PFDN4

Functionⁱ

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.1 Publication

GO - Molecular functionⁱ

chaperone binding
Source: UniProtKB
Traceable author statementⁱ
- 9630229
unfolded protein binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein folding
Source: UniProtKB
Traceable author statementⁱ
- 9630229

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone

Molecular function

Chaperone

Enzyme and pathway databases

Reactomeⁱ	R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
SIGNORⁱ	Q9NQP4

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Prefoldin subunit 4 Alternative name(s): Protein C-1
Gene namesⁱ	Name:PFDN4 Synonyms:PFD4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101132.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8868 PFDN4
MIMⁱ	604898 gene
neXtProtⁱ	NX_Q9NQP4

Keywords - Cellular componentⁱ

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5203
Open Targets More...OpenTargetsⁱ	ENSG00000101132
PharmGKBⁱ	PA33209

Polymorphism and mutation databases

BioMutaⁱ	PFDN4
DMDMⁱ	12643815

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000124842	2 – 134	Prefoldin subunit 4Add BLAST		133

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1
Modified residueⁱ	125	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9NQP4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NQP4
PaxDbⁱ	Q9NQP4
PeptideAtlas More...PeptideAtlasⁱ	Q9NQP4
PRIDEⁱ	Q9NQP4
ProteomicsDBⁱ	82167
TopDownProteomicsⁱ	Q9NQP4

PTM databases

iPTMnetⁱ	Q9NQP4
PhosphoSitePlusⁱ	Q9NQP4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000101132 Expressed in 234 organ(s), highest expression level in neocortex
CleanExⁱ	HS_PFDN4
ExpressionAtlasⁱ	Q9NQP4 baseline and differential
Genevisibleⁱ	Q9NQP4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024055

HPAⁱ

HPA024055

Interactionⁱ

Subunit structureⁱ

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
VBP1	P61758	5	EBI-357021,EBI-357430

With

Entry

#Exp.

IntAct

Notes

VBP1

P61758

5

EBI-357021,EBI-357430

GO - Molecular functionⁱ

chaperone binding
Source: UniProtKB
Traceable author statementⁱ
- 9630229
unfolded protein binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111225, 66 interactors
CORUMⁱ	Q9NQP4
IntActⁱ	Q9NQP4, 19 interactors
STRINGⁱ	9606.ENSP00000360473

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NQP4
SMRⁱ	Q9NQP4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1760 Eukaryota COG1382 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006696
HOGENOMⁱ	HOG000204477
HOVERGENⁱ	HBG005034
InParanoidⁱ	Q9NQP4
KEGG Orthology (KO) More...KOⁱ	K09550
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G10MO
PhylomeDBⁱ	Q9NQP4
TreeFamⁱ	TF106491

Family and domain databases

Gene3Dⁱ	1.10.287.370, 1 hit
InterProⁱ	View protein in InterPro IPR002777 PFD_beta-like IPR016661 PFDN4 IPR009053 Prefoldin
PANTHERⁱ	PTHR21100 PTHR21100, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01920 Prefoldin_2, 1 hit
PIRSFⁱ	PIRSF016477 Prefoldin_subunit_4, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9NQP4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAATMKKAAA EDVNVTFEDQ QKINKFARNT SRITELKEEI EVKKKQLQNL 
        60         70         80         90        100
EDACDDIMLA DDDCLMIPYQ IGDVFISHSQ EETQEMLEEA KKNLQEEIDA 
       110        120        130 
LESRVESIQR VLADLKVQLY AKFGSNINLE ADES

Length:134

Mass (Da):15,314

Last modified:October 1, 2000 - v1

Checksum:ⁱC727F0FCB9343DC3

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E9PQY2	E9PQY2_HUMAN		Prefoldin subunit 4 Prefoldin subunit 4	PFDN4	136	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U41816 mRNA Translation: AAB17063.1 AL133335 Genomic DNA No translation available. BC010953 mRNA Translation: AAH10953.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13445.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002614.2, NM_002623.3
UniGeneⁱ	Hs.91161

Genome annotation databases

Ensemblⁱ	ENST00000371419; ENSP00000360473; ENSG00000101132
GeneIDⁱ	5203
KEGGⁱ	hsa:5203
UCSC genome browser More...UCSCⁱ	uc002xwx.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NQP4	Prefoldin subunit 4		CALJA		134	UniRef100_Q9NQP4
Prefoldin subunit 4		PANTR		134
Prefoldin subunit 4		MACMU		134
Prefoldin subunit 4		MACFA		134
Prefoldin subunit 4		PONAB		134
+14

