UniProtKB - Q9NQQ7 (S35C2_HUMAN)
Solute carrier family 35 member C2
SLC35C2
Functioni
May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.
1 PublicationGO - Molecular functioni
- antiporter activity Source: GO_Central
GO - Biological processi
- negative regulation of gene expression Source: Ensembl
- positive regulation of Notch signaling pathway Source: Ensembl
- protein O-linked fucosylation Source: Ensembl
- UDP-glucose transmembrane transport Source: GO_Central
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9NQQ7 |
SignaLinki | Q9NQQ7 |
Protein family/group databases
TCDBi | 2.A.7.9.16, the drug/metabolite transporter (dmt) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 35 member C2Alternative name(s): Ovarian cancer-overexpressed gene 1 protein |
Gene namesi | Name:SLC35C2 Synonyms:C20orf5, OVCOV1 ORF Names:CGI-15 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17117, SLC35C2 |
MIMi | 619530, gene |
neXtProti | NX_Q9NQQ7 |
VEuPathDBi | HostDB:ENSG00000080189 |
Subcellular locationi
Golgi apparatus
- cis-Golgi network membrane 1 Publication
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
- Endoplasmic reticulum-Golgi intermediate compartment membrane 1 Publication
Golgi apparatus
- cis-Golgi network Source: MGI
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- endoplasmic reticulum-Golgi intermediate compartment Source: MGI
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 14 – 34 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 42 – 62 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 104 – 124 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 136 – 156 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 202 – 222 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 242 – 262 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 294 – 316 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000080189 |
PharmGKBi | PA32850 |
Miscellaneous databases
Pharosi | Q9NQQ7, Tdark |
Genetic variation databases
BioMutai | SLC35C2 |
DMDMi | 41017506 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213399 | 1 – 365 | Solute carrier family 35 member C2Add BLAST | 365 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 335 | PhosphoserineCombined sources | 1 | |
Modified residuei | 336 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q9NQQ7 |
MassIVEi | Q9NQQ7 |
MaxQBi | Q9NQQ7 |
PaxDbi | Q9NQQ7 |
PeptideAtlasi | Q9NQQ7 |
PRIDEi | Q9NQQ7 |
ProteomicsDBi | 82169 [Q9NQQ7-1] 82170 [Q9NQQ7-2] |
TopDownProteomicsi | Q9NQQ7-2 [Q9NQQ7-2] |
PTM databases
GlyGeni | Q9NQQ7, 1 site |
iPTMneti | Q9NQQ7 |
PhosphoSitePlusi | Q9NQQ7 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000080189, Expressed in tendon of biceps brachii and 208 other tissues |
ExpressionAtlasi | Q9NQQ7, baseline and differential |
Genevisiblei | Q9NQQ7, HS |
Organism-specific databases
HPAi | ENSG00000080189, Low tissue specificity |
Interactioni
Binary interactionsi
Isoform 3 [Q9NQQ7-3]
Protein-protein interaction databases
BioGRIDi | 119214, 97 interactors |
IntActi | Q9NQQ7, 90 interactors |
MINTi | Q9NQQ7 |
STRINGi | 9606.ENSP00000318960 |
Miscellaneous databases
RNActi | Q9NQQ7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 344 – 365 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1443, Eukaryota |
GeneTreei | ENSGT00510000048078 |
HOGENOMi | CLU_022332_1_3_1 |
InParanoidi | Q9NQQ7 |
OMAi | ASMMIWG |
OrthoDBi | 1337371at2759 |
PhylomeDBi | Q9NQQ7 |
TreeFami | TF314994 |
Family and domain databases
InterProi | View protein in InterPro IPR004853, Sugar_P_trans_dom |
Pfami | View protein in Pfam PF03151, TPT, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGRWALDVAF LWKAVLTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM
60 70 80 90 100
LHLAVIFLFS ALSRALVQCS SHRARVVLSW ADYLRRVAPT ALATALDVGL
110 120 130 140 150
SNWSFLYVTV SLYTMTKSSA VLFILIFSLI FKLEELRAAL VLVVLLIAGG
160 170 180 190 200
LFMFTYKSTQ FNVEGFALVL GASFIGGIRW TLTQMLLQKA ELGLQNPIDT
210 220 230 240 250
MFHLQPLMFL GLFPLFAVFE GLHLSTSEKI FRFQDTGLLL RVLGSLFLGG
