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Entry version 173 (12 Aug 2020)
Sequence version 2 (23 Jan 2002)
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Protein

Probable ATP-dependent RNA helicase DDX4

Gene

DDX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity). Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi332 – 339ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Helicase, Hydrolase
Biological processDifferentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.4.13, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NQI0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5601884, PIWI-interacting RNA (piRNA) biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX4 (EC:3.6.4.13By similarity)
Alternative name(s):
DEAD box protein 4
Vasa homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DDX4
Synonyms:VASA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000152670.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18700, DDX4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605281, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NQI0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54514

Open Targets

More...
OpenTargetsi
ENSG00000152670

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38646

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NQI0, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DDX4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20138033

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000549771 – 724Probable ATP-dependent RNA helicase DDX4Add BLAST724

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei222PhosphoserineBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei722PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NQI0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NQI0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NQI0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NQI0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NQI0

PeptideAtlas

More...
PeptideAtlasi
Q9NQI0

PRoteomics IDEntifications database

More...
PRIDEi
Q9NQI0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
14124
19429
82159 [Q9NQI0-1]
82160 [Q9NQI0-2]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00456933

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NQI0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NQI0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152670, Expressed in testis and 80 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NQI0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NQI0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000152670, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4 (By similarity).

Interacts with RANBP9 (PubMed:27622290).

Interacts with RANBP10.

Interacts with PIWIL2 and MAEL.

Interacts with ARNTL/BMAL1 and CLOCK.

Interacts with Tex19.1 and, probably, Tex19.2 (By similarity).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120009, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NQI0, 7 interactors

Molecular INTeraction database

More...
MINTi
Q9NQI0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000424838

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NQI0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NQI0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini319 – 502Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST184
Domaini530 – 675Helicase C-terminalPROSITE-ProRule annotationAdd BLAST146

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni228 – 247Interaction with RANBP91 PublicationAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi288 – 316Q motifAdd BLAST29
Motifi446 – 449DEAD boxBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi58 – 234Gly-richAdd BLAST177

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0335, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157507

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003041_16_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NQI0

KEGG Orthology (KO)

More...
KOi
K13982

Identification of Orthologs from Complete Genome Data

More...
OMAi
NRXSNND

Database of Orthologous Groups

More...
OrthoDBi
595675at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NQI0

TreeFam database of animal gene trees

More...
TreeFami
TF300364

Family and domain databases

Database of protein disorder

More...
DisProti
DP01065
DP01066 [Q9NQI0-2]

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR000629, RNA-helicase_DEAD-box_CS
IPR014014, RNA_helicase_DEAD_Q_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00039, DEAD_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51195, Q_MOTIF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDEDWEAEI NPHMSSYVPI FEKDRYSGEN GDNFNRTPAS SSEMDDGPSR
60 70 80 90 100
RDHFMKSGFA SGRNFGNRDA GECNKRDNTS TMGGFGVGKS FGNRGFSNSR
110 120 130 140 150
FEDGDSSGFW RESSNDCEDN PTRNRGFSKR GGYRDGNNSE ASGPYRRGGR
160 170 180 190 200
GSFRGCRGGF GLGSPNNDLD PDECMQRTGG LFGSRRPVLS GTGNGDTSQS
210 220 230 240 250
RSGSGSERGG YKGLNEEVIT GSGKNSWKSE AEGGESSDTQ GPKVTYIPPP
260 270 280 290 300
PPEDEDSIFA HYQTGINFDK YDTILVEVSG HDAPPAILTF EEANLCQTLN
310 320 330 340 350
NNIAKAGYTK LTPVQKYSIP IILAGRDLMA CAQTGSGKTA AFLLPILAHM
360 370 380 390 400
MHDGITASRF KELQEPECII VAPTRELVNQ IYLEARKFSF GTCVRAVVIY
410 420 430 440 450
GGTQLGHSIR QIVQGCNILC ATPGRLMDII GKEKIGLKQI KYLVLDEADR
460 470 480 490 500
MLDMGFGPEM KKLISCPGMP SKEQRQTLMF SATFPEEIQR LAAEFLKSNY
510 520 530 540 550
LFVAVGQVGG ACRDVQQTVL QVGQFSKREK LVEILRNIGD ERTMVFVETK
560 570 580 590 600
KKADFIATFL CQEKISTTSI HGDREQRERE QALGDFRFGK CPVLVATSVA
610 620 630 640 650
ARGLDIENVQ HVINFDLPST IDEYVHRIGR TGRCGNTGRA ISFFDLESDN
660 670 680 690 700
HLAQPLVKVL TDAQQDVPAW LEEIAFSTYI PGFSGSTRGN VFASVDTRKG
710 720
KSTLNTAGFS SSQAPNPVDD ESWD
Length:724
Mass (Da):79,308
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D313DD98B177067
GO
Isoform 2 (identifier: Q9NQI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-166: GYRDGNNSEASGPYRRGGRGSFRGCRGGFGLGSPN → D

