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Protein

Thymus-specific serine protease

Gene

PRSS16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protease that may play a role in T-cell development.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei185Charge relay systemSequence analysis1
Active sitei447Charge relay systemSequence analysis1
Active sitei472Charge relay systemSequence analysis1

GO - Molecular functioni

  • dipeptidyl-peptidase activity Source: GO_Central
  • serine-type peptidase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

ESTHERihuman-PRSS16 Prolylcarboxypeptidase
MEROPSiS28.003

Names & Taxonomyi

Protein namesi
Recommended name:
Thymus-specific serine protease (EC:3.4.-.-)
Alternative name(s):
Serine protease 16
Gene namesi
Name:PRSS16
Synonyms:TSSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112812.15
HGNCiHGNC:9480 PRSS16
MIMi607169 gene
neXtProtiNX_Q9NQE7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

DisGeNETi10279
OpenTargetsiENSG00000112812
PharmGKBiPA33832

Polymorphism and mutation databases

BioMutaiPRSS16
DMDMi13633990

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000002732025 – 514Thymus-specific serine proteaseAdd BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NQE7
PeptideAtlasiQ9NQE7
PRIDEiQ9NQE7
ProteomicsDBi82144

PTM databases

iPTMnetiQ9NQE7
PhosphoSitePlusiQ9NQE7

Expressioni

Tissue specificityi

Expressed predominantly in cortical thymic epithelial cells.

Developmental stagei

Expressed in fetal thymus.

Gene expression databases

BgeeiENSG00000112812 Expressed in 132 organ(s), highest expression level in thymus
CleanExiHS_PRSS16
ExpressionAtlasiQ9NQE7 baseline and differential
GenevisibleiQ9NQE7 HS

Organism-specific databases

HPAiHPA017743

Interactioni

Protein-protein interaction databases

BioGridi115568, 2 interactors
STRINGi9606.ENSP00000230582

Structurei

3D structure databases

ProteinModelPortaliQ9NQE7
SMRiQ9NQE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S28 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2182 Eukaryota
ENOG410XSGG LUCA
GeneTreeiENSGT00530000063027
HOGENOMiHOG000267153
HOVERGENiHBG018007
InParanoidiQ9NQE7
KOiK09649
OMAiNSYYGGQ
OrthoDBiEOG091G05N0
PhylomeDBiQ9NQE7
TreeFamiTF314855

Family and domain databases

Gene3Di3.40.50.1820, 3 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR008758 Peptidase_S28
PfamiView protein in Pfam
PF05577 Peptidase_S28, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9NQE7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVWLAQWLG PLLLVSLWGL LAPASLLRRL GEHIQQFQES SAQGLGLSLG
60 70 80 90 100
PGAAALPKVG WLEQLLDPFN VSDRRSFLQR YWVNDQHWVG QDGPIFLHLG
110 120 130 140 150
GEGSLGPGSV MRGHPAALAP AWGALVISLE HRFYGLSIPA GGLEMAQLRF
160 170 180 190 200
LSSRLALADV VSARLALSRL FNISSSSPWI CFGGSYAGSL AAWARLKFPH
210 220 230 240 250
LIFASVASSA PVRAVLDFSE YNDVVSRSLM STAIGGSLEC RAAVSVAFAE
260 270 280 290 300
VERRLRSGGA AQAALRTELS ACGPLGRAEN QAELLGALQA LVGGVVQYDG
310 320 330 340 350
QTGAPLSVRQ LCGLLLGGGG NRSHSTPYCG LRRAVQIVLH SLGQKCLSFS
360 370 380 390 400
RAETVAQLRS TEPQLSGVGD RQWLYQTCTE FGFYVTCENP RCPFSQLPAL
410 420 430 440 450
PSQLDLCEQV FGLSALSVAQ AVAQTNSYYG GQTPGANKVL FVNGDTDPWH
460 470 480 490 500
VLSVTQALGS SESTLLIRTG SHCLDMAPER PSDSPSLRLG RQNIFQQLQT
510
WLKLAKESQI KGEV
Length:514
Mass (Da):55,049
Last modified:April 27, 2001 - v2
Checksum:iEF39BC06C560709A
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DZV2B4DZV2_HUMAN
Thymus-specific serine protease
PRSS16
145Annotation score:
F8WBG5F8WBG5_HUMAN
Thymus-specific serine protease
PRSS16
92Annotation score:
F8WF25F8WF25_HUMAN
Thymus-specific serine protease
PRSS16
99Annotation score:
F2Z2N5F2Z2N5_HUMAN
Thymus-specific serine protease
PRSS16
257Annotation score:
C9JDN6C9JDN6_HUMAN
Thymus-specific serine protease
PRSS16
166Annotation score:
H0Y893H0Y893_HUMAN
Thymus-specific serine protease
PRSS16
138Annotation score:
H0Y8B9H0Y8B9_HUMAN
Thymus-specific serine protease
PRSS16
164Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051826104S → I. Corresponds to variant dbSNP:rs5030965Ensembl.1
Natural variantiVAR_051827204A → G. Corresponds to variant dbSNP:rs35466700Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052514 mRNA Translation: AAC33563.1
AL021808 Genomic DNA No translation available.
CCDSiCCDS4623.1
RefSeqiNP_005856.1, NM_005865.3
UniGeneiHs.274407

