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UniProtKB - Q9NQH7 (XPP3_HUMAN)

Entry version 177 (23 Feb 2022)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

Xaa-Pro aminopeptidase 3

Gene

XPNPEP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala (PubMed:25609706, PubMed:28476889).

Also shows low activity towards peptides with Ala or Ser at the P1 position (PubMed:28476889).

2 Publications

Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+1 PublicationNote: Binds 2 manganese ions per subunit.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.62 mM for Met-Pro-Ala1 Publication
  2. KM=2.45 mM for Leu-Pro-Ala1 Publication
  3. KM=3.06 mM for Phe-Pro-Ala1 Publication
  4. KM=0.55 mM for Tyr-Pro-Ala1 Publication
  5. KM=4.91 mM for Tyr-Ser-Ser1 Publication
  6. KM=4.20 mM for Tyr-Ala-Ala1 Publication
  7. KM=3.74 mM for Tyr-Ser-Ser-Ala-Ala-Ala-Ala1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei300SubstrateCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi331Manganese 2Combined sources1 Publication1
Binding sitei331SubstrateCombined sources1 Publication1
Metal bindingi342Manganese 1Combined sources1 Publication1
Metal bindingi342Manganese 2Combined sources1 Publication1
Binding sitei342SubstrateCombined sources1 Publication1 Publication1
Metal bindingi424Manganese 1Combined sources1 Publication1
Binding sitei424SubstrateCombined sources1 Publication1
Binding sitei431SubstrateCombined sources1 Publication1
Metal bindingi451Manganese 1Combined sources1 Publication1
Binding sitei451SubstrateCombined sources1 Publication1
Metal bindingi475Manganese 1Combined sources1 Publication1
Metal bindingi475Manganese 2Combined sources1 Publication1
Binding sitei475SubstrateCombined sources1 Publication1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
LigandManganese, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.11.9, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NQH7

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NQH7

Protein family/group databases

MEROPS protease database

More...MEROPSi		M24.026

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Xaa-Pro aminopeptidase 3Imported (EC:3.4.11.92 Publications)
Short name:
X-Pro aminopeptidase 3
Alternative name(s):
Aminopeptidase P3
Short name:
APP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XPNPEP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28052, XPNPEP3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613553, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NQH7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196236

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Nephronophthisis-like nephropathy 1 (NPHPL1)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder with features of nephronophthisis, a cystic kidney disease leading to end-stage renal failure. Nephronophthisis is histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. Typical clinical manifestation are chronic renal failure, anemia, polyuria, polydipsia, isosthenuria, and growth retardation. Associations with extrarenal symptoms are frequent. In NPHPL1 patients, extrarenal symptoms include hypertension, essential tremor, sensorineural hearing loss and gout. Severely affected individuals can manifest a mitochondrial disorder with isolated complex I deficiency activity in muscle, seizures, mental retardation and hypertrophic dilated cardiomyopathy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_063820453G → C in NPHPL1. 1 PublicationCorresponds to variant dbSNP:rs267607179EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi18R → A: Prevents cleavage of N-terminal transit peptide; when associated with A-29-30-A; A-39-40-A and A-44. 1 Publication1
Mutagenesisi29 – 30RR → AA: Prevents cleavage of N-terminal transit peptide; when associated with A-18; A-39-40-A and A-44. 1 Publication2
Mutagenesisi39 – 40RR → AA: Prevents cleavage of N-terminal transit peptide; when associated with A-18; A-29-30-A and A-44. 1 Publication2
Mutagenesisi44R → A: Prevents cleavage of N-terminal transit peptide; when associated with A-18; A-29-30-A and A-39-40-A. 1 Publication1
Mutagenesisi314H → A: Impairs catalytic activity. 1 Publication1
Mutagenesisi342D → A: Impairs catalytic activity. 1 Publication1
Mutagenesisi475E → A: Impairs catalytic activity. 1 Publication1

Keywords - Diseasei

Disease variant, Nephronophthisis

Organism-specific databases

DisGeNET

More...DisGeNETi		63929

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		XPNPEP3

MalaCards human disease database

More...MalaCardsi		XPNPEP3
MIMi613159, phenotype

Open Targets

More...OpenTargetsi		ENSG00000196236

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		93589, Late-onset nephronophthisis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA147357130

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NQH7, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3831223

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		XPNPEP3

Domain mapping of disease mutations (DMDM)

More...DMDMi		74761652

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 31MitochondrionSequence analysis1 PublicationAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025565432 – 507Xaa-Pro aminopeptidase 3Add BLAST476

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NQH7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NQH7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NQH7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NQH7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NQH7

PeptideAtlas

More...PeptideAtlasi		Q9NQH7

PRoteomics IDEntifications database

More...PRIDEi		Q9NQH7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82154 [Q9NQH7-1]
82155 [Q9NQH7-2]
82156 [Q9NQH7-3]
82157 [Q9NQH7-4]
82158 [Q9NQH7-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NQH7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NQH7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196236, Expressed in testis and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NQH7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NQH7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196236, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:28476889).