Show »
Length:690
Mass (Da):75,821
Checksum:i8D37259B5DED0EBD
GO
Isoform 3 (identifier: Q9NQI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: MGDEDWEAEI...EDGDSSGFWR → MGSRNLFLTNSP
     132-166: GYRDGNNSEASGPYRRGGRGSFRGCRGGFGLGSPN → D
     209-225: GGYKGLNEEVITGSGKN → D

Show »
Length:575
Mass (Da):63,211
Checksum:i04F943C83BD71828
GO
Isoform 4 (identifier: Q9NQI0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-131: Missing.

Show »
Length:704
Mass (Da):77,056
Checksum:iA1A44F186461C9D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCM4D6RCM4_HUMAN
RNA helicase
DDX4
518Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y960H0Y960_HUMAN
RNA helicase
DDX4
305Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAF5D6RAF5_HUMAN
Probable ATP-dependent RNA helicase...
DDX4
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBL3D6RBL3_HUMAN
Probable ATP-dependent RNA helicase...
DDX4
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAT7D6RAT7_HUMAN
Probable ATP-dependent RNA helicase...
DDX4
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIB2D6RIB2_HUMAN
Probable ATP-dependent RNA helicase...
DDX4
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBW0H0YBW0_HUMAN
Probable ATP-dependent RNA helicase...
DDX4
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti240Q → R in BAG52716 (PubMed:14702039).Curated1
Sequence conflicti380Q → K in AAH47455 (PubMed:15489334).Curated1
Sequence conflicti556I → T in AAF86585 (PubMed:10920202).Curated1
Sequence conflicti713Q → R in AAF86585 (PubMed:10920202).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019574148G → D. Corresponds to variant dbSNP:rs2306259Ensembl.1
Natural variantiVAR_052159287I → V. Corresponds to variant dbSNP:rs2305123Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0461321 – 111MGDED…SGFWR → MGSRNLFLTNSP in isoform 3. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_047177112 – 131Missing in isoform 4. CuratedAdd BLAST20
Alternative sequenceiVSP_011197132 – 166GYRDG…LGSPN → D in isoform 2 and isoform 3. 2 PublicationsAdd BLAST35
Alternative sequenceiVSP_046133209 – 225GGYKG…GSGKN → D in isoform 3. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY004154 mRNA Translation: AAF86585.1
AF262962 mRNA Translation: AAF72705.1
AK093439 mRNA Translation: BAG52716.1
AK292417 mRNA Translation: BAF85106.1
AC016632 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54929.1
BC047455 mRNA Translation: AAH47455.1
BC088362 mRNA Translation: AAH88362.1
AL137462 mRNA Translation: CAB70750.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3969.1 [Q9NQI0-1]
CCDS47208.1 [Q9NQI0-2]
CCDS54854.1 [Q9NQI0-4]
CCDS54855.1 [Q9NQI0-3]

Protein sequence database of the Protein Information Resource

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PIRi
T46407

NCBI Reference Sequences

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RefSeqi
NP_001136021.1, NM_001142549.1 [Q9NQI0-2]
NP_001160005.1, NM_001166533.1 [Q9NQI0-4]
NP_001160006.1, NM_001166534.1 [Q9NQI0-3]
NP_077726.1, NM_024415.2 [Q9NQI0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000353507; ENSP00000334167; ENSG00000152670 [Q9NQI0-2]
ENST00000354991; ENSP00000347087; ENSG00000152670 [Q9NQI0-2]
ENST00000505374; ENSP00000424838; ENSG00000152670 [Q9NQI0-1]
ENST00000511853; ENSP00000423123; ENSG00000152670 [Q9NQI0-3]
ENST00000514278; ENSP00000425359; ENSG00000152670 [Q9NQI0-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54514