Protein	Similar proteins		Species	Score	Length	Source
Q9NQP4	Prefoldin subunit 4		BOVIN		134	UniRef90_Q9NQP4
Prefoldin subunit 4		CALJA		134
Prefoldin subunit 4		PANTR		134
Prefoldin subunit 4		MACMU		134
Prefoldin subunit 4		MACFA		134
+46

Protein	Similar proteins		Species	Score	Length	Source
Q9NQP4	Prefoldin subunit 4		BOVIN		134	UniRef50_Q9NQP4
Prefoldin subunit 4		CALJA		134
Prefoldin subunit 4		PANTR		134
Prefoldin subunit 4		MACMU		134
Prefoldin subunit 4		MACFA		134
+285

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U41816 mRNA Translation: AAB17063.1 AL133335 Genomic DNA No translation available. BC010953 mRNA Translation: AAH10953.1
CCDSⁱ	CCDS13445.1
RefSeqⁱ	NP_002614.2, NM_002623.3
UniGeneⁱ	Hs.91161

3D structure databases

ProteinModelPortalⁱ	Q9NQP4
SMRⁱ	Q9NQP4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111225, 66 interactors
CORUMⁱ	Q9NQP4
IntActⁱ	Q9NQP4, 19 interactors
STRINGⁱ	9606.ENSP00000360473

PTM databases

iPTMnetⁱ	Q9NQP4
PhosphoSitePlusⁱ	Q9NQP4

Polymorphism and mutation databases

BioMutaⁱ	PFDN4
DMDMⁱ	12643815

Proteomic databases

EPDⁱ	Q9NQP4
MaxQBⁱ	Q9NQP4
PaxDbⁱ	Q9NQP4
PeptideAtlasⁱ	Q9NQP4
PRIDEⁱ	Q9NQP4
ProteomicsDBⁱ	82167
TopDownProteomicsⁱ	Q9NQP4

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5203
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371419; ENSP00000360473; ENSG00000101132
GeneIDⁱ	5203
KEGGⁱ	hsa:5203
UCSCⁱ	uc002xwx.4 human

Organism-specific databases

CTDⁱ	5203
DisGeNETⁱ	5203
EuPathDBⁱ	HostDB:ENSG00000101132.9
GeneCardsⁱ	PFDN4
HGNCⁱ	HGNC:8868 PFDN4
HPAⁱ	HPA024055
MIMⁱ	604898 gene
neXtProtⁱ	NX_Q9NQP4
OpenTargetsⁱ	ENSG00000101132
PharmGKBⁱ	PA33209
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1760 Eukaryota COG1382 LUCA
GeneTreeⁱ	ENSGT00390000006696
HOGENOMⁱ	HOG000204477
HOVERGENⁱ	HBG005034
InParanoidⁱ	Q9NQP4
KOⁱ	K09550
OrthoDBⁱ	EOG091G10MO
PhylomeDBⁱ	Q9NQP4
TreeFamⁱ	TF106491

Enzyme and pathway databases

Reactomeⁱ	R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
SIGNORⁱ	Q9NQP4

Miscellaneous databases

ChiTaRSⁱ	PFDN4 human
GeneWikiⁱ	PFDN4
GenomeRNAiⁱ	5203
Protein Ontology More...PROⁱ	PR:Q9NQP4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101132 Expressed in 234 organ(s), highest expression level in neocortex
CleanExⁱ	HS_PFDN4
ExpressionAtlasⁱ	Q9NQP4 baseline and differential
Genevisibleⁱ	Q9NQP4 HS

Family and domain databases

Gene3Dⁱ	1.10.287.370, 1 hit
InterProⁱ	View protein in InterPro IPR002777 PFD_beta-like IPR016661 PFDN4 IPR009053 Prefoldin
PANTHERⁱ	PTHR21100 PTHR21100, 1 hit
Pfamⁱ	View protein in Pfam PF01920 Prefoldin_2, 1 hit
PIRSFⁱ	PIRSF016477 Prefoldin_subunit_4, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PFD4_HUMAN
Accessionⁱ	Q9NQP4Primary (citable) accession number: Q9NQP4 Secondary accession number(s): Q5TD11, Q92779
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniProtKB - Q9NQP4 (PFD4_HUMAN)

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Prefoldin subunit 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Nucleus

Other locations

Cytosol

Mitochondrion

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