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UniProtKB - Q9NQQ7 (S35C2_HUMAN)

Entry version 154 (12 Aug 2020)
Sequence version 2 (01 Jun 2001)
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Protein

Solute carrier family 35 member C2

Gene

SLC35C2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NQQ7

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.7.9.16, the drug/metabolite transporter (dmt) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 35 member C2
Alternative name(s):
Ovarian cancer-overexpressed gene 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC35C2
Synonyms:C20orf5, OVCOV1
ORF Names:CGI-15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000080189.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:17117, SLC35C2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NQQ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Transmembranei294 – 316HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000080189

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA32850

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NQQ7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC35C2

Domain mapping of disease mutations (DMDM)

More...DMDMi		41017506

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002133991 – 365Solute carrier family 35 member C2Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei335PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NQQ7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NQQ7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NQQ7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NQQ7

PeptideAtlas

More...PeptideAtlasi		Q9NQQ7

PRoteomics IDEntifications database

More...PRIDEi		Q9NQQ7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82169 [Q9NQQ7-1]
82170 [Q9NQQ7-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9NQQ7-2 [Q9NQQ7-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NQQ7, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NQQ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NQQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In hypoxic trophoblast cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000080189, Expressed in tendon of biceps brachii and 209 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NQQ7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NQQ7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000080189, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Isoform 3 [Q9NQQ7-3]
With#Exp.IntAct
ACSL5 [Q9ULC5]3EBI-17295964,EBI-2876927
ADIPOQ [Q15848]3EBI-17295964,EBI-10827839
AGPAT3 [Q9NRZ7]3EBI-17295964,EBI-2803601
AGPAT4 [Q9NRZ5]3EBI-17295964,EBI-1754287
APOD [P05090]3EBI-17295964,EBI-715495
ARL6IP1 [Q15041]3EBI-17295964,EBI-714543
ASGR1 [P07306]3EBI-17295964,EBI-1172335
ATP13A1 - isoform C [Q9HD20-3]3EBI-17295964,EBI-12069500
BCL2L2 [Q92843]3EBI-17295964,EBI-707714
BMP10 [O95393]3EBI-17295964,EBI-3922513
C16orf58 [Q96GQ5]3EBI-17295964,EBI-8636004
C2 [P06681]3EBI-17295964,EBI-2835920
C4orf3 - isoform 2 [Q8WVX3-2]3EBI-17295964,EBI-12003442
CCDC167 [Q9P0B6]3EBI-17295964,EBI-9083477
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-17295964,EBI-12256978
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-17295964,EBI-11522780
CNIH1 [O95406]3EBI-17295964,EBI-12172273
COL4A5 - isoform 2 [P29400-2]3EBI-17295964,EBI-12211159
CREB3L1 [Q96BA8]3EBI-17295964,EBI-6942903
CYB561 [P49447]3EBI-17295964,EBI-8646596
CYBC1 [Q9BQA9]3EBI-17295964,EBI-2680384
DNAJC30 [Q96LL9]3EBI-17295964,EBI-8639143
EFNA5 [P52803]3EBI-17295964,EBI-1753674
EMP3 [P54852]3EBI-17295964,EBI-3907816