Isoform 1 interacts with TNFRSF1B/TNFR2 (activated) and TRAF2 (PubMed:25609706).

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121997, 62 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9NQH7

Protein interaction database and analysis system

More...IntActi		Q9NQH7, 44 interactors

Molecular INTeraction database

More...MINTi		Q9NQH7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000349658

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NQH7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1507
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NQH7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni54 – 79Interaction with TNFRSF1B1 PublicationAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M24B family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2414, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153657

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_017266_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NQH7

Identification of Orthologs from Complete Genome Data

More...OMAi		HHVGHYI

Database of Orthologous Groups

More...OrthoDBi		352329at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NQH7

TreeFam database of animal gene trees

More...TreeFami		TF314484

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.350.10, 1 hit
3.90.230.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007865, Aminopep_P_N
IPR029149, Creatin/AminoP/Spt16_NTD
IPR036005, Creatinase/aminopeptidase-like
IPR000994, Pept_M24

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05195, AMP_N, 1 hit
PF00557, Peptidase_M24, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01011, AMP_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53092, SSF53092, 1 hit
SSF55920, SSF55920, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQH7-1) [UniParc]FASTAAdd to basket
Also known as: m1 Publication

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPWLLSAPKL VPAVANVRGL SGCMLCSQRR YSLQPVPERR IPNRYLGQPS 
        60         70         80         90        100
PFTHPHLLRP GEVTPGLSQV EYALRRHKLM SLIQKEAQGQ SGTDQTVVVL 
       110        120        130        140        150
SNPTYYMSND IPYTFHQDNN FLYLCGFQEP DSILVLQSLP GKQLPSHKAI 
       160        170        180        190        200
LFVPRRDPSR ELWDGPRSGT DGAIALTGVD EAYTLEEFQH LLPKMKAETN 
       210        220        230        240        250
MVWYDWMRPS HAQLHSDYMQ PLTEAKAKSK NKVRGVQQLI QRLRLIKSPA 
       260        270        280        290        300
EIERMQIAGK LTSQAFIETM FTSKAPVEEA FLYAKFEFEC RARGADILAY 
       310        320        330        340        350
PPVVAGGNRS NTLHYVKNNQ LIKDGEMVLL DGGCESSCYV SDITRTWPVN 
       360        370        380        390        400
GRFTAPQAEL YEAVLEIQRD CLALCFPGTS LENIYSMMLT LIGQKLKDLG 
       410        420        430        440        450
IMKNIKENNA FKAARKYCPH HVGHYLGMDV HDTPDMPRSL PLQPGMVITI 
       460        470        480        490        500
EPGIYIPEDD KDAPEKFRGL GVRIEDDVVV TQDSPLILSA DCPKEMNDIE 

QICSQAS
Length:507
Mass (Da):57,034
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82D886736ABD0B5B
GO
Isoform 2 (identifier: Q9NQH7-2) [UniParc]FASTAAdd to basket
Also known as: c1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:428
Mass (Da):48,112
Checksum:iE95AFE73A5D94D49
GO
Isoform 3 (identifier: Q9NQH7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-278: AFIETMFTSKAPVE → RQGFSVLSRLVSNS
     279-507: Missing.

Show »
Length:278
Mass (Da):31,529
Checksum:iB4AD5CEB13853823
GO
Isoform 4 (identifier: Q9NQH7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:484
Mass (Da):54,672
Checksum:i6320B2E5975918BB
GO
Isoform 5 (identifier: Q9NQH7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-288: AFIETMFTSKAPVEEAFLYAKFEF → KSVLLARHGGSRLYSHHFGRPRLS
     289-507: Missing.

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Length:288
Mass (Da):32,712
Checksum:iE245C092422567ED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0Z2A0A087X0Z2_HUMAN
Xaa-Pro aminopeptidase 3
XPNPEP3 LOC63929, hCG_41117
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z316F2Z316_HUMAN
Xaa-Pro aminopeptidase 3
XPNPEP3
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti340V → A in CAG33677 (Ref. 1) Curated1
Sequence conflicti486L → F in AAH01681 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051573450I → L. Corresponds to variant dbSNP:rs17002243Ensembl.1
Natural variantiVAR_063820453G → C in NPHPL1. 1 PublicationCorresponds to variant dbSNP:rs267607179EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0212961 – 79Missing in isoform 2. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_0401421 – 23Missing in isoform 4. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_040143265 – 288AFIET…AKFEF → KSVLLARHGGSRLYSHHFGR PRLS in isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_021297265 – 278AFIET…KAPVE → RQGFSVLSRLVSNS in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_021298279 – 507Missing in isoform 3. 1 PublicationAdd BLAST229
Alternative sequenceiVSP_040144289 – 507Missing in isoform 5. 1 PublicationAdd BLAST219

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CR457396 mRNA Translation: CAG33677.1
AL365514 mRNA Translation: CAB97210.1
CR456442 mRNA Translation: CAG30328.1
AK301635 mRNA Translation: BAH13526.1
AK301758 mRNA Translation: BAH13548.1
AK313770 mRNA Translation: BAG36508.1
AL834310 mRNA Translation: CAD38980.1
AL035450 Genomic DNA No translation available.
Z98048 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60399.1
BC001208 mRNA Translation: AAH01208.1
BC001681 mRNA Translation: AAH01681.1
BC004989 mRNA Translation: AAH04989.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14007.1 [Q9NQH7-1]