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54514

UCSC genome browser

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UCSCi
uc003jqg.5, human [Q9NQI0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004154 mRNA Translation: AAF86585.1
AF262962 mRNA Translation: AAF72705.1
AK093439 mRNA Translation: BAG52716.1
AK292417 mRNA Translation: BAF85106.1
AC016632 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54929.1
BC047455 mRNA Translation: AAH47455.1
BC088362 mRNA Translation: AAH88362.1
AL137462 mRNA Translation: CAB70750.1
CCDSiCCDS3969.1 [Q9NQI0-1]
CCDS47208.1 [Q9NQI0-2]
CCDS54854.1 [Q9NQI0-4]
CCDS54855.1 [Q9NQI0-3]
PIRiT46407
RefSeqiNP_001136021.1, NM_001142549.1 [Q9NQI0-2]
NP_001160005.1, NM_001166533.1 [Q9NQI0-4]
NP_001160006.1, NM_001166534.1 [Q9NQI0-3]
NP_077726.1, NM_024415.2 [Q9NQI0-1]

3D structure databases

SMRiQ9NQI0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120009, 13 interactors
IntActiQ9NQI0, 7 interactors
MINTiQ9NQI0
STRINGi9606.ENSP00000424838

PTM databases

iPTMnetiQ9NQI0
PhosphoSitePlusiQ9NQI0

Polymorphism and mutation databases

BioMutaiDDX4
DMDMi20138033

2D gel databases

REPRODUCTION-2DPAGEiIPI00456933

Proteomic databases

EPDiQ9NQI0
jPOSTiQ9NQI0
MassIVEiQ9NQI0
MaxQBiQ9NQI0
PaxDbiQ9NQI0
PeptideAtlasiQ9NQI0
PRIDEiQ9NQI0
ProteomicsDBi14124
19429
82159 [Q9NQI0-1]
82160 [Q9NQI0-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q9NQI0, 7 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23442, 362 antibodies

Genome annotation databases

EnsembliENST00000353507; ENSP00000334167; ENSG00000152670 [Q9NQI0-2]
ENST00000354991; ENSP00000347087; ENSG00000152670 [Q9NQI0-2]
ENST00000505374; ENSP00000424838; ENSG00000152670 [Q9NQI0-1]
ENST00000511853; ENSP00000423123; ENSG00000152670 [Q9NQI0-3]
ENST00000514278; ENSP00000425359; ENSG00000152670 [Q9NQI0-4]
GeneIDi54514
KEGGihsa:54514
UCSCiuc003jqg.5, human [Q9NQI0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54514
DisGeNETi54514
EuPathDBiHostDB:ENSG00000152670.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DDX4
HGNCiHGNC:18700, DDX4
HPAiENSG00000152670, Tissue enriched (testis)
MIMi605281, gene
neXtProtiNX_Q9NQI0
OpenTargetsiENSG00000152670
PharmGKBiPA38646

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0335, Eukaryota
GeneTreeiENSGT00940000157507
HOGENOMiCLU_003041_16_3_1
InParanoidiQ9NQI0
KOiK13982
OMAiNRXSNND
OrthoDBi595675at2759
PhylomeDBiQ9NQI0
TreeFamiTF300364

Enzyme and pathway databases

BRENDAi3.6.4.13, 2681
PathwayCommonsiQ9NQI0
ReactomeiR-HSA-5601884, PIWI-interacting RNA (piRNA) biogenesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
54514, 1 hit in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DDX4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54514
PharosiQ9NQI0, Tbio

Protein Ontology

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PROi
PR:Q9NQI0
RNActiQ9NQI0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152670, Expressed in testis and 80 other tissues
ExpressionAtlasiQ9NQI0, baseline and differential
GenevisibleiQ9NQI0, HS

Family and domain databases

DisProtiDP01065
DP01066 [Q9NQI0-2]
InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR000629, RNA-helicase_DEAD-box_CS
IPR014014, RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00039, DEAD_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51195, Q_MOTIF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDDX4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQI0
Secondary accession number(s): A8K8Q2
, B3KSF4, D6RDK4, E9PCD8, Q5M7Z3, Q86VX0, Q9NT92, Q9NYB1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: August 12, 2020
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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