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Protein

Olfactory receptor 2S2

Gene

OR2S2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2S2
Alternative name(s):
Olfactory receptor OR9-3
Gene namesi
Name:OR2S2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000122718.5
HostDB:ENSG00000278889.3
HGNCiHGNC:8276 OR2S2
neXtProtiNX_Q9NQN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 50Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini51 – 58CytoplasmicSequence analysis8
Transmembranei59 – 80Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini81 – 101ExtracellularSequence analysisAdd BLAST21
Transmembranei102 – 121Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 159Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini160 – 196ExtracellularSequence analysisAdd BLAST37
Transmembranei197 – 220Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini221 – 237CytoplasmicSequence analysisAdd BLAST17
Transmembranei238 – 260Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini261 – 279ExtracellularSequence analysisAdd BLAST19
Transmembranei280 – 299Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini300 – 319CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56656
PharmGKBiPA32200

Polymorphism and mutation databases

BioMutaiOR2S2
DMDMi14423818

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504951 – 319Olfactory receptor 2S2Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NQN1
PRIDEiQ9NQN1
ProteomicsDBi82165

PTM databases

iPTMnetiQ9NQN1
PhosphoSitePlusiQ9NQN1

Expressioni

Gene expression databases

BgeeiENSG00000122718
CleanExiHS_OR2S2
GenevisibleiQ9NQN1 HS

Interactioni

Protein-protein interaction databases

BioGridi121169, 2 interactors
STRINGi9606.ENSP00000344040

Structurei

3D structure databases

ProteinModelPortaliQ9NQN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IENR Eukaryota
ENOG4111CQX LUCA
GeneTreeiENSGT00760000119058
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ9NQN1
KOiK04257
OMAiMEVTNVI
OrthoDBiEOG091G0CU6
PhylomeDBiQ9NQN1
TreeFamiTF352686

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NQN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKANETSPV MGFVLLRLSA HPELEKTFFV LILLMYLVIL LGNGVLILVT
60 70 80 90 100
ILDSRLHTPM YFFLGNLSFL DICFTTSSVP LVLDSFLTPQ ETISFSACAV
110 120 130 140 150
QMALSFAMAG TECLLLSMMA FDRYVAICNP LRYSVIMSKA AYMPMAASSW
160 170 180 190 200
AIGGAASVVH TSLAIQLPFC GDNVINHFTC EILAVLKLAC ADISINVISM
210 220 230 240 250
EVTNVIFLGV PVLFISFSYV FIITTILRIP SAEGRKKVFS TCSAHLTVVI
260 270 280 290 300
VFYGTLFFMY GKPKSKDSMG ADKEDLSDKL IPLFYGVVTP MLNPIIYSLR
310
NKDVKAAVRR LLRPKGFTQ
Length:319
Mass (Da):35,172
Last modified:June 20, 2001 - v2
Checksum:i602602FCA96A179F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05999417R → G. Corresponds to variant dbSNP:rs2233558Ensembl.1
Natural variantiVAR_05999530V → M. Corresponds to variant dbSNP:rs2233559Ensembl.1
Natural variantiVAR_05999689P → S. Corresponds to variant dbSNP:rs2233560Ensembl.1
Natural variantiVAR_059997123R → H. Corresponds to variant dbSNP:rs2233563Ensembl.1
Natural variantiVAR_059998143M → V. Corresponds to variant dbSNP:rs2233564Ensembl.1
Natural variantiVAR_059999161T → A. Corresponds to variant dbSNP:rs2233565Ensembl.1
Natural variantiVAR_060000287V → A. Corresponds to variant dbSNP:rs2233570Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135841 Genomic DNA No translation available.
BC104869 mRNA Translation: AAI04870.1
BC113651 mRNA Translation: AAI13652.1
AF399601 Genomic DNA Translation: AAK95086.1
BK004443 Genomic DNA Translation: DAA04841.1
CCDSiCCDS6596.2
RefSeqiNP_063950.2, NM_019897.2
UniGeneiHs.553540

Genome annotation databases

EnsembliENST00000341959; ENSP00000344040; ENSG00000278889
GeneIDi56656
KEGGihsa:56656
UCSCiuc011lpi.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR2S1_HUMAN
AccessioniPrimary (citable) accession number: Q9NQN1
Secondary accession number(s): Q2M3L0, Q6IF19, Q96R42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: June 20, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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