NCBI Reference Sequences

More...RefSeqi		NP_071381.1, NM_022098.3 [Q9NQH7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000357137; ENSP00000349658; ENSG00000196236

Database of genes from NCBI RefSeq genomes

More...GeneIDi		63929

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:63929

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000357137.9; ENSP00000349658.4; NM_022098.4; NP_071381.1

UCSC genome browser

More...UCSCi		uc003azh.4, human [Q9NQH7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR457396 mRNA Translation: CAG33677.1
AL365514 mRNA Translation: CAB97210.1
CR456442 mRNA Translation: CAG30328.1
AK301635 mRNA Translation: BAH13526.1
AK301758 mRNA Translation: BAH13548.1
AK313770 mRNA Translation: BAG36508.1
AL834310 mRNA Translation: CAD38980.1
AL035450 Genomic DNA No translation available.
Z98048 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60399.1
BC001208 mRNA Translation: AAH01208.1
BC001681 mRNA Translation: AAH01681.1
BC004989 mRNA Translation: AAH04989.1
CCDSiCCDS14007.1 [Q9NQH7-1]
RefSeqiNP_071381.1, NM_022098.3 [Q9NQH7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5X49X-ray1.65A/B54-507[»]
SMRiQ9NQH7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121997, 62 interactors
CORUMiQ9NQH7
IntActiQ9NQH7, 44 interactors
MINTiQ9NQH7
STRINGi9606.ENSP00000349658

Chemistry databases

ChEMBLiCHEMBL3831223

Protein family/group databases

MEROPSiM24.026

PTM databases

iPTMnetiQ9NQH7
PhosphoSitePlusiQ9NQH7

Genetic variation databases

BioMutaiXPNPEP3
DMDMi74761652

Proteomic databases

EPDiQ9NQH7
jPOSTiQ9NQH7
MassIVEiQ9NQH7
MaxQBiQ9NQH7
PaxDbiQ9NQH7
PeptideAtlasiQ9NQH7
PRIDEiQ9NQH7
ProteomicsDBi82154 [Q9NQH7-1]
82155 [Q9NQH7-2]
82156 [Q9NQH7-3]
82157 [Q9NQH7-4]
82158 [Q9NQH7-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		259, 146 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		63929

Genome annotation databases

EnsembliENST00000357137; ENSP00000349658; ENSG00000196236
GeneIDi63929
KEGGihsa:63929
MANE-SelectiENST00000357137.9; ENSP00000349658.4; NM_022098.4; NP_071381.1
UCSCiuc003azh.4, human [Q9NQH7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		63929
DisGeNETi63929

GeneCards: human genes, protein and diseases

More...GeneCardsi		XPNPEP3
GeneReviewsiXPNPEP3
HGNCiHGNC:28052, XPNPEP3
HPAiENSG00000196236, Low tissue specificity
MalaCardsiXPNPEP3
MIMi613159, phenotype
613553, gene
neXtProtiNX_Q9NQH7
OpenTargetsiENSG00000196236
Orphaneti93589, Late-onset nephronophthisis
PharmGKBiPA147357130
VEuPathDBiHostDB:ENSG00000196236

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2414, Eukaryota
GeneTreeiENSGT00940000153657
HOGENOMiCLU_017266_1_1_1
InParanoidiQ9NQH7
OMAiHHVGHYI
OrthoDBi352329at2759
PhylomeDBiQ9NQH7
TreeFamiTF314484

Enzyme and pathway databases

BRENDAi3.4.11.9, 2681
PathwayCommonsiQ9NQH7
SignaLinkiQ9NQH7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		63929, 21 hits in 1046 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		XPNPEP3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		XPNPEP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		63929
PharosiQ9NQH7, Tbio

Protein Ontology

More...PROi		PR:Q9NQH7
RNActiQ9NQH7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196236, Expressed in testis and 216 other tissues
ExpressionAtlasiQ9NQH7, baseline and differential
GenevisibleiQ9NQH7, HS

Family and domain databases

Gene3Di3.40.350.10, 1 hit
3.90.230.10, 1 hit
InterProiView protein in InterPro
IPR007865, Aminopep_P_N
IPR029149, Creatin/AminoP/Spt16_NTD
IPR036005, Creatinase/aminopeptidase-like
IPR000994, Pept_M24
PfamiView protein in Pfam
PF05195, AMP_N, 1 hit
PF00557, Peptidase_M24, 1 hit
SMARTiView protein in SMART
SM01011, AMP_N, 1 hit
SUPFAMiSSF53092, SSF53092, 1 hit
SSF55920, SSF55920, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPP3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQH7
Secondary accession number(s): B2R9G1
, B7Z790, B7Z7B2, Q6I9V9, Q8NDA6, Q9BV27, Q9BVH0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: February 23, 2022
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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