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UniProtKB - Q9NQC7 (CYLD_HUMAN)

Protein

Ubiquitin carboxyl-terminal hydrolase CYLD

Gene

CYLD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18636086, PubMed:26670046, PubMed:27458237, PubMed:26997266, PubMed:27591049, PubMed:29291351, PubMed:18313383). Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26997266, PubMed:26670046, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351).By similarity15 Publications

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).3 Publications

Activity regulationi

Inhibited by phosphorylation at serine residues.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei601NucleophilePROSITE-ProRule annotation1 Publication1
Metal bindingi788Zinc 11
Metal bindingi791Zinc 11
Metal bindingi799Zinc 21
Metal bindingi802Zinc 21
Metal bindingi817Zinc 11
Metal bindingi820Zinc 11
Metal bindingi825Zinc 21
Metal bindingi833Zinc 21
Active sitei871Proton acceptor1 Publication1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processCell cycle, Immunity, Innate immunity, Ubl conjugation pathway, Wnt signaling pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-5357786 TNFR1-induced proapoptotic signaling
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-5689880 Ub-specific processing proteases
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
SIGNORiQ9NQC7

Protein family/group databases

MEROPSiC67.001

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase CYLD (EC:3.4.19.123 Publications)
Alternative name(s):
Deubiquitinating enzyme CYLD
Ubiquitin thioesterase CYLD
Ubiquitin-specific-processing protease CYLD
Gene namesi
Name:CYLD1 PublicationImported
Synonyms:CYLD1, KIAA08491 Publication
ORF Names:HSPC057
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000083799.17
HGNCiHGNC:2584 CYLD
MIMi605018 gene
neXtProtiNX_Q9NQC7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechi

Involvement in diseasei

Cylindromatosis, familial (FCYL)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by multiple skin tumors that develop from skin appendages, such as hair follicles and sweat glands. Affected individuals typically develop large numbers of tumors called cylindromas that arise predominantly in hairy parts of the body with approximately 90% on the head and neck. In severely affected individuals, cylindromas may combine into a confluent mass which may ulcerate or become infected (turban tumor syndrome). Individuals with familial cylindromatosis occasionally develop other types of tumors including spiradenomas that begin in sweat glands, and trichoepitheliomas arising from hair follicles.
See also OMIM:132700
Multiple familial trichoepithelioma 1 (MFT1)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal dominant dermatosis characterized by the presence of many skin tumors predominantly on the face. Since histologic examination shows dermal aggregates of basaloid cells with connection to or differentiation toward hair follicles, this disorder has been thought to represent a benign hamartoma of the pilosebaceous apparatus. Trichoepitheliomas can degenerate into basal cell carcinoma.
See also OMIM:601606
Brooke-Spiegler syndrome (BRSS)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by the appearance of multiple skin appendage tumors such as cylindroma, trichoepithelioma, and spiradenoma. These tumors are typically located in the head and neck region, appear in early adulthood, and gradually increase in size and number throughout life.
See also OMIM:605041