FAM3C [Q92520]3EBI-17295964,EBI-2876774
FDFT1 [P37268]3EBI-17295964,EBI-714550
FFAR2 [O15552]3EBI-17295964,EBI-2833872
FXYD3 - isoform 3 [Q14802-3]3EBI-17295964,EBI-12175685
FXYD6 [Q9H0Q3]3EBI-17295964,EBI-713304
GIMAP5 [Q96F15]3EBI-17295964,EBI-6166686
GOLT1A [Q6ZVE7]3EBI-17295964,EBI-17231387
GPR152 [Q8TDT2]3EBI-17295964,EBI-13345167
ITGAM [P11215]3EBI-17295964,EBI-2568251
LAT - isoform 2 [O43561-2]3EBI-17295964,EBI-8070286
LEPROTL1 [O95214]3EBI-17295964,EBI-750776
LHFPL5 [Q8TAF8]3EBI-17295964,EBI-2820517
LPAR3 [Q9UBY5]3EBI-17295964,EBI-12033434
MAL [P21145]3EBI-17295964,EBI-3932027
MAL2 [Q969L2]3EBI-17295964,EBI-944295
MALL [Q13021]3EBI-17295964,EBI-750078
MS4A1 [P11836]3EBI-17295964,EBI-2808234
NRAC [Q8N912]3EBI-17295964,EBI-12051377
NRM [Q8IXM6]3EBI-17295964,EBI-10262547
ORMDL1 [Q9P0S3]3EBI-17295964,EBI-1054848
ORMDL3 [Q8N138]3EBI-17295964,EBI-721750
PDCD1LG2 [Q9BQ51]3EBI-17295964,EBI-16427978
PEX16 [Q9Y5Y5]3EBI-17295964,EBI-981985
PLN [P26678]3EBI-17295964,EBI-692836
PLP2 [Q04941]3EBI-17295964,EBI-608347
PNLIPRP1 [P54315]3EBI-17295964,EBI-8652812
PRB1 [A5D903]3EBI-17295964,EBI-10173935
SACM1L [Q9NTJ5]3EBI-17295964,EBI-3917235
SEC22A [Q96IW7]3EBI-17295964,EBI-8652744
SEC22B [O75396]3EBI-17295964,EBI-1058865
SELENOK [Q9Y6D0]3EBI-17295964,EBI-9679163
SERP1 [Q9Y6X1]3EBI-17295964,EBI-10329948
SLC10A6 [Q3KNW5]3EBI-17295964,EBI-18159983
SLC12A7 - isoform 2 [Q9Y666-2]3EBI-17295964,EBI-12854384
SLC30A3 [Q99726]3EBI-17295964,EBI-10294651
SLC35F1 [Q5T1Q4]3EBI-17295964,EBI-13365456
SLC66A1 - isoform 3 [Q6ZP29-3]3EBI-17295964,EBI-12889586
SMCO4 [Q9NRQ5]3EBI-17295964,EBI-8640191
SSMEM1 [Q8WWF3]3EBI-17295964,EBI-17280858
STRIT1 [P0DN84]3EBI-17295964,EBI-12200293
STX3 [Q13277]3EBI-17295964,EBI-1394295
SYNDIG1 [Q9H7V2]3EBI-17295964,EBI-726331
SYS1 [Q8N2H4]3EBI-17295964,EBI-13075176
TAP1 [Q03518]3EBI-17295964,EBI-747259
THBD [P07204]3EBI-17295964,EBI-941422
TMEM107 [Q6UX40]3EBI-17295964,EBI-12845616
TMEM14B [Q9NUH8]3EBI-17295964,EBI-8638294
TMEM239 - isoform 2 [Q8WW34-2]3EBI-17295964,EBI-11528917
TMEM50B [P56557]3EBI-17295964,EBI-12366453
TMEM65 [Q6PI78]3EBI-17295964,EBI-6656213
TMEM86A [Q8N2M4]3EBI-17295964,EBI-12015604
TPRG1 [Q6ZUI0]3EBI-17295964,EBI-17249488
TSNARE1 [A0AVG3]3EBI-17295964,EBI-12003468
TSPAN2 [O60636]3EBI-17295964,EBI-3914288
TSPAN33 [Q86UF1]3EBI-17295964,EBI-12045841
TVP23B [Q9NYZ1]3EBI-17295964,EBI-11343401
UNC93B1 [Q9H1C4]3EBI-17295964,EBI-4401271
UPK1B [O75841]3EBI-17295964,EBI-12237619
VAPB [O95292]3EBI-17295964,EBI-1188298
VEGFA - isoform L-VEGF121 [P15692-12]3EBI-17295964,EBI-6622053
VTI1B [Q9UEU0]3EBI-17295964,EBI-723716
YIF1A [O95070]3EBI-17295964,EBI-2799703
YIPF4 [Q9BSR8]3EBI-17295964,EBI-751253
YIPF6 [Q96EC8]3EBI-17295964,EBI-751210

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119214, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q9NQQ7, 90 interactors

Molecular INTeraction database

More...MINTi		Q9NQQ7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000318960

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NQQ7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TPT transporter family. SLC35C subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1443, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000048078

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022332_1_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NQQ7

KEGG Orthology (KO)

More...KOi		K15280

Identification of Orthologs from Complete Genome Data

More...OMAi		ASMMIWG

Database of Orthologous Groups

More...OrthoDBi		1337371at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NQQ7