Genome annotation databases

EnsembliENST00000230582; ENSP00000230582; ENSG00000112812
GeneIDi10279
KEGGihsa:10279
UCSCiuc003nja.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052514 mRNA Translation: AAC33563.1
AL021808 Genomic DNA No translation available.
CCDSiCCDS4623.1
RefSeqiNP_005856.1, NM_005865.3
UniGeneiHs.274407

3D structure databases

ProteinModelPortaliQ9NQE7
SMRiQ9NQE7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115568, 2 interactors
STRINGi9606.ENSP00000230582

Protein family/group databases

ESTHERihuman-PRSS16 Prolylcarboxypeptidase
MEROPSiS28.003

PTM databases

iPTMnetiQ9NQE7
PhosphoSitePlusiQ9NQE7

Polymorphism and mutation databases

BioMutaiPRSS16
DMDMi13633990

Proteomic databases

PaxDbiQ9NQE7
PeptideAtlasiQ9NQE7
PRIDEiQ9NQE7
ProteomicsDBi82144

Protocols and materials databases

DNASUi10279
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230582; ENSP00000230582; ENSG00000112812
GeneIDi10279
KEGGihsa:10279
UCSCiuc003nja.4 human

Organism-specific databases

CTDi10279
DisGeNETi10279
EuPathDBiHostDB:ENSG00000112812.15
GeneCardsiPRSS16
HGNCiHGNC:9480 PRSS16
HPAiHPA017743
MIMi607169 gene
neXtProtiNX_Q9NQE7
OpenTargetsiENSG00000112812
PharmGKBiPA33832
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2182 Eukaryota
ENOG410XSGG LUCA
GeneTreeiENSGT00530000063027
HOGENOMiHOG000267153
HOVERGENiHBG018007
InParanoidiQ9NQE7
KOiK09649
OMAiNSYYGGQ
OrthoDBiEOG091G05N0
PhylomeDBiQ9NQE7
TreeFamiTF314855

Miscellaneous databases

GeneWikiiPRSS16
GenomeRNAii10279
PROiPR:Q9NQE7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112812 Expressed in 132 organ(s), highest expression level in thymus
CleanExiHS_PRSS16
ExpressionAtlasiQ9NQE7 baseline and differential
GenevisibleiQ9NQE7 HS

Family and domain databases

Gene3Di3.40.50.1820, 3 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR008758 Peptidase_S28
PfamiView protein in Pfam
PF05577 Peptidase_S28, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSSP_HUMAN
AccessioniPrimary (citable) accession number: Q9NQE7
Secondary accession number(s): O75416
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: September 12, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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