UniProtKB - Q9NQC7 (CYLD_HUMAN)
Ubiquitin carboxyl-terminal hydrolase CYLD
CYLD
Functioni
Catalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).3 Publications EC:3.4.19.12
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 601 | NucleophilePROSITE-ProRule annotation1 Publication | 1 | |
Metal bindingi | 788 | Zinc 1 | 1 | |
Metal bindingi | 791 | Zinc 1 | 1 | |
Metal bindingi | 799 | Zinc 2 | 1 | |
Metal bindingi | 802 | Zinc 2 | 1 | |
Metal bindingi | 817 | Zinc 1 | 1 | |
Metal bindingi | 820 | Zinc 1 | 1 | |
Metal bindingi | 825 | Zinc 2 | 1 | |
Metal bindingi | 833 | Zinc 2 | 1 | |
Active sitei | 871 | Proton acceptor1 Publication | 1 |
GO - Molecular functioni
- cysteine-type peptidase activity Source: UniProtKB-KW
- Lys48-specific deubiquitinase activity Source: Ensembl
- Lys63-specific deubiquitinase activity Source: UniProtKB
- proline-rich region binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- CD4-positive or CD8-positive, alpha-beta T cell lineage commitment Source: Ensembl
- cell cycle Source: UniProtKB-KW
- homeostasis of number of cells Source: Ensembl
- innate immune response Source: UniProtKB
- necroptotic process Source: GO_Central
- negative regulation of canonical Wnt signaling pathway Source: UniProtKB
- negative regulation of JNK cascade Source: UniProtKB
- negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
- negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
- negative regulation of p38MAPK cascade Source: UniProtKB
- negative regulation of type I interferon production Source: Reactome
- nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
- positive regulation of cellular protein localization Source: Ensembl
- positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
- positive regulation of T cell differentiation Source: Ensembl
- positive regulation of T cell receptor signaling pathway Source: Ensembl
- protein deubiquitination Source: UniProtKB
- protein K63-linked deubiquitination Source: UniProtKB
- protein linear deubiquitination Source: UniProtKB
- regulation of B cell differentiation Source: Ensembl
- regulation of cilium assembly Source: UniProtKB
- regulation of inflammatory response Source: UniProtKB
- regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
- regulation of microtubule cytoskeleton organization Source: UniProtKB
- regulation of mitotic cell cycle Source: UniProtKB
- regulation of necroptotic process Source: UniProtKB
- regulation of protein binding Source: Ensembl
- regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
- ripoptosome assembly involved in necroptotic process Source: Ensembl
- ubiquitin-dependent protein catabolic process Source: InterPro
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Biological process | Cell cycle, Immunity, Innate immunity, Ubl conjugation pathway, Wnt signaling pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9NQC7 |
Reactomei | R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-5357786, TNFR1-induced proapoptotic signaling R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-5689880, Ub-specific processing proteases R-HSA-936440, Negative regulators of DDX58/IFIH1 signaling |
SIGNORi | Q9NQC7 |
Protein family/group databases
