UniProtKB - Q9NQL2 (RRAGD_HUMAN)

BLAST

>sp|Q9NQL2|RRAGD_HUMAN Ras-related GTP-binding protein D OS=Homo sapiens OX=9606 GN=RRAGD PE=1 SV=1
MSQVLGKPQPQDEDDAEEEEEEDELVGLADYGDGPDSSDADPDSGTEEGVLDFSDPFSTE
VKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKICREDVSNSSFVNFQIWDFPG
QIDFFDPTFDYEMIFRGTGALIFVIDSQDDYMEALARLHLTVTRAYKVNTDINFEVFIHK
VDGLSDDHKIETQRDIHQRANDDLADAGLEKIHLSFYLTSIYDHSIFEAFSKVVQKLIPQ
LPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSTPVDMQTYELCCDMIDVVIDISCIY
GLKEDGAGTPYDKESTAIIKLNNTTVLYLKEVTKFLALVCFVREESFERKGLIDYNFHCF
RKAIHEVFEVRMKVVKSRKVQNRLQKKKRATPNGTPRVLL

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History
Entry version 127 (07 Nov 2018)
Sequence version 1 (01 Oct 2000)
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Protein

Ras-related GTP-binding protein D

Gene

RRAGD

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	69 – 77	GTP	9
Nucleotide bindingⁱ	117 – 121	GTP	5
Nucleotide bindingⁱ	179 – 182	GTP	4

GO - Molecular functionⁱ

GDP binding
Source: CAFA
Inferred from mutant phenotypeⁱ
- 22424946
GTPase activity
Source: CAFA
Inferred from mutant phenotypeⁱ
- 22424946
GTPase binding
Source: CAFA
Inferred from physical interactionⁱ
- 22424946
GTP binding
Source: CAFA
Inferred from mutant phenotypeⁱ
- 22424946
protein heterodimerization activity
Source: CAFA
Inferred from mutant phenotypeⁱ
- 22424946

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle arrest Source: Reactome
cellular protein localization Source: UniProtKB
cellular response to amino acid stimulus Source: UniProtKB
cellular response to leucine
Source: CAFA
Inferred from mutant phenotypeⁱ
- 22424946
cellular response to leucine starvation
Source: CAFA
Inferred from mutant phenotypeⁱ
- 22424946
cellular response to starvation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of TORC1 signaling
Source: CAFA
Inferred from mutant phenotypeⁱ
- 22424946
positive regulation of TOR signaling
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of autophagy
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of macroautophagy Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1632852 Macroautophagy R-HSA-165159 mTOR signalling R-HSA-166208 mTORC1-mediated signalling R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORⁱ	Q9NQL2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related GTP-binding protein D Short name: Rag D Short name: RagD
Gene namesⁱ	Name:RRAGDImported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000025039.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19903 RRAGD
MIMⁱ	608268 gene
neXtProtⁱ	NX_Q9NQL2

Keywords - Cellular componentⁱ

Cytoplasm, Lysosome, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	76	S → L: Increased RPTOR-binding. 1 Publication		1
Mutagenesisⁱ	121	Q → L: Decreased RPTOR-binding. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	58528
Open Targets More...OpenTargetsⁱ	ENSG00000025039
PharmGKBⁱ	PA134957148

Polymorphism and mutation databases

BioMutaⁱ	RRAGD
DMDMⁱ	74752904

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000239953	1 – 400	Ras-related GTP-binding protein DAdd BLAST		400

Proteomic databases

EPDⁱ	Q9NQL2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NQL2
PaxDbⁱ	Q9NQL2
PeptideAtlas More...PeptideAtlasⁱ	Q9NQL2
PRIDEⁱ	Q9NQL2
ProteomicsDBⁱ	82161 82162 [Q9NQL2-2]

PTM databases

iPTMnetⁱ	Q9NQL2
PhosphoSitePlusⁱ	Q9NQL2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000025039 Expressed in 240 organ(s), highest expression level in saliva-secreting gland
CleanExⁱ	HS_RRAGD
Genevisibleⁱ	Q9NQL2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA068664

HPAⁱ

HPA068664

Interactionⁱ

Subunit structureⁱ

Forms a heterodimer with RRAGA in a sequence-independent manner and RRAGB. Heterodimerization stabilizes RRAG proteins. In complex with RRAGB, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. Interacts with NOL8. Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGD and is negatively regulated by amino acids (PubMed:11073942, PubMed:14660641, PubMed:18497260, PubMed:22575674, Ref. 14). The Rag heterodimer interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with SESN1, SESN2 AND SESN3 (PubMed:25259925).8 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
LARS	Q9P2J5	13	EBI-992949,EBI-356077
RRAGA	Q7L523	8	EBI-992949,EBI-752376
RRAGB	Q5VZM2	7	EBI-992949,EBI-993049

GO - Molecular functionⁱ

GTPase binding
Source: CAFA
Inferred from physical interactionⁱ
- 22424946
protein heterodimerization activity
Source: CAFA
Inferred from mutant phenotypeⁱ
- 22424946