TreeFam database of animal gene trees

More...TreeFami		TF314994

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004853, Sugar_P_trans_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03151, TPT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRWALDVAF LWKAVLTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM 
        60         70         80         90        100
LHLAVIFLFS ALSRALVQCS SHRARVVLSW ADYLRRVAPT ALATALDVGL 
       110        120        130        140        150
SNWSFLYVTV SLYTMTKSSA VLFILIFSLI FKLEELRAAL VLVVLLIAGG 
       160        170        180        190        200
LFMFTYKSTQ FNVEGFALVL GASFIGGIRW TLTQMLLQKA ELGLQNPIDT 
       210        220        230        240        250
MFHLQPLMFL GLFPLFAVFE GLHLSTSEKI FRFQDTGLLL RVLGSLFLGG 
       260        270        280        290        300
ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW 
       310        320        330        340        350
LGFALCLSGI SLHVALKALH SRGDGGPKAL KGLGSSPDLE LLLRSSQREE 
       360 
GDNEEEEYFV AQGQQ
Length:365
Mass (Da):40,432
Last modified:June 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5EACE6A4953411A9
GO
Isoform 2 (identifier: Q9NQQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-157: Missing.

Show »
Length:344
Mass (Da):38,154
Checksum:i20DCAF1DC8048736
GO
Isoform 3 (identifier: Q9NQQ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRVSTSHQPLRGVPAPADSGAPVLQPPRM

Show »
Length:394
Mass (Da):43,393
Checksum:i4D09EDA573349783
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JW04Q5JW04_HUMAN
Solute carrier family 35 member C2
SLC35C2
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JW03Q5JW03_HUMAN
Solute carrier family 35 member C2
SLC35C2
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD27724 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti66L → S in AAD27724 (PubMed:10810093).Curated1
Sequence conflicti126I → V in BAD96648 (Ref. 4) Curated1
Sequence conflicti247F → L in BAH13392 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0567291M → MGRVSTSHQPLRGVPAPADS GAPVLQPPRM in isoform 3. 1 Publication1
Alternative sequenceiVSP_009229137 – 157Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF455052 mRNA Translation: AAL59605.1
AF132949 mRNA Translation: AAD27724.1 Frameshift.
AK301022 mRNA Translation: BAH13392.1
AK222928 mRNA Translation: BAD96648.1
AL133227 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75748.1
CH471077 Genomic DNA Translation: EAW75747.1
CH471077 Genomic DNA Translation: EAW75750.1
CH471077 Genomic DNA Translation: EAW75751.1
CH471077 Genomic DNA Translation: EAW75752.1
BC014191 mRNA Translation: AAH14191.1
BC021138 mRNA Translation: AAH21138.1
BC025277 mRNA Translation: AAH25277.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13396.1 [Q9NQQ7-1]
CCDS13397.1 [Q9NQQ7-2]
CCDS63292.1 [Q9NQQ7-3]

NCBI Reference Sequences

More...RefSeqi		NP_001268386.1, NM_001281457.1
NP_001268387.1, NM_001281458.1 [Q9NQQ7-3]
NP_001268388.1, NM_001281459.1
NP_001268389.1, NM_001281460.1 [Q9NQQ7-1]
NP_057029.8, NM_015945.11 [Q9NQQ7-1]
NP_775096.1, NM_173073.3 [Q9NQQ7-2]
NP_775271.1, NM_173179.3 [Q9NQQ7-1]
XP_011527133.1, XM_011528831.1 [Q9NQQ7-1]
XP_011527134.1, XM_011528832.1 [Q9NQQ7-1]
XP_011527135.1, XM_011528833.1 [Q9NQQ7-1]
XP_016883345.1, XM_017027856.1
XP_016883346.1, XM_017027857.1
XP_016883347.1, XM_017027858.1
XP_016883348.1, XM_017027859.1
XP_016883349.1, XM_017027860.1
XP_016883350.1, XM_017027861.1 [Q9NQQ7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000243896; ENSP00000243896; ENSG00000080189 [Q9NQQ7-1]
ENST00000317734; ENSP00000318960; ENSG00000080189 [Q9NQQ7-3]
ENST00000372227; ENSP00000361301; ENSG00000080189 [Q9NQQ7-1]
ENST00000372230; ENSP00000361304; ENSG00000080189 [Q9NQQ7-1]
ENST00000543605; ENSP00000439974; ENSG00000080189 [Q9NQQ7-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51006