MEROPSi | C67.001 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin carboxyl-terminal hydrolase CYLD (EC:3.4.19.123 Publications)Alternative name(s): Deubiquitinating enzyme CYLD Ubiquitin thioesterase CYLD Ubiquitin-specific-processing protease CYLD |
Gene namesi | ORF Names:HSPC057 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2584, CYLD |
MIMi | 605018, gene |
neXtProti | NX_Q9NQC7 |
VEuPathDBi | HostDB:ENSG00000083799.17 |
Subcellular locationi
Plasma membrane
Cytoskeleton
- cytoskeleton
- centrosome 1 Publication
- spindle 1 Publication
- cilium basal body By similarity
Other locations
- Cytoplasm 1 Publication
- perinuclear region
Note: Detected at the microtubule cytoskeleton during interphase. Detected at the midbody during telophase. During metaphase, it remains localized to the centrosome but is also present along the spindle (PubMed:25134987).By similarity1 Publication
Cytoskeleton
- centrosome Source: UniProtKB
- ciliary basal body Source: UniProtKB
- microtubule Source: UniProtKB-KW
- spindle Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
Other locations
- ciliary tip Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, MicrotubulePathology & Biotechi
Involvement in diseasei
Cylindromatosis, familial (FCYL)2 Publications
Multiple familial trichoepithelioma 1 (MFT1)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_045967 | 747 | E → G in MFT1 and BRSS. 1 PublicationCorresponds to variant dbSNP:rs121908389EnsemblClinVar. | 1 |
Brooke-Spiegler syndrome (BRSS)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_045967 | 747 | E → G in MFT1 and BRSS. 1 PublicationCorresponds to variant dbSNP:rs121908389EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 418 | S → A: Reduced phosphorylation; when associated with A-422; A-432 and A-436. Loss of phosphorylation; when associated with A-422; A-432; A-436; A-439; A-441 and A-444. 1 Publication | 1 | |
Mutagenesisi | 418 | S → E: Abolishes deubiquitination of TRAF2; when associated with E-422; E-432; E-436; E-439; E-441 and E-444. 1 Publication | 1 | |
Mutagenesisi | 422 | S → A: Reduced phosphorylation; when associated with A-418; A-432 and A-436. Loss of phosphorylation; when associated with A-418; A-432; A-436; A-439; A-441 and A-444. 1 Publication | 1 | |
Mutagenesisi | 422 | S → E: Abolishes deubiquitination of TRAF2; when associated with E-418; E-432; E-436; E-439; E-441 and E-444. 1 Publication | 1 | |
Mutagenesisi | 432 | S → A: Slightly reduced phosphorylation; when associated with A-436. Reduced phosphorylation; when associated with A-418; A-422 and A-436. Loss of phosphorylation; when associated with A-418; A-422; A-436; A-439; A-441 and A-444. 1 Publication | 1 | |
Mutagenesisi | 432 | S → E: Abolishes deubiquitination of TRAF2; when associated with E-418; E-422; E-436; E-439; E-441 and E-444. 1 Publication | 1 | |
Mutagenesisi | 436 | S → A: Slightly reduced phosphorylation; when associated with A-432. Reduced phosphorylation; when associated with A-418; A-422 and A-432. Loss of phosphorylation; when associated with A-418; A-422; A-432; A-439; A-441 and A-444. 1 Publication | 1 | |