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121848, 14 interactors
IntActⁱ	Q9NQL2, 10 interactors
STRINGⁱ	9606.ENSP00000358423

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	64 – 70	Combined sources	7
Helixⁱ	75 – 84	Combined sources	10
Helixⁱ	88 – 93	Combined sources	6
Beta strandⁱ	101 – 105	Combined sources	5
Beta strandⁱ	113 – 117	Combined sources	5
Helixⁱ	131 – 136	Combined sources	6
Beta strandⁱ	138 – 146	Combined sources	9
Helixⁱ	152 – 168	Combined sources	17
Beta strandⁱ	173 – 179	Combined sources	7
Helixⁱ	181 – 183	Combined sources	3
Helixⁱ	188 – 206	Combined sources	19
Beta strandⁱ	214 – 219	Combined sources	6
Helixⁱ	225 – 235	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NQL2
SMRⁱ	Q9NQL2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9NQL2

EvolutionaryTraceⁱ

Q9NQL2

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GTR/RAG GTP-binding protein family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3887 Eukaryota ENOG410XQS9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074708
HOGENOMⁱ	HOG000203695
HOVERGENⁱ	HBG059482
InParanoidⁱ	Q9NQL2
KEGG Orthology (KO) More...KOⁱ	K16186
OMAⁱ	DIQTYEV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AN4
PhylomeDBⁱ	Q9NQL2
TreeFamⁱ	TF300659

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11385 RagC_like, 1 hit
InterProⁱ	View protein in InterPro IPR006762 Gtr1_RagA IPR027417 P-loop_NTPase IPR039400 RagC/D
PANTHERⁱ	PTHR11259 PTHR11259, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04670 Gtr1_RagA, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 11 Publication (identifier: Q9NQL2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQVLGKPQP QDEDDAEEEE EEDELVGLAD YGDGPDSSDA DPDSGTEEGV 
        60         70         80         90        100
LDFSDPFSTE VKPRILLMGL RRSGKSSIQK VVFHKMSPNE TLFLESTNKI 
       110        120        130        140        150
CREDVSNSSF VNFQIWDFPG QIDFFDPTFD YEMIFRGTGA LIFVIDSQDD 
       160        170        180        190        200
YMEALARLHL TVTRAYKVNT DINFEVFIHK VDGLSDDHKI ETQRDIHQRA 
       210        220        230        240        250
NDDLADAGLE KIHLSFYLTS IYDHSIFEAF SKVVQKLIPQ LPTLENLLNI 
       260        270        280        290        300
FISNSGIEKA FLFDVVSKIY IATDSTPVDM QTYELCCDMI DVVIDISCIY 
       310        320        330        340        350
GLKEDGAGTP YDKESTAIIK LNNTTVLYLK EVTKFLALVC FVREESFERK 
       360        370        380        390        400
GLIDYNFHCF RKAIHEVFEV RMKVVKSRKV QNRLQKKKRA TPNGTPRVLL

Length:400

Mass (Da):45,588

Last modified:October 1, 2000 - v1

Checksum:ⁱ96FF0854B11AA1BC

Isoform 21 Publication (identifier: Q9NQL2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-151: Missing.

« Hide

        10         20         30         40         50
MEALARLHLT VTRAYKVNTD INFEVFIHKV DGLSDDHKIE TQRDIHQRAN 
        60         70         80         90        100
DDLADAGLEK IHLSFYLTSI YDHSIFEAFS KVVQKLIPQL PTLENLLNIF 
       110        120        130        140        150
ISNSGIEKAF LFDVVSKIYI ATDSTPVDMQ TYELCCDMID VVIDISCIYG 
       160        170        180        190        200
LKEDGAGTPY DKESTAIIKL NNTTVLYLKE VTKFLALVCF VREESFERKG 
       210        220        230        240 
LIDYNFHCFR KAIHEVFEVR MKVVKSRKVQ NRLQKKKRAT PNGTPRVLL

Note: No experimental confirmation available.Curated

Show »

Length:249

Mass (Da):28,611

Checksum:ⁱ4A6435D188BE8283

Sequence cautionⁱ

The sequence AAH03088 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_052078	1 – 151	Missing in isoform 2. 1 PublicationAdd BLAST		151

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF272036 mRNA Translation: AAG32663.1 AK289799 mRNA Translation: BAF82488.1 AL138717 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48554.1 AL137502 mRNA Translation: CAB70775.2 BC003088 mRNA Translation: AAH03088.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5022.1 [Q9NQL2-1]
PIRⁱ	T46254
NCBI Reference Sequences More...RefSeqⁱ	NP_067067.1, NM_021244.4 [Q9NQL2-1]
UniGeneⁱ	Hs.31712

