SLC35C2

Functionⁱ

May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.1 Publication

GO - Biological processⁱ

negative regulation of gene expression Source: Ensembl
positive regulation of Notch signaling pathway Source: Ensembl
protein O-linked fucosylation Source: Ensembl
UDP-glucose transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Protein family/group databases

TCDBⁱ	2.A.7.9.16 the drug/metabolite transporter (dmt) superfamily

TCDBⁱ

2.A.7.9.16 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 35 member C2 Alternative name(s): Ovarian cancer-overexpressed gene 1 protein
Gene namesⁱ	Name:SLC35C2 Synonyms:C20orf5, OVCOV1 ORF Names:CGI-15
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000080189.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17117 SLC35C2
neXtProtⁱ	NX_Q9NQQ7

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	14 – 34	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	42 – 62	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	104 – 124	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	136 – 156	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	158 – 178	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	202 – 222	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	242 – 262	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	294 – 316	HelicalSequence analysisAdd BLAST	23

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000080189
PharmGKBⁱ	PA32850

Polymorphism and mutation databases

DMDMⁱ	41017506

DMDMⁱ

41017506

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000213399	1 – 365	Solute carrier family 35 member C2Add BLAST		365

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	102	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	335	PhosphoserineCombined sources	1
Modified residueⁱ	336	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NQQ7
PaxDbⁱ	Q9NQQ7
PeptideAtlas More...PeptideAtlasⁱ	Q9NQQ7
PRIDEⁱ	Q9NQQ7
ProteomicsDBⁱ	82169 82170 [Q9NQQ7-2]
TopDownProteomicsⁱ	Q9NQQ7-2 [Q9NQQ7-2]

PTM databases

iPTMnetⁱ	Q9NQQ7
PhosphoSitePlusⁱ	Q9NQQ7

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer.

Inductionⁱ

In hypoxic trophoblast cells.

Gene expression databases

Bgeeⁱ	ENSG00000080189 Expressed in 194 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_SLC35C2
ExpressionAtlasⁱ	Q9NQQ7 baseline and differential
Genevisibleⁱ	Q9NQQ7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027011

HPAⁱ

HPA027011

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TMEM14B	Q9NUH8	4	EBI-17295964,EBI-8638294

With

Entry

#Exp.

IntAct

Notes

TMEM14B

Q9NUH8

4

EBI-17295964,EBI-8638294

Protein-protein interaction databases

BioGridⁱ	119214, 2 interactors
IntActⁱ	Q9NQQ7, 87 interactors
Molecular INTeraction database More...MINTⁱ	Q9NQQ7
STRINGⁱ	9606.ENSP00000243896

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NQQ7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TPT transporter family. SLC35C subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1443 Eukaryota COG0697 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048078
HOGENOMⁱ	HOG000007454
HOVERGENⁱ	HBG055852
InParanoidⁱ	Q9NQQ7
KEGG Orthology (KO) More...KOⁱ	K15280
OMAⁱ	HTSNEIT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09SR
PhylomeDBⁱ	Q9NQQ7
TreeFamⁱ	TF314994

Family and domain databases

InterProⁱ	View protein in InterPro IPR004853 Sugar_P_trans_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03151 TPT, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NQQ7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRWALDVAF LWKAVLTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM 
        60         70         80         90        100
LHLAVIFLFS ALSRALVQCS SHRARVVLSW ADYLRRVAPT ALATALDVGL 
       110        120        130        140        150
SNWSFLYVTV SLYTMTKSSA VLFILIFSLI FKLEELRAAL VLVVLLIAGG 
       160        170        180        190        200
LFMFTYKSTQ FNVEGFALVL GASFIGGIRW TLTQMLLQKA ELGLQNPIDT 
       210        220        230        240        250
MFHLQPLMFL GLFPLFAVFE GLHLSTSEKI FRFQDTGLLL RVLGSLFLGG 
       260        270        280        290        300
ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW 
       310        320        330        340        350
LGFALCLSGI SLHVALKALH SRGDGGPKAL KGLGSSPDLE LLLRSSQREE 
       360 
GDNEEEEYFV AQGQQ

Length:365

Mass (Da):40,432

Last modified:June 1, 2001 - v2

Checksum:ⁱ5EACE6A4953411A9

GO

Isoform 2 (identifier: Q9NQQ7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
137-157: Missing.