Mutagenesisi | 436 | S → E: Abolishes deubiquitination of TRAF2; when associated with E-418; E-422; E-432; E-439; E-441 and E-444. 1 Publication | 1 | |
Mutagenesisi | 439 | S → A: Loss of phosphorylation; when associated with A-418; A-422; A-432; A-436; A-441 and A-444. 1 Publication | 1 | |
Mutagenesisi | 439 | S → E: Abolishes deubiquitination of TRAF2; when associated with E-418; E-422; E-432; E-436; E-441 and E-444. 1 Publication | 1 | |
Mutagenesisi | 441 | S → A: Loss of phosphorylation; when associated with A-418; A-422; A-432; A-436; A-439 and A-444. 1 Publication | 1 | |
Mutagenesisi | 441 | S → E: Abolishes deubiquitination of TRAF2; when associated with E-418; E-422; E-432; E-436; E-439 and E-444. 1 Publication | 1 | |
Mutagenesisi | 444 | S → A: Loss of phosphorylation; when associated with A-418; A-422; A-432; A-436; A-439 and A-441. 1 Publication | 1 | |
Mutagenesisi | 444 | S → E: Abolishes deubiquitination of TRAF2; when associated with E-418; E-422; E-432; E-436; E-439 and E-441. 1 Publication | 1 | |
Mutagenesisi | 457 | S → A: Abolishes binding to TRAF2. 1 Publication | 1 | |
Mutagenesisi | 601 | C → A or S: Loss of deubiquitinating activity. 5 Publications | 1 | |
Mutagenesisi | 622 | L → D: Impaired interaction with SPATA2. 1 Publication | 1 | |
Mutagenesisi | 871 | H → N: Loss of deubiquitinating activity. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Tumor suppressorOrganism-specific databases
DisGeNETi | 1540 |
MalaCardsi | CYLD |
MIMi | 132700, phenotype 601606, phenotype 605041, phenotype |
OpenTargetsi | ENSG00000083799 |
Orphaneti | 211, Familial cylindromatosis 867, Familial multiple trichoepithelioma |
PharmGKBi | PA27084 |
Miscellaneous databases
Pharosi | Q9NQC7, Tbio |
Genetic variation databases
BioMutai | CYLD |
DMDMi | 51316104 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080698 | 1 – 956 | Ubiquitin carboxyl-terminal hydrolase CYLDAdd BLAST | 956 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 387 | PhosphoserineCombined sources | 1 | |
Modified residuei | 418 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 422 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q9NQC7 |
MassIVEi | Q9NQC7 |
MaxQBi | Q9NQC7 |
PaxDbi | Q9NQC7 |
PeptideAtlasi | Q9NQC7 |
PRIDEi | Q9NQC7 |
ProteomicsDBi | 82139 [Q9NQC7-1] 82140 [Q9NQC7-2] |
PTM databases
iPTMneti | Q9NQC7 |
PhosphoSitePlusi | Q9NQC7 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000083799, Expressed in caudate nucleus and 243 other tissues |
ExpressionAtlasi | Q9NQC7, baseline and differential |
Genevisiblei | Q9NQC7, HS |
Organism-specific databases
HPAi | ENSG00000083799, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via CAP-Gly domain) with IKBKG/NEMO (via proline-rich C-terminal region) (PubMed:12917689, PubMed:12917690, PubMed:12917691, PubMed:15341735).
Interacts with TRAF2 and TRIP (PubMed:12917691, PubMed:14676304).
Interacts with PLK1, DVL1, DVL3, MAVS, TBK1, IKKE and DDX58 (PubMed:17495026, PubMed:18636086, PubMed:20227366).
Interacts (via CAP-Gly domain) with microtubules (PubMed:19893491).
Interacts with HDAC6 and BCL3 (PubMed:19893491).
Interacts with MAP3K7 (By similarity).
Identified in a complex with TRAF6 and SQSTM1 (By similarity).
Interacts with CEP350 (PubMed:25134987).