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi418S → A: Reduced phosphorylation; when associated with A-422; A-432 and A-436. Loss of phosphorylation; when associated with A-422; A-432; A-436; A-439; A-441 and A-444. 1 Publication1
Mutagenesisi418S → E: Abolishes deubiquitination of TRAF2; when associated with E-422; E-432; E-436; E-439; E-441 and E-444. 1 Publication1
Mutagenesisi422S → A: Reduced phosphorylation; when associated with A-418; A-432 and A-436. Loss of phosphorylation; when associated with A-418; A-432; A-436; A-439; A-441 and A-444. 1 Publication1
Mutagenesisi422S → E: Abolishes deubiquitination of TRAF2; when associated with E-418; E-432; E-436; E-439; E-441 and E-444. 1 Publication1
Mutagenesisi432S → A: Slightly reduced phosphorylation; when associated with A-436. Reduced phosphorylation; when associated with A-418; A-422 and A-436. Loss of phosphorylation; when associated with A-418; A-422; A-436; A-439; A-441 and A-444. 1 Publication1
Mutagenesisi432S → E: Abolishes deubiquitination of TRAF2; when associated with E-418; E-422; E-436; E-439; E-441 and E-444. 1 Publication1
Mutagenesisi436S → A: Slightly reduced phosphorylation; when associated with A-432. Reduced phosphorylation; when associated with A-418; A-422 and A-432. Loss of phosphorylation; when associated with A-418; A-422; A-432; A-439; A-441 and A-444. 1 Publication1
Mutagenesisi436S → E: Abolishes deubiquitination of TRAF2; when associated with E-418; E-422; E-432; E-439; E-441 and E-444. 1 Publication1
Mutagenesisi439S → A: Loss of phosphorylation; when associated with A-418; A-422; A-432; A-436; A-441 and A-444. 1 Publication1
Mutagenesisi439S → E: Abolishes deubiquitination of TRAF2; when associated with E-418; E-422; E-432; E-436; E-441 and E-444. 1 Publication1
Mutagenesisi441S → A: Loss of phosphorylation; when associated with A-418; A-422; A-432; A-436; A-439 and A-444. 1 Publication1
Mutagenesisi441S → E: Abolishes deubiquitination of TRAF2; when associated with E-418; E-422; E-432; E-436; E-439 and E-444. 1 Publication1
Mutagenesisi444S → A: Loss of phosphorylation; when associated with A-418; A-422; A-432; A-436; A-439 and A-441. 1 Publication1
Mutagenesisi444S → E: Abolishes deubiquitination of TRAF2; when associated with E-418; E-422; E-432; E-436; E-439 and E-441. 1 Publication1
Mutagenesisi457S → A: Abolishes binding to TRAF2. 1 Publication1
Mutagenesisi601C → A or S: Loss of deubiquitinating activity. 5 Publications1
Mutagenesisi622L → D: Impaired interaction with SPATA2. 1 Publication1
Mutagenesisi871H → N: Loss of deubiquitinating activity. 1 Publication1

Keywords - Diseasei

Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNETi1540
MalaCardsiCYLD
MIMi132700 phenotype
601606 phenotype
605041 phenotype
OpenTargetsiENSG00000083799
Orphaneti211 Familial cylindromatosis
867 Familial multiple trichoepithelioma
PharmGKBiPA27084

Polymorphism and mutation databases

BioMutaiCYLD
DMDMi51316104

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806981 – 956Ubiquitin carboxyl-terminal hydrolase CYLDAdd BLAST956

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei387PhosphoserineCombined sources1
Modified residuei418PhosphoserineCombined sources1 Publication1
Modified residuei422PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated. Polyubiquitinated in hepatocytes treated with palmitic acid. Ubiquitination is mediated by E3 ligase TRIM47 and leads to proteasomal degradation.1 Publication
Phosphorylated on several serine residues by IKKA and/or IKKB in response to immune stimuli. Phosphorylation requires IKBKG. Phosphorylation abolishes TRAF2 deubiquitination, interferes with the activation of Jun kinases, and strongly reduces CD40-dependent gene activation by NF-kappa-B.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NQC7
MaxQBiQ9NQC7
PaxDbiQ9NQC7
PeptideAtlasiQ9NQC7
PRIDEiQ9NQC7
ProteomicsDBi82139
82140 [Q9NQC7-2]

PTM databases

iPTMnetiQ9NQC7
PhosphoSitePlusiQ9NQC7

Expressioni

Tissue specificityi

Detected in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney.2 Publications

Gene expression databases

BgeeiENSG00000083799 Expressed in 229 organ(s), highest expression level in caudate nucleus
CleanExiHS_CYLD
ExpressionAtlasiQ9NQC7 baseline and differential
GenevisibleiQ9NQC7 HS

Organism-specific databases

HPAiCAB011713
HPA050095

Interactioni

Subunit structurei

Interacts (via CAP-Gly domain) with IKBKG/NEMO (via proline-rich C-terminal region) (PubMed:12917689, PubMed:12917690, PubMed:12917691, PubMed:15341735). Interacts with TRAF2 and TRIP (PubMed:12917691, PubMed:14676304). Interacts with PLK1, DVL1, DVL3, MAVS, TBK1, IKKE and DDX58 (PubMed:17495026, PubMed:18636086, PubMed:20227366). Interacts (via CAP-Gly domain) with microtubules (PubMed:19893491). Interacts with HDAC6 and BCL3 (PubMed:19893491). Interacts with MAP3K7 (By similarity). Identified in a complex with TRAF6 and SQSTM1 (By similarity). Interacts with CEP350 (PubMed:25134987). Interacts with RNF31; the interaction is indirect and is mediated via SPATA2 (PubMed:26997266). Interacts with SPATA2 (via the PUB domain); the interaction is direct and recruits CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049).By similarity15 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi107920, 616 interactors
CORUMiQ9NQC7
IntActiQ9NQC7, 32 interactors
MINTiQ9NQC7
STRINGi9606.ENSP00000308928

