UniProtKB - Q9NQP4 (PFD4_HUMAN)
Prefoldin subunit 4
PFDN4
Functioni
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
1 PublicationGO - Molecular functioni
- amyloid-beta binding Source: FlyBase
- chaperone binding Source: UniProtKB
- unfolded protein binding Source: FlyBase
GO - Biological processi
- negative regulation of amyloid fibril formation Source: FlyBase
- protein folding Source: FlyBase
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
PathwayCommonsi | Q9NQP4 |
Reactomei | R-HSA-389957, Prefoldin mediated transfer of substrate to CCT/TriC |
SignaLinki | Q9NQP4 |
SIGNORi | Q9NQP4 |
Names & Taxonomyi
Protein namesi | Recommended name: Prefoldin subunit 4Alternative name(s): Protein C-1 |
Gene namesi | Name:PFDN4 Synonyms:PFD4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8868, PFDN4 |
MIMi | 604898, gene |
neXtProti | NX_Q9NQP4 |
VEuPathDBi | HostDB:ENSG00000101132 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: UniProtKB
Mitochondrion
- mitochondrion Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- prefoldin complex Source: FlyBase
Keywords - Cellular componenti
Cytoplasm, Mitochondrion, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 5203 |
OpenTargetsi | ENSG00000101132 |
PharmGKBi | PA33209 |
Miscellaneous databases
Pharosi | Q9NQP4, Tbio |
Genetic variation databases
BioMutai | PFDN4 |
DMDMi | 12643815 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000124842 | 2 – 134 | Prefoldin subunit 4Add BLAST | 133 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 125 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9NQP4 |
jPOSTi | Q9NQP4 |
MassIVEi | Q9NQP4 |
MaxQBi | Q9NQP4 |
PaxDbi | Q9NQP4 |
PeptideAtlasi | Q9NQP4 |
PRIDEi | Q9NQP4 |
ProteomicsDBi | 82167 |
TopDownProteomicsi | Q9NQP4 |
PTM databases
GlyGeni | Q9NQP4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NQP4 |
PhosphoSitePlusi | Q9NQP4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000101132, Expressed in neocortex and 245 other tissues |
ExpressionAtlasi | Q9NQP4, baseline and differential |
Genevisiblei | Q9NQP4, HS |
Organism-specific databases
HPAi | ENSG00000101132, Low tissue specificity |
Interactioni
Subunit structurei
Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.
1 PublicationBinary interactionsi
GO - Molecular functioni
- chaperone binding Source: UniProtKB
- unfolded protein binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 111225, 105 interactors |
ComplexPortali | CPX-6149, Prefoldin co-chaperone complex |
CORUMi | Q9NQP4 |
IntActi | Q9NQP4, 51 interactors |
MINTi | Q9NQP4 |
STRINGi | 9606.ENSP00000360473 |
Miscellaneous databases
RNActi | Q9NQP4, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1760, Eukaryota |
GeneTreei | ENSGT00390000006696 |
HOGENOMi | CLU_130032_0_1_1 |
InParanoidi | Q9NQP4 |
OMAi | IQYKIGD |
OrthoDBi | 1459797at2759 |
PhylomeDBi | Q9NQP4 |
TreeFami | TF106491 |
Family and domain databases
Gene3Di | 1.10.287.370, 1 hit |
InterProi | View protein in InterPro IPR002777, PFD_beta-like IPR016661, PFDN4 IPR009053, Prefoldin |
PANTHERi | PTHR21100, PTHR21100, 1 hit |
Pfami | View protein in Pfam PF01920, Prefoldin_2, 1 hit |
PIRSFi | PIRSF016477, Prefoldin_subunit_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAATMKKAAA EDVNVTFEDQ QKINKFARNT SRITELKEEI EVKKKQLQNL
60 70 80 90 100
EDACDDIMLA DDDCLMIPYQ IGDVFISHSQ EETQEMLEEA KKNLQEEIDA
110 120 130
LESRVESIQR VLADLKVQLY AKFGSNINLE ADES
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PQY2 | E9PQY2_HUMAN | Prefoldin subunit 4 | PFDN4 | 136 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U41816 mRNA Translation: AAB17063.1 AL133335 Genomic DNA No translation available. BC010953 mRNA Translation: AAH10953.1 |