Interacts with RNF31; the interaction is indirect and is mediated via SPATA2 (PubMed:26997266).
Interacts with SPATA2 (via the PUB domain); the interaction is direct and recruits CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049).
By similarity15 PublicationsBinary interactionsi
Hide detailsQ9NQC7
GO - Molecular functioni
- proline-rich region binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107920, 809 interactors |
CORUMi | Q9NQC7 |
IntActi | Q9NQC7, 56 interactors |
MINTi | Q9NQC7 |
STRINGi | 9606.ENSP00000392025 |
Miscellaneous databases
RNActi | Q9NQC7, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9NQC7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NQC7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 153 – 198 | CAP-Gly 1PROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 253 – 286 | CAP-Gly 2PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 492 – 535 | CAP-Gly 3PROSITE-ProRule annotationAdd BLAST | 44 | |
Domaini | 592 – 950 | USPAdd BLAST | 359 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 106 – 593 | Interaction with TRIP1 PublicationAdd BLAST | 488 | |
Regioni | 394 – 469 | Interaction with TRAF2Add BLAST | 76 | |
Regioni | 470 – 554 | Interaction with IKBKG/NEMO1 PublicationAdd BLAST | 85 | |
Regioni | 781 – 833 | B-box2 PublicationsAdd BLAST | 53 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3556, Eukaryota |
GeneTreei | ENSGT00390000018123 |
InParanoidi | Q9NQC7 |
OMAi | FNGVQLC |
OrthoDBi | 119442at2759 |
PhylomeDBi | Q9NQC7 |
TreeFami | TF318734 |
Family and domain databases
Gene3Di | 2.30.30.190, 3 hits |
InterProi | View protein in InterPro IPR036859, CAP-Gly_dom_sf IPR000938, CAP-Gly_domain IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF01302, CAP_GLY, 2 hits PF00443, UCH, 1 hit |
SMARTi | View protein in SMART SM01052, CAP_GLY, 3 hits |
SUPFAMi | SSF54001, SSF54001, 1 hit SSF74924, SSF74924, 3 hits |
PROSITEi | View protein in PROSITE PS00845, CAP_GLY_1, 1 hit PS50245, CAP_GLY_2, 2 hits PS00972, USP_1, 1 hit PS50235, USP_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI
60 70 80 90 100
QDRSVGHSRI PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL
110 120 130 140 150
LAITNCEERF SLFKNRNRLS KGLQIDVGCP VKVQLRSGEE KFPGVVRFRG
160 170 180 190 200
PLLAERTVSG IFFGVELLEE GRGQGFTDGV YQGKQLFQCD EDCGVFVALD
210 220 230 240 250
KLELIEDDDT ALESDYAGPG DTMQVELPPL EINSRVSLKV GETIESGTVI
260 270 280 290 300
FCDVLPGKES LGYFVGVDMD NPIGNWDGRF DGVQLCSFAC VESTILLHIN
310 320 330 340 350
DIIPALSESV TQERRPPKLA FMSRGVGDKG SSSHNKPKAT GSTSDPGNRN
360 370 380 390 400
RSELFYTLNG SSVDSQPQSK SKNTWYIDEV AEDPAKSLTE ISTDFDRSSP
410 420 430 440 450
PLQPPPVNSL TTENRFHSLP FSLTKMPNTN GSIGHSPLSL SAQSVMEELN
460 470 480 490 500
TAPVQESPPL AMPPGNSHGL EVGSLAEVKE NPPFYGVIRW IGQPPGLNEV
510 520 530 540 550
LAGLELEDEC AGCTDGTFRG TRYFTCALKK ALFVKLKSCR PDSRFASLQP
560 570 580 590 600
VSNQIERCNS LAFGGYLSEV VEENTPPKME KEGLEIMIGK KKGIQGHYNS
610 620 630 640 650
CYLDSTLFCL FAFSSVLDTV LLRPKEKNDV EYYSETQELL RTEIVNPLRI
660 670 680 690 700
YGYVCATKIM KLRKILEKVE AASGFTSEEK DPEEFLNILF HHILRVEPLL
710 720 730 740 750
KIRSAGQKVQ DCYFYQIFME KNEKVGVPTI QQLLEWSFIN SNLKFAEAPS
760 770 780 790 800
CLIIQMPRFG KDFKLFKKIF PSLELNITDL LEDTPRQCRI CGGLAMYECR