Structurei

Secondary structure

1956
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NQC7
SMRiQ9NQC7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NQC7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 198CAP-Gly 1PROSITE-ProRule annotationAdd BLAST46
Domaini253 – 286CAP-Gly 2PROSITE-ProRule annotationAdd BLAST34
Domaini492 – 535CAP-Gly 3PROSITE-ProRule annotationAdd BLAST44
Domaini592 – 950USPAdd BLAST359

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 593Interaction with TRIP1 PublicationAdd BLAST488
Regioni394 – 469Interaction with TRAF2Add BLAST76
Regioni470 – 554Interaction with IKBKG/NEMO1 PublicationAdd BLAST85
Regioni781 – 833B-box2 PublicationsAdd BLAST53

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3556 Eukaryota
ENOG410XP6I LUCA
GeneTreeiENSGT00390000018123
HOGENOMiHOG000006796
HOVERGENiHBG051281
InParanoidiQ9NQC7
KOiK08601
OMAiYWEERIF
OrthoDBiEOG091G015D
PhylomeDBiQ9NQC7
TreeFamiTF318734

Family and domain databases

Gene3Di2.30.30.190, 3 hits
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF01302 CAP_GLY, 2 hits
PF00443 UCH, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 3 hits
SUPFAMiSSF54001 SSF54001, 1 hit
SSF74924 SSF74924, 3 hits
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 2 hits
PS00972 USP_1, 1 hit
PS50235 USP_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NQC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI 
        60         70         80         90        100
QDRSVGHSRI PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL 
       110        120        130        140        150
LAITNCEERF SLFKNRNRLS KGLQIDVGCP VKVQLRSGEE KFPGVVRFRG 
       160        170        180        190        200
PLLAERTVSG IFFGVELLEE GRGQGFTDGV YQGKQLFQCD EDCGVFVALD 
       210        220        230        240        250
KLELIEDDDT ALESDYAGPG DTMQVELPPL EINSRVSLKV GETIESGTVI 
       260        270        280        290        300
FCDVLPGKES LGYFVGVDMD NPIGNWDGRF DGVQLCSFAC VESTILLHIN 
       310        320        330        340        350
DIIPALSESV TQERRPPKLA FMSRGVGDKG SSSHNKPKAT GSTSDPGNRN 
       360        370        380        390        400
RSELFYTLNG SSVDSQPQSK SKNTWYIDEV AEDPAKSLTE ISTDFDRSSP 
       410        420        430        440        450
PLQPPPVNSL TTENRFHSLP FSLTKMPNTN GSIGHSPLSL SAQSVMEELN 
       460        470        480        490        500
TAPVQESPPL AMPPGNSHGL EVGSLAEVKE NPPFYGVIRW IGQPPGLNEV 
       510        520        530        540        550
LAGLELEDEC AGCTDGTFRG TRYFTCALKK ALFVKLKSCR PDSRFASLQP 
       560        570        580        590        600
VSNQIERCNS LAFGGYLSEV VEENTPPKME KEGLEIMIGK KKGIQGHYNS 
       610        620        630        640        650
CYLDSTLFCL FAFSSVLDTV LLRPKEKNDV EYYSETQELL RTEIVNPLRI 
       660        670        680        690        700
YGYVCATKIM KLRKILEKVE AASGFTSEEK DPEEFLNILF HHILRVEPLL 
       710        720        730        740        750
KIRSAGQKVQ DCYFYQIFME KNEKVGVPTI QQLLEWSFIN SNLKFAEAPS 
       760        770        780        790        800
CLIIQMPRFG KDFKLFKKIF PSLELNITDL LEDTPRQCRI CGGLAMYECR 
       810        820        830        840        850
ECYDDPDISA GKIKQFCKTC NTQVHLHPKR LNHKYNPVSL PKDLPDWDWR 
       860        870        880        890        900
HGCIPCQNME LFAVLCIETS HYVAFVKYGK DDSAWLFFDS MADRDGGQNG 
       910        920        930        940        950
FNIPQVTPCP EVGEYLKMSL EDLHSLDSRR IQGCARRLLC DAYMCMYQSP 

TMSLYK
Length:956
Mass (Da):107,316
Last modified:October 1, 2000 - v1
Checksum:i01831F9A83424631
GO
Isoform 2 (identifier: Q9NQC7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-307: Missing.

