
    Synonyms:IGRP
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:28906 G6PC2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    608058 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9NQR9

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 24LumenalSequence analysisAdd BLAST24
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
    Topological domaini46 – 56CytoplasmicSequence analysisAdd BLAST11
    Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
    Topological domaini78 – 115LumenalSequence analysisAdd BLAST38
    Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
    Topological domaini137 – 146CytoplasmicSequence analysis10
    Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
    Topological domaini168LumenalSequence analysis1
    Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
    Topological domaini190 – 211CytoplasmicSequence analysisAdd BLAST22
    Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
    Topological domaini233 – 261LumenalSequence analysisAdd BLAST29
    Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
    Topological domaini283 – 293CytoplasmicSequence analysisAdd BLAST11
    Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
    Topological domaini315 – 318LumenalSequence analysis4
    Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
    Topological domaini340 – 355CytoplasmicSequence analysisAdd BLAST16

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi50N → A: No effect on N-glycosylation. 1 Publication1
    Mutagenesisi92N → A: Loss of N-glycosylation. 1 Publication1
    Mutagenesisi287N → A: No effect on N-glycosylation. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    57818
    MIMi612108 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000152254

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134944773

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    G6PC2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74725272

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003345091 – 355Glucose-6-phosphatase 2Add BLAST355

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi92N-linked (GlcNAc...) asparagine1 Publication1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated; the non-glycosylated form is more unstable and is degraded through the proteasome.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9NQR9

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9NQR9

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9NQR9

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    19098
    82175 [Q9NQR9-1]
    82176 [Q9NQR9-2]

    PTM databases

    DEPOD human dephosphorylation database

    More...
    DEPODi
    Q9NQR9

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9NQR9

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9NQR9

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Specifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level).1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000152254 Expressed in 46 organ(s), highest expression level in body of pancreas

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9NQR9 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9NQR9 HS

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000364512

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi352 – 355Prevents secretion from ERSequence analysis4

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glucose-6-phosphatase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410IDXG Eukaryota
    ENOG4110AJ7 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00950000183150

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000264239

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9NQR9

    KEGG Orthology (KO)

    More...
    KOi
    K01084

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    LTWSFLW

    Database of Orthologous Groups

    More...
    OrthoDBi
    743717at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9NQR9

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF324388

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR016275 Glucose-6-phosphatase
    IPR036938 P_Acid_Pase_2/haloperoxi_sf
    IPR000326 P_Acid_Pase_2/haloperoxidase

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01569 PAP2, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000905 Glucose-6-phosphatase, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00014 acidPPc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48317 SSF48317, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9NQR9-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MDFLHRNGVL IIQHLQKDYR AYYTFLNFMS NVGDPRNIFF IYFPLCFQFN
    60 70 80 90 100
    QTVGTKMIWV AVIGDWLNLI FKWILFGHRP YWWVQETQIY PNHSSPCLEQ
    110 120 130 140 150
    FPTTCETGPG SPSGHAMGAS CVWYVMVTAA LSHTVCGMDK FSITLHRLTW
    160 170 180 190 200
    SFLWSVFWLI QISVCISRVF IATHFPHQVI LGVIGGMLVA EAFEHTPGIQ
    210 220 230 240 250
    TASLGTYLKT NLFLFLFAVG FYLLLRVLNI DLLWSVPIAK KWCANPDWIH
    260 270 280 290 300
    IDTTPFAGLV RNLGVLFGLG FAINSEMFLL SCRGGNNYTL SFRLLCALTS
    310 320 330 340 350
    LTILQLYHFL QIPTHEEHLF YVLSFCKSAS IPLTVVAFIP YSVHMLMKQS

    GKKSQ
    Length:355
    Mass (Da):40,580
    Last modified:October 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD642C37496B6C4EB
    GO
    Isoform 2 (identifier: Q9NQR9-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         74-102: ILFGHRPYWWVQETQIYPNHSSPCLEQFP → KSIWPCNGRILCLVCHGNRCPEPHCLWDG
         103-355: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:102
    Mass (Da):12,160
    Checksum:i45E36A48F44C0C93
    GO
    Isoform 3 (identifier: Q9NQR9-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         148-154: LTWSFLW → HAGGRGL
         155-355: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:154
    Mass (Da):17,757
    Checksum:i7203B17AA6D4CF40
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    C9IYU7C9IYU7_HUMAN
    Glucose-6-phosphatase 2
    G6PC2
    80Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

    Genetic variations in G6PC2 define the fasting plasma glucose levels quantitative trait locus 1 (FGQTL1) [MIMi:612108]. The normal fasting plasma glucose level in the plasma is defined as less than 100 mg per deciliter (5.55 mmol per liter). Higher fasting plasma glucose levels predict type 2 diabetes in young adults and increases the risk of mortality.