810 820 830 840 850
ECYDDPDISA GKIKQFCKTC NTQVHLHPKR LNHKYNPVSL PKDLPDWDWR
860 870 880 890 900
HGCIPCQNME LFAVLCIETS HYVAFVKYGK DDSAWLFFDS MADRDGGQNG
910 920 930 940 950
FNIPQVTPCP EVGEYLKMSL EDLHSLDSRR IQGCARRLLC DAYMCMYQSP
TMSLYK
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BS09 | H3BS09_HUMAN | Deubiquitinating enzyme CYLD | CYLD | 771 | Annotation score: | ||
J3KRR7 | J3KRR7_HUMAN | Deubiquitinating enzyme CYLD | CYLD | 910 | Annotation score: | ||
H3BSW9 | H3BSW9_HUMAN | Ubiquitin carboxyl-terminal hydrola... | CYLD | 304 | Annotation score: | ||
J3QKR2 | J3QKR2_HUMAN | Ubiquitin carboxyl-terminal hydrola... | CYLD | 104 | Annotation score: | ||
H3BPZ5 | H3BPZ5_HUMAN | Ubiquitin carboxyl-terminal hydrola... | CYLD | 33 | Annotation score: | ||
I3L117 | I3L117_HUMAN | Ubiquitin carboxyl-terminal hydrola... | CYLD | 66 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_045967 | 747 | E → G in MFT1 and BRSS. 1 PublicationCorresponds to variant dbSNP:rs121908389EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011277 | 305 – 307 | Missing in isoform 2. 2 Publications | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ250014 mRNA Translation: CAB93533.1 AB020656 mRNA Translation: BAA74872.2 Different initiation. BC012342 mRNA Translation: AAH12342.1 AF161542 mRNA Translation: AAF29029.1 Frameshift. |
CCDSi | CCDS42164.1 [Q9NQC7-2] CCDS45482.1 [Q9NQC7-1] |
RefSeqi | NP_001035814.1, NM_001042355.1 [Q9NQC7-2] NP_001035877.1, NM_001042412.1 [Q9NQC7-2] NP_056062.1, NM_015247.2 [Q9NQC7-1] XP_005255869.1, XM_005255812.2 XP_006721212.1, XM_006721149.1 XP_011521209.1, XM_011522907.2 XP_016878466.1, XM_017022977.1 XP_016878467.1, XM_017022978.1 [Q9NQC7-2] XP_016878468.1, XM_017022979.1 XP_016878469.1, XM_017022980.1 [Q9NQC7-2] |
Genome annotation databases
Ensembli | ENST00000311559; ENSP00000308928; ENSG00000083799 [Q9NQC7-1] ENST00000398568; ENSP00000381574; ENSG00000083799 [Q9NQC7-2] ENST00000427738; ENSP00000392025; ENSG00000083799 [Q9NQC7-1] ENST00000564326; ENSP00000454515; ENSG00000083799 [Q9NQC7-2] ENST00000569418; ENSP00000457576; ENSG00000083799 [Q9NQC7-2] |
GeneIDi | 1540 |
KEGGi | hsa:1540 |
UCSCi | uc002egq.2, human [Q9NQC7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ250014 mRNA Translation: CAB93533.1 AB020656 mRNA Translation: BAA74872.2 Different initiation. BC012342 mRNA Translation: AAH12342.1 AF161542 mRNA Translation: AAF29029.1 Frameshift. |
CCDSi | CCDS42164.1 [Q9NQC7-2] CCDS45482.1 [Q9NQC7-1] |
RefSeqi | NP_001035814.1, NM_001042355.1 [Q9NQC7-2] NP_001035877.1, NM_001042412.1 [Q9NQC7-2] NP_056062.1, NM_015247.2 [Q9NQC7-1] XP_005255869.1, XM_005255812.2 XP_006721212.1, XM_006721149.1 XP_011521209.1, XM_011522907.2 XP_016878466.1, XM_017022977.1 XP_016878467.1, XM_017022978.1 [Q9NQC7-2] XP_016878468.1, XM_017022979.1 XP_016878469.1, XM_017022980.1 [Q9NQC7-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IXD | NMR | - | A | 460-550 | [»] | |
1WHL | NMR | - | A | 125-206 | [»] | |
1WHM | NMR | - | A | 228-304 | [»] | |
2VHF | X-ray | 2.80 | A/B | 583-956 | [»] | |
SMRi | Q9NQC7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107920, 809 interactors |
CORUMi | Q9NQC7 |
IntActi | Q9NQC7, 56 interactors |
MINTi | Q9NQC7 |
