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Protein

Solute carrier family 35 member C2

Gene

SLC35C2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.1 Publication

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.7.9.16 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member C2
Alternative name(s):
Ovarian cancer-overexpressed gene 1 protein
Gene namesi
Name:SLC35C2
Synonyms:C20orf5, OVCOV1
ORF Names:CGI-15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000080189.14
HGNCiHGNC:17117 SLC35C2
neXtProtiNX_Q9NQQ7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Transmembranei294 – 316HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000080189
PharmGKBiPA32850

Polymorphism and mutation databases

DMDMi41017506

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002133991 – 365Solute carrier family 35 member C2Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei335PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9NQQ7
PaxDbiQ9NQQ7
PeptideAtlasiQ9NQQ7
PRIDEiQ9NQQ7
ProteomicsDBi82169
82170 [Q9NQQ7-2]
TopDownProteomicsiQ9NQQ7-2 [Q9NQQ7-2]

PTM databases

iPTMnetiQ9NQQ7
PhosphoSitePlusiQ9NQQ7

Expressioni

Tissue specificityi

Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer.

Inductioni

In hypoxic trophoblast cells.

Gene expression databases

BgeeiENSG00000080189 Expressed in 194 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_SLC35C2
ExpressionAtlasiQ9NQQ7 baseline and differential
GenevisibleiQ9NQQ7 HS

Organism-specific databases

HPAiHPA027011

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TMEM14BQ9NUH84EBI-17295964,EBI-8638294

Protein-protein interaction databases

BioGridi119214, 2 interactors
IntActiQ9NQQ7, 87 interactors
MINTiQ9NQQ7
STRINGi9606.ENSP00000243896

Structurei

3D structure databases

ProteinModelPortaliQ9NQQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1443 Eukaryota
COG0697 LUCA
GeneTreeiENSGT00510000048078
HOGENOMiHOG000007454
HOVERGENiHBG055852
InParanoidiQ9NQQ7
KOiK15280
OMAiHTSNEIT
OrthoDBiEOG091G09SR
PhylomeDBiQ9NQQ7
TreeFamiTF314994

Family and domain databases

InterProiView protein in InterPro
IPR004853 Sugar_P_trans_dom
PfamiView protein in Pfam
PF03151 TPT, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9NQQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRWALDVAF LWKAVLTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM
60 70 80 90 100
LHLAVIFLFS ALSRALVQCS SHRARVVLSW ADYLRRVAPT ALATALDVGL
110 120 130 140 150
SNWSFLYVTV SLYTMTKSSA VLFILIFSLI FKLEELRAAL VLVVLLIAGG
160 170 180 190 200
LFMFTYKSTQ FNVEGFALVL GASFIGGIRW TLTQMLLQKA ELGLQNPIDT
210 220 230 240 250
MFHLQPLMFL GLFPLFAVFE GLHLSTSEKI FRFQDTGLLL RVLGSLFLGG
260 270 280 290 300
ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW
310 320 330 340 350
LGFALCLSGI SLHVALKALH SRGDGGPKAL KGLGSSPDLE LLLRSSQREE
360
GDNEEEEYFV AQGQQ
Length:365
Mass (Da):40,432
Last modified:June 1, 2001 - v2
Checksum:i5EACE6A4953411A9
GO
Isoform 2 (identifier: Q9NQQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-157: Missing.

Show »
Length:344
Mass (Da):38,154
Checksum:i20DCAF1DC8048736
GO
Isoform 3 (identifier: Q9NQQ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRVSTSHQPLRGVPAPADSGAPVLQPPRM

Show »
Length:394
Mass (Da):43,393
Checksum:i4D09EDA573349783
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JW04Q5JW04_HUMAN
Solute carrier family 35 member C2
SLC35C2
196Annotation score:
Q5JW03Q5JW03_HUMAN
Solute carrier family 35 member C2
SLC35C2
157Annotation score:

