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Protein

Prefoldin subunit 4

Gene

PFDN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.1 Publication

GO - Molecular functioni

  • chaperone binding Source: UniProtKB
  • unfolded protein binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
SIGNORiQ9NQP4

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 4
Alternative name(s):
Protein C-1
Gene namesi
Name:PFDN4
Synonyms:PFD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101132.9
HGNCiHGNC:8868 PFDN4
MIMi604898 gene
neXtProtiNX_Q9NQP4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5203
OpenTargetsiENSG00000101132
PharmGKBiPA33209

Polymorphism and mutation databases

BioMutaiPFDN4
DMDMi12643815

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001248422 – 134Prefoldin subunit 4Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei125PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NQP4
MaxQBiQ9NQP4
PaxDbiQ9NQP4
PeptideAtlasiQ9NQP4
PRIDEiQ9NQP4
ProteomicsDBi82167
TopDownProteomicsiQ9NQP4

PTM databases

iPTMnetiQ9NQP4
PhosphoSitePlusiQ9NQP4

Expressioni

Gene expression databases

BgeeiENSG00000101132 Expressed in 234 organ(s), highest expression level in neocortex
CleanExiHS_PFDN4
ExpressionAtlasiQ9NQP4 baseline and differential
GenevisibleiQ9NQP4 HS

Organism-specific databases

HPAiHPA024055

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
VBP1P617585EBI-357021,EBI-357430

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111225, 66 interactors
CORUMiQ9NQP4
IntActiQ9NQP4, 19 interactors
STRINGi9606.ENSP00000360473

Structurei

3D structure databases

ProteinModelPortaliQ9NQP4
SMRiQ9NQP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiKOG1760 Eukaryota
COG1382 LUCA
GeneTreeiENSGT00390000006696
HOGENOMiHOG000204477
HOVERGENiHBG005034
InParanoidiQ9NQP4
KOiK09550
OrthoDBiEOG091G10MO
PhylomeDBiQ9NQP4
TreeFamiTF106491

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR002777 PFD_beta-like
IPR016661 PFDN4
IPR009053 Prefoldin
PANTHERiPTHR21100 PTHR21100, 1 hit
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit
PIRSFiPIRSF016477 Prefoldin_subunit_4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9NQP4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATMKKAAA EDVNVTFEDQ QKINKFARNT SRITELKEEI EVKKKQLQNL
60 70 80 90 100
EDACDDIMLA DDDCLMIPYQ IGDVFISHSQ EETQEMLEEA KKNLQEEIDA
110 120 130
LESRVESIQR VLADLKVQLY AKFGSNINLE ADES
Length:134
Mass (Da):15,314
Last modified:October 1, 2000 - v1
Checksum:iC727F0FCB9343DC3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQY2E9PQY2_HUMAN
Prefoldin subunit 4
PFDN4
136Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41816 mRNA Translation: AAB17063.1
AL133335 Genomic DNA No translation available.
BC010953 mRNA Translation: AAH10953.1
CCDSiCCDS13445.1
RefSeqiNP_002614.2, NM_002623.3
UniGeneiHs.91161

Genome annotation databases

EnsembliENST00000371419; ENSP00000360473; ENSG00000101132
GeneIDi5203
KEGGihsa:5203
UCSCiuc002xwx.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41816 mRNA Translation: AAB17063.1
AL133335 Genomic DNA No translation available.
BC010953 mRNA Translation: AAH10953.1
CCDSiCCDS13445.1
RefSeqiNP_002614.2, NM_002623.3
UniGeneiHs.91161

3D structure databases

ProteinModelPortaliQ9NQP4
SMRiQ9NQP4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111225, 66 interactors
CORUMiQ9NQP4
IntActiQ9NQP4, 19 interactors
STRINGi9606.ENSP00000360473

PTM databases

iPTMnetiQ9NQP4
PhosphoSitePlusiQ9NQP4

Polymorphism and mutation databases

BioMutaiPFDN4
DMDMi12643815

Proteomic databases

EPDiQ9NQP4
MaxQBiQ9NQP4
PaxDbiQ9NQP4
PeptideAtlasiQ9NQP4
PRIDEiQ9NQP4
ProteomicsDBi82167
TopDownProteomicsiQ9NQP4

Protocols and materials databases

DNASUi5203
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371419; ENSP00000360473; ENSG00000101132
GeneIDi5203
KEGGihsa:5203
UCSCiuc002xwx.4 human

Organism-specific databases

CTDi5203
DisGeNETi5203
EuPathDBiHostDB:ENSG00000101132.9
GeneCardsiPFDN4
HGNCiHGNC:8868 PFDN4
HPAiHPA024055
MIMi604898 gene
neXtProtiNX_Q9NQP4
OpenTargetsiENSG00000101132
PharmGKBiPA33209
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1760 Eukaryota
COG1382 LUCA
GeneTreeiENSGT00390000006696
HOGENOMiHOG000204477
HOVERGENiHBG005034
InParanoidiQ9NQP4
KOiK09550
OrthoDBiEOG091G10MO
PhylomeDBiQ9NQP4
TreeFamiTF106491

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
SIGNORiQ9NQP4

Miscellaneous databases

ChiTaRSiPFDN4 human
GeneWikiiPFDN4
GenomeRNAii5203
PROiPR:Q9NQP4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101132 Expressed in 234 organ(s), highest expression level in neocortex
CleanExiHS_PFDN4
ExpressionAtlasiQ9NQP4 baseline and differential
GenevisibleiQ9NQP4 HS

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR002777 PFD_beta-like
IPR016661 PFDN4
IPR009053 Prefoldin
PANTHERiPTHR21100 PTHR21100, 1 hit
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit
PIRSFiPIRSF016477 Prefoldin_subunit_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPFD4_HUMAN
AccessioniPrimary (citable) accession number: Q9NQP4
Secondary accession number(s): Q5TD11, Q92779
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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