« Hide

        10         20         30         40         50
MGRWALDVAF LWKAVLTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM 
        60         70         80         90        100
LHLAVIFLFS ALSRALVQCS SHRARVVLSW ADYLRRVAPT ALATALDVGL 
       110        120        130        140        150
SNWSFLYVTV SLYTMTKSSA VLFILIFSLI FKLEELSTQF NVEGFALVLG 
       160        170        180        190        200
ASFIGGIRWT LTQMLLQKAE LGLQNPIDTM FHLQPLMFLG LFPLFAVFEG 
       210        220        230        240        250
LHLSTSEKIF RFQDTGLLLR VLGSLFLGGI LAFGLGFSEF LLVSRTSSLT 
       260        270        280        290        300
LSIAGIFKEV CTLLLAAHLL GDQISLLNWL GFALCLSGIS LHVALKALHS 
       310        320        330        340 
RGDGGPKALK GLGSSPDLEL LLRSSQREEG DNEEEEYFVA QGQQ

Show »

Length:344

Mass (Da):38,154

Checksum:ⁱ20DCAF1DC8048736

GO

Isoform 3 (identifier: Q9NQQ7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MGRVSTSHQPLRGVPAPADSGAPVLQPPRM

« Hide

        10         20         30         40         50
MGRVSTSHQP LRGVPAPADS GAPVLQPPRM GRWALDVAFL WKAVLTLGLV 
        60         70         80         90        100
LLYYCFSIGI TFYNKWLTKS FHFPLFMTML HLAVIFLFSA LSRALVQCSS 
       110        120        130        140        150
HRARVVLSWA DYLRRVAPTA LATALDVGLS NWSFLYVTVS LYTMTKSSAV 
       160        170        180        190        200
LFILIFSLIF KLEELRAALV LVVLLIAGGL FMFTYKSTQF NVEGFALVLG 
       210        220        230        240        250
ASFIGGIRWT LTQMLLQKAE LGLQNPIDTM FHLQPLMFLG LFPLFAVFEG 
       260        270        280        290        300
LHLSTSEKIF RFQDTGLLLR VLGSLFLGGI LAFGLGFSEF LLVSRTSSLT 
       310        320        330        340        350
LSIAGIFKEV CTLLLAAHLL GDQISLLNWL GFALCLSGIS LHVALKALHS 
       360        370        380        390 
RGDGGPKALK GLGSSPDLEL LLRSSQREEG DNEEEEYFVA QGQQ

Show »

Length:394

Mass (Da):43,393

Checksum:ⁱ4D09EDA573349783

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5JW04	Q5JW04_HUMAN	Solute carrier family 35 member C2 Solute carrier family 35 member C2	SLC35C2	196	Annotation score:
Q5JW03	Q5JW03_HUMAN	Solute carrier family 35 member C2 Solute carrier family 35 member C2	SLC35C2	157	Annotation score:

Sequence cautionⁱ

The sequence AAD27724 differs from that shown. Reason: Frameshift at positions 168, 211 and 305.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	66	L → S in AAD27724 (PubMed:10810093).Curated	1
Sequence conflictⁱ	126	I → V in BAD96648 (Ref. 4) Curated	1
Sequence conflictⁱ	247	F → L in BAH13392 (PubMed:14702039).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056729	1	M → MGRVSTSHQPLRGVPAPADS GAPVLQPPRM in isoform 3. 1 Publication		1
Alternative sequenceⁱVSP_009229	137 – 157	Missing in isoform 2. 1 PublicationAdd BLAST		21

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF455052 mRNA Translation: AAL59605.1 AF132949 mRNA Translation: AAD27724.1 Frameshift. AK301022 mRNA Translation: BAH13392.1 AK222928 mRNA Translation: BAD96648.1 AL133227 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75748.1 CH471077 Genomic DNA Translation: EAW75747.1 CH471077 Genomic DNA Translation: EAW75750.1 CH471077 Genomic DNA Translation: EAW75751.1 CH471077 Genomic DNA Translation: EAW75752.1 BC014191 mRNA Translation: AAH14191.1 BC021138 mRNA Translation: AAH21138.1 BC025277 mRNA Translation: AAH25277.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13396.1 [Q9NQQ7-1] CCDS13397.1 [Q9NQQ7-2] CCDS63292.1 [Q9NQQ7-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001268386.1, NM_001281457.1 NP_001268387.1, NM_001281458.1 [Q9NQQ7-3] NP_001268388.1, NM_001281459.1 NP_001268389.1, NM_001281460.1 [Q9NQQ7-1] NP_057029.8, NM_015945.11 [Q9NQQ7-1] NP_775096.1, NM_173073.3 [Q9NQQ7-2] NP_775271.1, NM_173179.3 [Q9NQQ7-1] XP_011527133.1, XM_011528831.1 [Q9NQQ7-1] XP_011527134.1, XM_011528832.1 [Q9NQQ7-1] XP_011527135.1, XM_011528833.1 [Q9NQQ7-1] XP_016883345.1, XM_017027856.1 XP_016883346.1, XM_017027857.1 XP_016883347.1, XM_017027858.1 XP_016883348.1, XM_017027859.1 XP_016883349.1, XM_017027860.1 XP_016883350.1, XM_017027861.1 [Q9NQQ7-2]
UniGeneⁱ	Hs.593344 Hs.723629