STRINGi | 9606.ENSP00000392025 |
Protein family/group databases
MEROPSi | C67.001 |
PTM databases
iPTMneti | Q9NQC7 |
PhosphoSitePlusi | Q9NQC7 |
Genetic variation databases
BioMutai | CYLD |
DMDMi | 51316104 |
Proteomic databases
jPOSTi | Q9NQC7 |
MassIVEi | Q9NQC7 |
MaxQBi | Q9NQC7 |
PaxDbi | Q9NQC7 |
PeptideAtlasi | Q9NQC7 |
PRIDEi | Q9NQC7 |
ProteomicsDBi | 82139 [Q9NQC7-1] 82140 [Q9NQC7-2] |
Protocols and materials databases
Antibodypediai | 3193, 295 antibodies |
Genome annotation databases
Ensembli | ENST00000311559; ENSP00000308928; ENSG00000083799 [Q9NQC7-1] ENST00000398568; ENSP00000381574; ENSG00000083799 [Q9NQC7-2] ENST00000427738; ENSP00000392025; ENSG00000083799 [Q9NQC7-1] ENST00000564326; ENSP00000454515; ENSG00000083799 [Q9NQC7-2] ENST00000569418; ENSP00000457576; ENSG00000083799 [Q9NQC7-2] |
GeneIDi | 1540 |
KEGGi | hsa:1540 |
UCSCi | uc002egq.2, human [Q9NQC7-1] |
Organism-specific databases
CTDi | 1540 |
DisGeNETi | 1540 |
GeneCardsi | CYLD |
HGNCi | HGNC:2584, CYLD |
HPAi | ENSG00000083799, Low tissue specificity |
MalaCardsi | CYLD |
MIMi | 132700, phenotype 601606, phenotype 605018, gene 605041, phenotype |
neXtProti | NX_Q9NQC7 |
OpenTargetsi | ENSG00000083799 |
Orphaneti | 211, Familial cylindromatosis 867, Familial multiple trichoepithelioma |
PharmGKBi | PA27084 |
VEuPathDBi | HostDB:ENSG00000083799.17 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3556, Eukaryota |
GeneTreei | ENSGT00390000018123 |
InParanoidi | Q9NQC7 |
OMAi | FNGVQLC |
OrthoDBi | 119442at2759 |
PhylomeDBi | Q9NQC7 |
TreeFami | TF318734 |
Enzyme and pathway databases
PathwayCommonsi | Q9NQC7 |
Reactomei | R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-5357786, TNFR1-induced proapoptotic signaling R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-5689880, Ub-specific processing proteases R-HSA-936440, Negative regulators of DDX58/IFIH1 signaling |
SIGNORi | Q9NQC7 |
Miscellaneous databases
BioGRID-ORCSi | 1540, 17 hits in 879 CRISPR screens |
ChiTaRSi | CYLD, human |
EvolutionaryTracei | Q9NQC7 |
GeneWikii | CYLD_(gene) |
GenomeRNAii | 1540 |
Pharosi | Q9NQC7, Tbio |
PROi | PR:Q9NQC7 |
RNActi | Q9NQC7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000083799, Expressed in caudate nucleus and 243 other tissues |
ExpressionAtlasi | Q9NQC7, baseline and differential |
Genevisiblei | Q9NQC7, HS |
Family and domain databases
Gene3Di | 2.30.30.190, 3 hits |
InterProi | View protein in InterPro IPR036859, CAP-Gly_dom_sf IPR000938, CAP-Gly_domain IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF01302, CAP_GLY, 2 hits PF00443, UCH, 1 hit |
SMARTi | View protein in SMART SM01052, CAP_GLY, 3 hits |
SUPFAMi | SSF54001, SSF54001, 1 hit SSF74924, SSF74924, 3 hits |
PROSITEi | View protein in PROSITE PS00845, CAP_GLY_1, 1 hit PS50245, CAP_GLY_2, 2 hits PS00972, USP_1, 1 hit PS50235, USP_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CYLD_HUMAN | |
Accessioni | Q9NQC7Primary (citable) accession number: Q9NQC7 Secondary accession number(s): O94934 Q9NZX9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 187 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Peptidase families
Classification of peptidase families and list of entries