Show »
Length:953
Mass (Da):107,044
Checksum:i0CCB3D21E2FF8851
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KRR7J3KRR7_HUMAN
Ubiquitin carboxyl-terminal hydrola...
CYLD
910Annotation score:
H3BS09H3BS09_HUMAN
Ubiquitin carboxyl-terminal hydrola...
CYLD
771Annotation score:
H3BSW9H3BSW9_HUMAN
Ubiquitin carboxyl-terminal hydrola...
CYLD
304Annotation score:
H3BTB8H3BTB8_HUMAN
Ubiquitin carboxyl-terminal hydrola...
CYLD
166Annotation score:
J3QKR2J3QKR2_HUMAN
Ubiquitin carboxyl-terminal hydrola...
CYLD
104Annotation score:
H3BPZ5H3BPZ5_HUMAN
Ubiquitin carboxyl-terminal hydrola...
CYLD
33Annotation score:
I3L117I3L117_HUMAN
Ubiquitin carboxyl-terminal hydrola...
CYLD
66Annotation score:

Sequence cautioni

The sequence AAF29029 differs from that shown. Reason: Frameshift at positions 776, 808 and 932.Curated
The sequence BAA74872 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045967747E → G in MFT1 and BRSS. 1 PublicationCorresponds to variant dbSNP:rs121908389EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011277305 – 307Missing in isoform 2. 2 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250014 mRNA Translation: CAB93533.1
AB020656 mRNA Translation: BAA74872.2 Different initiation.
BC012342 mRNA Translation: AAH12342.1
AF161542 mRNA Translation: AAF29029.1 Frameshift.
CCDSiCCDS42164.1 [Q9NQC7-2]
CCDS45482.1 [Q9NQC7-1]
RefSeqiNP_001035814.1, NM_001042355.1 [Q9NQC7-2]
NP_001035877.1, NM_001042412.1 [Q9NQC7-2]
NP_056062.1, NM_015247.2 [Q9NQC7-1]
XP_005255869.1, XM_005255812.2 [Q9NQC7-2]
XP_006721212.1, XM_006721149.1 [Q9NQC7-2]
XP_011521209.1, XM_011522907.2 [Q9NQC7-2]
XP_016878466.1, XM_017022977.1 [Q9NQC7-2]
XP_016878467.1, XM_017022978.1 [Q9NQC7-2]
XP_016878468.1, XM_017022979.1 [Q9NQC7-2]
XP_016878469.1, XM_017022980.1 [Q9NQC7-2]
UniGeneiHs.578973

Genome annotation databases

EnsembliENST00000311559; ENSP00000308928; ENSG00000083799 [Q9NQC7-1]
ENST00000398568; ENSP00000381574; ENSG00000083799 [Q9NQC7-2]
ENST00000427738; ENSP00000392025; ENSG00000083799 [Q9NQC7-1]
ENST00000564326; ENSP00000454515; ENSG00000083799 [Q9NQC7-2]
ENST00000569418; ENSP00000457576; ENSG00000083799 [Q9NQC7-2]
GeneIDi1540
KEGGihsa:1540
UCSCiuc002egq.2 human [Q9NQC7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250014 mRNA Translation: CAB93533.1
AB020656 mRNA Translation: BAA74872.2 Different initiation.
BC012342 mRNA Translation: AAH12342.1
AF161542 mRNA Translation: AAF29029.1 Frameshift.
CCDSiCCDS42164.1 [Q9NQC7-2]
CCDS45482.1 [Q9NQC7-1]
RefSeqiNP_001035814.1, NM_001042355.1 [Q9NQC7-2]
NP_001035877.1, NM_001042412.1 [Q9NQC7-2]
NP_056062.1, NM_015247.2 [Q9NQC7-1]
XP_005255869.1, XM_005255812.2 [Q9NQC7-2]
XP_006721212.1, XM_006721149.1 [Q9NQC7-2]
XP_011521209.1, XM_011522907.2 [Q9NQC7-2]
XP_016878466.1, XM_017022977.1 [Q9NQC7-2]
XP_016878467.1, XM_017022978.1 [Q9NQC7-2]
XP_016878468.1, XM_017022979.1 [Q9NQC7-2]
XP_016878469.1, XM_017022980.1 [Q9NQC7-2]
UniGeneiHs.578973

