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Protein

Coiled-coil domain-containing protein 177

Gene

CCDC177

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 177
Alternative name(s):
Myelin proteolipid protein-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC177
Synonyms:C14orf162, PLPL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000267909.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23243 CCDC177

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NQR7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000267909

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
425906070

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000899541 – 707Coiled-coil domain-containing protein 177Add BLAST707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei311PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NQR7

PeptideAtlas

More...
PeptideAtlasi
Q9NQR7

PRoteomics IDEntifications database

More...
PRIDEi
Q9NQR7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82174

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NQR7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NQR7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000267909 Expressed in 46 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_C14orf162

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NQR7 HS

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9NQR7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NQR7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili364 – 605Sequence analysisAdd BLAST242

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi170 – 208Ala-richAdd BLAST39
Compositional biasi181 – 282Ser-richAdd BLAST102
Compositional biasi320 – 696Arg-richAdd BLAST377

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKWT Eukaryota
ENOG410XUIU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00740000115643

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081284

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NQR7

Identification of Orthologs from Complete Genome Data

More...
OMAi
EREHQAH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0GKK

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029090 DUF4659

The PANTHER Classification System

More...
PANTHERi
PTHR33663 PTHR33663, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15558 DUF4659, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NQR7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDPVPEEEK AGAEPGDSGG DEAVASVPPD SQGAQEPAAS SASASASAAV
60 70 80 90 100
PRKAEVPCAA AEGGRREQSP LLHLDLFNFD CPEAEGSRYV LTSPRSLEAC
110 120 130 140 150
ARCAVKPVEL LPRALADLVR EAPGRSMRVA TGLYEAYEAE RRAKLQQCRA
160 170 180 190 200
ERERIMREEK RRLFTPLSPA AAAAAAAAAA SAPSAGSSSS CSSASLPASP
210 220 230 240 250
APRAARKASP SPSSARTQPP PAGSRTGRKS HSLDSLSRRR EGALSSESGA
260 270 280 290 300
SSSSYSGESL RELRWPPRAS ARNSCPAGSA SSTTNAPGRP SALTLVPITG
310 320 330 340 350
RSFSLGDLSH SPQTAQHVER IVRQVRAERG LRGVPERDRK IAALMLARHQ
360 370 380 390 400
EELLLLEQRA AAHGQWELQR VHAKQRRERE EREKQRALEQ GRRAWAAQVE
410 420 430 440 450
ERRGRRGREE REAARRRQRQ YERSEERRRE LAERQGLLRR ERAERAARED
460 470 480 490 500
RLRKLQQEQN LKQREEGLQE GRERAEQIRR ERAQRAARAK QRQEGQLQRE
510 520 530 540 550
KRELSRAERA RHEALLQGRT RQQRQEREGL RSSLEASLGR AQENYEHLVE
560 570 580 590 600
QRTRELRERA RREELQGRRA KEAAERKERE HQAHLEALAR AGERRLQHAT
610 620 630 640 650
QVAEEAVQQK ARRVGQSRLE KERAQRANKE KVERDEDCRR RELLQAIGRK
660 670 680 690 700
LERSEQLTRE RRSALESARS TARASFHVRE KVREETNTRS FDRMVREAQL

HASLDRK
Length:707
Mass (Da):79,739
Last modified:November 28, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF43347A58CC833E
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF86288 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAG35108 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF284217 mRNA Translation: AAF86288.1 Sequence problems.
AK312175 mRNA Translation: BAG35108.1 Sequence problems.
AL133445 Genomic DNA No translation available.
BC105025 mRNA No translation available.
BC105027 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59245.1

NCBI Reference Sequences

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RefSeqi
NP_001258436.1, NM_001271507.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.458319

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000599174; ENSP00000469474; ENSG00000267909

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56936

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56936

UCSC genome browser

More...
UCSCi
uc010aqy.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284217 mRNA Translation: AAF86288.1 Sequence problems.
AK312175 mRNA Translation: BAG35108.1 Sequence problems.
AL133445 Genomic DNA No translation available.
BC105025 mRNA No translation available.
BC105027 mRNA No translation available.
CCDSiCCDS59245.1
RefSeqiNP_001258436.1, NM_001271507.1
UniGeneiHs.458319

3D structure databases

ProteinModelPortaliQ9NQR7
SMRiQ9NQR7
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9NQR7
PhosphoSitePlusiQ9NQR7

Polymorphism and mutation databases

DMDMi425906070

Proteomic databases

PaxDbiQ9NQR7
PeptideAtlasiQ9NQR7
PRIDEiQ9NQR7
ProteomicsDBi82174

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000599174; ENSP00000469474; ENSG00000267909
GeneIDi56936
KEGGihsa:56936
UCSCiuc010aqy.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56936
EuPathDBiHostDB:ENSG00000267909.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC177
HGNCiHGNC:23243 CCDC177
neXtProtiNX_Q9NQR7
OpenTargetsiENSG00000267909

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKWT Eukaryota
ENOG410XUIU LUCA
GeneTreeiENSGT00740000115643
HOVERGENiHBG081284
InParanoidiQ9NQR7
OMAiEREHQAH
OrthoDBiEOG091G0GKK

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56936

Protein Ontology

More...
PROi
PR:Q9NQR7

Gene expression databases

BgeeiENSG00000267909 Expressed in 46 organ(s), highest expression level in secondary oocyte
CleanExiHS_C14orf162
GenevisibleiQ9NQR7 HS

Family and domain databases

InterProiView protein in InterPro
IPR029090 DUF4659
PANTHERiPTHR33663 PTHR33663, 1 hit
PfamiView protein in Pfam
PF15558 DUF4659, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC177_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQR7
Secondary accession number(s): B2R5G1, Q2M359
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 28, 2012
Last modified: November 7, 2018
This is version 83 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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