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51006

UCSC genome browser

More...UCSCi		uc002xrp.5, human [Q9NQQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455052 mRNA Translation: AAL59605.1
AF132949 mRNA Translation: AAD27724.1 Frameshift.
AK301022 mRNA Translation: BAH13392.1
AK222928 mRNA Translation: BAD96648.1
AL133227 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75748.1
CH471077 Genomic DNA Translation: EAW75747.1
CH471077 Genomic DNA Translation: EAW75750.1
CH471077 Genomic DNA Translation: EAW75751.1
CH471077 Genomic DNA Translation: EAW75752.1
BC014191 mRNA Translation: AAH14191.1
BC021138 mRNA Translation: AAH21138.1
BC025277 mRNA Translation: AAH25277.1
CCDSiCCDS13396.1 [Q9NQQ7-1]
CCDS13397.1 [Q9NQQ7-2]
CCDS63292.1 [Q9NQQ7-3]
RefSeqiNP_001268386.1, NM_001281457.1
NP_001268387.1, NM_001281458.1 [Q9NQQ7-3]
NP_001268388.1, NM_001281459.1
NP_001268389.1, NM_001281460.1 [Q9NQQ7-1]
NP_057029.8, NM_015945.11 [Q9NQQ7-1]
NP_775096.1, NM_173073.3 [Q9NQQ7-2]
NP_775271.1, NM_173179.3 [Q9NQQ7-1]
XP_011527133.1, XM_011528831.1 [Q9NQQ7-1]
XP_011527134.1, XM_011528832.1 [Q9NQQ7-1]
XP_011527135.1, XM_011528833.1 [Q9NQQ7-1]
XP_016883345.1, XM_017027856.1
XP_016883346.1, XM_017027857.1
XP_016883347.1, XM_017027858.1
XP_016883348.1, XM_017027859.1
XP_016883349.1, XM_017027860.1
XP_016883350.1, XM_017027861.1 [Q9NQQ7-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119214, 2 interactors
IntActiQ9NQQ7, 90 interactors
MINTiQ9NQQ7
STRINGi9606.ENSP00000318960

Protein family/group databases

TCDBi2.A.7.9.16, the drug/metabolite transporter (dmt) superfamily

PTM databases

GlyGeniQ9NQQ7, 1 site
iPTMnetiQ9NQQ7
PhosphoSitePlusiQ9NQQ7

Polymorphism and mutation databases

BioMutaiSLC35C2
DMDMi41017506

Proteomic databases

jPOSTiQ9NQQ7
MassIVEiQ9NQQ7
MaxQBiQ9NQQ7
PaxDbiQ9NQQ7
PeptideAtlasiQ9NQQ7
PRIDEiQ9NQQ7
ProteomicsDBi82169 [Q9NQQ7-1]
82170 [Q9NQQ7-2]
TopDownProteomicsiQ9NQQ7-2 [Q9NQQ7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		53835, 41 antibodies

The DNASU plasmid repository

More...DNASUi		51006

Genome annotation databases

EnsembliENST00000243896; ENSP00000243896; ENSG00000080189 [Q9NQQ7-1]
ENST00000317734; ENSP00000318960; ENSG00000080189 [Q9NQQ7-3]
ENST00000372227; ENSP00000361301; ENSG00000080189 [Q9NQQ7-1]
ENST00000372230; ENSP00000361304; ENSG00000080189 [Q9NQQ7-1]
ENST00000543605; ENSP00000439974; ENSG00000080189 [Q9NQQ7-2]
GeneIDi51006
KEGGihsa:51006
UCSCiuc002xrp.5, human [Q9NQQ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51006
EuPathDBiHostDB:ENSG00000080189.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC35C2
HGNCiHGNC:17117, SLC35C2
HPAiENSG00000080189, Low tissue specificity
neXtProtiNX_Q9NQQ7
OpenTargetsiENSG00000080189
PharmGKBiPA32850

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1443, Eukaryota
GeneTreeiENSGT00510000048078
HOGENOMiCLU_022332_1_3_1
InParanoidiQ9NQQ7
KOiK15280
OMAiASMMIWG
OrthoDBi1337371at2759
PhylomeDBiQ9NQQ7
TreeFamiTF314994

Enzyme and pathway databases

PathwayCommonsiQ9NQQ7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51006, 7 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC35C2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SLC35C2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51006
PharosiQ9NQQ7, Tdark

Protein Ontology

More...PROi		PR:Q9NQQ7
RNActiQ9NQQ7, protein

Gene expression databases

BgeeiENSG00000080189, Expressed in tendon of biceps brachii and 209 other tissues
ExpressionAtlasiQ9NQQ7, baseline and differential
GenevisibleiQ9NQQ7, HS

Family and domain databases

InterProiView protein in InterPro
IPR004853, Sugar_P_trans_dom
PfamiView protein in Pfam
PF03151, TPT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS35C2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQQ7
Secondary accession number(s): B7Z6V6
, E1P5T0, Q53GK3, Q5JW05, Q96CJ8, Q9Y304
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2001
Last modified: August 12, 2020
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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