Sequence cautioni

The sequence AAD27724 differs from that shown. Reason: Frameshift at positions 168, 211 and 305.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66L → S in AAD27724 (PubMed:10810093).Curated1
Sequence conflicti126I → V in BAD96648 (Ref. 4) Curated1
Sequence conflicti247F → L in BAH13392 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0567291M → MGRVSTSHQPLRGVPAPADS GAPVLQPPRM in isoform 3. 1 Publication1
Alternative sequenceiVSP_009229137 – 157Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455052 mRNA Translation: AAL59605.1
AF132949 mRNA Translation: AAD27724.1 Frameshift.
AK301022 mRNA Translation: BAH13392.1
AK222928 mRNA Translation: BAD96648.1
AL133227 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75748.1
CH471077 Genomic DNA Translation: EAW75747.1
CH471077 Genomic DNA Translation: EAW75750.1
CH471077 Genomic DNA Translation: EAW75751.1
CH471077 Genomic DNA Translation: EAW75752.1
BC014191 mRNA Translation: AAH14191.1
BC021138 mRNA Translation: AAH21138.1
BC025277 mRNA Translation: AAH25277.1
CCDSiCCDS13396.1 [Q9NQQ7-1]
CCDS13397.1 [Q9NQQ7-2]
CCDS63292.1 [Q9NQQ7-3]
RefSeqiNP_001268386.1, NM_001281457.1
NP_001268387.1, NM_001281458.1 [Q9NQQ7-3]
NP_001268388.1, NM_001281459.1
NP_001268389.1, NM_001281460.1 [Q9NQQ7-1]
NP_057029.8, NM_015945.11 [Q9NQQ7-1]
NP_775096.1, NM_173073.3 [Q9NQQ7-2]
NP_775271.1, NM_173179.3 [Q9NQQ7-1]
XP_011527133.1, XM_011528831.1 [Q9NQQ7-1]
XP_011527134.1, XM_011528832.1 [Q9NQQ7-1]
XP_011527135.1, XM_011528833.1 [Q9NQQ7-1]
XP_016883345.1, XM_017027856.1 [Q9NQQ7-1]
XP_016883346.1, XM_017027857.1 [Q9NQQ7-1]
XP_016883347.1, XM_017027858.1 [Q9NQQ7-1]
XP_016883348.1, XM_017027859.1 [Q9NQQ7-1]
XP_016883349.1, XM_017027860.1 [Q9NQQ7-1]
XP_016883350.1, XM_017027861.1 [Q9NQQ7-2]
UniGeneiHs.593344
Hs.723629

Genome annotation databases

EnsembliENST00000243896; ENSP00000243896; ENSG00000080189 [Q9NQQ7-1]
ENST00000317734; ENSP00000318960; ENSG00000080189 [Q9NQQ7-3]
ENST00000372227; ENSP00000361301; ENSG00000080189 [Q9NQQ7-1]
ENST00000372230; ENSP00000361304; ENSG00000080189 [Q9NQQ7-1]
ENST00000543605; ENSP00000439974; ENSG00000080189 [Q9NQQ7-2]
GeneIDi51006
KEGGihsa:51006
UCSCiuc002xrp.5 human [Q9NQQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455052 mRNA Translation: AAL59605.1
AF132949 mRNA Translation: AAD27724.1 Frameshift.
AK301022 mRNA Translation: BAH13392.1
AK222928 mRNA Translation: BAD96648.1
AL133227 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75748.1
CH471077 Genomic DNA Translation: EAW75747.1
CH471077 Genomic DNA Translation: EAW75750.1
CH471077 Genomic DNA Translation: EAW75751.1
CH471077 Genomic DNA Translation: EAW75752.1
BC014191 mRNA Translation: AAH14191.1
BC021138 mRNA Translation: AAH21138.1
BC025277 mRNA Translation: AAH25277.1
CCDSiCCDS13396.1 [Q9NQQ7-1]
CCDS13397.1 [Q9NQQ7-2]
CCDS63292.1 [Q9NQQ7-3]
RefSeqiNP_001268386.1, NM_001281457.1
NP_001268387.1, NM_001281458.1 [Q9NQQ7-3]
NP_001268388.1, NM_001281459.1
NP_001268389.1, NM_001281460.1 [Q9NQQ7-1]
NP_057029.8, NM_015945.11 [Q9NQQ7-1]
NP_775096.1, NM_173073.3 [Q9NQQ7-2]
NP_775271.1, NM_173179.3 [Q9NQQ7-1]
XP_011527133.1, XM_011528831.1 [Q9NQQ7-1]
XP_011527134.1, XM_011528832.1 [Q9NQQ7-1]
XP_011527135.1, XM_011528833.1 [Q9NQQ7-1]
XP_016883345.1, XM_017027856.1 [Q9NQQ7-1]
XP_016883346.1, XM_017027857.1 [Q9NQQ7-1]
XP_016883347.1, XM_017027858.1 [Q9NQQ7-1]
XP_016883348.1, XM_017027859.1 [Q9NQQ7-1]
XP_016883349.1, XM_017027860.1 [Q9NQQ7-1]
XP_016883350.1, XM_017027861.1 [Q9NQQ7-2]
UniGeneiHs.593344
Hs.723629

