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Entry version 115 (08 May 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Protein MANBAL

Gene

MANBAL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein MANBAL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MANBAL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:15799 MANBAL

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9NQG1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 44HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000101363

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30578

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MANBAL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
30316137

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001941791 – 85Protein MANBALAdd BLAST85

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NQG1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NQG1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NQG1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NQG1

PeptideAtlas

More...
PeptideAtlasi
Q9NQG1

PRoteomics IDEntifications database

More...
PRIDEi
Q9NQG1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82147

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9NQG1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NQG1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NQG1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000101363 Expressed in 198 organ(s), highest expression level in left uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NQG1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NQG1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052348

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN1Q9UMX0-23EBI-3867271,EBI-10173939

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121981, 5 interactors

Protein interaction database and analysis system

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IntActi
Q9NQG1, 20 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362707

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NQG1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0239 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J2IC Eukaryota
ENOG4112515 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003422

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232155

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NQG1

Identification of Orthologs from Complete Genome Data

More...
OMAi
PIPKSYE

Database of Orthologous Groups

More...
OrthoDBi
1597344at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NQG1

TreeFam database of animal gene trees

More...
TreeFami
TF324668

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009621 UPF0239

The PANTHER Classification System

More...
PANTHERi
PTHR14409 PTHR14409, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06783 UPF0239, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NQG1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASDLDFSPP EVPEPTFLEN LLRYGLFLGA IFQLICVLAI IVPIPKSHEA
60 70 80
EAEPSEPRSA EVTRKPKAAV PSVNKRPKKE TKKKR
Length:85
Mass (Da):9,467
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EB01B680C9C06A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A2E0A2A2E0_HUMAN
Protein MANBAL
MANBAL
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK292971 mRNA Translation: BAF85660.1
AL034422 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76069.1
CH471077 Genomic DNA Translation: EAW76070.1
BC014672 mRNA Translation: AAH14672.1
BC016822 mRNA Translation: AAH16822.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13293.1

NCBI Reference Sequences

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RefSeqi
NP_001003897.1, NM_001003897.1
NP_071360.1, NM_022077.3
XP_016883495.1, XM_017028006.1
XP_016883496.1, XM_017028007.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373605; ENSP00000362707; ENSG00000101363
ENST00000373606; ENSP00000362708; ENSG00000101363
ENST00000397151; ENSP00000380338; ENSG00000101363
ENST00000397152; ENSP00000380339; ENSG00000101363

Database of genes from NCBI RefSeq genomes

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GeneIDi
63905

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:63905

UCSC genome browser

More...
UCSCi
uc002xgv.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292971 mRNA Translation: BAF85660.1
AL034422 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76069.1
CH471077 Genomic DNA Translation: EAW76070.1
BC014672 mRNA Translation: AAH14672.1
BC016822 mRNA Translation: AAH16822.1
CCDSiCCDS13293.1
RefSeqiNP_001003897.1, NM_001003897.1
NP_071360.1, NM_022077.3
XP_016883495.1, XM_017028006.1
XP_016883496.1, XM_017028007.1

3D structure databases

SMRiQ9NQG1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121981, 5 interactors
IntActiQ9NQG1, 20 interactors
STRINGi9606.ENSP00000362707

PTM databases

iPTMnetiQ9NQG1
PhosphoSitePlusiQ9NQG1

Polymorphism and mutation databases

BioMutaiMANBAL
DMDMi30316137

Proteomic databases

EPDiQ9NQG1
jPOSTiQ9NQG1
MaxQBiQ9NQG1
PaxDbiQ9NQG1
PeptideAtlasiQ9NQG1
PRIDEiQ9NQG1
ProteomicsDBi82147
TopDownProteomicsiQ9NQG1

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
63905
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373605; ENSP00000362707; ENSG00000101363
ENST00000373606; ENSP00000362708; ENSG00000101363
ENST00000397151; ENSP00000380338; ENSG00000101363
ENST00000397152; ENSP00000380339; ENSG00000101363
GeneIDi63905
KEGGihsa:63905
UCSCiuc002xgv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63905

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MANBAL
HGNCiHGNC:15799 MANBAL
HPAiHPA052348
neXtProtiNX_Q9NQG1
OpenTargetsiENSG00000101363
PharmGKBiPA30578

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J2IC Eukaryota
ENOG4112515 LUCA
GeneTreeiENSGT00390000003422
HOGENOMiHOG000232155
InParanoidiQ9NQG1
OMAiPIPKSYE
OrthoDBi1597344at2759
PhylomeDBiQ9NQG1
TreeFamiTF324668

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MANBAL human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
63905

Protein Ontology

More...
PROi
PR:Q9NQG1

Gene expression databases

BgeeiENSG00000101363 Expressed in 198 organ(s), highest expression level in left uterine tube
ExpressionAtlasiQ9NQG1 baseline and differential
GenevisibleiQ9NQG1 HS

Family and domain databases

InterProiView protein in InterPro
IPR009621 UPF0239
PANTHERiPTHR14409 PTHR14409, 1 hit
PfamiView protein in Pfam
PF06783 UPF0239, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMANBL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NQG1
Secondary accession number(s): A8KAA6, E1P5V3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 1, 2000
Last modified: May 8, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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