Genome annotation databases

Ensemblⁱ	ENST00000243896; ENSP00000243896; ENSG00000080189 [Q9NQQ7-1] ENST00000317734; ENSP00000318960; ENSG00000080189 [Q9NQQ7-3] ENST00000372227; ENSP00000361301; ENSG00000080189 [Q9NQQ7-1] ENST00000372230; ENSP00000361304; ENSG00000080189 [Q9NQQ7-1] ENST00000543605; ENSP00000439974; ENSG00000080189 [Q9NQQ7-2]
GeneIDⁱ	51006
KEGGⁱ	hsa:51006
UCSC genome browser More...UCSCⁱ	uc002xrp.5 human [Q9NQQ7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NQQ7	SLC35C2 isoform 1		PANTR		394	UniRef100_Q9NQQ7
UPI0003831CED		HUMAN		251
SLC35C2 isoform 3		PANTR		365
UPI0000494B73		HUMAN		213
UPI0000E256EF		PANTR		318
Q9NQQ7-2	SLC35C2 isoform 2		PANTR		344	UniRef100_K7BKG0

Protein	Similar proteins		Species	Score	Length	Source
Q9NQQ7	Solute carrier family 35 member C2		MOUSE		364	UniRef90_Q9NQQ7
SLC35C2 isoform 1		PANTR		394
Solute carrier family 35 member C2		CAMFR		446
Uncharacterized protein		RHIRO		394
Uncharacterized protein		RHIBE		394
+170
Q9NQQ7-2	solute carrier family 35 member C2 isoform X2		ERIEU		346	UniRef90_A0A1S3ACW5
solute carrier family 35 member C2 isoform X1		LIPVE		345
Solute carrier family 35 member C2 isoform b		MACMU		344
cDNA FLJ52766, highly similar to Solute carrier family 35 member C2		HUMAN		230
SLC35C2 isoform 2		PANTR		344
+17

Protein	Similar proteins		Species	Score	Length	Source
Q9NQQ7	Solute carrier family 35 member C2		MOUSE		364	UniRef50_Q9NQQ7
SLC35C2 isoform 1		PANTR		394
Solute carrier family 35 member C2		CAMFR		446
Isoform 3 of Solute carrier family 35 member C2		HUMAN		394
Uncharacterized protein		CERAT		394
+229
Q9NQQ7-2	Solute carrier family 35 member C2		CHICK		358	UniRef50_Q5ZJ63
Putative solute carrier family 35 member c2 (Fragment)		DESRO		339
solute carrier family 35 member C2 isoform X2		ERIEU		346
solute carrier family 35 member C2 isoform X1		LIPVE		345
SLC35C2 isoform 2		PANTR		344
+84

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF455052 mRNA Translation: AAL59605.1 AF132949 mRNA Translation: AAD27724.1 Frameshift. AK301022 mRNA Translation: BAH13392.1 AK222928 mRNA Translation: BAD96648.1 AL133227 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75748.1 CH471077 Genomic DNA Translation: EAW75747.1 CH471077 Genomic DNA Translation: EAW75750.1 CH471077 Genomic DNA Translation: EAW75751.1 CH471077 Genomic DNA Translation: EAW75752.1 BC014191 mRNA Translation: AAH14191.1 BC021138 mRNA Translation: AAH21138.1 BC025277 mRNA Translation: AAH25277.1
CCDSⁱ	CCDS13396.1 [Q9NQQ7-1] CCDS13397.1 [Q9NQQ7-2] CCDS63292.1 [Q9NQQ7-3]
RefSeqⁱ	NP_001268386.1, NM_001281457.1 NP_001268387.1, NM_001281458.1 [Q9NQQ7-3] NP_001268388.1, NM_001281459.1 NP_001268389.1, NM_001281460.1 [Q9NQQ7-1] NP_057029.8, NM_015945.11 [Q9NQQ7-1] NP_775096.1, NM_173073.3 [Q9NQQ7-2] NP_775271.1, NM_173179.3 [Q9NQQ7-1] XP_011527133.1, XM_011528831.1 [Q9NQQ7-1] XP_011527134.1, XM_011528832.1 [Q9NQQ7-1] XP_011527135.1, XM_011528833.1 [Q9NQQ7-1] XP_016883345.1, XM_017027856.1 XP_016883346.1, XM_017027857.1 XP_016883347.1, XM_017027858.1 XP_016883348.1, XM_017027859.1 XP_016883349.1, XM_017027860.1 XP_016883350.1, XM_017027861.1 [Q9NQQ7-2]
UniGeneⁱ	Hs.593344 Hs.723629