3D structure databases

ProteinModelPortaliQ9NQQ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119214, 2 interactors
IntActiQ9NQQ7, 87 interactors
MINTiQ9NQQ7
STRINGi9606.ENSP00000243896

Protein family/group databases

TCDBi2.A.7.9.16 the drug/metabolite transporter (dmt) superfamily

PTM databases

iPTMnetiQ9NQQ7
PhosphoSitePlusiQ9NQQ7

Polymorphism and mutation databases

DMDMi41017506

Proteomic databases

MaxQBiQ9NQQ7
PaxDbiQ9NQQ7
PeptideAtlasiQ9NQQ7
PRIDEiQ9NQQ7
ProteomicsDBi82169
82170 [Q9NQQ7-2]
TopDownProteomicsiQ9NQQ7-2 [Q9NQQ7-2]

Protocols and materials databases

DNASUi51006
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243896; ENSP00000243896; ENSG00000080189 [Q9NQQ7-1]
ENST00000317734; ENSP00000318960; ENSG00000080189 [Q9NQQ7-3]
ENST00000372227; ENSP00000361301; ENSG00000080189 [Q9NQQ7-1]
ENST00000372230; ENSP00000361304; ENSG00000080189 [Q9NQQ7-1]
ENST00000543605; ENSP00000439974; ENSG00000080189 [Q9NQQ7-2]
GeneIDi51006
KEGGihsa:51006
UCSCiuc002xrp.5 human [Q9NQQ7-1]

Organism-specific databases

CTDi51006
EuPathDBiHostDB:ENSG00000080189.14
GeneCardsiSLC35C2
H-InvDBiHIX0015879
HGNCiHGNC:17117 SLC35C2
HPAiHPA027011
neXtProtiNX_Q9NQQ7
OpenTargetsiENSG00000080189
PharmGKBiPA32850
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1443 Eukaryota
COG0697 LUCA
GeneTreeiENSGT00510000048078
HOGENOMiHOG000007454
HOVERGENiHBG055852
InParanoidiQ9NQQ7
KOiK15280
OMAiHTSNEIT
OrthoDBiEOG091G09SR
PhylomeDBiQ9NQQ7
TreeFamiTF314994

Miscellaneous databases

ChiTaRSiSLC35C2 human
GeneWikiiSLC35C2
GenomeRNAii51006
PROiPR:Q9NQQ7

Gene expression databases

BgeeiENSG00000080189 Expressed in 194 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_SLC35C2
ExpressionAtlasiQ9NQQ7 baseline and differential
GenevisibleiQ9NQQ7 HS

Family and domain databases

InterProiView protein in InterPro
IPR004853 Sugar_P_trans_dom
PfamiView protein in Pfam
PF03151 TPT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS35C2_HUMAN
AccessioniPrimary (citable) accession number: Q9NQQ7
Secondary accession number(s): B7Z6V6
, E1P5T0, Q53GK3, Q5JW05, Q96CJ8, Q9Y304
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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