Genome annotation databases

Ensemblⁱ	ENST00000359203; ENSP00000352131; ENSG00000025039 [Q9NQL2-2] ENST00000369415; ENSP00000358423; ENSG00000025039 [Q9NQL2-1]
GeneIDⁱ	58528
KEGGⁱ	hsa:58528
UCSC genome browser More...UCSCⁱ	uc003pnd.5 human [Q9NQL2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NQL2	RRAGD isoform 1		PANTR		400	UniRef100_Q9NQL2
RRAGD isoform 1		PONAB		400
Uncharacterized protein		PANPA		400
Uncharacterized protein		NOMLE		400
Ras related GTP binding D		GORGO		400
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9NQL2	RRAGD isoform 1		PANTR		400	UniRef90_Q9NQL2
RRAGD isoform 1		PONAB		400
Uncharacterized protein		PANPA		400
Uncharacterized protein		NOMLE		400
Ras related GTP binding D		GORGO		400
+82

Protein	Similar proteins		Species	Score	Length	Source
Q9NQL2	Ras-related GTP-binding protein C	)	HUMAN		399	UniRef50_Q9HB90
Ras-related GTP-binding protein C	)	MOUSE		398
RRAGC isoform 1		PANTR		399
Uncharacterized protein		CALJA		399
Uncharacterized protein		PAPAN		399
+263

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF272036 mRNA Translation: AAG32663.1 AK289799 mRNA Translation: BAF82488.1 AL138717 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48554.1 AL137502 mRNA Translation: CAB70775.2 BC003088 mRNA Translation: AAH03088.1 Different initiation.
CCDSⁱ	CCDS5022.1 [Q9NQL2-1]
PIRⁱ	T46254
RefSeqⁱ	NP_067067.1, NM_021244.4 [Q9NQL2-1]
UniGeneⁱ	Hs.31712

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2Q3F	X-ray	2.10	A/B	60-239	[»]
ProteinModelPortalⁱ	Q9NQL2
SMRⁱ	Q9NQL2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121848, 14 interactors
IntActⁱ	Q9NQL2, 10 interactors
STRINGⁱ	9606.ENSP00000358423

PTM databases

iPTMnetⁱ	Q9NQL2
PhosphoSitePlusⁱ	Q9NQL2

Polymorphism and mutation databases

BioMutaⁱ	RRAGD
DMDMⁱ	74752904

Proteomic databases

EPDⁱ	Q9NQL2
MaxQBⁱ	Q9NQL2
PaxDbⁱ	Q9NQL2
PeptideAtlasⁱ	Q9NQL2
PRIDEⁱ	Q9NQL2
ProteomicsDBⁱ	82161 82162 [Q9NQL2-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	58528
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000359203; ENSP00000352131; ENSG00000025039 [Q9NQL2-2] ENST00000369415; ENSP00000358423; ENSG00000025039 [Q9NQL2-1]
GeneIDⁱ	58528
KEGGⁱ	hsa:58528
UCSCⁱ	uc003pnd.5 human [Q9NQL2-1]

Organism-specific databases

CTDⁱ	58528
DisGeNETⁱ	58528
EuPathDBⁱ	HostDB:ENSG00000025039.14
GeneCardsⁱ	RRAGD
HGNCⁱ	HGNC:19903 RRAGD
HPAⁱ	HPA068664
MIMⁱ	608268 gene
neXtProtⁱ	NX_Q9NQL2
OpenTargetsⁱ	ENSG00000025039
PharmGKBⁱ	PA134957148
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3887 Eukaryota ENOG410XQS9 LUCA
GeneTreeⁱ	ENSGT00550000074708
HOGENOMⁱ	HOG000203695
HOVERGENⁱ	HBG059482
InParanoidⁱ	Q9NQL2
KOⁱ	K16186
OMAⁱ	DIQTYEV
OrthoDBⁱ	EOG091G0AN4
PhylomeDBⁱ	Q9NQL2
TreeFamⁱ	TF300659

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1632852 Macroautophagy R-HSA-165159 mTOR signalling R-HSA-166208 mTORC1-mediated signalling R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORⁱ	Q9NQL2

Miscellaneous databases

ChiTaRSⁱ	RRAGD human
EvolutionaryTraceⁱ	Q9NQL2
GenomeRNAiⁱ	58528
Protein Ontology More...PROⁱ	PR:Q9NQL2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000025039 Expressed in 240 organ(s), highest expression level in saliva-secreting gland
CleanExⁱ	HS_RRAGD
Genevisibleⁱ	Q9NQL2 HS

Family and domain databases

CDDⁱ	cd11385 RagC_like, 1 hit
InterProⁱ	View protein in InterPro IPR006762 Gtr1_RagA IPR027417 P-loop_NTPase IPR039400 RagC/D
PANTHERⁱ	PTHR11259 PTHR11259, 1 hit
Pfamⁱ	View protein in Pfam PF04670 Gtr1_RagA, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RRAGD_HUMAN
Accessionⁱ	Q9NQL2Primary (citable) accession number: Q9NQL2 Secondary accession number(s): A8K184, Q7L8F9, Q9NPG0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q9NQL2 (RRAGD_HUMAN)

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Ras-related GTP-binding protein D

RRAGD

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Nucleus

Other locations

Cytoskeleton

Cytosol

Endosome

Lysosome

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