260 270 280 290 300
ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW
310 320 330 340 350
LGFALCLSGI SLHVALKALH SRGDGGPKAL KGLGSSPDLE LLLRSSQREE
360
GDNEEEEYFV AQGQQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5JW04 | Q5JW04_HUMAN | Solute carrier family 35 member C2 | SLC35C2 | 196 | Annotation score: | ||
Q5JW03 | Q5JW03_HUMAN | Solute carrier family 35 member C2 | SLC35C2 | 157 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 66 | L → S in AAD27724 (PubMed:10810093).Curated | 1 | |
Sequence conflicti | 126 | I → V in BAD96648 (Ref. 4) Curated | 1 | |
Sequence conflicti | 247 | F → L in BAH13392 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056729 | 1 | M → MGRVSTSHQPLRGVPAPADS GAPVLQPPRM in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_009229 | 137 – 157 | Missing in isoform 2. 1 PublicationAdd BLAST | 21 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000243896; ENSP00000243896; ENSG00000080189 ENST00000317734; ENSP00000318960; ENSG00000080189 [Q9NQQ7-3] ENST00000372227; ENSP00000361301; ENSG00000080189 ENST00000372230; ENSP00000361304; ENSG00000080189 ENST00000543605; ENSP00000439974; ENSG00000080189 [Q9NQQ7-2] |
GeneIDi | 51006 |
KEGGi | hsa:51006 |
MANE-Selecti | ENST00000372230.10; ENSP00000361304.5; NM_015945.12; NP_057029.8 |
UCSCi | uc002xrp.5, human [Q9NQQ7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q9NQQ7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119214, 97 interactors |
IntActi | Q9NQQ7, 90 interactors |
MINTi | Q9NQQ7 |
STRINGi | 9606.ENSP00000318960 |
Protein family/group databases
TCDBi | 2.A.7.9.16, the drug/metabolite transporter (dmt) superfamily |
PTM databases
GlyGeni | Q9NQQ7, 1 site |
iPTMneti | Q9NQQ7 |
PhosphoSitePlusi | Q9NQQ7 |
Genetic variation databases
BioMutai | SLC35C2 |
DMDMi | 41017506 |
Proteomic databases
jPOSTi | Q9NQQ7 |
MassIVEi | Q9NQQ7 |
MaxQBi | Q9NQQ7 |
PaxDbi | Q9NQQ7 |
PeptideAtlasi | Q9NQQ7 |
PRIDEi | Q9NQQ7 |
ProteomicsDBi | 82169 [Q9NQQ7-1] 82170 [Q9NQQ7-2] |
TopDownProteomicsi | Q9NQQ7-2 [Q9NQQ7-2] |
Protocols and materials databases
Antibodypediai | 53835, 45 antibodies from 14 providers |
DNASUi | 51006 |
Genome annotation databases
Ensembli | ENST00000243896; ENSP00000243896; ENSG00000080189 ENST00000317734; ENSP00000318960; ENSG00000080189 [Q9NQQ7-3] ENST00000372227; ENSP00000361301; ENSG00000080189 ENST00000372230; ENSP00000361304; ENSG00000080189 ENST00000543605; ENSP00000439974; ENSG00000080189 [Q9NQQ7-2] |
GeneIDi | 51006 |
KEGGi | hsa:51006 |
MANE-Selecti | ENST00000372230.10; ENSP00000361304.5; NM_015945.12; NP_057029.8 |
UCSCi | uc002xrp.5, human [Q9NQQ7-1] |
Organism-specific databases
CTDi | 51006 |
GeneCardsi | SLC35C2 |
HGNCi | HGNC:17117, SLC35C2 |
HPAi | ENSG00000080189, Low tissue specificity |
MIMi | 619530, gene |
neXtProti | NX_Q9NQQ7 |
OpenTargetsi | ENSG00000080189 |
PharmGKBi | PA32850 |
VEuPathDBi | HostDB:ENSG00000080189 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1443, Eukaryota |
GeneTreei | ENSGT00510000048078 |
HOGENOMi | CLU_022332_1_3_1 |
InParanoidi | Q9NQQ7 |
OMAi | ASMMIWG |
OrthoDBi | 1337371at2759 |
PhylomeDBi | Q9NQQ7 |
TreeFami | TF314994 |
Enzyme and pathway databases
PathwayCommonsi | Q9NQQ7 |
SignaLinki | Q9NQQ7 |
Miscellaneous databases
BioGRID-ORCSi | 51006, 10 hits in 1048 CRISPR screens |
ChiTaRSi | SLC35C2, human |
GeneWikii | SLC35C2 |
GenomeRNAii | 51006 |
Pharosi | Q9NQQ7, Tdark |
PROi | PR:Q9NQQ7 |
RNActi | Q9NQQ7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000080189, Expressed in tendon of biceps brachii and 208 other tissues |
ExpressionAtlasi | Q9NQQ7, baseline and differential |
Genevisiblei | Q9NQQ7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004853, Sugar_P_trans_dom |
Pfami | View protein in Pfam PF03151, TPT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S35C2_HUMAN | |
Accessioni | Q9NQQ7Primary (citable) accession number: Q9NQQ7 Secondary accession number(s): B7Z6V6 Q9Y304 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families