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Protein

Serine hydrolase-like protein

Gene

SERHL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative serine hydrolase.

Miscellaneous

This gene may have been partially duplicated (see SERHL2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108Sequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERihuman-SERHL AlphaBeta_hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Serine hydrolase-like protein (EC:3.1.-.-)
Short name:
SHL
Gene namesi
Name:SERHL
Synonyms:SERHL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14408 SERHL
neXtProtiNX_Q9NQF3

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi21362940

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976651 – 203Serine hydrolase-like proteinAdd BLAST203

Proteomic databases

PeptideAtlasiQ9NQF3
PRIDEiQ9NQF3
ProteomicsDBi82146

Expressioni

Gene expression databases

CleanExiHS_SERHL
HS_SERHL2

Interactioni

Protein-protein interaction databases

IntActiQ9NQF3, 5 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9NQF3
SMRiQ9NQF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 145AB hydrolase-1Sequence analysisAdd BLAST113

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiKOG1454 Eukaryota
COG0596 LUCA
HOVERGENiHBG093937
InParanoidiQ9NQF3
PhylomeDBiQ9NQF3

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PRINTSiPR00111 ABHYDROLASE
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NQF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENAAPGLI SELKLAVPWG HIAAKAWGSL QGPPVLCLHG WLDNASSFDR
60 70 80 90 100
LIPLLPQDFY YVAMDFGGHG LSSHYSPGVP YYLQTFVSEI RRVVAALKWN
110 120 130 140 150
RFSILGHSFG GVVGGMFFCT FPEMVDKLIL LDTPLFLLES DEMENLLTYK
160 170 180 190 200
RRAIEHVLQV EASQEPSHVF SLKQLLQRQR TALTSSAGSC VRIPSGSCRP

MSC
Length:203
Mass (Da):22,471
Last modified:October 1, 2000 - v1
Checksum:i7451E5712595097E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0569853E → K. Corresponds to variant dbSNP:rs3213549Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365513 mRNA Translation: CAB97209.1
AL022316 Genomic DNA No translation available.
BC093888 mRNA Translation: AAH93888.1
UniGeneiHs.360940

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSERHL_HUMAN
AccessioniPrimary (citable) accession number: Q9NQF3
Secondary accession number(s): Q5JZ95, Q9UH21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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