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043372171I → V. Corresponds to variant dbSNP:rs2232322Ensembl.1
    Natural variantiVAR_043373207Y → S. Corresponds to variant dbSNP:rs2232323Ensembl.1
    Natural variantiVAR_043374219V → L. Corresponds to variant dbSNP:rs492594Ensembl.1
    Natural variantiVAR_043375324S → P. Corresponds to variant dbSNP:rs2232326Ensembl.1
    Natural variantiVAR_043376340P → L. Corresponds to variant dbSNP:rs2232327Ensembl.1
    Natural variantiVAR_043377342S → C. Corresponds to variant dbSNP:rs2232328Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03364874 – 102ILFGH…LEQFP → KSIWPCNGRILCLVCHGNRC PEPHCLWDG in isoform 2. 1 PublicationAdd BLAST29
    Alternative sequenceiVSP_033649103 – 355Missing in isoform 2. 1 PublicationAdd BLAST253
    Alternative sequenceiVSP_046180148 – 154LTWSFLW → HAGGRGL in isoform 3. 1 Publication7
    Alternative sequenceiVSP_046181155 – 355Missing in isoform 3. 1 PublicationAdd BLAST201

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF283835 Genomic DNA Translation: AAF82810.1
    BQ777188 mRNA No translation available.
    CR627438 mRNA Translation: CAH10524.1
    AC069137 Genomic DNA No translation available.
    CH471058 Genomic DNA Translation: EAX11291.1
    BC104778 mRNA Translation: AAI04779.1
    BC113376 mRNA Translation: AAI13377.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS2230.1 [Q9NQR9-1]
    CCDS46443.1 [Q9NQR9-3]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001075155.1, NM_001081686.1 [Q9NQR9-3]
    NP_066999.1, NM_021176.2 [Q9NQR9-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000282075; ENSP00000282075; ENSG00000152254 [Q9NQR9-2]
    ENST00000375363; ENSP00000364512; ENSG00000152254 [Q9NQR9-1]
    ENST00000429379; ENSP00000396939; ENSG00000152254 [Q9NQR9-3]
    ENST00000612807; ENSP00000481098; ENSG00000278373 [Q9NQR9-3]
    ENST00000617403; ENSP00000483899; ENSG00000278373 [Q9NQR9-2]
    ENST00000622133; ENSP00000482583; ENSG00000278373 [Q9NQR9-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    57818

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:57818

    UCSC genome browser

    More...
    UCSCi
    uc002uem.4 human [Q9NQR9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF283835 Genomic DNA Translation: AAF82810.1
    BQ777188 mRNA No translation available.
    CR627438 mRNA Translation: CAH10524.1
    AC069137 Genomic DNA No translation available.
    CH471058 Genomic DNA Translation: EAX11291.1
    BC104778 mRNA Translation: AAI04779.1
    BC113376 mRNA Translation: AAI13377.1
    CCDSiCCDS2230.1 [Q9NQR9-1]
    CCDS46443.1 [Q9NQR9-3]
    RefSeqiNP_001075155.1, NM_001081686.1 [Q9NQR9-3]
    NP_066999.1, NM_021176.2 [Q9NQR9-1]

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    STRINGi9606.ENSP00000364512

    PTM databases

    DEPODiQ9NQR9
    iPTMnetiQ9NQR9
    PhosphoSitePlusiQ9NQR9

    Polymorphism and mutation databases

    BioMutaiG6PC2
    DMDMi74725272

    Proteomic databases

    PaxDbiQ9NQR9
    PeptideAtlasiQ9NQR9
    PRIDEiQ9NQR9
    ProteomicsDBi19098
    82175 [Q9NQR9-1]
    82176 [Q9NQR9-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    57818
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000282075; ENSP00000282075; ENSG00000152254 [Q9NQR9-2]
    ENST00000375363; ENSP00000364512; ENSG00000152254 [Q9NQR9-1]
    ENST00000429379; ENSP00000396939; ENSG00000152254 [Q9NQR9-3]
    ENST00000612807; ENSP00000481098; ENSG00000278373 [Q9NQR9-3]
    ENST00000617403; ENSP00000483899; ENSG00000278373 [Q9NQR9-2]
    ENST00000622133; ENSP00000482583; ENSG00000278373 [Q9NQR9-1]
    GeneIDi57818
    KEGGihsa:57818
    UCSCiuc002uem.4 human [Q9NQR9-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    57818
    DisGeNETi57818

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    G6PC2
    HGNCiHGNC:28906 G6PC2
    MIMi608058 gene
    612108 phenotype
    neXtProtiNX_Q9NQR9
    OpenTargetsiENSG00000152254
    PharmGKBiPA134944773

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiENOG410IDXG Eukaryota
    ENOG4110AJ7 LUCA
    GeneTreeiENSGT00950000183150
    HOGENOMiHOG000264239
    InParanoidiQ9NQR9
    KOiK01084
    OMAiLTWSFLW
    OrthoDBi743717at2759
    PhylomeDBiQ9NQR9
    TreeFamiTF324388

    Enzyme and pathway databases

    UniPathwayiUPA00138
    BioCyciMetaCyc:HS14422-MONOMER
    BRENDAi3.1.3.9 2681
    ReactomeiR-HSA-70263 Gluconeogenesis
    SABIO-RKiQ9NQR9

    Miscellaneous databases

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    G6PC2

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    57818

    Protein Ontology

    More...
    PROi
    PR:Q9NQR9

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000152254 Expressed in 46 organ(s), highest expression level in body of pancreas
    ExpressionAtlasiQ9NQR9 baseline and differential
    GenevisibleiQ9NQR9 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR016275 Glucose-6-phosphatase
    IPR036938 P_Acid_Pase_2/haloperoxi_sf
    IPR000326 P_Acid_Pase_2/haloperoxidase
    PfamiView protein in Pfam
    PF01569 PAP2, 1 hit
    PIRSFiPIRSF000905 Glucose-6-phosphatase, 1 hit
    SMARTiView protein in SMART
    SM00014 acidPPc, 1 hit
    SUPFAMiSSF48317 SSF48317, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG6PC2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQR9
    Secondary accession number(s): E9PAX2, Q6AHZ0
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 1, 2000
    Last modified: July 31, 2019
    This is version 132 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again