CCDSi | CCDS13445.1 |
RefSeqi | NP_002614.2, NM_002623.3 |
Genome annotation databases
Ensembli | ENST00000371419; ENSP00000360473; ENSG00000101132 |
GeneIDi | 5203 |
KEGGi | hsa:5203 |
MANE-Selecti | ENST00000371419.7; ENSP00000360473.2; NM_002623.4; NP_002614.2 |
UCSCi | uc002xwx.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U41816 mRNA Translation: AAB17063.1 AL133335 Genomic DNA No translation available. BC010953 mRNA Translation: AAH10953.1 |
CCDSi | CCDS13445.1 |
RefSeqi | NP_002614.2, NM_002623.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6NR8 | electron microscopy | 7.80 | 4 | 19-122 | [»] | |
6NR9 | electron microscopy | 8.50 | 4 | 19-122 | [»] | |
6NRB | electron microscopy | 8.70 | 4 | 19-122 | [»] | |
6NRC | electron microscopy | 8.30 | 4 | 19-122 | [»] | |
6NRD | electron microscopy | 8.20 | 4 | 19-122 | [»] | |
SMRi | Q9NQP4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111225, 105 interactors |
ComplexPortali | CPX-6149, Prefoldin co-chaperone complex |
CORUMi | Q9NQP4 |
IntActi | Q9NQP4, 51 interactors |
MINTi | Q9NQP4 |
STRINGi | 9606.ENSP00000360473 |
PTM databases
GlyGeni | Q9NQP4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NQP4 |
PhosphoSitePlusi | Q9NQP4 |
Genetic variation databases
BioMutai | PFDN4 |
DMDMi | 12643815 |
Proteomic databases
EPDi | Q9NQP4 |
jPOSTi | Q9NQP4 |
MassIVEi | Q9NQP4 |
MaxQBi | Q9NQP4 |
PaxDbi | Q9NQP4 |
PeptideAtlasi | Q9NQP4 |
PRIDEi | Q9NQP4 |
ProteomicsDBi | 82167 |
TopDownProteomicsi | Q9NQP4 |
Protocols and materials databases
Antibodypediai | 13961, 162 antibodies from 23 providers |
DNASUi | 5203 |
Genome annotation databases
Ensembli | ENST00000371419; ENSP00000360473; ENSG00000101132 |
GeneIDi | 5203 |
KEGGi | hsa:5203 |
MANE-Selecti | ENST00000371419.7; ENSP00000360473.2; NM_002623.4; NP_002614.2 |
UCSCi | uc002xwx.4, human |
Organism-specific databases
CTDi | 5203 |
DisGeNETi | 5203 |
GeneCardsi | PFDN4 |
HGNCi | HGNC:8868, PFDN4 |
HPAi | ENSG00000101132, Low tissue specificity |
MIMi | 604898, gene |
neXtProti | NX_Q9NQP4 |
OpenTargetsi | ENSG00000101132 |
PharmGKBi | PA33209 |
VEuPathDBi | HostDB:ENSG00000101132 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1760, Eukaryota |
GeneTreei | ENSGT00390000006696 |
HOGENOMi | CLU_130032_0_1_1 |
InParanoidi | Q9NQP4 |
OMAi | IQYKIGD |
OrthoDBi | 1459797at2759 |
PhylomeDBi | Q9NQP4 |
TreeFami | TF106491 |
Enzyme and pathway databases
PathwayCommonsi | Q9NQP4 |
Reactomei | R-HSA-389957, Prefoldin mediated transfer of substrate to CCT/TriC |
SignaLinki | Q9NQP4 |
SIGNORi | Q9NQP4 |
Miscellaneous databases
BioGRID-ORCSi | 5203, 190 hits in 1034 CRISPR screens |
ChiTaRSi | PFDN4, human |
GeneWikii | PFDN4 |
GenomeRNAii | 5203 |
Pharosi | Q9NQP4, Tbio |
PROi | PR:Q9NQP4 |
RNActi | Q9NQP4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101132, Expressed in neocortex and 245 other tissues |
ExpressionAtlasi | Q9NQP4, baseline and differential |
Genevisiblei | Q9NQP4, HS |
Family and domain databases
Gene3Di | 1.10.287.370, 1 hit |
InterProi | View protein in InterPro IPR002777, PFD_beta-like IPR016661, PFDN4 IPR009053, Prefoldin |
PANTHERi | PTHR21100, PTHR21100, 1 hit |
Pfami | View protein in Pfam PF01920, Prefoldin_2, 1 hit |
PIRSFi | PIRSF016477, Prefoldin_subunit_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PFD4_HUMAN | |
Accessioni | Q9NQP4Primary (citable) accession number: Q9NQP4 Secondary accession number(s): Q5TD11, Q92779 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families