3D structure databases

ProteinModelPortalⁱ	Q9NQQ7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119214, 2 interactors
IntActⁱ	Q9NQQ7, 87 interactors
MINTⁱ	Q9NQQ7
STRINGⁱ	9606.ENSP00000243896

Protein family/group databases

TCDBⁱ	2.A.7.9.16 the drug/metabolite transporter (dmt) superfamily

TCDBⁱ

2.A.7.9.16 the drug/metabolite transporter (dmt) superfamily

PTM databases

iPTMnetⁱ	Q9NQQ7
PhosphoSitePlusⁱ	Q9NQQ7

Polymorphism and mutation databases

DMDMⁱ	41017506

DMDMⁱ

41017506

Proteomic databases

MaxQBⁱ	Q9NQQ7
PaxDbⁱ	Q9NQQ7
PeptideAtlasⁱ	Q9NQQ7
PRIDEⁱ	Q9NQQ7
ProteomicsDBⁱ	82169 82170 [Q9NQQ7-2]
TopDownProteomicsⁱ	Q9NQQ7-2 [Q9NQQ7-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51006
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000243896; ENSP00000243896; ENSG00000080189 [Q9NQQ7-1] ENST00000317734; ENSP00000318960; ENSG00000080189 [Q9NQQ7-3] ENST00000372227; ENSP00000361301; ENSG00000080189 [Q9NQQ7-1] ENST00000372230; ENSP00000361304; ENSG00000080189 [Q9NQQ7-1] ENST00000543605; ENSP00000439974; ENSG00000080189 [Q9NQQ7-2]
GeneIDⁱ	51006
KEGGⁱ	hsa:51006
UCSCⁱ	uc002xrp.5 human [Q9NQQ7-1]

Organism-specific databases

CTDⁱ	51006
EuPathDBⁱ	HostDB:ENSG00000080189.14
GeneCardsⁱ	SLC35C2
H-InvDBⁱ	HIX0015879
HGNCⁱ	HGNC:17117 SLC35C2
HPAⁱ	HPA027011
neXtProtⁱ	NX_Q9NQQ7
OpenTargetsⁱ	ENSG00000080189
PharmGKBⁱ	PA32850
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1443 Eukaryota COG0697 LUCA
GeneTreeⁱ	ENSGT00510000048078
HOGENOMⁱ	HOG000007454
HOVERGENⁱ	HBG055852
InParanoidⁱ	Q9NQQ7
KOⁱ	K15280
OMAⁱ	HTSNEIT
OrthoDBⁱ	EOG091G09SR
PhylomeDBⁱ	Q9NQQ7
TreeFamⁱ	TF314994

Miscellaneous databases

ChiTaRSⁱ	SLC35C2 human
GeneWikiⁱ	SLC35C2
GenomeRNAiⁱ	51006
Protein Ontology More...PROⁱ	PR:Q9NQQ7

Gene expression databases

Bgeeⁱ	ENSG00000080189 Expressed in 194 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_SLC35C2
ExpressionAtlasⁱ	Q9NQQ7 baseline and differential
Genevisibleⁱ	Q9NQQ7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004853 Sugar_P_trans_dom
Pfamⁱ	View protein in Pfam PF03151 TPT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S35C2_HUMAN
Accessionⁱ	Q9NQQ7Primary (citable) accession number: Q9NQQ7 Secondary accession number(s): B7Z6V6 , E1P5T0, Q53GK3, Q5JW05, Q96CJ8, Q9Y304
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
	Last sequence update:	June 1, 2001
	Last modified:	October 10, 2018
	This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NQQ7 (S35C2_HUMAN)

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Solute carrier family 35 member C2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Other locations

Golgi apparatus

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