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IXDNMR-A460-550[»]
1WHLNMR-A125-206[»]
1WHMNMR-A228-304[»]
2VHFX-ray2.80A/B583-956[»]
ProteinModelPortaliQ9NQC7
SMRiQ9NQC7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107920, 616 interactors
CORUMiQ9NQC7
IntActiQ9NQC7, 32 interactors
MINTiQ9NQC7
STRINGi9606.ENSP00000308928

Protein family/group databases

MEROPSiC67.001

PTM databases

iPTMnetiQ9NQC7
PhosphoSitePlusiQ9NQC7

Polymorphism and mutation databases

BioMutaiCYLD
DMDMi51316104

Proteomic databases

EPDiQ9NQC7
MaxQBiQ9NQC7
PaxDbiQ9NQC7
PeptideAtlasiQ9NQC7
PRIDEiQ9NQC7
ProteomicsDBi82139
82140 [Q9NQC7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311559; ENSP00000308928; ENSG00000083799 [Q9NQC7-1]
ENST00000398568; ENSP00000381574; ENSG00000083799 [Q9NQC7-2]
ENST00000427738; ENSP00000392025; ENSG00000083799 [Q9NQC7-1]
ENST00000564326; ENSP00000454515; ENSG00000083799 [Q9NQC7-2]
ENST00000569418; ENSP00000457576; ENSG00000083799 [Q9NQC7-2]
GeneIDi1540
KEGGihsa:1540
UCSCiuc002egq.2 human [Q9NQC7-1]

Organism-specific databases

CTDi1540
DisGeNETi1540
EuPathDBiHostDB:ENSG00000083799.17
GeneCardsiCYLD
HGNCiHGNC:2584 CYLD
HPAiCAB011713
HPA050095
MalaCardsiCYLD
MIMi132700 phenotype
601606 phenotype
605018 gene
605041 phenotype
neXtProtiNX_Q9NQC7
OpenTargetsiENSG00000083799
Orphaneti211 Familial cylindromatosis
867 Familial multiple trichoepithelioma
PharmGKBiPA27084
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3556 Eukaryota
ENOG410XP6I LUCA
GeneTreeiENSGT00390000018123
HOGENOMiHOG000006796
HOVERGENiHBG051281
InParanoidiQ9NQC7
KOiK08601
OMAiYWEERIF
OrthoDBiEOG091G015D
PhylomeDBiQ9NQC7
TreeFamiTF318734

Enzyme and pathway databases

ReactomeiR-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-5357786 TNFR1-induced proapoptotic signaling
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-5689880 Ub-specific processing proteases
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
SIGNORiQ9NQC7

Miscellaneous databases

ChiTaRSiCYLD human
EvolutionaryTraceiQ9NQC7
GeneWikiiCYLD_(gene)
GenomeRNAii1540
PROiPR:Q9NQC7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000083799 Expressed in 229 organ(s), highest expression level in caudate nucleus
CleanExiHS_CYLD
ExpressionAtlasiQ9NQC7 baseline and differential
GenevisibleiQ9NQC7 HS

Family and domain databases

Gene3Di2.30.30.190, 3 hits
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF01302 CAP_GLY, 2 hits
PF00443 UCH, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 3 hits
SUPFAMiSSF54001 SSF54001, 1 hit
SSF74924 SSF74924, 3 hits
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 2 hits
PS00972 USP_1, 1 hit
PS50235 USP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYLD_HUMAN
AccessioniPrimary (citable) accession number: Q9NQC7
Secondary accession number(s): O94934
, Q7L3N6, Q96EH0, Q9NZX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2000
Last modified: October 10, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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